Avocado oil ( Persea americana ) protects SH‐SY5Y cells against cytotoxicity triggered by cortisol by the modulation of BDNF, oxidative stress, and apoptosis molecules

2021 ◽  
Vol 45 (2) ◽  
Author(s):  
Jéssica Rosso Motta ◽  
Ivo Emilio da Cruz Jung ◽  
Verônica Farina Azzolin ◽  
Cibele Ferreira Teixeira ◽  
Luiza Elizabete Braun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Persea Americana ◽  
Avocado Oil

Attenuation of Alloxan-induced Low-grade Inflammation by Persea Americana Polyphenolic Peel Extract in Male Wistar Rats

2021 ◽  
Author(s):  
OLAREWAJU MICHAEL oluba ◽  
Daniel O. Abasiri ◽  
Babatunde Ibitoye ◽  
Samuel Ojeaburu ◽  
George Eidangbe ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Diabetic Control ◽  
Diabetic Rats ◽  
Persea Americana ◽  
Low Grade ◽  
Distilled Water ◽  
Management Of Complications ◽  
Low Grade Inflammation ◽  
Peel Extract

Abstract Background: Based on the conceived causal relationship that exist between oxidative stress, hyperglycemia and low‐grade inflammation, this study was hypothesized to evaluate how treatment with polyphenolic peel extract of avocado pear (APPE), with established antioxidant activity, may be deployed in the management of complications arising from diabetes. Methods: Twenty adult male alloxan-induced diabetic Wistar rats randomly assigned to five groups (n = 5) designated: diabetic control (DC), treated with distilled water; and 25, 50, 100 and 200 mg/kg APPE, respectively. A sixth group comprising of five normal rats administered distilled water served as normal control (NC). Results: Following a 21-day single daily oral administration of APPE, remarkable improvements in body weight and blood glucose concentration were noted in diabetic rats especially at 200 mg/kg compared to DC. A dose-related significant reductions in glycated hemoglobin, interleukins (1β and 6), tumour necrosis factor-α (TNF-α) levels in diabetic rats treated with APPE compared to DC. Conversely, serum insulin and interleukin-10 concentrations were significantly elevated in a dose-related fashion in APPE administered diabetic rats compared to DC. Unlike the intestine and heart which were spared severe morphological treatment due to alloxan intoxication, diabetic control rat and those on low dose of the extract showed varying degree of interface hepatitis and glomerulosclerosis. However, diabetic rats on 200 mg/kg APPE were protected from the damaging effects of diabetes mellitus on the liver and kidney.Conclusion: APPE abrogated the oxidative stress-induced hepatic and nephrotic damage in diabetic rats.

Antioxidant and cytoprotective effects of avocado oil and extract (Persea americana Mill) against rotenone using monkey kidney epithelial cells (Vero)

2021 ◽  
pp. 1-16
Author(s):  
Nelzi Ferreira Queiroz Junior ◽  
Jovani Antônio Steffani ◽  
Larissa Machado ◽  
Pâmela Jéssyca Hoss Longhi ◽  
Marco Aurélio Echart Montano ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Persea Americana ◽  
Monkey Kidney ◽  
Avocado Oil ◽  
Kidney Epithelial Cells

scholarly journals Synthesis of Poly-(R-hydroxyalkanoates) byCupriavidus necatorATCC 17699 Using Mexican Avocado(Persea americana)Oil as a Carbon Source

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Araceli Flores-Sánchez ◽  
Ma. del Rocío López-Cuellar ◽  
Fermín Pérez-Guevara ◽  
Ulises Figueroa López ◽  
José Mauricio Martín-Bufájer ◽  
...  
Keyword(s):  
Carbon Source ◽  
Bacterial Species ◽  
Persea Americana ◽  
Growth Stages ◽  
Vast Number ◽  
Chromatography Analysis ◽  
Avocado Oil ◽  
Gas Chromatography Analysis ◽  
Third Stage ◽  
Pha Production

