Association between Self-Reported Gluten Avoidance and Irritable Bowel Syndrome: Findings of the NutriNet-Santé Study

Self-management of irritable bowel syndrome (IBS) is increasingly focusing on exclusion diets. In particular; patients are showing a significant interest in the gluten-free diet for the treatment of IBS. However; the lack of scientific evidence prevents the establishment of clear dietary guidelines and attention is needed as dietary restriction can lead to potentially adverse effects. This cross-sectional study aims to explore the practice of gluten avoidance in participants identified with IBS in a large cohort of non-celiac French adults. The population included 15,103 participants of the NutriNet-Santé study who completed a functional gastrointestinal disorder questionnaire based on the Rome III criteria to identify IBS in 2013 and a food avoidance questionnaire in 2016. Data on diet and anthropometric and sociodemographic characteristics were collected. Multivariate logistic regression models were used to compare the avoidance of gluten between IBS and non-IBS participants. Participants were mainly women (73.4%) and the mean age in this population was 55.8 ± 13.2 years. Among these individuals, 804 (5.4%) participants were identified as IBS cases. Among them, the prevalence of gluten avoidance was estimated at 14.8%, of which 3.0% reported total avoidance; versus 8.8% and 1.6% in non-IBS participants. After adjustments; gluten avoidance was higher in IBS participants compared to their non-IBS counterparts: (OR = 1.86; 95%CI = 1.21, 2.85) for total and (OR = 1.71; 95%CI = 1.36, 2.14) for partial avoidance. Participants identified with IBS were more associated with gluten avoidance than non-IBS participants. Further studies are needed to explore the long-term consequences of dietary interventions and to provide consistent dietary guidance connected to patient perception.

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Irritable bowel syndrome and its associated factors in adolescents

Paediatrica Indonesiana ◽

10.14238/pi54.6.2014.344-50 ◽

2014 ◽

Vol 54 (6) ◽

pp. 344 ◽

Cited By ~ 2

Author(s):

Lara Fillekes ◽

Ari Prayogo ◽

Fatima Safira Alatas ◽

Badriul Hegar

Keyword(s):

Irritable Bowel Syndrome ◽

Lower Abdominal Pain ◽

Gastrointestinal Disorder ◽

Cross Sectional Study ◽

Rome Iii Criteria ◽

Parental Form ◽

Cross Sectional ◽

Rome Iii ◽

Irritable Bowel ◽

Upper Abdominal

Background Irritable bowel syndrome (IBS) is a commonfunctional gastrointestinal disorder. Increasing prevalences havebeen reported in Asian adolescent populations, however, therehave been few reports on Indonesian adolescents.Objective To investigate the prevalence of IBS and associatedfactors among adolescents in Jakarta.Methods This cross-sectional study included senior high schoolstudents in a district of Jakarta. Students were asked to fillquestionnaires based on the Rome III criteria for IBS. They werethen divided into groups: those with IBS and those without IBS,for the purposes of comparison.Results Out of 232 adolescents (145 females and 87 males) withmean age of 16.06 (SD 0.91) years, 14 (6.0%) had IBS. Elevenout of 14 adolescents with IBS reported upper abdominal painas well as periumbilical/lower abdominal pain. Irritable bowelsyndrome was not associated with socioeconomic status, food anddrink habits, the use of antibiotics, or scolding as a parental formof discipline. However, a significant higher proportion in the useof corporal punishment was found in IBS adolescents comparedto the non-IBS (P=0.034). In addition, stress related to scolding,as a parental form of discipline was more likely to be found in theIBS group than in the non-IBS group (P=0.019).Conclusion The prevalence of IBS among adolescents in Jakartais 6%, which is lower compared to those of other Asian countries.Corporal punishment at home and stress related to scolding athome are found to be associated with IBS.

