scholarly journals Side Effects of mRNA-Based COVID-19 Vaccines among Young Adults (18–30 Years Old): An Independent Post-Marketing Study

2021 ◽  
Vol 14 (10) ◽  
pp. 1049
Author(s):  
Abanoub Riad ◽  
Andrea Pokorná ◽  
Jitka Klugarová ◽  
Natália Antalová ◽  
Lucia Kantorová ◽  
...  
Keyword(s):  
Young Adults ◽  
Side Effects ◽  
Side Effect ◽  
Demographic Data ◽  
Herd Immunity ◽  
Age Groups ◽  
Common Side Effect ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Validated Questionnaire

Young adults had been widely perceived as a low-risk group for COVID-19 severity; therefore, they were deprioritised within the mass vaccination strategies as their prognosis of COVID-19 infection is relatively more favourable than older age groups. On the other hand, vaccination of this demographic group is indispensable to achieve herd immunity. A cross-sectional survey-based study was used to evaluate the side effects of mRNA-based COVID-19 vaccines among university students in the Czech Republic. The validated questionnaire was delivered in a digital form, and it consisted of demographic data; COVID-19 vaccine-related anamnesis; and local, systemic, orofacial, and skin-related side effects’ prevalence, onset, and duration. Out of the 539 included participants, 70.1% were females and 45.8% were <23 years old. The vast majority (95.2%) reported at least one side effect. The most common side effect was injection site pain (91.8%), followed by fatigue (62.5%), headache (36.4%), and muscle pain (34.9%). The majority of local side effects occurred after both doses (74.4%), while most systemic side effects occurred after the second dose only (56.2%). Most local (94.2%) and systemic (93.3%) side effects resolved within three days after vaccination. Females participants’ adjusted odds ratio (AOR) showed they were 2.566 (CI 95%: 1.103–5.970) times more likely to experience post-vaccination side effects, and the participants who received two doses reported an increased AOR of 1.896 (0.708–5.077) for experiencing side effects. The results of this study imply that mRNA-based COVID-19 vaccines are highly probably safe for young adults, and further studies are required to investigate the role of medical anamnesis, prior COVID-19 infection, and gender in side effects incidence.

scholarly journals COVID-19 Vaccination Attitudes, Perceptions, and Side Effect Experiences in Malaysia: Do Age, Gender, and Vaccine Type Matter?

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1156
Author(s):  
Mohamed Hassan Elnaem ◽  
Nor Hidayah Mohd Taufek ◽  
Norny Syafinaz Ab Rahman ◽  
Nor Ilyani Mohd Nazar ◽  
Che Suraya Zin ◽  
...  
Keyword(s):  
Side Effects ◽  
Injection Site ◽  
Side Effect ◽  
Lower Risk ◽  
Age Groups ◽  
Vaccine Safety ◽  
Vaccination Program ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Vaccine Type

This study aimed to investigate the attitudes, perceptions, and experiences of side effects with the COVID-19 vaccines in Malaysia among participants in the National Vaccination Program. A cross-sectional survey was conducted among a sample of vaccine-eligible and vaccinated individuals in Malaysia between May and July 2021. A total of 428 respondents completed the survey. A vast majority (98.6%) of the respondents had registered to be vaccinated. Twenty participants (4.7%) expressed concerns about either registering or receiving the COVID-19 vaccination, mainly due to their uncertainty of vaccine safety. Approximately 77.5% received their vaccinations. Of them, 76.8% had experienced vaccine-related side effects. About 40% of the side effects occurred more with the second dose, particularly those who received the Pfizer-BioNTech vaccine (p < 0.001). Pain at the injection site (61.1%) and tiredness (48.8%) were the most reported side effects. Compared to those aged ≥60 years, all age groups were more likely to exhibit vaccine-related side effects; meanwhile, males (OR: 0.51, 95% CI: 0.27–0.93) were less likely to experience side effects than females. Those who received the Sinovac vaccine were at lower risk of experiencing side effects (OR: 0.08, 95% CI: 0.03–0.22) and were more likely to report fewer side effects than Pfizer-BioNTech (p = 0.012) and Oxford-AstraZeneca groups (p= 0.001). The overall attitudes toward the COVID-19 vaccination program were positive. Several differences in the experiences of vaccine-related side effects, in terms of prevalence and numbers, were attributed to age, gender, and received vaccine type.

