scholarly journals Evaluation in Cellulose Nanocrystals Effectiveness on Composite Film based Wound Dressing from Poly(vinyl alcohol) and Gum Tragacanth

2021 ◽  
Author(s):  
Luong Ngoc Diem ◽  
Indranil Banerjee ◽  
Kunal Pal ◽  
Udomlak Sukatta ◽  
Prapassorn Rugthaworn ◽  
...  
Keyword(s):  
Composite Film ◽  
Polymer Matrix ◽  
Cellulose Nanocrystals ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Biological Properties ◽  
Mouse Fibroblast ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Gum Tragacanth

Abstract Biomaterial-based wound dressings were fabricated using cellulose nanocrystals (CNCs) as nano-filler in a polymeric mixture of poly(vinyl alcohol) (PVA) and gum tragacanth (GT) via solution casting. Physical and chemical characteristics of neat PVA, PVA/GT and PVA/GT/CNC films with varying concentrations (2 to 10%) of CNCs were observed. Initial analysis of CNCs showed nanosized particles of 104 nm length and 7 nm width. Scanning electron microscopy (SEM) illustrated cluster formations of CNCs in the polymer matrix. Fourier transform infrared (FTIR) spectrometry was used to confirm the chemical functional groups in the material. The presence of GT and CNCs in the polymer matrix improved water uptake and prolonged stability for 7 days. The CNCs enhanced tensile strength from 54.63 MPa to 80.39MPa. Biological properties of PVA/GT/CNC films were analyzed. Results showed that the dressing material was nontoxic to mouse fibroblast cells L929, while film loaded with betel leaf extract exhibited excellent antibacterial activities against Staphylococcus aureus DMST 8840 and Pseudomonas aeruginosa TISTR 781, indicating that composite film was suitable for application in wound dressing.

A study on the viscoelastic behavior of chitosan-polyvinyl alcohol-graphene oxide nanocomposite films as a wound dressing

2020 ◽  
pp. 096739112096237
Author(s):  
Fariba Saeedi ◽  
Arash Montazeri ◽  
Yaser Bahari ◽  
Malihe Pishvaei ◽  
Behrooz Jannat
Keyword(s):  
Graphene Oxide ◽  
Wound Dressing ◽  
Viscoelastic Behavior ◽  
Biological Properties ◽  
Mouse Fibroblast ◽  
Wound Dressings ◽  
Nanocomposite Films ◽  
Poly Vinyl Alcohol ◽  
Cole Diagram

The nanocomposites of Chitosan (CS)-poly vinyl alcohol (PVA) reinforced with graphene oxide (GO) were fabricated by casting in a mold. The nanocomposite films were characterized by various techniques. The viscoelastic properties of the wound dressings were evaluated by dynamic mechanical thermal analysis (DMTA) since the healing quality of a wound dressing depends on such properties. DMTA results also were modeled by the Cole-Cole diagram. Finally, the effects of GO on antimicrobial and biological properties of films were studied. It has been shown that nanocomposite films support the initial attachment, proliferation, and growth of mouse fibroblast cells.

scholarly journals Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

Polymers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 2104
Author(s):  
Sibusiso Alven ◽  
Blessing Atim Aderibigbe
Keyword(s):  
Mechanical Properties ◽  
Wound Healing ◽  
Vinyl Alcohol ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Cellular Adhesion ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
High Porosity ◽  
Hybrid Nanofibers

The management of chronic wounds is challenging. The factors that impede wound healing include malnutrition, diseases (such as diabetes, cancer), and bacterial infection. Most of the presently utilized wound dressing materials suffer from severe limitations, including poor antibacterial and mechanical properties. Wound dressings formulated from the combination of biopolymers and synthetic polymers (i.e., poly (vinyl alcohol) or poly (ε-caprolactone) display interesting properties, including good biocompatibility, improved biodegradation, good mechanical properties and antimicrobial effects, promote tissue regeneration, etc. Formulation of these wound dressings via electrospinning technique is cost-effective, useful for uniform and continuous nanofibers with controllable pore structure, high porosity, excellent swelling capacity, good gaseous exchange, excellent cellular adhesion, and show a good capability to provide moisture and warmth environment for the accelerated wound healing process. Based on the above-mentioned outstanding properties of nanofibers and the unique properties of hybrid wound dressings prepared from poly (vinyl alcohol) and poly (ε-caprolactone), this review reports the in vitro and in vivo outcomes of the reported hybrid nanofibers.

