scholarly journals Green Optimization of Glutaraldehyde Vapor-Based Crosslinking on Poly(Vinyl Alcohol)/Cellulose Acetate Electrospun Mats for Applications as Chronic Wound Dressings

Proceedings ◽  
2020 ◽  
Vol 69 (1) ◽  
pp. 30
Author(s):  
Marta A. Teixeira ◽  
Joana C. Antunes ◽  
M. Teresa P. Amorim ◽  
Helena P. Felgueiras
Keyword(s):  
Cellulose Acetate ◽  
Vinyl Alcohol ◽  
Chronic Wounds ◽  
Low Cost ◽  
Social Systems ◽  
Healing Process ◽  
Aqueous Media ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Ease Of Access

In the last years, chronic wounds have become more prevalent, leading to a huge burden on the healthcare and social systems by requiring specialized protection. Indeed, wound dressings capable of assisting in the healing process are in urgent need. To that effect, nanofibrous dressings with a structure resembling the extracellular matrix have been engineered by electrospinning from combinations of poly(vinyl alcohol) (PVA) and cellulose acetate (CA) and optimized to endure physiological media contact and mechanical stress after crosslinking. Mats were prepared at different PVA/CA ratios, 100/0, 90/10 and 80/20 v/v%, at 10 w/v% concentration in acetic acid and water in a 75/25 v/v% proportion and processed via electrospinning. Processing conditions were optimized to obtain uniform, continuous, bead free mats, with a flexible structure. The instant solubilization of the PVA portion of the mat in aqueous media was surpassed via crosslinking. Even though there are many chemical agents available to accomplish such task, glutaraldehyde (GA) is by far the most common due to its efficiency, ease of access and processing, and low cost. Further, in its vapor form, GA has demonstrated reduced or no cytotoxic effects. The amount of GA, crosslinking time, temperature, and drying procedure were optimized to guarantee mechanically resilient mats by means of the greenest methodology possible. Indeed, it was determined that GA vapor at 25% in water could be applied for 7 h at 60 °C, using 6 mL of solution, in a 130 × 120 mm2 mat with optimal results. All traces of GA were then eliminated from the mats in a controlled environment (41% relative-humidity and 19 °C). In the end, it was seen that the mechanical resilience and thermal stability of the mats were improved after the application of the modified, green GA-based crosslinking, revealing the engineered methodology potential for applications in biomedical devices.

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

Cellulose acetate/poly(vinyl alcohol) hybrid fibrous mat containing tetracycline hydrochloride and phenytoin sodium: Morphology, drug release, antibacterial, and cell culture studies

2018 ◽  
Vol 33 (6) ◽  
pp. 597-611 ◽  
Author(s):  
Hamed Souriyan-Reyhani pour ◽  
Ramin Khajavi ◽  
Mohammad Esmaeil Yazdanshenas ◽  
Payam Zahedi ◽  
Mohammad Mirjalili
Keyword(s):  
Drug Release ◽  
Cellulose Acetate ◽  
Vinyl Alcohol ◽  
Aqueous Media ◽  
Tetracycline Hydrochloride ◽  
Diameter Distribution ◽  
Poly Vinyl Alcohol ◽  
Release Kinetic ◽  
Phenytoin Sodium ◽  
20 Nm

The objective of this study was to introduce an electrospun hybrid fibrous mat (a dual-fiber drug delivery system) based on cellulose acetate and poly(vinyl alcohol) containing tetracycline hydrochloride and phenytoin sodium, respectively. Characterization of samples was carried by morphology, drug release, cell cytotoxicity, adhesion, antibacterial property, and wettability investigations. The results showed a uniform shape and a narrow diameter distribution of fibers (between 160 ± 20 nm) for fabricated cellulose acetate/poly(vinyl alcohol) hybrid fibrous mat. The tetracycline hydrochloride release from cellulose acetate significantly decreased due to gel formation of poly(vinyl alcohol) in aqueous media. The best fit for drug release kinetic of hybrid sample was Higuchi model. Sample with tetracycline hydrochloride and phenytoin sodium drugs showed improved cell growth, viability, and antibacterial activity against Escherichia coli (~89%) and Staphylococcus aureus (~98%) in comparison with sample without drugs. The hydrophilic property of cellulose acetate/poly(vinyl alcohol) fibrous sample containing the drugs was also remarkable (~45°). To consider the obtained results, the presented hybrid fibrous mat shows a high potent for biomedical applications.

scholarly journals Self-Healing Polymer-Clay Hybrids by Facile Complexation of a Waterborne Polymer with a Clay