scholarly journals Side Effect Profile of COVID-19 Vaccine among Health Workers in a Tertiary Health Institution in South-South Nigeria

2021 ◽  
Vol 3 (3) ◽  
pp. 59-64
Author(s):  
Peter C. Oriji ◽  
Dennis O. Allagoa ◽  
Lukman Obagah ◽  
Obielumani I. Oguche ◽  
Onyekachi S. Ohaeri ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Health Workers ◽  
Herd Immunity ◽  
Cross Sectional Study ◽  
Medical Centre ◽  
Common Side Effect ◽  
Side Effect Profile ◽  
Cross Sectional ◽  
The Face

Background: Side effect following vaccination usually ranges from mild to moderate and occasionally severe in a small proportion of people. Covid-19 vaccine is no exception as side effects have been reported which are mostly mild to moderate and transient. The chances of any of these side effect following vaccination differ according to the specific COVID-19 vaccine. Objective: To determine the side effect profile of the Health workers that received the COVID-19 vaccination in the Federal Medical Centre, Yenagoa, Bayelsa State, Nigeria. Materials and Method: This study was a descriptive cross-sectional study. It was carried out between 15th and 30th April 2021 among 151 health workers that received COVID-19 vaccination in the Federal Medical Centre, Yenagoa, Bayelsa State, Nigeria. The data were collected with a predesigned questionnaire and were analysed using IBM SPSS 23.0 version. Results: About 52.3% were female health workers, 49.0% were aged between 36–45 years. Side effects were reported in 9 of every 10 health workers who received the vaccine. Most side effects (53.0%) started on the day of vaccination. The most common side effect was pain at the injection site, and it was reported by 104 recipients of the vaccine (68.9%). Fever, headache, tiredness and chills were reported in 57.0%, 49.0%, 47.7% and 43.7%, respectively. Conclusion: As with medications and other vaccines, COVID-19 vaccines have side effects. Protective immunity against COVID-19 is developed following vaccination. In the face of a still rapidly evolving situation, what seems obvious is that vaccination currently remains the best route to achieving herd immunity.

Medicinal plants’ use among patients with dyslipidemia: an Iranian cross-sectional survey

2018 ◽  
Vol 16 (3) ◽  
Author(s):  
Mohammad Hashem Hashempur ◽  
Seyed Hamdollah Mosavat ◽  
Mojtaba Heydari ◽  
Mesbah Shams
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Demographic Data ◽  
Zingiber Officinale ◽  
Cross Sectional Study ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Herbal Preparations ◽  
Positive Effects ◽  
High Prevalence

Abstract Background Despite growing demand for medicinal plants, there is little data about their use by patients with dyslipidemia. We aimed to determine the prevalence, pattern, and associated factors for the use of medicinal plants among patients with dyslipidemia. Methods A 17-item semi-structured questionnaire was filled out by 195 patients with dyslipidemia in a cross-sectional study carried out in two academic endocrinology clinics in Shiraz, Iran. The questionnaire comprised of three main domains of demographic data (6 questions), clinical data (2 of them), and data related to the use of medicinal plants (totally 9 questions). Results A total of 77.4% of patients took medicinal plants. The most common medicinal herbs used by dyslipidemic patients were Zataria multiflora, Cinnamomum zeylanicum, and Zingiber officinale. Duration of dyslipidemia was significantly longer in herbal users than non-herbal users (p=0.04). Patients believing that concomitant use of conventional drugs and herbal preparations had synergic positive effects in addition to those persuaded that herbal preparations possessed less side effects, were significantly more likely to use medicinal plants (p=0.008 and 0.005, respectively). Additionally, most of the medicinal herb users (87.4%) changed neither the pattern nor the dosage of their medications all during herbal preparations use. Conclusions This study demonstrated a high prevalence of medicinal plants’ use among patients with dyslipidemia, which was associated with the duration of dyslipidemia, patients’ viewpoints about herbal preparations’ synergic positive effects, and their fewer side effects.

