scholarly journals Beneficial Effects of Plant Extracts and Bioactive Food Components in Childhood Supplementation

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3157
Author(s):  
Hammad Ullah ◽  
Anna De Filippis ◽  
Alessandra Baldi ◽  
Marco Dacrema ◽  
Cristina Esposito ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Serious Adverse Events ◽  
Childhood Disorders ◽  
Respiratory Illnesses ◽  
Childhood Nutrition ◽  
Beneficial Effects ◽  
Food Components ◽  
Bioactive Food Components ◽  
Dietary Components ◽  
Botanical Extract

The pivotal role of childhood nutrition has always roused a growing interest from the scientific community. Plant extracts and bioactive dietary components play a significant role in the maintenance of human health and wellness, with the potential to modulate risk factors and manage symptoms for a large number of common childhood disorders such as memory impairment, respiratory illnesses, gastrointestinal disorders, metabolic derangements, and pathologies related to the oral cavity. This review is designed to highlight the health benefits of botanical extracts and bioactive dietary components in children as evidenced by clinical trials, considering their safety with regards to childhood sensibilities. The supplementation of children with the herbal extracts or bioactive components mentioned in this review leads to the conclusion that they are useful for treating various ailments, with no serious adverse events being reported. However, for the limited number of investigations specifically focused on the safety of such products in children, time is needed to expand the literature data covering the safety of childhood supplementation with botanical extract and bioactive food components.

scholarly journals Bioactive Food Components and Cancer-Specific Metabonomic Profiles

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Young S. Kim ◽  
John A. Milner
Keyword(s):  
Stable Isotope ◽  
Fatty Acid Synthase ◽  
De Novo ◽  
Aerobic Glycolysis ◽  
Effective Prevention ◽  
Effective Strategies ◽  
Food Components ◽  
Bioactive Food Components ◽  
Dietary Components ◽  
Effective Prevention Strategies

Cancer cells possess unique metabolic signatures compared to normal cells, including shifts in aerobic glycolysis, glutaminolysis, andde novobiosynthesis of macromolecules. Targeting these changes with agents (drugs and dietary components) has been employed as strategies to reduce the complications associated with tumorigenesis. This paper highlights the ability of several food components to suppress tumor-specific metabolic pathways, including increased expression of glucose transporters, oncogenic tyrosine kinase, tumor-specific M2-type pyruvate kinase, and fatty acid synthase, and the detection of such effects using various metabonomic technologies, including liquid chromatography/mass spectrometry (LC/MS) and stable isotope-labeled MS. Stable isotope-mediated tracing technologies offer exciting opportunities for defining specific target(s) for food components. Exposures, especially during the early transition phase from normal to cancer, are critical for the translation of knowledge about food components into effective prevention strategies. Although appropriate dietary exposures needed to alter cellular metabolism remain inconsistent and/or ill-defined, validated metabonomic biomarkers for dietary components hold promise for establishing effective strategies for cancer prevention.

scholarly journals Kill and cure: dietary augmentation of immune defences against colon cancer

2000 ◽  
Vol 59 (2) ◽  
pp. 215-220 ◽  
Author(s):  
Fiona Armstrong ◽  
J. C. Mathers
Keyword(s):  
Colon Cancer ◽  
Immune System ◽  
Genetic Disease ◽  
Selective Pressure ◽  
Transformed Cells ◽  
Tumour Suppressor Genes ◽  
Food Components ◽  
Immune Attack ◽  
Dietary Components ◽  
Immune Defences

At its most fundamental, cancer is a genetic disease resulting from inherited or acquired mutations in tumour suppressor genes and proto-oncogenes. Environmental factors, including ingested food components, interact with genetic inheritance to determine individual cancer risk. There is growing evidence that the immune system exerts selective pressure during neoplastic development. Tumour cells that evade this immunosurveillance because they are non-antigenic or because they defend themselves successfully against immune attack have a survival advantage. Effective chemopreventative agents will include dietary components that enhance the immune system’s ability to identify transformed cells and to target them for apoptosis.