Preclinical assessment of chitosan–polyvinyl alcohol–graphene oxide nanocomposite scaffolds as a wound dressing

2021 ◽  
pp. 096739112110292
Author(s):  
Arash Montazeri ◽  
Fariba Saeedi ◽  
Yaser Bahari ◽  
Ahmad Ahmadi Daryakenari
Keyword(s):  
Graphene Oxide ◽  
Polyvinyl Alcohol ◽  
Wound Dressing ◽  
Biological Properties ◽  
Mouse Fibroblast ◽  
Wound Dressings ◽  
In Vivo Studies ◽  
Nanocomposite Scaffolds

The present research aimed to examine the biological properties of chitosan (CS)–polyvinyl alcohol (PVA) scaffolds reinforced with graphene oxide (GO) nanosheets, as wound dressings. The scaffolds were characterized by various techniques. The scanning electron microscopy (SEM) and thermogravimetry analyses (TGAs) were used to investigate distribution of the GO within the polymer. The viscoelastic properties were evaluated by dynamic mechanical thermal analysis (DMTA) to examine the quality of a wound dressing. In vitro and in vivo studies were conducted to assess the biocompatibility of the scaffolds as wound dressing. The cell viability and proliferation results indicated that mouse fibroblast cells (L929) could adhere on the 50CS–50PVA/3 wt% GO scaffold. Herewith, the fabricated CS–PVA–GO nanocomposite scaffolds are suggested as promising biomaterials for skin tissue engineering and wound dressing.

Fabrication of curcumin-loaded gum tragacanth/poly(vinyl alcohol) nanofibers with optimized electrospinning parameters

2016 ◽  
Vol 46 (5) ◽  
pp. 1170-1192 ◽  
Author(s):  
Marziyeh Ranjbar-Mohammadi ◽  
Saeid Kargozar ◽  
S Hajir Bahrami ◽  
MT Joghataei
Keyword(s):  
Response Surface ◽  
Vinyl Alcohol ◽  
Polymer Concentration ◽  
Back Propagation ◽  
Average Diameter ◽  
Biological Properties ◽  
Poly Vinyl Alcohol ◽  
Surface Model ◽  
Back Propagation Algorithm ◽  
Gum Tragacanth

This paper focuses on using response surface methodology (RSM) and artificial neural network (ANN) to optimize the diameter of Gum tragacanth (GT)/poly(vinyl alcohol) (PVA) nanofibers. However, producing curcumin-loaded GT/PVA nanofibers with using these optimized conditions is another aim. RSM methodology based on four variables (voltage, feed rate, distance between nozzle and collector, and solution concentration) with three levels and ANN technique were compared for modeling the average diameter of nanofibers. In the RSM method, the individual and interaction effects between the parameters on the average diameter of nanofibers were determined using Box-Behnken design (BBD). Data sets of input–output patterns were used for training the multilayer perceptron (MP) neural networks trained with back-propagation algorithm for modeling purpose. Experimental results for both ANN and RSM techniques showed agreement with the predicted fiber diameter. High-regression coefficient between the variables and the response displayed that the performance of RSM for minimizing diameter of nanofibers was better than ANN. Based on response surface model, optimum conditions (polymer concentration of 4.2% (w/v), distance between the capillary and collector 20 cm, applied voltage of 20 kV and flow rate of 0.5 mL/h) were obtained for producing GT/PVA nanofibers with minimized diameter. Then curcumin-loaded GT/PVA nanofibers were produced with acquired optimum condition and the effect of curcumin concentration (3 and 5% (w/v)) on the morphology, diameter and biological properties of nanofibers was investigated.

