scholarly journals Antimicrobial Activities of Chitosan Derivatives

Pharmaceutics ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1639
Author(s):  
Cristina Ardean ◽  
Corneliu Mircea Davidescu ◽  
Nicoleta Sorina Nemeş ◽  
Adina Negrea ◽  
Mihaela Ciopec ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Activities ◽  
Culture Collection ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
New Materials ◽  
Direct Control ◽  
Antifungal Effects ◽  
Antibacterial And Antifungal ◽  
Reference Strains

Considering the challenge created by the development of bacterial and fungal strains resistant to multiple therapeutic variants, new molecules and materials with specific properties against these microorganisms can be synthesized, like those synthesized from biopolymers such as chitosan with improved antimicrobial activities. Antimicrobial activities of seven obtained materials were tested on four reference strains belonging to American Type Culture Collection. The best antimicrobial activity was obtained by functionalization by impregnation of chitosan with quaternary ammonium salts, followed by that obtained by functionalization of chitosan with phosphonium. The lowest antibacterial and antifungal effects were expressed by Ch-THIO and Ch-MBT, but new materials obtained with these extractants may be precursors with a significant role in the direct control of active molecules, such as cell growth factors or cell signaling molecules.

scholarly journals Biological Activity of Quaternary Ammonium Salts and Their Derivatives

Pathogens ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 459 ◽  
Author(s):  
Dobrawa Kwaśniewska ◽  
Ying-Lien Chen ◽  
Daria Wieczorek
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activity ◽  
Quaternary Ammonium ◽  
Quaternary Ammonium Salts ◽  
Ammonium Salts ◽  
Food Spoilage ◽  
Biocidal Activity ◽  
Positive Role ◽  
Current State ◽  
Potential Use

Besides their positive role, microorganisms are related to a number of undesirable effects, including many diseases, biodeterioration and food spoilage, so when their presence is undesired, they must be controlled. Numerous biocides limiting the development of microorganisms have been proposed, however, in this paper the biocidal and inhibitory activity of quaternary ammonium salts (QASs) and their zwitterionic derivatives is addressed. This paper presents the current state of knowledge about the biocidal activity of QAS and their derivatives. Moreover, the known mechanisms of antimicrobial activity and the problem of emerging resistance to QAS are discussed. The latest trends in the study of surfactants and their potential use are also presented.

scholarly journals Identification and Antimicrobial Activity of Marine Streptomyces from Geographically Different Regions of Indonesia

2015 ◽  
Vol 10 (1) ◽  
pp. 17
Author(s):  
Rofiq Sunaryanto ◽  
Anis Herliyani Mahsunah
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Activities ◽  
Culture Collection ◽  
Rrna Gene ◽  
16S Rrna Gene Analysis ◽  
Streptomyces Species ◽  
Subtilis Atcc ◽  
Phylogenetic Cluster ◽  
Marine Streptomyces ◽  
Peptone Medium

Identification and antimicrobial assay of indegenous marine Streptomyces have been conducted. Samples were obtained from culture collection of Biotech Center, Agency for the Assessment and Application of Technology (BPPT). They were originated from several Indonesian seashores including Pelabuhan Ratu, Pangandaran, Manokwari, Pulau Seribu, Garut, Bangka, Banjarmasin, Belitung, Cirebon, and Palu. Isolates stored as glycerol stocks were inoculated onto HV (Humic acid vitamin) agar and incubated for 5 days at 30 °C. Each colony was cultivated using yeast-peptone medium and then extracted by butanol. Antimicrobial activities were monitored by the agar diffusion paper-disc method against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Bacillus subtilis ATCC 66923, Pseudomonas aeruginosa ATCC 27853, Candida albicans BIOMCC 00122 and Aspergillus niger BIOMCC 0013. Molecular identification of Streptomyces was carried out based on 16S rRNA gene analysis. Our research results showed that 71 isolates obtained from several Indonesian seashore were identified as 57 different Streptomyces species. Fifty of them showed antimicrobial activity. Twenty three isolates inhibited B. subtilis ATCC 66923, 14 isolates inhibited S. aureus ATCC 25923, 24 isolates inhibited C. albicans BIOMCC 00122 and 26 isolates inhibited A. niger BIOMCC 0013 and there was no active isolates inhibited the growth of E. coli ATCC 25922 and P. aeruginosa ATCC 27853. Phylogenetic analysis showed that Streptomyces isolates originated from the same geographically region was not necessarily grouped into the same cluster. Likewise a phylogenetic cluster may contain isolates of the same Streptomyces species, but from geographically different locations.

