scholarly journals Bitter Melon (Momordica charantia L.) Fruit Bioactives Charantin and Vicine Potential for Diabetes Prophylaxis and Treatment

Plants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 730
Author(s):  
Mahwish ◽  
Farhan Saeed ◽  
M. Sultan ◽  
Ayesha Riaz ◽  
Sagheer Ahmed ◽  
...  

Natural products are gaining clinical significance in modern day health care systems to prevent diseases. Bitter melon, a health promoting vegetable, is traditionally used for medical nutrition therapy to cure diabetes but to reap maximum health claims, vigilant control of its substances in diet is crucial as part of curative action for effective diabetes management. In the present research, first phase focused on detection of key bioactive components, i.e., charantin and vicine in different parts of its fruit. In the second phase, normal and hyperglycemic Sprague Dawley rats were fed on skin, flesh and whole fruit of bitter melon at 150 and 300 mg/kg body weight and assessed for diabetes prophylaxis and treatment. The highest amount of charantin (0.16 ± 0.02 mg/g) was recorded in flesh while vicine was present in abundance in whole fruit (0.21 ± 0.01 μg/100 g). In normal rats, bitter melon supplementation was helpful in managing the onset of diabetes. Hyperglycemic rats showed diabetic complications including polydipsia, polyuria, glycosuria, renal hypertrophy and increased glomerular filtration rate. However, bitter melon consumption showed significant improvements in these parameters. The most potent dose was 300 mg/kg whole fruit that resulted in 31.64% lowering of blood glucose level and 27.35% increase in insulin level in hyperglycemic rats.

2019 ◽  
Author(s):  
Erin Rogers ◽  
Sneha R Aidasani ◽  
Rebecca Friedes ◽  
Lu Hu ◽  
Aisha T. Langford ◽  
...  

BACKGROUND In 2016, a text-messaging intervention to titrate insulin in patients with uncontrolled type 2 diabetes was implemented at two health care systems in New York City. OBJECTIVE This study conducted a qualitative evaluation assessing barriers to, and facilitators of, implementation of the mobile insulin titration intervention (called “MITI”) into usual care. METHODS We conducted in-depth interviews with patients enrolled in the MITI program (N=36) and staff involved in MITI (N=19) at the two health care systems. Interviews were transcribed and iteratively coded by two study investigators both inductively and deductively using a codebook guided by the Consolidated Framework for Implementation Research. RESULTS Multiple facilitator themes emerged: 1) MITI had strong relative advantages to in-person titration including its convenience and time-saving design; 2) the free cost of MITI was important to patients; 3) MITI was easy to use and patients were confident in their ability to use MITI; 4) MITI was compatible with patients’ home routines and clinic workflow; 5) patients and staff perceived MITI to have value beyond insulin titration by reminding and motivating patients to engage in healthy behaviors and providing a source of patient support; and 6) implementation in clinics was made easy by having a strong implementation climate, communication networks to spread information about MITI, and a strong program champion. Barriers identified included: 1) language limitations; 2) initial nurse concerns about scope of practice changes required to deliver MITI; 2) initial provider knowledge gaps about the program; and 3) provider perceptions that MITI may not be appropriate for some patients (e.g., older, not tech-savvy). There was also a theme that emerged during patient and staff interviewees of an unmet need for longer-term, additional diabetes management support among this population, specifically diet, nutrition and exercise support. CONCLUSIONS Patients and staff were overwhelmingly supportive of MITI, believed it had many benefits and believed it was compatible with the clinic workflow and patient’s lives. Initial implementation efforts should address staff training and nurse concerns. Future research should explore options for integrating additional diabetes support for patients.


2018 ◽  
Vol 14 (1) ◽  
pp. 18
Author(s):  
Sanjay Kalra

The prevalence of type 2 diabetes is increasing worldwide, and the cost of managing this global epidemic is considerable, particularly in developing countries with poorer health care systems.1 There is, therefore, a need for a more holistic approach to diabetes management, which focuses on all aspects of diabetes, from managing blood glucose to addressing the emotional and social aspects of living with diabetes. In an expert interview, Sanjay Kalra of the Bharti Hospital, Karnal, India, discusses the role of mindfulness meditation (MM), which is the practice of working with concentrated awareness to live each moment fully, in the management of diabetes.


2019 ◽  
Vol 13 (6) ◽  
pp. 1112-1122 ◽  
Author(s):  
Katharina Fritzen ◽  
Kornelia Basinska ◽  
Matilde Rubio-Almanza ◽  
Antonio Nicolucci ◽  
Brian Kennon ◽  
...  