scholarly journals Side Effects of mRNA-Based COVID-19 Vaccine: Nationwide Phase IV Study among Healthcare Workers in Slovakia

2021 ◽  
Vol 14 (9) ◽  
pp. 873
Author(s):  
Abanoub Riad ◽  
Barbora Hocková ◽  
Lucia Kantorová ◽  
Rastislav Slávik ◽  
Lucia Spurná ◽  
...  
Keyword(s):  
Side Effects ◽  
Side Effect ◽  
Healthcare Workers ◽  
Large Scale ◽  
Large Population ◽  
Medical Attention ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Post Vaccination ◽  
Phase Iv

mRNA-based COVID-19 vaccines such as BNT162b2 have recently been a target of anti-vaccination campaigns due to their novelty in the healthcare industry; nevertheless, these vaccines have exhibited excellent results in terms of efficacy and safety. As a consequence, they acquired the first approvals from drug regulators and were deployed at a large scale among priority groups, including healthcare workers. This phase IV study was designed as a nationwide cross-sectional survey to evaluate the post-vaccination side effects among healthcare workers in Slovakia. The study used a validated self-administered questionnaire that inquired about participants’ demographic information, medical anamneses, COVID-19-related anamnesis, and local, systemic, oral, and skin-related side effects following receiving the BNT162b2 vaccine. A total of 522 participants were included in this study, of whom 77% were females, 55.7% were aged between 31 and 54 years, and 41.6% were from Banska Bystrica. Most of the participants (91.6%) reported at least one side effect. Injection site pain (85.2%) was the most common local side effect, while fatigue (54.2%), headache (34.3%), muscle pain (28.4%), and chills (26.4%) were the most common systemic side effects. The reported side effects were of a mild nature (99.6%) that did not require medical attention and a short duration, as most of them (90.4%) were resolved within three days. Females and young adults were more likely to report post-vaccination side effects; such a finding is also consistent with what was previously reported by other phase IV studies worldwide. The role of chronic illnesses and medical treatments in post-vaccination side effect incidence and intensity requires further robust investigation among large population groups.

scholarly journals Prevalence and Predictors of Dietary and Nutritional Supplement Use in the Australian Army: A Cross-Sectional Survey

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1462 ◽  
Author(s):  
Bradley Baker ◽  
Bianka Probert ◽  
Diane Pomeroy ◽  
Julia Carins ◽  
Katie Tooley
Keyword(s):  
Side Effects ◽  
Age Groups ◽  
Nutritional Supplement ◽  
Hard Copy ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Special Operations ◽  
Supplement Use ◽  
The Face ◽  
Ongoing Surveillance

