scholarly journals Advanced Microfluidic Technologies for Lipid Nano-Microsystems from Synthesis to Biological Application

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 141
Author(s):  
Bruna Carvalho ◽  
Bruno Ceccato ◽  
Mariano Michelon ◽  
Sang Han ◽  
Lucimara de la Torre
Keyword(s):  
Lipid Nanoparticles ◽  
Future Trends ◽  
Biological Applications ◽  
Biological Application ◽  
Shell Nanoparticles ◽  
Cellular Environment ◽  
Wide Range ◽  
Core Shell Nanoparticles ◽  
New Strategies ◽  
Lipid Structures

Microfluidics is an emerging technology that can be employed as a powerful tool for designing lipid nano-microsized structures for biological applications. Those lipid structures can be used as carrying vehicles for a wide range of drugs and genetic materials. Microfluidic technology also allows the design of sustainable processes with less financial demand, while it can be scaled up using parallelization to increase production. From this perspective, this article reviews the recent advances in the synthesis of lipid-based nanostructures through microfluidics (liposomes, lipoplexes, lipid nanoparticles, core-shell nanoparticles, and biomimetic nanovesicles). Besides that, this review describes the recent microfluidic approaches to produce lipid micro-sized structures as giant unilamellar vesicles. New strategies are also described for the controlled release of the lipid payloads using microgels and droplet-based microfluidics. To address the importance of microfluidics for lipid-nanoparticle screening, an overview of how microfluidic systems can be used to mimic the cellular environment is also presented. Future trends and perspectives in designing novel nano and micro scales are also discussed herein.

scholarly journals Synthesis and Advanced Characterization of Polymer-Protein Core-Shell Nanoparticles

Catalysts ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 730
Author(s):  
Erik Sarnello ◽  
Tao Li
Keyword(s):  
Particle Size ◽  
Small Angle ◽  
Core Shell ◽  
Assembly Process ◽  
Shell Nanoparticles ◽  
X Ray ◽  
X Ray Scattering ◽  
Wide Range ◽  
Core Shell Nanoparticles ◽  
Ray Scattering

Enzyme immobilization techniques are widely researched due to their wide range of applications. Polymer–protein core–shell nanoparticles (CSNPs) have emerged as a promising technique for enzyme/protein immobilization via a self-assembly process. Based on the desired application, different sizes and distribution of the polymer–protein CSNPs may be required. This work systematically studies the assembly process of poly(4-vinyl pyridine) and bovine serum albumin CSNPs. Average particle size was controlled by varying the concentrations of each reagent. Particle size and size distributions were monitored by dynamic light scattering, ultra-small-angle X-ray scattering, small-angle X-ray scattering and transmission electron microscopy. Results showed a wide range of CSNPs could be assembled ranging from an average radius as small as 52.3 nm, to particles above 1 µm by adjusting reagent concentrations. In situ X-ray scattering techniques monitored particle assembly as a function of time showing the initial particle growth followed by a decrease in particle size as they reach equilibrium. The results outline a general strategy that can be applied to other CSNP systems to better control particle size and distribution for various applications.

Controlled Synthesis and Characterization of Co-Au Core-shell Nanoparticles

2005 ◽  
Vol 877 ◽  
Author(s):  
Yuping Bao ◽  
Hector Calderon ◽  
Kannan M. Krishnan
Keyword(s):  
Core Shell ◽  
Gold Compound ◽  
Contrast Imaging ◽  
Shell Nanoparticles ◽  
Transmission Electron ◽  
Wide Range ◽  
High Resolution Tem ◽  
Core Shell Nanoparticles ◽  
Z Contrast ◽  
First Time

AbstractCo-Au Core-shell nanoparticles are synthesized by slowly reducing an organo-gold compound on pre-made cobalt seeds with a weak reducer at mild condition. For the first time, these coreshell nanoparticles are generated in non-polar solvent in a controlled manner. The formation theory of core-shell structure, especially the seed size effect, is addressed as well. These coreshell structures are confirmed with a wide range of transmission electron microscopy (TEM) methods, which includes routine TEM images, high resolution TEM, and z-contrast imaging.

scholarly journals Bubble nucleation and migration in a lead–iron hydr(oxide) core–shell nanoparticle