Poly-R-hydroxyalkanoates (PHAs) are polymers produced by a vast number of bacterial species under stress conditions. PHAs exhibit different thermal and mechanical properties that depend on their molecular structure. In this work, PHAs were produced using avocado oil as the carbon source.Cupriavidus necatorH16 was cultured in three-stage fermentation using fructose during the cell growth stages and avocado oil during the PHA synthesis stage. Different concentrations of avocado oil were used during the third stage to test the incorporation of various monomeric units into the PHAs. Biomass and PHA production were measured during the fermentation. DSC, FTIR, and gas chromatography analysis aided the PHA characterization. Different proportions of 3-hydroxyvalerate were present in the 3-hydroxybutyrate main chain depending on the concentration of avocado oil. The results suggest that avocado oil is a viable new substrate for PHA production.

scholarly journals Fatty Acid Derivatives Isolated from the Oil of Persea americana (Avocado) Protects against Neomycin-Induced Hair Cell Damage

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 171
Author(s):  
SeonJu Park ◽  
Seo Yule Jeong ◽  
Youn Hee Nam ◽  
Jun Hyung Park ◽  
Isabel Rodriguez ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Hair Cells ◽  
Spectroscopic Analysis ◽  
Cell Damage ◽  
Persea Americana ◽  
Zebrafish Model ◽  
Beneficial Effects ◽  
Fatty Acid Derivatives ◽  
Avocado Oil ◽  
New Compounds

Avocado oil is beneficial to human health and has been reported to have beneficial effects on sensorineural hearing loss (SNHL). However, the compounds in avocado oil that affect SNHL have not been identified. In this study, we identified 20 compounds from avocado oil, including two new and 18 known fatty acid derivatives, using extensive spectroscopic analysis. The efficacy of the isolated compounds for improving SNHL was investigated in an ototoxic zebrafish model. The two new compounds, namely (2R,4R,6Z)-1,2,4-trihydroxynonadec-6-ene and (2R,4R)-1,2,4-trihydroxyheptadecadi-14,16-ene (compounds 1 and 2), as well as compounds 7, 9, 14, 17 and 19 showed significant improvement in damaged hair cells in toxic zebrafish. These results led to the conclusion that compounds from avocado oil as well as oil itself have a regenerative effect on damaged otic hair cells in ototoxic zebrafish.

scholarly journals Consumption of avocado oil (Persea americana) improves the biochemical profile of rats submitted to long-term androgenic stimulation

2020 ◽  
Author(s):  
Mauricio Alves Chagas ◽  
Vivian Alves Pereira Silva ◽  
Gilson Teles Boaventura ◽  
Renato de Souza Abboud ◽  
José Antônio Silva Ribas
Keyword(s):  
Persea Americana ◽  
Biochemical Profile ◽  
Avocado Oil

scholarly journals Persea americana Leaf Ethyl Acetate Extract Phytochemical, In-vitro Antioxidant and In-vivo Potentials to Mitigate Oxidative Stress in Alloxan-induced Hyperglycaemic Rats

2019 ◽  
pp. 1-11
Author(s):  
J. A. Mashi ◽  
A. M. Sa’id ◽  
R. I. Idris ◽  
I. Aminu ◽  
A. A. Muhammad ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Diabetic Rats ◽  
Persea Americana ◽  
Albino Rats ◽  
Standard Drug

