Cancer, Natural Products and Nanodrug Delivery Systems

As an offshoot of nanotechnology, nanomedicine has made great impact in the field of pharmaceutical and biomedical sciences by achieving breakthroughs in therapeutics and diagnostics of diseases in living organisms. One of the promising breakthroughs is the application of natural product-based nanoformulations for the treatment of various human diseases, such as cancer. Principally, the nanoparticle-based drug delivery system (NDDS) aims to overcome the limitations of conventional drug delivery system. NDDS improves the in vivo pharmacological and therapeutic properties of the poorly soluble drugs by dissolving, encapsulating, absorbing and/or attaching the drugs with the matrices of the nanoparticles. The nanoparticles that act as drug reservoirs also aim to control the drug release, enhance the drug uptake by targeted delivery and protect the drug against enzymatic degradation. This review presents a summary of the integration of nanotechnology and phytotherapy to achieve an improved pharmacological response and better clinical outcome in patients undergoing chemotherapy.

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Development of a nanodrug-delivery system camouflaged by erythrocyte membranes for the chemo/phototherapy of cancer

Nanomedicine ◽

10.2217/nnm-2019-0454 ◽

2020 ◽

Vol 15 (7) ◽

pp. 691-709 ◽

Cited By ~ 1

Author(s):

Muhammad Daniyal ◽

YuQing Jian ◽

Feng Xiao ◽

Wenbing Sheng ◽

Jialong Fan ◽

...

Keyword(s):

Drug Delivery ◽

Cervical Cancer ◽

B Cell ◽

Drug Delivery System ◽

Delivery System ◽

Cell Lymphoma ◽

B Cell Lymphoma ◽

Erythrocyte Membranes ◽

Nanodrug Delivery

Aim: Development of a new drug-delivery system using a compound derived from Pronephrium penangianum (J5) for the treatment of cervical cancer. Materials & methods: The delivery system was developed using Prussian blue nanoparticles, camouflaged by red blood cell membrane and with folic acid surface modifications. Results: Our results showed the successful development of a nanodrug-delivery system, which increases the half-life and immune evasion ability of the drug. The mechanism of this system was through suppressing B-cell lymphoma 2 and increasing B-cell lymphoma 2-associated X protein and the cleaved caspase level. An in vivo study also confirmed good antitumor activity without any side effects to normal tissue. Conclusion: This drug-delivery system provides a good alternative for the treatment of cervical cancer using J5.

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A smart pH-responsive nano-carrier as a drug delivery system for the targeted delivery of ursolic acid: suppresses cancer growth and metastasis by modulating P53/MMP-9/PTEN/CD44 mediated multiple signaling pathways

Nanoscale ◽

10.1039/c7nr01677h ◽

2017 ◽

Vol 9 (27) ◽

pp. 9428-9439 ◽

Cited By ~ 45

Author(s):

Kai Jiang ◽

Ting Chi ◽

Tao Li ◽

Guirong Zheng ◽

Lulu Fan ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Ursolic Acid ◽

Delivery System ◽

Targeted Delivery ◽

Cancer Growth ◽

Ph Responsive ◽

Nanodrug Delivery ◽

System P ◽

Multiple Signaling

Anti-tumor and anti-metastatic effects of ursolic acid based on one novel nanodrug delivery system.

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MICROSPHERE A DRUG DELIVERY SYSTEM–A REVIEW

International Journal of Current Pharmaceutical Research ◽

10.22159/ijcpr.2019v11i4.34941 ◽

2019 ◽

pp. 34-41

Author(s):

MANOJ KUMAR DAS ◽

ABDUL BAQUEE AHMED ◽

DIPANKAR SAHA

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Therapeutic Efficacy ◽

Relative Concentration ◽

Central Place ◽

The Body ◽

Polymeric Membrane ◽

Conventional Drug

The targeted drug delivery is designed for endeavoring to concentrate the drug in the tissues of curiosity while reducing relative concentration of medication in the remaining tissues. There for drug is localized on the targeted site. Hence, surrounding tissues are not affected by the drug. Controlled drug delivery system can overcome the problems of conventional drug therapy and gives better therapeutic efficacy of a drug. Microspheres are characteristically free flowing powders consisting of proteins or synthetic polymers having a particle size ranging from 1-1000 µm. The range of Techniques for the preparation of microspheres offers a Variety of opportunities to control aspects of drug administration and enhance the therapeutic efficacy of a given drug. There are various approaches in delivering a therapeutic substance to the target site in a sustained controlled release fashion. Microspheres has a drug located centrally within the particle, where it is encased within a unique polymeric membrane. In future various other strategies, microspheres will find the central place in novel drug delivery, particularly in diseased cell sorting, diagnostics, gene and genetic materials, safe, targeted and effective in vivo delivery and supplements as miniature versions of diseased organ and tissues in the body.