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Screening for Celiac Disease in Patients with Irritable Bowel Syndrome Fulfilling Rome III Criteria

Journal of Coloproctology ◽

10.1055/s-0041-1736645 ◽

2021 ◽

Author(s):

Khaldoon Thanoon Al-Abachi

Keyword(s):

Irritable Bowel Syndrome ◽

Celiac Disease ◽

Gastrointestinal Disorder ◽

Cross Sectional Study ◽

Rome Iii Criteria ◽

Positive Serology ◽

Cross Sectional ◽

Rome Iii ◽

The Mean ◽

Irritable Bowel

Abstract Background Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. Celiac disease (CD), a treatable autoimmune enteropathy, with varied presentations, may simulate clinically symptoms of IBS. The aim of the present study is to screen for CD in patients with IBS diagnosed based on the Rome III criteria. Patients and Methods A cross-sectional study was conducted at a secondary care gastrointestinal unit in Al-Salam General Hospital in Mosul city, Iraq, from November 2015 to October 2016. All patients fulfilling the Rome III criteria for IBS were screened for CD using antitissue transglutaminase IgA antibodies (anti-tTG). Patients who tested positive were subjected to endoscopic duodenal biopsy to confirm the diagnosis of CD. Results A total of 100 patients were included in the present study (58 female and 42 male), the mean age of the participants was 40.8 years old (standard deviation [SD] ± 11.57). Ten patients (10/100, 10%) tested positive for anti-tTG antibodies. Five of the seropositive patients (5/10, 50%) showed positive biopsy results according to the Marsh classification, 3 of whom having diarrhea, and 2 with constipation. Conclusion Positive serology and biopsy results suggestive of CD are common among patients with IBS. Screening patients with IBS for CD is justified.

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Irritable Bowel Syndrome Among University Students in Jordan

10.21203/rs.2.11508/v1 ◽

2019 ◽

Author(s):

Amjad Al-Shdaifat ◽

Anwar Al-Kassar ◽

Asgeir Johannessen ◽

Zaid Al-Dabbagh ◽

Mohamed Al-Ethawi ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

University Students ◽

Multivariable Analysis ◽

Cross Sectional Study ◽

Poor Sleep ◽

Rome Iii Criteria ◽

Cross Sectional ◽

Rome Iii ◽

Irritable Bowel ◽

Hashemite University

Abstract Background Irritable bowel syndrome (IBS) is one of the commonest diagnosed gastrointestinal disorders (GI) in primary care and gastroenterology practices. This study aimed to explore the prevalence of IBS, and identify associated factors, among university students in Jordan. Methods A cross-sectional study was conducted among students at the Hashemite University in Jordan. A validated, confidential, self-administered data collection questionnaire was used for the collection of personal and sociodemographic data, and the Rome III criteria were used to define IBS. Logistic regression analysis was done to identify factors associated with IBS. Results A total of 198 students participated in the study, of whom 163 had complete data and could be assessed by the Rome III criteria. The age range of the students was 18 to 35 years, and 91 (55.8%) were women. Overall, 26 (16.0%) of the respondents were diagnosed with IBS. Poor sleep (Adjusted Odds Ratio [AOR] 3.9; 95% confidence interval [CI] 1.5-10.4; p<0.01), being married (AOR 7.6; 95% CI 2.0-28.8; p<0.01) and a family history of IBS (AOR 2.9; 95% CI 1.1-7.7; p=0.03) were independently associated with IBS in multivariable analysis. Conclusion IBS was common among otherwise healthy university student in Jordan. Lifestyle factors such as poor sleep appeared to be associated with IBS symptoms.

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Patients Suspected of Irritable Bowel Syndrome—Cross-Sectional Study Exploring the Sensitivity of Rome III Criteria in Primary Care

The American Journal of Gastroenterology ◽

10.1038/ajg.2013.15 ◽

2013 ◽

Vol 108 (6) ◽

pp. 972-980 ◽

Cited By ~ 37

Author(s):

Anne Line Engsbro ◽

Luise Mølenberg Begtrup ◽

Jens Kjeldsen ◽

Pia Veldt Larsen ◽

Ove Schaffalitzky de Muckadell ◽

...