Dietary supplements (DSs) and nutritional supplements (NSs) can enhance performance, recovery or training adaptations, however, some substances, dosages, and usage protocols are unsafe. Knowledge of the type and extent of use within populations enables strategies to be formulated to promote safe and effective use (where needed) and to avoid adverse side effects. The purpose of this study was to understand DS and NS use by active-duty Australian soldiers. Surveys were distributed by e-mail and hard copy to eligible participants (n = 23,195). Respondents (males n = 1833; females n = 296) comprised 9.3% of the total population. Use of ≥1 DSs/week was reported by 76.4% of males and 86.8% of females, and use of ≥1 NSs/week was reported by 21.7% of males and 20.9% of females. The most commonly used supplements were protein or amino acids (55.6%), multivitamins and minerals (38.2%), other DSs (37.8%), individual vitamins and minerals (33.0%), and combination products (32.8%). Logistic regression revealed the number of DSs respondents used simultaneously was significantly different between males and females, age groups, BMI ranges, and body weight actions. Engagement in special operations was a significant predictor of the use of any DS, individual vitamin and minerals and multivitamin and minerals. Approximately 16% of regular DS users reported experiencing one or more side effects, with the most common being palpitations (10.6%), tingling or numbness in the face, fingers, arms, or legs (5.5%), tremors or shaking (2.9%), flushing (2.3%), headache (2.0%), abdominal pain (1.6%), anxiety (1.4%), and dizziness or confusion (0.9%). The results revealed more prevalent use of several categories of DSs and NSs among some subgroups. Ongoing surveillance of DS and NS use is important for tracking trends in use over time and gauging the effectiveness of any strategies employed to enhance the quality of supplement use.

scholarly journals Use of information sources regarding medicine side effects among the general population: a cross-sectional survey

2019 ◽  
Vol 20 ◽  
Author(s):  
Bernadine O’Donovan ◽  
Ruth M. Rodgers ◽  
Anthony R. Cox ◽  
Janet Krska
Keyword(s):  
Side Effects ◽  
Information Seeking ◽  
Side Effect ◽  
Information Sources ◽  
Negative Impact ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Information Leaflets ◽  
Increased Risk ◽  
Use Of Information Sources

Abstract Aim: To determine the use and perceived value of different information sources that patients may use to support identification of medicine side effects; to explore associations between coping styles and use of information sources. Background: Side effects from medicines can have considerable negative impact on peoples’ daily lives. As a result of an ageing UK population and attendant multi-morbidity, an increasing number of medicines are being prescribed for patients, leading to increased risk of unintended side effects. Methods: A cross-sectional survey of patients who use medicine, recruited from community pharmacies. The survey sought views on attributes of various information sources, their predicted and actual use, incorporating a shortened Side Effects Coping Questionnaire (SECope) scale and the abbreviated Miller Behavioural Style Scale (MBSS). Findings: Of 935 questionnaires distributed, 230 (25.0%) were returned, 61.3% from females; 44.7% were retired and 84.6% used at least one medicine regularly. 69.6% had experienced a side effect, resulting in 57.5% of these stopping the medicine. Patient information leaflets (PILs) and GPs were both predicted and actually most widely used sources, despite GPs being judged as relatively less accessible and PILs less trustworthy, particularly by regular medicine users. Pharmacists, considered both easy to access and trustworthy, were used by few in practice, while the internet was considered easy to access, but less trustworthy and was also little used. SECope sub-scales for non-adherence and information seeking showed positive associations with stopping a medicine and seeking information from a health professional. More high monitors than low monitors stopped a medicine themselves, but there were no differences in use of information sources. Information seeking following a side effect is a common strategy, potentially predicted by the SECope, but not the MBSS. Limited GP accessibility could contribute to high internet use. Further research could determine how the trustworthiness of PILs can be improved.

scholarly journals Deaflympians' Satisfaction With Athletic Training Services at the 2013 Deaflympic Summer Games

2017 ◽  
Vol 52 (7) ◽  
pp. 708-718 ◽  
Author(s):  
Matthew Paul Brancaleone ◽  
René Revis Shingles ◽  
Nailya DeLellis
Keyword(s):  
Athletic Training ◽  
Athletic Trainers ◽  
Demographic Data ◽  
Age Groups ◽  
Collegiate Athletes ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Frequency Of Use ◽  
Or Team ◽  
Training Services