2021 ◽  
Author(s):  
Aranee Pleng Teepakakorn ◽  
Makoto Ogawa
Keyword(s):  
Vinyl Alcohol ◽  
Aqueous Media ◽  
Water Soluble ◽  
Poly Vinyl Alcohol ◽  
Self Healing ◽  
Soluble Polymer ◽  
Water Soluble Polymer ◽  
Smectite Clay

Water-induced self-healing materials were prepared by the hybridization of a water-soluble polymer, poly(vinyl alcohol), with a smectite clay by mixing in an aqueous media and subsequent casting. Without using chemical...

scholarly journals Designing New Antibacterial Wound Dressings: Development of a Dual Layer Cotton Material Coated with Poly(Vinyl Alcohol)_Chitosan Nanofibers Incorporating Agrimonia eupatoria L. Extract

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 83
Author(s):  
Cláudia Mouro ◽  
Colum P. Dunne ◽  
Isabel C. Gouveia
Keyword(s):  
Composite Material ◽  
Vinyl Alcohol ◽  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Coating Layer ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Microbial Invasion ◽  
Layer Composite ◽  
Medicinal Plant Extracts

Wounds display particular vulnerability to microbial invasion and infections by pathogenic bacteria. Therefore, to reduce the risk of wound infections, researchers have expended considerable energy on developing advanced therapeutic dressings, such as electrospun membranes containing antimicrobial agents. Among the most used antimicrobial agents, medicinal plant extracts demonstrate considerable potential for clinical use, due primarily to their efficacy allied to relatively low incidence of adverse side-effects. In this context, the present work aimed to develop a unique dual-layer composite material with enhanced antibacterial activity derived from a coating layer of Poly(vinyl alcohol) (PVA) and Chitosan (CS) containing Agrimonia eupatoria L. (AG). This novel material has properties that facilitate it being electrospun above a conventional cotton gauze bandage pre-treated with 2,2,6,6-tetramethylpiperidinyl-1-oxy free radical (TEMPO). The produced dual-layer composite material demonstrated features attractive in production of wound dressings, specifically, wettability, porosity, and swelling capacity. Moreover, antibacterial assays showed that AG-incorporated into PVA_CS’s coating layer could effectively inhibit Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth. Equally important, the cytotoxic profile of the dual-layer material in normal human dermal fibroblast (NHDF) cells demonstrated biocompatibility. In summary, these data provide initial confidence that the TEMPO-oxidized cotton/PVA_CS dressing material containing AG extract demonstrates adequate mechanical attributes for use as a wound dressing and represents a promising approach to prevention of bacterial wound contamination.

scholarly journals The Design, Characterization and Antibacterial Activity of Heat and Silver Crosslinked Poly(Vinyl Alcohol) Hydrogel Forming Dressings Containing Silver Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 96
Author(s):  
John Jackson ◽  
Helen Burt ◽  
Dirk Lange ◽  
In Whang ◽  
Robin Evans ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Silver Nitrate ◽  
Vinyl Alcohol ◽  
Unmet Need ◽  
Chemical Characterization ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Burn Wound

The prompt treatment of burn wounds is essential but can be challenging in remote parts of Africa, where burns from open fires are a constant hazard for children and suitable medical care may be far away. Consequently, there is an unmet need for an economical burn wound dressing with a sustained antimicrobial activity that might be manufactured locally at low cost. This study describes and characterizes the novel preparation of a silver nitrate-loaded/poly(vinyl alcohol) (PVA) film. Using controlled heating cycles, films may be crosslinked with in situ silver nanoparticle production using only a low heat oven and little technical expertise. Our research demonstrated that heat-curing of PVA/silver nitrate films converted the silver to nanoparticles. These films swelled in water to form a robust, wound-compatible hydrogel which exhibited controlled release of the antibacterial silver nanoparticles. An optimal formulation was obtained using 5% (w/w) silver nitrate in PVA membrane films that had been heated at 140 °C for 90 min. Physical and chemical characterization of such films was complemented by in vitro studies that confirmed the effective antibacterial activity of the released silver nanoparticles against both gram positive and negative bacteria. Overall, these findings provide economical and simple methods to manufacture stable, hydrogel forming wound dressings that release antibiotic silver over prolonged periods suitable for emergency use in remote locations.