scholarly journals SYNTHESIS OF SOME NOVEL (E)-METHYL 2,4-DIMETHYL-5-(3-OXO-3-PHENYLPROP-1-EN-1- YL)-1H-PYRROLE-3-CARBOXYLATE DERIVATIVES AS ANTIMICROBIAL AGENT

2019 ◽  
pp. 464-469
Author(s):  
MAHESH HUBLIKAR ◽  
PRASHANT DIXIT ◽  
VIKAS KADU ◽  
SACHIN SHIRAME ◽  
DATTATRAYA RAUT ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Agents ◽  
Heterocyclic Ring ◽  
Antimicrobial Activities ◽  
Activity Data ◽  
Acetophenone Derivatives ◽  
1H Nuclear Magnetic Resonance ◽  
Therapeutic Tools ◽  
Antibacterial And Antifungal

Objective: The objective of the present study was to synthesize a series of some novel (E)-methyl 2,4-dimethyl-5-(3-oxo-3-phenylprop-1-en-1-yl)-1H-pyrrole-3-carboxylate derivatives and to evaluate it’s in vitro antimicrobial activities. Methods: A novel series of (E)-methyl 2,4-dimethyl-5-(3-oxo-3-phenylprop-1-en-1-yl)-1H-pyrrole-3-carboxylate derivative (8a-l) has been synthesized by cyclization (Knorr reaction) hydrolysis, decarboxylation, and Vilsmeier–Haack formylation reaction. 5-formyl-2,4-dimethyl-1H-pyrrole-3-carboxylate 6 undergo condensation with acetophenone derivatives 7a-l in methanol and potassium hydroxide. The synthesized compounds were screened for in vitro antimicrobial screening. Results: The structures of the synthesized compounds were characterized by infrared, 1H nuclear magnetic resonance, and mass spectroscopy. The antimicrobial activity data revealed that the synthesized derivatives possess good antibacterial and antifungal activity which is attributed due to the presence of the heterocyclic ring; further, the activity increased with the introduction of a methoxy group in the structure. Conclusions: New pyrrole chalcone derivatives act as significant antimicrobial agents, easy work-up procedure and reaction take place with minimum side product. Antimicrobial activity report provides an interesting template for the syntheses of new antimicrobial agents and may be helpful for the design of new therapeutic tools.

Antimicrobial Activity of Quaternary Ammonium Salts of Some Saturated Heterocycloalkyl Amines [1]

1979 ◽  
Vol 34 (5-6) ◽  
pp. 485-486 ◽  
Author(s):  
Ivan Lacko ◽  
Ferdinand Devínsky ◽  
Ľudovít Krasnec ◽  
Dušan Mlynarčik
Keyword(s):  
Antimicrobial Activity ◽  
Quaternary Ammonium ◽  
Alkyl Chain ◽  
Heterocyclic Ring ◽  
Substantial Effect ◽  
Quaternary Ammonium Salts ◽  
Heterocyclic Amines ◽  
Ammonium Salts ◽  
Activity Change ◽  
Inhibition Concentration

Abstract N,N-Dialkyl Ammonium Salts of Saturated Heterocyclic Amines, Antimicrobial Activity Antimicrobial activity of N-alkyl-N-dodecylpiperidinium bromides and N-ethyl-N-dodecylheterocycloalkyl ammonium bromides (pyrrolidine, morpholine, perhydroazepine) deter­ mined on grampositive and gramnegative bacteria, yeasts and moulds, presented as minimum inhibition concentration (MIC). Comparison of the effect of change of structure: lenghtening of alkyl chain, change of heterocyclic ring. Change in the lenght of alkyl chain markedly affects the antimicrobial activity, change of heterocyclic ring has no substantial effect. The most active compounds were N-heptyl-and N-hexyl-N-dodecylpiperidinium bromides.