Context:  Athletic trainers have the opportunity to treat unique populations. Determining athletes' satisfaction with the athletic training services supplied can offer insights into how to improve the health care provided to athletes. Objective:  To explore Deaflympians' satisfaction with athletic training services at the 2013 Deaflympic Summer Games. Design:  Cross-sectional survey. Setting:  The 2013 Deaflympic Summer Games in Sofia, Bulgaria. Patients or Other Participants:  Of the 115 Deaflympians contacted, 55 completed the questionnaire, for a 48% response rate (women = 33, men = 22). Main Outcome Measure(s):  The Medical Interview Satisfaction Survey–Athletic Training was used. The questionnaire gathered demographic data and included 25 Likert-scale items that assessed 6 components of athletic training. Descriptive statistics were calculated as normalized scores to adjust for the different numbers of questions for each item. On a 5-point scale, the scores ranged from 3.82 (management) to 4.24 (environment), with an overall satisfaction score of 3.89. We conducted comparison tests to assess possible differences in overall satisfaction and satisfaction components. Satisfaction with frequency of use of the athletic training room and knowledge were the only areas that showed statistically significant differences. Other differences were in perceptions of medical coverage among age groups and management between sexes. Results:  Satisfaction with the athletic training services provided was lower among these Deaflympians than among collegiate athletes in other studies. However, we observed no differences in overall satisfaction scores by age, sex, race, previous Deaflympic experience, or individual or team sport. Deaflympians who used and visited the athletic training facility more often had higher overall satisfaction scores than individuals who used and visited the facility less. Conclusions:  Deaflympians were satisfied with the athletic training services provided at the 2013 Deaflympic Summer Games.

scholarly journals Use of eye drops self-medication in Aseer region, Southern Saudi Arabia

2021 ◽  
Vol 19 (2) ◽  
Author(s):  
Abdulrahman Alamri ◽  
Razan Asiri ◽  
Abdulaziz Alnami ◽  
Raneem Hijazi ◽  
Lamya Almobty
Keyword(s):  
Side Effects ◽  
Demographic Data ◽  
Eye Drops ◽  
Cross Sectional Survey ◽  
Self Medication ◽  
Blurred Vision ◽  
Cross Sectional ◽  
Gender And Education ◽  
Social Media Platforms ◽  
Structured Questionnaire

Background: Self-medication is defined as the use of drugs to manage a self-diagnosed disease or complaint, or the intermittent or continued use of a prescribed drug for chronic or recurrent disease or symptoms. Self-medication includes getting medications without a prescription, resubmitting old prescriptions to buy medicines, sharing medicines with relatives or members of one’s social circle, or using leftover medicines stored at home. Risks are related to many factors including not only the possible severe side effects of the drug itself, but also hazardous because of improper treatment. Methodology: A descriptive cross-sectional survey was used targeting all population in Aseer region. The study was conducted during the period from May 2020 to August 2020. Data were collected using structured questionnaire which was developed by the researchers after intensive literature review and expert’s consultation. The questionnaire data included person’s socio-demographic data such as age, gender, and education. The second section of the questionnaire covered eye drops self-medication data. The questionnaire was uploaded online using social media platforms by the researchers and their relatives and friends to be filled in by all population in Aseer region. Results: A total of 209 participants completed the study questionnaire. Participants’ ages ranged from 18 to 65 years old with mean age of 32.9 ± 11.6 years. Exactly 152 (72.7%) participants were females and 158 (75.6%) had educational level of university or more. Regarding persons who advised participants to use eye drops, the most reported was the person themself (34.4%; 72) followed by family and friends (29.2%), and pharmacist (20.6%). As for causes of using unprescribed eye drops, 105 (50.2%) participants used the eye drops for itching in the eye, followed by eye redness (47.4%), eye pain (22.5%). Regarding side effects of used drops, the most reported was excessive lacrimation (5.7%), followed by blurred vision (5.7%), and eye inflammations (4.3%), Conclusions: In conclusion, the study revealed that there is a large portion of Aseer region population practicing self-medicating behavior based on their own concept or advice from friends and family most of the time, without consulting a specialized physician. Key words: Eye drops, self-medication, unprescribed, use, population, causes, practice

scholarly journals FREQUENCY OF OBESE PEOPLE AT HIGH RISK FOR DEVELOPING OBSTRUCTIVE SLEEP APNEA; A CROSS-SECTIONAL SURVEY

