scholarly journals Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1945
Author(s):  
Mengru Cai ◽  
Yawen Zeng ◽  
Manting Liu ◽  
Longtai You ◽  
Huating Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Imaging ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Systemic Toxicity ◽  
In Vivo Studies ◽  
Functionalized Nanoparticles ◽  
Metal Organic

The antitumor activity of triptolide (TP) has received widespread attention, although its toxicity severely limits its clinical application. Therefore, the design of a targeted drug delivery system (TDDS) has important application prospects in tumor treatment. Metal–organic frameworks (MOFs), with high drug-carrying capacity and good biocompatibility, have aroused widespread interest for drug delivery systems. Herein, folic acid (FA) and 5-carboxylic acid fluorescein (5-FAM) were used to modify Fe-MIL-101 to construct a functionalized nano-platform (5-FAM/FA/TP@Fe-MIL-101) for the targeted delivery of the anti-tumor drug triptolide and realize in vivo fluorescence imaging. Compared with Fe-MIL-101, functionalized nanoparticles not only showed better targeted therapy efficiency, but also reduced the systemic toxicity of triptolide. In addition, the modification of 5-FAM facilitated fluorescence imaging of the tumor site and realized the construction of an integrated nano-platform for fluorescence imaging and treatment. Both in vitro and in vivo studies of functionalized nanoparticles have demonstrated excellent fluorescence imaging and synergistic targeting anticancer activity with negligible systemic toxicity. The development of functional nano-platform provides new ideas for the design of MOF-based multifunctional nano-drug delivery system, which can be used for precise treatment of tumor.

Novel Self-Micro Emulsifying Drug Delivery System for safe intra muscular delivery with improved pharmacodynamics and pharmacokinetics

2021 ◽  
Vol 18 ◽  
Author(s):  
Subheet Kumar Jain ◽  
Neha Panchal ◽  
Amrinder Singh ◽  
Shubham Thakur ◽  
Navid Reza Shahtaghi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inflammatory Diseases ◽  
Diclofenac Sodium ◽  
Physical Stability ◽  
In Vivo Studies ◽  
High Concentration

Background: Diclofenac sodium (DS) injection is widely used in the management of acute or chronic pain and inflammatory diseases. It incorporates 20 % w/v Transcutol-P as a solubilizer to make the stable injectable formulation. However, the use of Transcutol-P in high concentration leads to adverse effects such as severe nephrotoxicity, etc. Some advancements resulted in the formulation of an aqueous based injectable but that too used benzyl alcohol reported to be toxic for human use. Objective: To develop an injectable self-micro emulsifying drug delivery system (SMEDDS) as a novel carrier of DS for prompt release with better safety and efficacy. Methods: A solubility study was performed with different surfactants and co-surfactants. The conventional stirring method was employed for the formulation of SMEDDS. Detailed in vitro characterization was done for different quality control parameters. In vivo studies were performed using Wistar rats for pharmacokinetic evaluation, toxicological analysis, and analgesic activity. Results: The optimized formulation exhibited good physical stability, ideal globule size (156±0.4 nm), quick release, better therapeutics, and safety, increase in LD50 (221.9 mg/kg) to that of the commercial counterpart (109.9 mg/kg). Further, pre-treatment with optimized formulation reduced the carrageenan-induced rat paw oedema by 88±1.2 % after 4 h, compared to 77±1.6 % inhibition with commercial DS formulation. Moreover, optimized formulation significantly (p<0.05) inhibited the pain sensation in the acetic-acid induced writhing test in mice compared to its commercial equivalent with a better pharmacokinetic profile. Conclusion: The above findings confirmed that liquid SMEDDS could be a successful carrier for the safe and effective delivery of DS

scholarly journals Self‐nanoemulsifying drug delivery system to improve transcorneal permeability of voriconazole: in‐vivo studies

2020 ◽  
Vol 72 (7) ◽  
pp. 889-896
Author(s):  
Bakoliarisoa Nivomalala Voahangy Rasoanirina ◽  
Mohamed Ali Lassoued ◽  
Karim Miladi ◽  
Zoarilala Razafindrakoto ◽  
Raja Chaâbane‐Banaoues ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vivo Studies ◽  
Transcorneal Permeability

Preparation and in vivo studies of a new drug delivery system

1984 ◽  
Vol 10 (1-3) ◽  
pp. 263-265 ◽  
Author(s):  
P. Maincent ◽  
J. P. Devissaguet ◽  
R. LeVerge ◽  
P. A. Sado ◽  
P. Couveur
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vivo Studies ◽  
New Drug

