scholarly journals Fatty Acid Derivatives Isolated from the Oil of Persea americana (Avocado) Protects against Neomycin-Induced Hair Cell Damage

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 171
Author(s):  
SeonJu Park ◽  
Seo Yule Jeong ◽  
Youn Hee Nam ◽  
Jun Hyung Park ◽  
Isabel Rodriguez ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Hair Cells ◽  
Spectroscopic Analysis ◽  
Cell Damage ◽  
Persea Americana ◽  
Zebrafish Model ◽  
Beneficial Effects ◽  
Fatty Acid Derivatives ◽  
Avocado Oil ◽  
New Compounds

Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.

scholarly journals New Cyclopentyl Fatty Acid and Cyanohydrin Glycosides from Fruits of Hydnocarpus hainanensis

2017 ◽  
Vol 12 (2) ◽  
pp. 1934578X1701200
Author(s):  
Thanh Tra Nguyen ◽  
Bich Ngan Truong ◽  
Huong Doan Thi Mai ◽  
Marc Litaudon ◽  
Van Hung Nguyen ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Spectroscopic Analysis ◽  
2D Nmr ◽  
New Compounds ◽  
Line Compound

Three new compounds, hydnohainanic acid (1), and hydnohainanin A (2) and B (3) were isolated from the fruits of Hydnocarpus hainanensis (Achariaceae). Their structures were determined by spectroscopic analysis, including 2D NMR, and MS. Compounds 1-3 were evaluated for their cytotoxic activity against the KB cell line. Compound 1 had a moderate cytotoxicity with an IC50 value of 32.5 μg/mL, while the two remaining compounds did not exhibit inhibition, even at a concentration of 128 μg/mL.

scholarly journals Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes

Nutrients ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 113 ◽  
Author(s):  
Youn Hee Nam ◽  
Isabel Rodriguez ◽  
Seo Yeon Jeong ◽  
Thu Nguyen Minh Pham ◽  
Wanlapa Nuankaew ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Hair Cells ◽  
Cell Function ◽  
Cell Damage ◽  
Transmission Function ◽  
Pathway Enrichment Analysis ◽  
Avocado Oil ◽  
Oil Extract

Sensorineural hearing loss (SNHL) is one of the most common causes of disability, affecting over 466 million people worldwide. However, prevention or therapy of SNHL has not been widely studied. Avocado oil has shown many health benefits but it has not yet been studied in regards to SNHL. Therefore, we aimed to investigate the efficacy of avocado oil on SNHL in vitro and in vivo and elucidate its mode of action. For the present study, we used enhanced functional avocado oil extract (DKB122). DKB122 led to recovery of otic hair cells in zebrafish after neomycin-induced otic cell damage. Also, DKB122 improved auditory sensory transmission function in a mouse model of noise induced-hearing loss and protected sensory hair cells in the cochlea. In addition, RNA sequencing was performed to elucidate the mechanism involved. KEGG pathway enrichment analysis of differentially expressed genes showed that DKB122 protected House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against neomycin-related alterations in gene expression due to oxidative stress, cytokine production and protein synthesis.

Lactic acid fermentation enriches the profile of biogenic fatty acid derivatives of avocado fruit (Persea americana Mill.)

2020 ◽  
Vol 317 ◽  
pp. 126384 ◽  
Author(s):  
Pasquale Filannino ◽  
Ali Z.A. Tlais ◽  
Ksenia Morozova ◽  
Ivana Cavoski ◽  
Matteo Scampicchio ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Fatty Acid ◽  
Persea Americana ◽  
Lactic Acid Fermentation ◽  
Acid Fermentation ◽  
Fatty Acid Derivatives ◽  
Avocado Fruit ◽  
Derivatives Of

A targeted metabolomics approach to characterize acetogenin profiles in avocado fruit (Persea americana Mill.)

RSC Advances ◽  
2015 ◽  
Vol 5 (128) ◽  
pp. 106019-106029 ◽  
Author(s):  
Carlos Eduardo Rodríguez-López ◽  
Carmen Hernández-Brenes ◽  
Rocío I. Díaz de la Garza
Keyword(s):  
Fatty Acid ◽  
Persea Americana ◽  
Aliphatic Chain ◽  
Targeted Metabolomics ◽  
Fatty Acid Derivatives ◽  
Avocado Fruit

Lauraceous acetogenins are fatty acid derivatives with an odd-carbon aliphatic chain found in avocado (Persea americana Mill.).

Avocado oil ( Persea americana ) protects SH‐SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules

2021 ◽  
Vol 45 (2) ◽  
Author(s):  
Jéssica Rosso Motta ◽  
Ivo Emilio da Cruz Jung ◽  
Verônica Farina Azzolin ◽  
Cibele Ferreira Teixeira ◽  
Luiza Elizabete Braun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Persea Americana ◽  
Avocado Oil

scholarly journals Valorization of waste-cooking oil into sophorolipids and application of their methyl hydroxyl branched fatty acid derivatives to produce engineering bioplastics

2021 ◽  
Vol 124 ◽  
pp. 195-202
Author(s):  
Jeong-Hun Kim ◽  
Yu-Ri Oh ◽  
Juyoung Hwang ◽  
Jaeryeon Kang ◽  
Hyeri Kim ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Waste Cooking Oil ◽  
Cooking Oil ◽  
Fatty Acid Derivatives

Divinylcarbinol Desymmetrization Strategy: A Concise and Reliable Approach to Chiral Hydroxylated Fatty Acid Derivatives

2021 ◽  
Vol 86 (5) ◽  
pp. 3970-3980
Author(s):  
Kenji Sugimoto ◽  
Ami Kobayashi ◽  
Aki Kohyama ◽  
Haruka Sakai ◽  
Yuji Matsuya
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Derivatives

scholarly journals Inner Ear and Muscle Developmental Defects in Smpx-Deficient Zebrafish Embryos

2021 ◽  
Vol 22 (12) ◽  
pp. 6497
Author(s):  
Anna Ghilardi ◽  
Alberto Diana ◽  
Renato Bacchetta ◽  
Nadia Santo ◽  
Miriam Ascagni ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Inner Ear ◽  
Hair Cells ◽  
Muscle Fibers ◽  
Underlying Mechanism ◽  
Loss Of Function ◽  
Zebrafish Model ◽  
Developmental Defects ◽  
Inner Ear Development ◽  
Syndromic Hearing Loss

The last decade has witnessed the identification of several families affected by hereditary non-syndromic hearing loss (NSHL) caused by mutations in the SMPX gene and the loss of function has been suggested as the underlying mechanism. In the attempt to confirm this hypothesis we generated an Smpx-deficient zebrafish model, pointing out its crucial role in proper inner ear development. Indeed, a marked decrease in the number of kinocilia together with structural alterations of the stereocilia and the kinocilium itself in the hair cells of the inner ear were observed. We also report the impairment of the mechanotransduction by the hair cells, making SMPX a potential key player in the construction of the machinery necessary for sound detection. This wealth of evidence provides the first possible explanation for hearing loss in SMPX-mutated patients. Additionally, we observed a clear muscular phenotype consisting of the defective organization and functioning of muscle fibers, strongly suggesting a potential role for the protein in the development of muscle fibers. This piece of evidence highlights the need for more in-depth analyses in search for possible correlations between SMPX mutations and muscular disorders in humans, thus potentially turning this non-syndromic hearing loss-associated gene into the genetic cause of dysfunctions characterized by more than one symptom, making SMPX a novel syndromic gene.

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