Identifying New Pathways and Targets for Wound Healing and Therapeutics from Natural Sources

2021 ◽  
Vol 18 ◽  
Author(s):  
Xinchi Feng ◽  
Jinsong Hao
Keyword(s):  
Wound Healing ◽  
Molecular Mechanisms ◽  
Chronic Wounds ◽  
Wound Care ◽  
Healing Process ◽  
Unmet Need ◽  
Wound Dressings ◽  
Wound Healing Process ◽  
Natural Sources ◽  
Viable Approach

: Chronic wounds remain a significant public problem and the development of wound treatments has been a research focus for the past few decades. Despite advances in the products derived from endogenous substances involved in a wound healing process (e.g. growth factors, stem cells, and extracellular matrix), effective and safe wound therapeutics are still limited. There is an unmet need to develop new therapeutics. Various new pathways and targets have been identified and could become a molecular target in designing novel wound agents. Importantly, many existing drugs that target these newly identified pathways could be repositioned for wound therapy, which will facilitate fast translation of research findings to clinical applications. This review discusses the newly identified pathways/targets and their potential uses in the development of wound therapeutics. Some herbs and amphibian skins have been traditionally used for wound repairs and their active ingredients have been found to act in these new pathways. Hence, screening these natural products for novel wound therapeutics remains a viable approach. The outcomes of wound care using natural wound therapeutics could be improved if we can better understand their cellular and molecular mechanisms and fabricate them in appropriate formulations, such as using novel wound dressings and nano-engineered materials. Therefore, we also provide an update on the advances in the wound therapeutics from natural sources. Overall, this review offers new insights into novel wound therapeutics.

Nickel Nanoparticles Supported on Diphenylphosphinated Poly(Vinyl Alcohol-Co-ethylene) as a New Heterogeneous and Recyclable Catalyst for Mizoroki–Heck Reactions

2017 ◽  
Vol 41 (9) ◽  
pp. 541-546 ◽  
Author(s):  
Farzaneh Ebrahimzadeh
Keyword(s):  
Vinyl Alcohol ◽  
Nickel Nanoparticles ◽  
Supported Catalysts ◽  
Low Cost ◽  
Poly Vinyl Alcohol ◽  
X Ray Diffraction ◽  
Heck Reactions ◽  
Modified Polymer ◽  
Transmission Electron ◽  
High Metal

Nickel nanoparticles (NiNPs) supported on diphenylphosphinated poly(vinyl alcohol- co-ethylene) (DPP-PVA- co-PE) were synthesised by first reacting poly(vinyl alcohol- co-ethylene) with chlorodiphenylphosphine (ClPPh2) under basic conditions and then treating the product with Ni(OAc)2 followed by reduction with NaBH4. (DPP-PVA- co-PE)-NiNPs, a new metallised polymer, was then shown to efficiently catalyse Mizoroki–Heck reactions of aryl iodides, bromides or activated chlorides with olefins such as styrene and n-butyl acrylate in dimethylformamide. In contrast with other polymer-supported catalysts, the main advantage of this method is the low cost of the catalyst due to the simple synthetic route using easily obtained materials and good recoverability. Transmission electron microscopy and X-ray diffraction measurements were used to show the high metal dispersion and small sizes of Ni nanoparticle on the surface of the modified polymer. DPP-PVA- co-PE-NiNPs could be recycled several times.

scholarly journals Bioactive Agent-Loaded Electrospun Nanofiber Membranes for Accelerating Healing Process: A Review

Membranes ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 702
Author(s):  
Seyyed-Mojtaba Mousavi ◽  
Zohre Mousavi Nejad ◽  
Seyyed Alireza Hashemi ◽  
Marjan Salari ◽  
Ahmad Gholami ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Therapeutic Potential ◽  
Healing Process ◽  
Wound Dressings ◽  
Future Research ◽  
Wound Healing Process ◽  
Nanofiber Membranes ◽  
Bioactive Agents ◽  
Bioactive Agent

Despite the advances that have been achieved in developing wound dressings to date, wound healing still remains a challenge in the healthcare system. None of the wound dressings currently used clinically can mimic all the properties of normal and healthy skin. Electrospinning has gained remarkable attention in wound healing applications because of its excellent ability to form nanostructures similar to natural extracellular matrix (ECM). Electrospun dressing accelerates the wound healing process by transferring drugs or active agents to the wound site sooner. This review provides a concise overview of the recent developments in bioactive electrospun dressings, which are effective in treating acute and chronic wounds and can successfully heal the wound. We also discuss bioactive agents used to incorporate electrospun wound dressings to improve their therapeutic potential in wound healing. In addition, here we present commercial dressings loaded with bioactive agents with a comparison between their features and capabilities. Furthermore, we discuss challenges and promises and offer suggestions for future research on bioactive agent-loaded nanofiber membranes to guide future researchers in designing more effective dressing for wound healing and skin regeneration.

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