99mTc-citrate-gold nanoparticles as a tumor tracer: synthesis, characterization, radiolabeling and in-vivo studies

2020 ◽  
Vol 108 (10) ◽  
pp. 809-819 ◽  
Author(s):  
Basma M. Essa ◽  
Ahmed A. El-Mohty ◽  
Maher A. El-Hashash ◽  
Tamer M. Sakr
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Tumor ◽  
Tumor Imaging ◽  
In Vivo Studies ◽  
Post Injection ◽  
Tumor Bearing

AbstractTargeted drug delivery system can reduce the side effects of high drug concentration by improving drug pharmacokinetics at lower doses. Citrate-gold nanoparticles (AuNPs) as a drug delivery system were synthesized via green nanotechnology technique to be used as a new imaging platform for tumor targeting. Citrate-AuNPs were synthesized with core size of 10 nm. Citrate-AuNPs were labeled with technetium-99m (99mTc) with radiochemical yield of 95.20 ± 2.70% with good in-vitro stability in both saline and human serum and well in-vivo studied in both normal and solid tumor bearing mice. The in-vivo biodistribution study of [99mTc]Tc-citrate-AuNPs in solid tumor bearing mice (as preliminary study) showed a high accumulation in tumor site with tumor/muscle of 4.35 ± 0.22 after 30 min post injection. The direct intratumoral (I.T) injection of [99mTc]Tc-citrate-AuNPs showed that this complex was retained in the tumor up to 77.86 ± 1.90 % at 5 min and still around 50.00 ± 1.42 % after 30 min post injection (p.i.). The newly presented nano-platform could be presented as a new potential radiopharmaceutical tumor imaging probe.

Phytoniosomes: An emergent strategy for herbal drug delivery system.

2021 ◽  
Vol 11 ◽  
Author(s):  
Priya Kumari ◽  
Shaweta Sharma ◽  
Pramod Kumar Sharma ◽  
Mohd Aftab Alam
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Herbal Extract ◽  
In Vivo Studies ◽  
Original Research ◽  
Herbal Drugs ◽  
Research Papers ◽  
Factors Affecting

Background and Objective: In the current era of advancement in the field of pharmaceutics, there is a growing interest in applying nanomedicine technology for active phytoconstituents and herbal extracts. This revolution in the area of herbal medicine has led to the growth of different technological approaches for delivering poorly soluble active herbal constituents or phytoconstituents, and herbal extract to enhance the safety, bioavailability, efficacy as well as receptor binding selectivity of the active entity. These nano-medicinal approaches have shown to be more effective and reliable delivery system for herbal drugs. Niosomes are one of the novel drug delivery system approaches that have shown promising results when employed in the delivery of many drugs including herbal drugs. The term ‘phytoniosomes’ as mentioned in various research papers are phyto/herbal drugs encapsulated in a non-ionic vesicular system. During the past decade, several research articles have been published on the development and characterization of phytoniosome nano-vesicle along with their in vivo studies as well as delivery approaches via different routes. Methods: During the writing of this document, the data was derived from existing original research papers gathered from a variety of sources such as PubMed, Google Scholar, Science Direct, etc. Conclusion: This review discusses various aspects of phytoniosomes covering different areas such as techniques and methods involved in their preparation, various factors affecting their physicochemical properties while developing phytoniosomes, their characterization, and several applications and advantages.

scholarly journals Cancer, Natural Products and Nanodrug Delivery Systems

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Yong Sze Ong ◽  
Loh Teng-Hern Tan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Delivery ◽  
Drug Uptake ◽  
Biomedical Sciences ◽  
Nanodrug Delivery ◽  
Conventional Drug ◽  
Living Organisms

As an offshoot of nanotechnology, nanomedicine has made great impact in the field of pharmaceutical and biomedical sciences by achieving breakthroughs in therapeutics and diagnostics of diseases in living organisms. One of the promising breakthroughs is the application of natural product-based nanoformulations for the treatment of various human diseases, such as cancer. Principally, the nanoparticle-based drug delivery system (NDDS) aims to overcome the limitations of conventional drug delivery system. NDDS improves the in vivo pharmacological and therapeutic properties of the poorly soluble drugs by dissolving, encapsulating, absorbing and/or attaching the drugs with the matrices of the nanoparticles. The nanoparticles that act as drug reservoirs also aim to control the drug release, enhance the drug uptake by targeted delivery and protect the drug against enzymatic degradation. This review presents a summary of the integration of nanotechnology and phytotherapy to achieve an improved pharmacological response and better clinical outcome in patients undergoing chemotherapy.

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