Keyword(s):

Primary Care ◽

Irritable Bowel Syndrome ◽

Cross Sectional Study ◽

Sectional Study ◽

Rome Iii Criteria ◽

Cross Sectional ◽

Rome Iii ◽

Irritable Bowel

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Fermentable Oligo-, Di-, and Mono-Saccharides and Polyols (FODMAPs) Consumption and Irritable Bowel Syndrome in the French NutriNet-Santé Cohort

Nutrients ◽

10.3390/nu13124513 ◽

2021 ◽

Vol 13 (12) ◽

pp. 4513

Author(s):

Elodie Schneider ◽

Jean-Marc Sabaté ◽

Michel Bouchoucha ◽

Serge Hercberg ◽

Mathilde Touvier ◽

...

Keyword(s):

Irritable Bowel Syndrome ◽

Daily Intake ◽

Population Based ◽

Cross Sectional Study ◽

P Value ◽

Cross Sectional ◽

Logistic Regression Models ◽

The Mean ◽

Irritable Bowel ◽

Composition Table

(1) Background: Specific foods, and more particularly, fermentable oligo-, di-, and mono-saccharides and polyols (FODMAPs) are often considered as triggers of digestive symptoms in Irritable Bowel Syndrome (IBS). Our aim was to study FODMAP consumption in controls and IBS participants in a large French population-based cohort; (2) Methods: Participants from the NutriNet-Santé cohort study completed the Rome IV and IBS-SSS questionnaire in a cross sectional study. Among them, 27,949 eligible participants had previously completed three 24-h recalls as well as anthropometrics, socio-demographical and lifestyle data. Total FODMAP intake (in g/day) was computed using a specific composition table. The association between FODMAPs and IBS was estimated through multivariable logistic regression models; (3) Results: Included participants were mainly women (75.4%) and the mean age was 43.4 ± 14.1 years. FODMAPs accounted for a mean daily intake of 19.4 ± 9.5 g/day. Overall 1295 participants (4.6%) were identified with an IBS. After adjusting for confounding factors, IBS participants had lower intakes in FODMAPs than non-IBS ones (aOR: 0.88, 95% CI: 0.82–0.95, p-value: 0.001). IBS severity was associated with more frequent low FODMAP intakes (<9 g/day); (4) Conclusions: Participants tended to consume 19 g of FODMAPs per day, but slightly less for IBS participants than for controls. In IBS participants, higher severity was associated with lower intakes.

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Adherence to the pro-inflammatory diet in relation to prevalence of irritable bowel syndrome

Nutrition Journal ◽

10.1186/s12937-019-0487-6 ◽

2019 ◽

Vol 18 (1) ◽

Cited By ~ 2

Author(s):

Asma Salari-Moghaddam ◽

Ammar Hassanzadeh Keshteli ◽

Ahmad Esmaillzadeh ◽

Peyman Adibi

Keyword(s):

Irritable Bowel Syndrome ◽

Cross Sectional Study ◽

Dietary Intakes ◽

Dietary Inflammatory Index ◽

Sectional Study ◽

Cross Sectional ◽

Inflammatory Index ◽

Persian Version ◽

Rome Iii ◽

Irritable Bowel

Abstract Objective There is no prior study that examined the association between nutrient-based dietary inflammatory index (DII) and odds of Irritable Bowel Syndrome (IBS). We examined the association between DII score and odds of IBS and its severity among Iranian adults. Methods In this cross-sectional study, dietary intakes of 3363 Iranian adults were examined using a validated Dish-based 106-item Semi-quantitative Food Frequency Questionnaire (DS-FFQ). DII was calculated based on dietary intakes derived from DS-FFQ. IBS was assessed using a modified Persian version of Rome III questionnaire. Results After adjustment for potential confounders, we found that participants in the highest quintile of DII score had greater chance for IBS compared with those in the lowest quintile (OR: 1.36; 95% CI: 1.03–1.80). By gender, we found a significant association between DII score and IBS among women (OR: 1.41; 95% CI: 1.00–2.00). By BMI status, overweight or obese (BMI ≥ 25 kg/m2) individuals in top quintile of DII score had greater odds for IBS than those in the bottom quintile (OR: 1.64; 95% CI: 1.07–2.53). No significant association was observed between a pro-inflammatory diet and severity of IBS symptoms. Conclusions Consumption of a pro-inflammatory diet was associated with increased odds of IBS, in particular among women and those with BMI ≥ 25 kg/m2.

