scholarly journals Potential Protective Effects of Equol (Soy Isoflavone Metabolite) on Coronary Heart Diseases—From Molecular Mechanisms to Studies in Humans

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3739
Author(s):  
Xiao Zhang ◽  
Cole V. Veliky ◽  
Rahel L. Birru ◽  
Emma Barinas-Mitchell ◽  
Jared W. Magnani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Arterial Stiffness ◽  
Molecular Mechanisms ◽  
Disease Risk ◽  
Heart Diseases ◽  
Cardiovascular Disease Risk ◽  
Soy Isoflavones ◽  
Protective Effects ◽  
Soy Isoflavone ◽  
Coronary Heart Diseases

Equol, a soy isoflavone-derived metabolite of the gut microbiome, may be the key cardioprotective component of soy isoflavones. Systematic reviews have reported that soy isoflavones have no to very small effects on traditional cardiovascular disease risk factors. However, the potential mechanistic mode of action of equol on non-traditional cardiovascular risk factors has not been systematically reviewed. We searched the PubMed through to July 2021 by using terms for equol and each of the following markers: inflammation, oxidation, endothelial function, vasodilation, atherosclerosis, arterial stiffness, and coronary heart disease. Of the 231 records identified, 69 articles met the inclusion criteria and were summarized. Our review suggests that equol is more lipophilic, bioavailable, and generally more potent compared to soy isoflavones. Cell culture, animal, and human studies show that equol possesses antioxidative, anti-inflammatory, and vasodilatory properties and improves arterial stiffness and atherosclerosis. Many of these actions are mediated through the estrogen receptor β. Overall, equol may have a greater cardioprotective benefit than soy isoflavones. Clinical studies of equol are warranted because equol is available as a dietary supplement.

scholarly journals Promosi Pengetahuan, Sikap, dan Keterampilan Berpola Hidup Sehat pada Kelompok Senam

2013 ◽  
Vol 7 (9) ◽  
pp. 426
Author(s):  
L. Meily Kurniawidjaja ◽  
Dadan Erwandi ◽  
Ike Pujiriani
Keyword(s):  
Cardiovascular Disease ◽  
Health Promotion ◽  
Healthy Lifestyle ◽  
Disease Risk ◽  
Heart Diseases ◽  
Cardiovascular Disease Risk ◽  
Exercise Group ◽  
Promotion Strategy ◽  
Coronary Heart Diseases ◽  
Group Members

Pendirian grup senam masyarakat perkotaan sering dipicu oleh ancaman penyakit jantung koroner dan stroke (penyakit kardiovaskular). Banyak diantara mereka masih berisiko tinggi penyakit kardiovaskular antara lain berat badan lebih dan kadar kolesterol tinggi serta faktor umur dan genetik, tetapi faktor risiko penyakit kardiovaskular dapat diturunkan dengan pola hidup sehat. Tujuan penelitian ini adalah menilai pengaruh metode promosi kesehatan dengan pendekatan siklus rekognisi, analisis, perencanaan, komunikasi, persiapan, implementasi, evaluasi, dan kelanjutan dapat meningkatkan pengetahuan, sikap dan praktik ibu-ibu pesenam tentang pola hidup sehat. Penelitian ini menggunakan pretest and posttest design untuk menilai hasil intervensi pada 60 orang berusia rata-rata 58,26 tahun dan hampir semua (93,33%) adalah perempuan pada dua kelompok senam di Kelurahan Pulogadung selama 10 bulan. Hasil penelitian memperlihatkan peningkatan nilai posttest (58%) pengetahuan peserta, peningkatan sikap dengan mau berbagi menu sehat dan mengisi alat pantau diri, serta peningkatan keterampilan berpola hidup sehat berupa menyusun menu sehat, bersenam minimal empat kali seminggu, tidur 7-8 jam perhari dan cukup istirahat. Selain itu, kelompok ini berhasil menyusun buku Masak Makanan Sehat. Disarankan kegiatanini dapat diterusan dengan penyajian dan diskusi makanan bijak secara berkala sekali dalam dua bulan dengan menggunakan dana yang terkumpul dari iuran sukarela.Urban exercise groups are often triggered by the perception of the severity and threat of coronary heart diseases and stroke (cardiovascular disease). But many of them are still high in cardiovascular disease risk i.e.overweight and high cholesterol. Cardiovascular disease risk factors can be reduced by healthy lifestyle. This study aimed to assess the effectiveness of recogni-tion, analysis, planning, communication, preparation, implementation, evaluation and continuity health promotion strategy in enhancing the knowledge, attitude and practice of healthy lifestyle among the exercise group members. Pretest and posttest design was used to assess the effectiveness of 10 months intervention among 60 participants aged 58,26 (27-93) year old, most of them (93,33%) were ladies from two exercise groups in Kelurahan Pulogadung. The intervention improved the score of pre-posttest (58%), the willingness to share the healthy menu and to fill the healthy lifestyle self-monitoring form, and to practice healthy lifestyle e.g. cooking the prudent food, minimum 4 times a week exercise, 7-8 hours sleeping and enough leisure time. Additionally, this groups had successfully produced The Multiethnic Healthy Food Cooking book. It was concluded these health promotion model could enhance the healthy lifestyle of the exercise group members.

scholarly journals Roles of allostatic load, lifestyle and clinical risk factors in mediating the association between education and coronary heart disease risk in Europe

2021 ◽  
pp. jech-2020-215394
Author(s):  
Blánaid Hicks ◽  
Giovanni Veronesi ◽  
Marco M Ferrario ◽  
Hannah Forrest ◽  
Margaret Whitehead ◽  
...  
Keyword(s):  
Risk Factors ◽  
Allostatic Load ◽  
Disease Risk ◽  
Heart Diseases ◽  
Differential Susceptibility ◽  
Educational Status ◽  
Coronary Heart Diseases ◽  
Lifestyle Risk Factors ◽  
Differential Exposure ◽  
Lifestyle Risk