Background: Self-monitoring of blood glucose supported by the diabetes-app OneTouch Reveal® has demonstrated to improve HbA1c. We aimed at analyzing costs savings related the integration of telemedical features into diabetes management. Methods: Data from a randomized controlled trial were used to assess the 10-year risk of patients for fatal myocardial infarction (MI). On the basis of this risk assessments—also related to a 5% or 10% reduction of hypoglycemic episodes—cost savings for the health care systems of five European countries—France, Germany, Italy, Spain, and the United Kingdom—were modeled. Results: HbA1c reduction of 0.92% in insulin-treated type 2 diabetes patients (T2DM) was associated with a 2.3% decreased 10-year risk for fatal MI. In combination with a 10% reduction of hypoglycemic events this risk reduction led to cost savings of €16.1 million (France), €57.8 million (Germany), €30.9 million (Italy), €23.8 million (Spain), and €5.8 million (UK), considering all insulin-treated T2DM patients in the respective countries. Conclusion: Improving metabolic control and thus risk for comorbidities like MI by combining the glucose meter with CRI with telemedical features has the potential to reduce costs for European health care systems.


2019 ◽  
Vol 28 (4) ◽  
pp. 633-647 ◽  
Author(s):  
Ece Cetin Yagmur ◽  
Ahmet Sarucan

Abstract One of the advances made in the management of human resources for the effective implementation of service delivery is the creation of personnel schedules. In this context, especially in terms of the majority of health-care systems, creating nurse schedules comes to the fore. Nurse scheduling problem (NSP) is a complex optimization problem that allows for the preparation of an appropriate schedule for nurses and, in doing so, considers the system constraints such as legal regulations, nurses’ preferences, and hospital policies and requirements. There are many studies in the literature that use exact solution algorithms, heuristics, and meta-heuristics approaches. Especially in large-scale problems, for which deterministic methods may require too much time and cost to reach a solution, heuristics and meta-heuristic approaches come to the fore instead of exact methods. In the first phase of the study, harmony search algorithm (HSA), which has shown progress recently and can be adapted to many problems is applied for a dataset in the literature, and the algorithm’s performance is evaluated by comparing the results with other heuristics which is applied to the same dataset. As a result of the evaluation, the performance of the classical HSA is inadequate when compared to other heuristics. In the second phase of our study, by considering new approaches proposed by the literature for HSA, the effects on the algorithm’s performance of these approaches are investigated and we tried to improve the performance of the algorithm. With the results, it has been determined that the improved algorithm, which is called opposition-based parallel HSA, can be used effectively for NSPs.


2004 ◽  
Vol 171 (4S) ◽  
pp. 42-43 ◽  
Author(s):  
Yair Latan ◽  
David M. Wilhelm ◽  
David A. Duchene ◽  
Margaret S. Pearle

1967 ◽  
Vol 06 (01) ◽  
pp. 1-6
Author(s):  
P. Hall ◽  
Ch. Mellner ◽  
T. Danielsson

A system for medical information has been developed. The system is a general and flexible one which without reprogramming or new programs can accept any alphabetic and/or numeric information. Coded concepts and natural language can be read, stored, decoded and written out. Medical records or parts of records (diagnosis, operations, therapy, laboratory tests, symptoms etc.) can be retrieved and selected. The system can process simple statistics but even make linear pattern recognition analysis.The system described has been used for in-patients, outpatients and individuals in health examinations.The use of computers in hospitals, health examinations or health care systems is a problem of storing information in a general and flexible form. This problem has been solved, and now it is possible to add new routines like booking and follow-up-systems.


2020 ◽  
Vol 09 (04) ◽  
pp. 106-113
Author(s):  
Ysabeau Bernard-Willis ◽  
Emily De Oliveira ◽  
Shaheen E Lakhan

AbstractChildren with epilepsy often have impairments in cognitive and behavioral functioning which may hinder socio-occupational well-being as they reach adulthood. Adolescents with epilepsy have the added worry of health problems while starting the transition from family-centered pediatric care into largely autonomous adult care. If this transition is not appropriately planned and resourced, it may result in medical mistrust, nonadherence, and worsening biopsychosocial health as an adult. In recent years, there has been increased availability of digital health solutions that may be used during this stark change in care and treating teams. The digital health landscape includes a wide variety of technologies meant to address challenges faced by patients, caregivers, medical professionals, and health care systems. These technologies include mobile health products and wearable devices (e.g., seizure monitors and trackers, smartphone passive data collection), digital therapeutics (e.g., cognitive/behavioral health management; digital speech–language therapy), telehealth services (e.g., teleneurology visits), and health information technology (e.g., electronic medical records with patient portals). Such digital health solutions may empower patients in their journey toward optimal brain health during the vulnerable period of pediatric to adult care transition. Further research is needed to validate and measure their impact on clinical outcomes, health economics, and quality of life.


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