Dietary Strategies to Counteract the Effects of Mycotoxins: A Review

2001 ◽  
Vol 64 (1) ◽  
pp. 120-131 ◽  
Author(s):  
FABIO GALVANO ◽  
ANDREA PIVA ◽  
ALBERTO RITIENI ◽  
GIACOMO GALVANO
Keyword(s):  
Plant Extracts ◽  
Aflatoxin B1 ◽  
Activated Carbons ◽  
Antioxidant Properties ◽  
Medicinal Herbs ◽  
Sodium Calcium ◽  
Food Components ◽  
Ability To Act ◽  
Calcium Aluminosilicate ◽  
Dietary Strategies

We reviewed various dietary strategies to contain the toxic effects of mycotoxins using antioxidant compounds (selenium, vitamins, provitamins), food components (phenolic compounds, coumarin, chlorophyll and its derivatives, fructose, aspartame), medicinal herbs and plant extracts, and mineral and biological binding agents (hydrated sodium calcium aluminosilicate, bentonites, zeolites, activated carbons, bacteria, and yeast). Available data are primarily from in vitro studies and mainly focus on aflatoxin B1, whereas much less information is available about other mycotoxins. Compounds with antioxidant properties are potentially very efficacious because of their ability to act as superoxide anion scavengers. Interesting results have been obtained by food components contained in coffee, strawberries, tea, pepper, grapes, turmeric, Fava tonka, garlic, cabbage, and onions. Additionally, some medicinal herbs and plant extracts could potentially provide protection against aflatoxin B1 and fumonisin B1. Activated carbons, hydrated sodium calcium aluminosilicate, and bacteria seem to effectively act as binders. We conclude that dietary strategies are the most promising approach to the problem, considering their limited or nil interference in the food production process. Nevertheless, a great research effort is necessary to verify the in vivo detoxification ability of the purposed agents, their mode of action, possible long-term drawbacks of these detoxification-decontamination procedures, and their economical and technical feasibility.

Phytonutrients as Bioactive Food Components

2020 ◽  
pp. 311-321
Author(s):  
Mark L. Wahlqvist ◽  
Naiyana Wattanapenpaiboon
Keyword(s):  
Food Components ◽  
Bioactive Food Components

scholarly journals Bioactive Food Components, Inflammatory Targets, and Cancer Prevention

2009 ◽  
Vol 2 (3) ◽  
pp. 200-208 ◽  
Author(s):  
Y. S. Kim ◽  
M. R. Young ◽  
G. Bobe ◽  
N. H. Colburn ◽  
J. A. Milner
Keyword(s):  
Cancer Prevention ◽  
Food Components ◽  
Bioactive Food Components

scholarly journals Methyl Donor Micronutrients that Modify DNA Methylation and Cancer Outcome

Nutrients ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 608 ◽  
Author(s):  
Abeer Mahmoud ◽  
Mohamed Ali
Keyword(s):  
Dna Methylation ◽  
Environmental Factors ◽  
Critical Role ◽  
Epigenetic Mechanism ◽  
Enzymatic Reactions ◽  
Breast Cancers ◽  
Methyl Donors ◽  
Food Components ◽  
Dietary Nutrient ◽  
Bioactive Food Components

DNA methylation is an epigenetic mechanism that is essential for regulating gene transcription. However, aberrant DNA methylation, which is a nearly universal finding in cancer, can result in disturbed gene expression. DNA methylation is modified by environmental factors such as diet that may modify cancer risk and tumor behavior. Abnormal DNA methylation has been observed in several cancers such as colon, stomach, cervical, prostate, and breast cancers. These alterations in DNA methylation may play a critical role in cancer development and progression. Dietary nutrient intake and bioactive food components are essential environmental factors that may influence DNA methylation either by directly inhibiting enzymes that catalyze DNA methylation or by changing the availability of substrates required for those enzymatic reactions such as the availability and utilization of methyl groups. In this review, we focused on nutrients that act as methyl donors or methylation co-factors and presented intriguing evidence for the role of these bioactive food components in altering DNA methylation patterns in cancer. Such a role is likely to have a mechanistic impact on the process of carcinogenesis and offer possible therapeutic potentials.

Sign in / Sign up

Export Citation Format

Share Document