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Construction of a Multifunctional Nano-Scale Metal-Organic Framework-Based Drug Delivery System for Targeted Cancer Therapy

Pharmaceutics ◽

10.3390/pharmaceutics13111945 ◽

2021 ◽

Vol 13 (11) ◽

pp. 1945

Author(s):

Mengru Cai ◽

Yawen Zeng ◽

Manting Liu ◽

Longtai You ◽

Huating Huang ◽

...

Keyword(s):

Drug Delivery ◽

Fluorescence Imaging ◽

Drug Delivery System ◽

Delivery System ◽

Targeted Delivery ◽

Systemic Toxicity ◽

In Vivo Studies ◽

Functionalized Nanoparticles ◽

Metal Organic

The antitumor activity of triptolide (TP) has received widespread attention, although its toxicity severely limits its clinical application. Therefore, the design of a targeted drug delivery system (TDDS) has important application prospects in tumor treatment. Metal–organic frameworks (MOFs), with high drug-carrying capacity and good biocompatibility, have aroused widespread interest for drug delivery systems. Herein, folic acid (FA) and 5-carboxylic acid fluorescein (5-FAM) were used to modify Fe-MIL-101 to construct a functionalized nano-platform (5-FAM/FA/TP@Fe-MIL-101) for the targeted delivery of the anti-tumor drug triptolide and realize in vivo fluorescence imaging. Compared with Fe-MIL-101, functionalized nanoparticles not only showed better targeted therapy efficiency, but also reduced the systemic toxicity of triptolide. In addition, the modification of 5-FAM facilitated fluorescence imaging of the tumor site and realized the construction of an integrated nano-platform for fluorescence imaging and treatment. Both in vitro and in vivo studies of functionalized nanoparticles have demonstrated excellent fluorescence imaging and synergistic targeting anticancer activity with negligible systemic toxicity. The development of functional nano-platform provides new ideas for the design of MOF-based multifunctional nano-drug delivery system, which can be used for precise treatment of tumor.

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Glucan particles as anti-inflammatory agent and drug delivery system for natural compounds in experimentally induced intestinal inflammation in vivo

10.1055/s-0037-1608375 ◽

2017 ◽

Author(s):

D Rotrekl ◽

Z Vochyánová ◽

L Paráková ◽

I Saloň ◽

P Šalamúnová ◽

...

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Intestinal Inflammation ◽

Natural Compounds ◽

Inflammatory Agent ◽

Anti Inflammatory ◽

Experimentally Induced

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Development and Evaluation of Floating Pulsatile Drug Delivery System Using Meloxicam

International Journal of Drug Delivery Technology ◽

10.25258/ijddt.v7i04.10647 ◽

2017 ◽

Vol 7 (04) ◽

Author(s):

ShirishaG. Suddala ◽

S. K. Sahoo ◽

M. R. Yamsani

Keyword(s):

Rheumatoid Arthritis ◽

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Lag Time ◽

Oral Dosage ◽

Lag Phase ◽

Pulsatile Drug Delivery

Objective: The objective of this research work was to develop and evaluate the floating– pulsatile drug delivery system (FPDDS) of meloxicam intended for Chrono pharmacotherapy of rheumatoid arthritis. Methods: The system consisting of drug containing core, coated with hydrophilic erodible polymer, which is responsible for a lag phase for pulsatile release, top cover buoyant layer was prepared with HPMC K4M and sodium bicarbonate, provides buoyancy to increase retention of the oral dosage form in the stomach. Meloxicam is a COX-2 inhibitor used to treat joint diseases such as osteoarthritis and rheumatoid arthritis. For rheumatoid arthritis Chrono pharmacotherapy has been recommended to ensure that the highest blood levels of the drug coincide with peak pain and stiffness. Result and discussion: The prepared tablets were characterized and found to exhibit satisfactory physico-chemical characteristics. Hence, the main objective of present work is to formulate FPDDS of meloxicam in order to achieve drug release after pre-determined lag phase. Developed formulations were evaluated for in vitro drug release studies, water uptake and erosion studies, floating behaviour and in vivo radiology studies. Results showed that a certain lag time before drug release which was due to the erosion of the hydrophilic erodible polymer. The lag time clearly depends on the type and amount of hydrophilic polymer which was applied on the inner cores. Floating time and floating lag time was controlled by quantity and composition of buoyant layer. In vivo radiology studies point out the capability of the system of longer residence time of the tablets in the gastric region and releasing the drug after a programmed lag time. Conclusion: The optimized formulation of the developed system provided a lag phase while showing the gastroretension followed by pulsatile drug release that would be beneficial for chronotherapy of rheumatoid arthritis and osteoarthritis.

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