Preparation and characterization of poly(vinyl alcohol)/gum tragacanth/cellulose nanocomposite film

2021 ◽  
pp. 50672
Author(s):  
Majid Alizadeh Moghadam ◽  
Reza Mohammadi ◽  
Ehsan Sadeghi ◽  
Mohammad Amin Mohammadifar ◽  
Mohammad Nejatian ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Nanocomposite Film ◽  
Poly Vinyl Alcohol ◽  
Gum Tragacanth

scholarly journals Designing New Antibacterial Wound Dressings: Development of a Dual Layer Cotton Material Coated with Poly(Vinyl Alcohol)_Chitosan Nanofibers Incorporating Agrimonia eupatoria L. Extract

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 83
Author(s):  
Cláudia Mouro ◽  
Colum P. Dunne ◽  
Isabel C. Gouveia
Keyword(s):  
Composite Material ◽  
Vinyl Alcohol ◽  
Pathogenic Bacteria ◽  
Antimicrobial Agents ◽  
Coating Layer ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Microbial Invasion ◽  
Layer Composite ◽  
Medicinal Plant Extracts

Wounds display particular vulnerability to microbial invasion and infections by pathogenic bacteria. Therefore, to reduce the risk of wound infections, researchers have expended considerable energy on developing advanced therapeutic dressings, such as electrospun membranes containing antimicrobial agents. Among the most used antimicrobial agents, medicinal plant extracts demonstrate considerable potential for clinical use, due primarily to their efficacy allied to relatively low incidence of adverse side-effects. In this context, the present work aimed to develop a unique dual-layer composite material with enhanced antibacterial activity derived from a coating layer of Poly(vinyl alcohol) (PVA) and Chitosan (CS) containing Agrimonia eupatoria L. (AG). This novel material has properties that facilitate it being electrospun above a conventional cotton gauze bandage pre-treated with 2,2,6,6-tetramethylpiperidinyl-1-oxy free radical (TEMPO). The produced dual-layer composite material demonstrated features attractive in production of wound dressings, specifically, wettability, porosity, and swelling capacity. Moreover, antibacterial assays showed that AG-incorporated into PVA_CS’s coating layer could effectively inhibit Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) growth. Equally important, the cytotoxic profile of the dual-layer material in normal human dermal fibroblast (NHDF) cells demonstrated biocompatibility. In summary, these data provide initial confidence that the TEMPO-oxidized cotton/PVA_CS dressing material containing AG extract demonstrates adequate mechanical attributes for use as a wound dressing and represents a promising approach to prevention of bacterial wound contamination.

Reinforcement with cellulose nanocrystals of poly(vinyl alcohol) hydrogels prepared by cyclic freezing and thawing

Soft Matter ◽  
2011 ◽  
Vol 7 (6) ◽  
pp. 2373 ◽  
Author(s):  
Tiffany Abitbol ◽  
Timothy Johnstone ◽  
Thomas M. Quinn ◽  
Derek G. Gray
Keyword(s):  
Cellulose Nanocrystals ◽  
Vinyl Alcohol ◽  
Poly Vinyl Alcohol ◽  
Freezing And Thawing

scholarly journals The Design, Characterization and Antibacterial Activity of Heat and Silver Crosslinked Poly(Vinyl Alcohol) Hydrogel Forming Dressings Containing Silver Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 96
Author(s):  
John Jackson ◽  
Helen Burt ◽  
Dirk Lange ◽  
In Whang ◽  
Robin Evans ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Silver Nitrate ◽  
Vinyl Alcohol ◽  
Unmet Need ◽  
Chemical Characterization ◽  
Wound Dressings ◽  
Poly Vinyl Alcohol ◽  
Burn Wound

The prompt treatment of burn wounds is essential but can be challenging in remote parts of Africa, where burns from open fires are a constant hazard for children and suitable medical care may be far away. Consequently, there is an unmet need for an economical burn wound dressing with a sustained antimicrobial activity that might be manufactured locally at low cost. This study describes and characterizes the novel preparation of a silver nitrate-loaded/poly(vinyl alcohol) (PVA) film. Using controlled heating cycles, films may be crosslinked with in situ silver nanoparticle production using only a low heat oven and little technical expertise. Our research demonstrated that heat-curing of PVA/silver nitrate films converted the silver to nanoparticles. These films swelled in water to form a robust, wound-compatible hydrogel which exhibited controlled release of the antibacterial silver nanoparticles. An optimal formulation was obtained using 5% (w/w) silver nitrate in PVA membrane films that had been heated at 140 °C for 90 min. Physical and chemical characterization of such films was complemented by in vitro studies that confirmed the effective antibacterial activity of the released silver nanoparticles against both gram positive and negative bacteria. Overall, these findings provide economical and simple methods to manufacture stable, hydrogel forming wound dressings that release antibiotic silver over prolonged periods suitable for emergency use in remote locations.

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