2020 ◽  
Vol 11 (3) ◽  
pp. 39-45
Author(s):  
Komal Atta ◽  
Raza Ahmad ◽  
Ayesha Nawaz ◽  
Iqra Ishtiaq ◽  
Muhammad Farooq
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
High Risk ◽  
Age Groups ◽  
P Value ◽  
Cross Sectional Survey ◽  
Obese People ◽  
Cross Sectional ◽  
Validated Questionnaire ◽  
Obstructive Sleep

ABSTRACT BACKGROUND & OBJECTIVE: Obstructive sleep apnea (OSA) leads to multiple complications which may be life-threatening. In this study we determined the frequency of obese individuals at high risk for developing (OSA). METHODOLOGY: It was a cross-sectional survey. The study was conducted in the Medicine department of Services hospital, Lahore from February 6, 2016 to August 5, 2016. A sample size of 300 healthy obese individuals (BMI ≥ 30kg/m2) aged between 18-60 years who were accompanying a patient or visiting someone admitted, were enrolled in our study. Informed Verbal consent was obtained before administering a structured, validated questionnaire to the significant obese population; Survey was translated into Urdu for ease. The data were stratified for age, gender and BMI of the patients to control the effect modifiers. Post-stratification Chi-square test was used. A p-value ≤ 0.05 was taken as significant. RESULTS: A total of 300 subjects were enrolled. Mean age was calculated as 41.81±11.98 years, while 161(53.7%) individuals were females and 139(46.3%) were males. The frequency of risk of OSA was low in 241(80.3%) and high in 59(19.7%) of the population. The relationships of OSA with age groups and BMI were insignificant with p-value being 0.867 and 0.790 respectively. CONCLUSION: In this study, a significant population of male obese individuals was found to be at high risk for obstructive sleep apnea.

scholarly journals Side Effects and Perceptions Following Sinopharm COVID-19 Vaccination

2021 ◽  
Author(s):  
Balsam Qubais ◽  
Rula Al-Shahrabi ◽  
Shaikha Salah Alhaj ◽  
Zainab Mansour Alkokhardi ◽  
Ahmed Omar Adrees
Keyword(s):  
Side Effects ◽  
Injection Site ◽  
Demographic Data ◽  
Survey Study ◽  
Vaccine Hesitancy ◽  
Injection Site Pain ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Vaccination Site ◽  
Site Pain

Objectives Vaccines are one of the best interventions developed for eradicating COVID-19 the rapid creation of vaccinations was increased the risk of vaccine safety problems. The aim of this study to provide evidence on Sinopharm COVID-19 vaccine side effects. Methods A cross-sectional survey study was conducted between January and April 2021 to collect data on the effects of COVID-19 vaccine among individuals in the UAE. Demographic data chronic conditions side effects of the 1st and 2nd dose toward the vaccination, and the response of unwilling taking COVID-19 vaccine were reported. Results The most common side effects of post 1st dose (less than 49 years old vs >49 years) were normal injection site pain, fatigue, and headache while pain at the vaccination site fatigue lethargy headache and tenderness were the most side effects of the post 2nd dose in both groups. All the side effects in both doses were more prevalent among the participants less than 49-year-old group. Among females vs males side effects were more common in females compared with males in both doses in both doses. The most common adverse reactions of 1st dose in (females vs males) were fatigue lethargy headache while in 2nd dose were fatigue sever injection site pain. The most common reason of not willing to take the COVID-19 vaccine were the vaccines are not effective and they were not authorized to take vaccine. Conclusion The 1st and 2nd dose post-vaccination side effects were mild predictable and there were no hospitalization cases this data will help to reduce the vaccine hesitancy.

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