scholarly journals Antibacterial Potential of Citral Derivatives

2011 ◽  
Vol 6 (9) ◽  
pp. 1934578X1100600
Author(s):  
Soni A. Singh ◽  
Yogesh A. Potdar ◽  
Rasika S. Pawar ◽  
Sujata V. Bhat
Keyword(s):  
Antimicrobial Activity ◽  
Antimicrobial Activities ◽  
Serial Dilution ◽  
Disc Diffusion ◽  
Antifungal Activities ◽  
Antibacterial And Antifungal Activities ◽  
Antibacterial And Antifungal ◽  
Antibacterial Potential

Nine conjugated acid derivatives from monoterpene citral have been synthesized using ester, amide condensations, Wittig, Knoevenagel, Baylis-Hillman reactions and their antimicrobial activities were evaluated through disc diffusion and serial dilution methods. Several derivatives displayed interesting antimicrobial activity. Particularly, the Baylis-Hillman adducts 8-10 were found to have more potent antibacterial and antifungal activities than standard drugs namely chloramphenicol and nystatin respectively.

Preliminary phytochemical screening and antimicrobial activities of plant extract of Elaeocarpus ganitrus Roxb.

2016 ◽  
Vol 5 (09) ◽  
pp. 4885 ◽  
Author(s):  
Khushbu Pandey ◽  
Mahendra Singh* ◽  
Bharat Pandey ◽  
Anshulika Upadhyaya ◽  
Kamal K. Pande
Keyword(s):  
Antimicrobial Activity ◽  
Rhizopus Oryzae ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Phytochemical Analysis ◽  
Phytochemical Screening ◽  
Bacterial Strains ◽  
E Coli ◽  
Antibacterial And Antifungal ◽  
Anti Fungal

The present study was carried out for phytochemical screening of principle bioactive compounds and antimicrobial activity in Elaeocarpus ganitrus Roxb., Phytochemical analysis revealed the presence of saponin, terpenoid, steroid, saponin, flavonoid, tannin and alkaloid. The petroleum, ether, chloroform, methanol, acetone and aqueous extracts were subjected to antimicrobial activity against bacterial strains Staphylococcus aureus, Pseudomonas, E. coli and Bacillus subtilis against anti-fungal strains A.awamori, A.fumigatus, Rhizopus oryzae, Trichoderma viridae and C.oryzae. The antibacterial and antifungal activity was evaluated by disc-diffusion method.

scholarly journals Antibacterial and antifungal effects of alcoholic extracts of 41 medicinal plants growing in Turkey

2010 ◽  
Vol 28 (No. 1) ◽  
pp. 53-60 ◽  
Author(s):  
Ö. Ertürk
Keyword(s):  
Antimicrobial Activity ◽  
Alnus Glutinosa ◽  
Viscum Album ◽  
Antibacterial And Antifungal Activities ◽  
Galega Officinalis ◽  
Ethanolic Extracts ◽  
Thymus Capitatus ◽  
Antifungal Effects ◽  
Rhus Coriaria ◽  
Antibacterial And Antifungal

The antibacterial and antifungal activities of crude ethanolic extracts of 41 traditional medicinal plant species belonging to 26 families were tested against four bacteria and two fungi: <I>Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans</I>, and <I>Aspergillus niger</I>. Of the 41 plants tested, 39 showed antimicrobial activity against one or more species of microorganisms. While the crude extracts from <I>Nigellea arvensis</I> did not show antimicrobial activity against the test microorganisms, <I>Pistasia lentiscus</I> showed only antifungal activity against A. <I>niger</I>. The most active antimicrobial plants were <I>Cuminum cyminum, Jasminium officinale, Thymus capitatus, Viscum album, Tanecetum sorbifolium, Pimpinella anisum, Galega officinalis, Liguidamber orientalis, Rhus coriaria, Alnus glutinosa, Pimental officinalis, Achillea coarctata</I>, and <I>Cameli sinensis</I>.

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