2015 ◽  
Vol 112 (42) ◽  
pp. 12928-12932 ◽  
Author(s):  
Kaiyang Niu ◽  
Timofey Frolov ◽  
Huolin L. Xin ◽  
Junling Wang ◽  
Mark Asta ◽  
...  
Keyword(s):  
Iron Hydroxide ◽  
Steel Corrosion ◽  
Elastic Interaction ◽  
Bubble Nucleation ◽  
Core Shell ◽  
In Situ Observation ◽  
Shell Nanoparticles ◽  
Wide Range ◽  
And Migration ◽  
Core Shell Nanoparticles

Iron hydroxide is found in a wide range of contexts ranging from biominerals to steel corrosion, and it can transform to anhydrous oxide via releasing O2 gas and H2O. However, it is not well understood how gases transport through a crystal lattice. Here, we present in situ observation of the nucleation and migration of gas bubbles in iron (hydr)oxide using transmission electron microscopy. We create Pb–FeOOH model core–shell nanoparticles in a liquid cell. Under electron irradiation, iron hydroxide transforms to iron oxide, during which bubbles are generated, and they migrate through the shell to the nanoparticle surface. Geometric phase analysis of the shell lattice shows an inhomogeneous stain field at the bubbles. Our modeling suggests that the elastic interaction between the core and the bubble provides a driving force for bubble migration.

scholarly journals Facile synthesis of high-performance SiO2@Au core–shell nanoparticles with high SERS activity

RSC Advances ◽  
2018 ◽  
Vol 8 (54) ◽  
pp. 30825-30831 ◽  
Author(s):  
Keli Wang ◽  
Yanping Wang ◽  
Chongwen Wang ◽  
Xiaofei Jia ◽  
Jia Li ◽  
...  
Keyword(s):  
High Performance ◽  
Core Shell ◽  
Facile Synthesis ◽  
Shell Nanoparticles ◽  
Wide Range ◽  
Core Shell Nanoparticles ◽  
General Method

This study proposes a facile and general method for fabricating a wide range of high-performance SiO2@Au core–shell nanoparticles (NPs).

scholarly journals Influence of Shell Parameters on Optical Properties of Spherical Metallic Core-Oxide Shell Nanoparticles

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Victor K. Pustovalov ◽  
Liudmila G. Astafyeva
Keyword(s):  
Metallic Nanoparticles ◽  
Oxide Shell ◽  
Spectral Interval ◽  
Metal Core ◽  
Metal Shell ◽  
Shell Nanoparticles ◽  
Wide Range ◽  
Potential Applications ◽  
Efficiency Factors ◽  
Core Shell Nanoparticles

Different metal homogeneous nanoparticles have been extensively studied in recent years due to their wide range of potential applications. It is very interesting to investigate core-shell nanoparticles with oxide shell from core metal. The formation of oxide shell on metallic nanoparticles can be achieved by different chemical and physical methods including also natural oxidation of pure metallic nanoparticles in gaseous or liquid media, containing oxygen components (air, water, etc.). We numerically calculated efficiency factors of absorptionKabs, scatteringKsca, and extinctionKextof radiation with wavelengthλin the spectral interval 150–1000 nm by spherical homogeneous metallic and two-layered (metal core – oxide metal shell) nanoparticles: Al, Al-Al2O3and Zn, Zn-ZnO with core radii in the range 5–50 nm and shell thickness 5 nm. Analysis of presented results has been carried out.

Luminescent core@shell nanoparticles functionalized with PEG for biological applications

2019 ◽  
Vol 297 (4) ◽  
pp. 603-611
Author(s):  
Shivani Bharti ◽  
Gurvir Kaur ◽  
Shikha Gupta ◽  
S. K. Tripathi
Keyword(s):  
Core Shell ◽  
Biological Applications ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles

scholarly journals Guanidine functionalized core–shell structured magnetic cobalt-ferrite: an efficient nanocatalyst for sonochemical synthesis of spirooxindoles in water

RSC Advances ◽  
2021 ◽  
Vol 11 (25) ◽  
pp. 15360-15368
Author(s):  
Mahla Dadaei ◽  
Hossein Naeimi
Keyword(s):  
Cobalt Ferrite ◽  
Core Shell ◽  
Shell Material ◽  
Sonochemical Synthesis ◽  
Shell Nanoparticles ◽  
The Core ◽  
Wide Range ◽  
Core Shell Nanoparticles

The core/shell nanoparticles have a wide range of applications in the science of chemistry and biomedical. The core-shell material can be different and modified by changing the ingredients or the ratio of core to the shell.

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