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High-Fat Foods and FODMAPs Containing Gluten Foods Primarily Contribute to Symptoms of Irritable Bowel Syndrome in Korean Adults

Nutrients ◽

10.3390/nu13041308 ◽

2021 ◽

Vol 13 (4) ◽

pp. 1308

Author(s):

Woori Na ◽

Yeji Lee ◽

Hyeji Kim ◽

Yong Sung Kim ◽

Cheongmin Sohn

Keyword(s):

Irritable Bowel Syndrome ◽

Dietary Intake ◽

Cross Sectional Study ◽

Dietary Control ◽

Fat Intake ◽

High Fat ◽

Cross Sectional ◽

Korean Adults ◽

Rome Iii ◽

Irritable Bowel

Dietary control plays an important role in the treatment of irritable bowel syndrome (IBS). However, few studies have examined the relationship between dietary intake and symptoms of IBS in Koreans. The current cross-sectional study aimed to examine the diet in food consumption and nutrient intake in Korean adults aged 20 to 40 with IBS. The data collected were completed by 857 subjects using a community-based web survey. The questionnaire covered functional bowel disorders based on Rome III, the semi-quantitative Food Frequency Questionnaire (SQ-FFQ), and the food items causing symptoms. In total, 186 of 857 subjects (21.7%) were diagnosed with IBS. The non-IBS group had a fat intake of 76.9 ± 47.9 g/day, while the IBS group had a fat intake of 86.6 ± 55.1 g/day (p = 0.014). The non-IBS group had a total fermentable oligosaccharide, disaccharide, monosaccharide, and polyol (FODMAP) intake of 12.6 ± 9.7 g/day, whereas the IBS group had a total FODMAP intake of 13.9 ± 9.9 g/day (p = 0.030). Foods that contributed to the onset of symptoms in the IBS group were instant noodles (70.8%), Chinese noodles with vegetables and seafood (68.7%), pizza (67.2%), and black bean sauce noodles (66.3%) which are mostly classified as high fat and high gluten foods. The dietary intake of IBS patients differs from that of non-IBS subjects. Increased intake of gluten-containing or high-fat foods due to the westernized diet caused more IBS symptoms than high FODMAPs and dairy products in Korean adults in their 20 s to 40 s.

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Anger Mediates the Relationship between Pain and Depression in Irritable Bowel Syndrome

Journal of Gastrointestinal and Liver Diseases ◽

10.15403/jgld-533 ◽

2019 ◽

Vol 28 (4) ◽

pp. 415-419

Author(s):

Mihaela Fadgyas Stanculete ◽

Octavia Capatina ◽

Cristina Pojoga ◽

Teodora Surdea Blaga

Keyword(s):

Irritable Bowel Syndrome ◽

Anger Expression ◽

Cross Sectional Study ◽

Pain Severity ◽

Trait Anger ◽

Cross Sectional ◽

Rome Iii ◽

Pain State ◽

Irritable Bowel ◽

The Relationship

Background and Aims: Anger has been linked to irritable bowel syndrome (IBS), but the mechanism underlying this relationship is still unknown. This cross-sectional study explores the possibility that anger mediates the relationship between pain severity and depression in IBS patients. Methods: The sample included 70 consecutively evaluated patients who met Rome III criteria for IBS diagnosis and 55 healthy controls. All participants completed measures of depression, pain, state and trait anger, and anger expression style. Results: Using a mediational model involving a series of linear regressions we found that trait anger and anger expression index partially mediated the association between depression and abdominal pain severity. The IBS patients with significant pain reported higher depressive symptoms; these results could be partially explained by their tendency to experience angry feelings generated by pain. Conclusions: The relation between pain and depression is not a direct and linear one, but works partly through patients’ tendency to become angry and through anger expression style regarding their pain.

