scholarly journals The Generic Risks and the Potential of SDN-1 Applications in Crop Plants

Plants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 2259
Author(s):  
Katharina Kawall
Keyword(s):  
Risk Assessment ◽  
European Commission ◽  
Animal Health ◽  
Genetic Alterations ◽  
Crop Plants ◽  
Targeted Mutagenesis ◽  
Genomic Alterations ◽  
Plant Genomes ◽  
High Level ◽  
Breeding Techniques

The use of site-directed nucleases (SDNs) in crop plants to alter market-oriented traits is expanding rapidly. At the same time, there is an on-going debate around the safety and regulation of crops altered with the site-directed nuclease 1 (SDN-1) technology. SDN-1 applications can be used to induce a variety of genetic alterations ranging from fairly ‘simple’ genetic alterations to complex changes in plant genomes using, for example, multiplexing approaches. The resulting plants can contain modified alleles and associated traits, which are either known or unknown in conventionally bred plants. The European Commission recently published a study on new genomic techniques suggesting an adaption of the current GMO legislation by emphasizing that targeted mutagenesis techniques can produce genomic alterations that can also be obtained by natural mutations or conventional breeding techniques. This review highlights the need for a case-specific risk assessment of crop plants derived from SDN-1 applications considering both the characteristics of the product and the process to ensure a high level of protection of human and animal health and the environment. The published literature on so-called market-oriented traits in crop plants altered with SDN-1 applications is analyzed here to determine the types of SDN-1 application in plants, and to reflect upon the complexity and the naturalness of such products. Furthermore, it demonstrates the potential of SDN-1 applications to induce complex alterations in plant genomes that are relevant to generic SDN-associated risks. In summary, it was found that nearly half of plants with so-called market-oriented traits contain complex genomic alterations induced by SDN-1 applications, which may also pose new types of risks. It further underscores the need for data on both the process and the end-product for a case-by-case risk assessment of plants derived from SDN-1 applications.

Psychological, Structural, Social and Economic Determinants of Suicide Attempt: Risk Assessment and Decision Making Strategies

2021 ◽  
pp. 003022282110034
Author(s):  
Azam Farmani ◽  
Mojtaba Rahimianbougar ◽  
Yousef Mohammadi ◽  
Hossein Faramarzi ◽  
Siamak Khodarahimi ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Suicide Attempt ◽  
Suicide Attempts ◽  
Psychological Services ◽  
Cross Sectional ◽  
Economic Determinants ◽  
History Of ◽  
Cross Sectional Design ◽  
High Level ◽  
Risk Assessment And Management

The aim of this research was to conduct a risk assessment and management of psychological, structural, social and economic determinants (PSSED) in a suicide attempt. The sample consisted of 353 individuals who had a recorded history of suicidal attempt; and 20 professional individuals by purposive sampling method within a descriptive cross-sectional design. Worksheets for RAM and AHP were used for data collection in this study. The rate of suicide attempt was 7.21 per 100,000 population in this study. Analysis showed that depression and mental disorders; personality disorders; family problems; socio-cultural and economic problems; lack of awareness; and low level of education have a high level of risk for suicide attempts. Psychiatric and psychological services; awareness and knowledge of life skills; medical services to dysfunctional families; development of community-based planning for PSSED of suicide; and employment and entrepreneurship services may lower suicide attempt risk.

Conducting a Risk Assessment of Outpatient Clinic Settings for Appropriate High Level Disinfection and Sterilization Processes

2018 ◽  
Vol 46 (6) ◽  
pp. S31-S32
Author(s):  
Laura Bardowski ◽  
Grace Barajas ◽  
Diane Cullen ◽  
Radhika Mehta ◽  
Christina Silkaitis
Keyword(s):  
Risk Assessment ◽  
Outpatient Clinic ◽  
High Level

scholarly journals Plant genome editing made easy: targeted mutagenesis in model and crop plants using the CRISPR/Cas system

Plant Methods ◽  
2013 ◽  
Vol 9 (1) ◽  
pp. 39 ◽  
Author(s):  
Khaoula Belhaj ◽  
Angela Chaparro-Garcia ◽  
Sophien Kamoun ◽  
Vladimir Nekrasov
Keyword(s):  
Genome Editing ◽  
Crop Plants ◽  
Targeted Mutagenesis ◽  
Plant Genome

scholarly journals DERMAL ABSORPTION OF DIQUAT AND POTENTIAL OCCUPATIONAL RISK

2020 ◽  
Vol 73 (7) ◽  
pp. 1459-1464
Author(s):  
Tatyana O. Yastrub ◽  
Sergii T. Omelchuk ◽  
Andrii M. Yastrub
Keyword(s):  
Risk Assessment ◽  
European Union ◽  
Plant Protection ◽  
Plant Protection Products ◽  
Dermal Absorption ◽  
The European Union ◽  
Association Agreement ◽  
Food And Agriculture ◽  
Food And Agriculture Organization ◽  
High Level

The aim: The toxicological-hygienic assessment of dermal absorption of diquat in terms of potential risk of its bioavailability in professional use. Materials and methods: The object of the study was cutaneous exposure of diquat, determined in toxicological experiments of different duration (data of scientific literature) and at the stage of state testing of pesticide preparations based on diquat dibromide (data of a full-scale hygiene experiment, prognostic model of risk assessment), the technical concentrate of diquat dibromide (active substance content not less than 377 g / kg) contains relevant supplements, the content of which is regulated by the Food and Agriculture Organization. Results and conclusions: Due to the high risk of the diquat adverse effects affecting the personnel, general public and environment, the European Union has introduced administrative decisions to forbid plant protection products containing the diquat. Fulfillment of the conditions of the Association Agreement between Ukraine and the European Union indicates the need to develop common regulations and risk assessment methods aimed at ensuring high level of protection of human health and the environment.

scholarly journals Administrative and legal supervision of the Veterinary Inspection over food safety in Poland – selected issues

2020 ◽  
Vol 31 ◽  
pp. 23-36
Author(s):  
Ewa Bonusiak ◽  
Keyword(s):  
Food Safety ◽  
Public Administration ◽  
Human Life ◽  
Animal Health ◽  
The European Union ◽  
Economic Interests ◽  
Protective Function ◽  
Health Quality ◽  
Food Market ◽  
High Level

Legal sciences, raising food safety as the subject of research, focus mainly on striving to ensure sufficiently effective legal regulations and the system of bodies controlling and supervising the food market that determine the correct health quality of food. One such body is the Veterinary Inspection. And while it focuses in its tasks mainly on the protection of animal health, it directly and indirectly affects the maintenance of food health requirements. Supervision exercised by the said Inspection plays an important role in ensuring a high level of protection of human life and health, and also protects the economic interests of the consumer. These two goals are basic. Additional objectives are protection of the reliability of commercial transactions, ensuring the free movement of food in the European Union, protection of animal health and living conditions and protection of the environment. They are of particular importance for determining acceptable limits of competences that can be entrusted to public administration bodies, including the said Inspection. The article presents the activities of the Veterinary Inspection to protect food safety and selected executive forms that it uses for this purpose. These types of entities are equipped with such forms of activity because they fulfill a protective function in the public administration system. However, this function implies the obligation to protect many different values desired individually, as well as maintain (ensure) objectively desired states of affairs, phenomena and processes.

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