BackgroundPrevious studies have shown that differential exposure to lifestyle factors may mediate the association between education and coronary heart diseases (CHD). However, few studies have examined the potential roles of allostatic load (AL) or differential susceptibility.Methods25 310 men and 26 018 women aged 35–74 and CHD free at baseline were identified from 21 European cohorts and followed for a median of 10 years, to investigate the mediating role of AL, as well as of smoking, alcohol use and body mass index (BMI), on educational differences in CHD incidence, applying marginal structural models and three-way decomposition.ResultsAL is a mediator of the association between educational status and CHD incidence, with the highest proportion mediated observed among women and largely attributable to differential exposure, (28% (95% CI 19% to 44%)), with 8% (95% CI 0% to 16%) attributable to differential susceptibility. The mediating effects of smoking, alcohol and BMI, compared with AL, were relatively small for both men and women.ConclusionOverall, the educational inequalities in CHD incidence were partially mediated through differential exposure to AL. By contrast, the mediation of the educational gradient in CHD by investigated lifestyle risk factors was limited. As differential susceptibility in men was found to have a predominant role in the accumulation of AL in low educational classes, the investigation of AL-related risk factors is warranted.

Effects of daidzein and genistein on markers of cardiovascular disease risk among women with impaired glucose regulation: A double-blind, randomized, placebo-controlled trial

2021 ◽  
Author(s):  
Yanbin Ye ◽  
Kai-yin He ◽  
Wan-lin Li ◽  
Shu-yu Zhuo ◽  
Yu M. Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Soy Protein ◽  
Disease Risk ◽  
Controlled Trial ◽  
Cardiovascular Disease Risk ◽  
Soy Isoflavones ◽  
Glucose Regulation ◽  
Impaired Glucose Regulation ◽  
Double Blind

Background and objective: Soy protein and soy isoflavones have been suggested to be associated with improved cardiovascular risk factors (e.g., lipid profiles and uric acid (UA)), but few studies have...

scholarly journals Effects of Chinese Liquors on Cardiovascular Disease Risk Factors in Healthy Young Humans

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Ju-Sheng Zheng ◽  
Jing Yang ◽  
Tao Huang ◽  
Xiao-Jie Hu ◽  
Ming Luo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Density Lipoprotein ◽  
Apolipoprotein A1 ◽  
Lipoprotein Cholesterol ◽  
Protective Effects ◽  
Cvd Risk Factors ◽  
Cvd Risk

Objectives. To elucidate whether consumption of two Chinese liquors, tea-flavor liquor (TFL) and traditional Chinese liquor (TCL) have protective effects on cardiovascular disease (CVD) risk factors in healthy human subjects.Methods. Forty-five healthy subjects (23 men, 22 women), aged 23–28, were recruited and randomized into two groups: TFL and TCL, and consumed 30 mL/day (45% (v/v) alcohol) of either liquor for 28 days.Results. Serum high-density lipoprotein cholesterol/low-density lipoprotein cholesterol (HDL-C/LDL-C) and apolipoprotein A1 were significantly increased, and total cholesterol (TC) and TC/HDL-C were significantly decreased after the intervention in both groups (P<0.05). Serum uric acid (P=0.004for TFL,P=0.001for TCL), glucose (P<0.001for TFL,P<0.001for TCL) and endothelial adhesion molecules (P<0.05) were significantly decreased after the intervention. ADP-induced whole blood platelet aggregation was also significantly decreased after the intervention in both TFL and TCL groups (P<0.05).Conclusions. TFL and TCL consumption had protective effects on CVD risk factors in young humans. However, the results were valid only for 28 days, and that the possibility of adverse effect (liver, kidney) of chronic alcohol consumption should be considered.

Protective effects of soy-isoflavones in cardiovascular disease

2008 ◽  
Vol 28 (01/02) ◽  
pp. 85-88 ◽  
Author(s):  
D. Fuchs ◽  
H. Daniel ◽  
U. Wenzel
Keyword(s):  
Cardiovascular Disease ◽  
Endothelial Cells ◽  
Molecular Mechanisms ◽  
Dietary Intervention ◽  
Mononuclear Cells ◽  
Oxidized Ldl ◽  
Proteome Analysis ◽  
Soy Isoflavones ◽  
Protective Effects ◽  
Estrogen Production

SummaryEpidemiological studies indicate that the consumption of soy-containing food may prevent or slow-down the development of cardiovascular disease. In endothelial cells application of a soy extract or a combination of the most abundant soy isoflavones genistein and daidzein both inhibited apoptosis, a driving force in atherosclerosis development, when applied in combination with oxidized LDL or homocysteine. Proteome analysis revealed that the stressorinduced alteration of protein expression profile was reversed by the soy extract or the genistein/daidzein mixture. Only few protein entities that could be functionally linked to mitochondrial dysfunction were regulated in common by both application forms of isoflavones. A dietary intervention with isoflavone-enriched soy extract in postmenopausal women, who generally show strongly increased cardiovascular risk due to diminished estrogen production, led to significant alterations in the steady state levels of proteins from mononuclear blood cells. The proteins identified by proteome analysis revealed that soy isoflavones may increase the anti-inflammatory response in blood mononuclear cells thereby contributing to the atherosclerosispreventive activities of a soy-rich diet. Conclusion: By proteome analysis protein targets were identified in vitro in endothelial cells that respond to soy isoflavones and that may decipher molecular mechanisms through which soy products exert their protective effects in the vasculature.

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