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Evaluation of irritable bowel syndrome prevalence in medical students

Journal of Preventive Epidemiology ◽

10.34172/jpe.2021.21 ◽

2021 ◽

Vol 6 (2) ◽

pp. e21-e21

Author(s):

Samin Maghsoudi ◽

Azam Teimouri

Keyword(s):

Irritable Bowel Syndrome ◽

Medical Students ◽

Gastrointestinal Disorder ◽

Cross Sectional Study ◽

Medical Sciences ◽

Cross Sectional ◽

Lifestyle Pattern ◽

Negative Impacts ◽

Irritable Bowel ◽

Rome Iv

Introduction: Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder and requires early diagnosis due to its negative impacts on the quality of life. According to the lifestyle pattern of medical students, IBS has a significant prevalence in these individuals. Objectives: The present study aims to investigate the prevalence and factors associated with IBS in medical students. Patients and Methods: This cross-sectional study has been conducted on 100 medical students studying at Isfahan University of Medical Sciences in 2019-2020. The Rome IV diagnostic criteria were administered to diagnose IBS and individuals were divided into four groups of constipation-dominant (IBS-C), diarrhea-dominant (IBS-D), mixed type (IBS-M) and unspecified (IBS-U). The association of studying grade, gender and residence with IBS was evaluated. Results: The mean age of the students was 23.2±4.8 years, including 68 (68%) women. According to Rome -IV criteria, 24 (24%) ones were diagnosed with IBS. The IBS cases were dominantly in IBS-C group (54.16%). IBS was not associated with gender (P=0.498), educational grade (P=0.661) and type of residence (P=0.562) in the studied medical students. Conclusion: According to the present study, the prevalence of IBS was 24% among medical students, which was higher among women. Most patients had IBS-C, but IBS did not show a statistically significant relationship with gender, educational grade and type of residence.

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Semiquantitative fecal calprotectin test in postinfectious and non-postinfectious irritable bowel syndrome: cross-sectional study

Sao Paulo Medical Journal ◽

10.1590/1516-3180.2014.8000815 ◽

2014 ◽

Vol 133 (4) ◽

pp. 343-349 ◽

Cited By ~ 5

Author(s):

Liliana-Elisabeta David ◽

Teodora Surdea-Blaga ◽

Dan-Lucian Dumitrascu

Keyword(s):

Irritable Bowel Syndrome ◽

Intestinal Inflammation ◽

Fecal Calprotectin ◽

Cross Sectional Study ◽

Positive Test ◽

Sectional Study ◽

Cross Sectional ◽

Bowel Diseases ◽

Rome Iii ◽

Irritable Bowel

CONTEXT AND OBJECTIVE:The presence of a certain degree of inflammation in the gut wall is now accepted in irritable bowel syndrome (IBS). Fecal calprotectin is considered to be a reliable test for detecting intestinal inflammation. Our aim was to assess the presence of inflammation in postinfectious IBS (PI-IBS), compared with non-postinfectious IBS (NPI-IBS). A secondary objective was to determine the usefulness of a rapid fecal calprotectin test in inflammatory bowel diseases (IBD).DESIGN AND SETTING:This was a cross-sectional study. Patients with IBS and IBD at a single tertiary gastroenterology center were prospectively included in this study.METHODS:116 patients with Rome III IBS score (76 females; 48 ± 12 years) were investigated; 24 patients (15 females) had PI-IBS. Intestinal inflammation was assessed using the semiquantitative fecal calprotectin test. The results were expressed as T1, T2 or T3 according to the severity of inflammation (< 15 μg/g; 15-60 μg/g; > 60 μg/g). Using the same test, we evaluated 20 patients with IBD (12 males; 47 ± 13 years).RESULTS:None of the patients with IBS had a T2 or T3 positive test. Among PI-IBS patients, 33% had a T1 positive test. Among NPI-IBS patients, 9.8% had a T1 positive test, which was significantly different to PI-IBS. The calprotectin test was positive in all IBD patients: 80% with T3, 10% with T2 and 10% with T1.CONCLUSIONS:Using a semiquantitative test for fecal calprotectin, positive tests were more frequent in PI-IBS patients than in NPI-IBS patients.

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