The purpose of this study was to investigate the in-vivo and in-vitro potentials of ethyl acetate extract of P. americana leaf in alloxan-induced diabetic rats. Quantitative phytochemicals analyzed includes; flavonoids, saponins, tannins, alkaloids and phenolics. Measurement of antioxidant activity using 1,1-Diphenyl-2-picrylhydrazyl, total antioxidant capacity, hydroxyl radical, hydrogen peroxide, superoxide radical and ferric reducing activity of the extract was carried out. Hyperglycemia was induced by intraperitoneal injection of alloxan monohydrate to albino rats. In-vivo anti-oxidant potentials of the extract were evaluated by measuring liver homogenate activity of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and malondyaldehyde in alloxan-induced diabetic rats administered with the extract.  A total of 30 Albino rats were used for this experiment and they were divided into six groups of 5 rats each. Group A; normal control, Group B; diabetic control, Groups C-E; experimental groups administered with different doses (100, 200 and 400 mg/kg body weight respectively); of the extract and Group F; glucophage (84 mg/kg body weight, standard drug) for 4 weeks. This study was conducted in the Department of Biochemistry, Bayero University, Kano, in August, 2018. Data was analyzed using one-way ANOVA with P=.05 value considered as significant. Results of the quantitative phytochemical investigation shows that the extract is rich in phenolics (184.1±0.6), flavonoids (115.8±2.1), alkaloids (41.5±1.8), with least concentration of tannis (21.2±0.8) and saponins (15.2±2.3). The extract exhibited high radical scavenging activity against synthetic free radicals (DPPH), reactive oxygen species (peroxide, superoxide and hydroxyl acid) and high ability to reduce Fe3+ to Fe2+ (FRAP). The activities of antioxidant enzymes of the treated rats were increased significantly (P=.05) while the level malondyaldehyde was significantly decreased (P=.05) in the treated groups. Ethyl acetate leaf extract of Persea americana contains phytochemical substances which improved antioxidant status and can be use as herbal therapy for the management of oxidative stress induced by diabetes mellitus and associated complications.

scholarly journals Comparative Physicochemical and Proximate Analyses of Different Extracts of Persea americana

2020 ◽  
Vol 45 (6) ◽  
Author(s):  
C. Imoisi ◽  
U.C. Michael
Keyword(s):  
Acid Value ◽  
Mean Value ◽  
Persea Americana ◽  
Crude Fibre ◽  
Avocado Oil ◽  
Saponification Value ◽  
Acidic Nature ◽  
Crude Fibre Content ◽  
Proximate Analyses

Avocado and Avocado oil are high in monosaturated oleic acid, a heart-healthy fatty acid that is believed to be one of the main reasons for the health benefits of olive oil. This study, was therefore carried out to determine the physicochemical and proximate composition of the seed and rind of avocado pear with the extraction and characterization of oil obtained from the seed and rind using solvent extraction. The phytochemical screening was also carried out on the seed and rind of avocado pear oil. The moisture contents were (51.05% and 71.77%) for the seed and rind respectively. The ash content of the unripe seed and rind were (0.52% and 0.55%) respectively. The fat (lipid) content in both the unripe seed and rind oil were (21.41g and 9.53 g) respectively. The unripe rind sample was richer in protein (6.4%) and unripe seed being lower (3.04%) to the rind. The crude fibre content for the seed and rind oil were (51.2 g and 2.54 g) respectively. Saponification value of the oil from unripe seed had a higher value of 258.82 mg KOH/g and for unripe rind was 203.47 mg KOH/g. The peroxide value for oil obtained from both unripe seed and rind of Persea americana were 0.91 mg/kg and 0.33 mg/kg respectively. Acid value was low in the unripe seed with a mean value of 0.057 mg KOH/g. It was observed that the Acid value for unripe rind was 0.058 mg KOH/g. The iodine value for rind was 182.85 (gI2/100 g), the seed oil contains 53.78 (gI2/100 g) of iodine. The refractive index was 1.21 and 1.35 for the unripe seed and rind oil respectively. The pH of the various avocado pear extracts also showed their slightly acidic nature.

scholarly journals Avocado oil increases cell viability and respiratory rate of yeast during oxidative stress induced by ferrous iron

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
J. Lucio Fernández Paz ◽  
Pedro Jesús Martínez-Morales ◽  
Elizabeth Calderón-Cortés ◽  
Maricela Fernández-Quintero ◽  
Rocío Carmen Montoya-Pérez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cell Viability ◽  
Respiratory Rate ◽  
Ferrous Iron ◽  
Avocado Oil
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