scholarly journals Bioactive Coatings Loaded with Osteogenic Protein for Metallic Implants

Polymers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 4303
Author(s):  
Oana Gherasim ◽  
Alexandru Mihai Grumezescu ◽  
Valentina Grumezescu ◽  
Ecaterina Andronescu ◽  
Irina Negut ◽  
...  
Keyword(s):  
Bone Cells ◽  
Bioactive Coatings ◽  
Metallic Implants ◽  
Morphogenetic Protein ◽  
Regeneration Of Bone Tissue ◽  
Osteogenic Protein ◽  
Advanced Biomaterials ◽  
Hard Tissue Engineering ◽  
Regeneration Of Bone ◽  
Local Modulation

Osteoconductive and osteoinductive coatings represent attractive and tunable strategies towards the enhanced biomechanics and osseointegration of metallic implants, providing accurate local modulation of bone-to-implant interface. Composite materials based on polylactide (PLA) and hydroxyapatite (HAp) are proved beneficial substrates for the modulation of bone cells’ development, being suitable mechanical supports for the repair and regeneration of bone tissue. Moreover, the addition of osteogenic proteins represents the next step towards the fabrication of advanced biomaterials for hard tissue engineering applications, as their regulatory mechanisms beneficially contribute to the new bone formation. In this respect, laser-processed composites, based on PLA, Hap, and bone morphogenetic protein 4(BMP4), are herein proposed as bioactive coatings for metallic implants. The nanostructured coatings proved superior ability to promote the adhesion, viability, and proliferation of osteoprogenitor cells, without affecting their normal development and further sustaining the osteogenic differentiation of the cells. Our results are complementary to previous studies regarding the successful use of chemically BMP-modified biomaterials in orthopedic and orthodontic applications.

Complete Regeneration of Bone in the Baboon by Recombinant Human Osteogenic Protein-1 (hOP-1, Bone Morphogenetic Protein-7)

1996 ◽  
Vol 13 (3-4) ◽  
pp. 273-289 ◽  
Author(s):  
Ugo Ripamonti ◽  
Barbara Van DenHeever ◽  
T. Kuber Sampath ◽  
Marjorie M. Tucker ◽  
David C. Rueger ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Bone Morphogenetic Protein 7 ◽  
Morphogenetic Protein ◽  
Osteogenic Protein ◽  
Regeneration Of Bone ◽  
Complete Regeneration

Regeneration of bone tissue under implantation of sapphire with titanium coating

2014 ◽  
Vol 0 (3) ◽  
pp. 24 ◽  
Author(s):  
Volodymyr Filipenko ◽  
Inna Batura ◽  
Anatoliy Andreyev ◽  
Оleksey Marushchak
Keyword(s):  
Bone Tissue ◽  
Titanium Coating ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Main Approaches to the Use of Biomaterials in Oral and Maxillofacial Surgery: A Brief Systematic Review

2021 ◽  
pp. 42-48
Author(s):  
Henrique Esteves Magalhães ◽  
Priscilla Janaína de Lima Borelli Bovo ◽  
Luciano Rodrigues Neves ◽  
Marcelo Henrique Batista Santos ◽  
Rogério Luiz de Araújo Vian ◽  
...  
Keyword(s):  
Systematic Review ◽  
Bone Tissue ◽  
Dental Implants ◽  
Bone Growth ◽  
Maxillofacial Surgery ◽  
Oral And Maxillofacial Surgery ◽  
Success Rates ◽  
Dental Implantation ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Introduction: In recent years, procedures with the use of dental implants have increased worldwide, reaching approximately one million dental implants per year. In recent years, a platelet concentrate called FRP (fibrin-rich plasma) has been the subject of clinical studies. Associated with this, the biomaterial Bio-Oss® (Geistlich), as it is biodegradable, biocompatible, non-toxic, and has low immunogenicity, and bio stimulators can act in the regeneration of bone tissue, as it establishes with the cells the appropriate biological niche (favorable microenvironment) for bone growth. Objective: Therefore, the present study aimed to evaluate, through a brief systematic review, the results that involve bone formation for dental implantation, with the use of biomaterials such as fibrin-rich plasma and Bio-Oss®. Methods: The model used for the review was PRISMA. Was used databases such as Scopus, Scielo, Lilacs, Google Scholar, PubMed. Results: Fibrin-rich plasma (FRP) as an autologous biomaterial for use in oral and maxillofacial surgery presents most leukocytes, platelets, and growth factors, forming a fibrin matrix, with three-dimensional architecture. The Bio-Oss® biomaterial (Geistlich), as it is biodegradable, biocompatible, non-toxic, and has low immunogenicity and bio stimulators can act in the regeneration of bone tissue, since it establishes with the adenomatous mesenchymal stem cells the appropriate biological niche for bone growth and, thus, allowing the dental implant to be as effective as possible. Conclusion: The use of FRP associated with Bio-Oss® seems to illustrate high success rates with minimal costs, which may reduce the amount of bone graft needed to fill the sinus cavity, reducing the costs of the procedure.

scholarly journals Electrophoretic deposition of biomaterials

2010 ◽  
Vol 7 (suppl_5) ◽  
Author(s):  
A. R. Boccaccini ◽  
S. Keim ◽  
R. Ma ◽  
Y. Li ◽  
I. Zhitomirsky
Keyword(s):  
Electrophoretic Deposition ◽  
Functional Coatings ◽  
Tissue Engineering Scaffolds ◽  
Bioactive Coatings ◽  
Inorganic Coatings ◽  
Wide Range ◽  
Particulate Form ◽  
Advanced Biomaterials ◽  
Biological Entities ◽  
And Control

Electrophoretic deposition (EPD) is attracting increasing attention as an effective technique for the processing of biomaterials, specifically bioactive coatings and biomedical nanostructures. The well-known advantages of EPD for the production of a wide range of microstructures and nanostructures as well as unique and complex material combinations are being exploited, starting from well-dispersed suspensions of biomaterials in particulate form (microsized and nanoscale particles, nanotubes, nanoplatelets). EPD of biological entities such as enzymes, bacteria and cells is also being investigated. The review presents a comprehensive summary and discussion of relevant recent work on EPD describing the specific application of the technique in the processing of several biomaterials, focusing on (i) conventional bioactive (inorganic) coatings, e.g. hydroxyapatite or bioactive glass coatings on orthopaedic implants, and (ii) biomedical nanostructures, including biopolymer–ceramic nanocomposites, carbon nanotube coatings, tissue engineering scaffolds, deposition of proteins and other biological entities for sensors and advanced functional coatings. It is the intention to inform the reader on how EPD has become an important tool in advanced biomaterials processing, as a convenient alternative to conventional methods, and to present the potential of the technique to manipulate and control the deposition of a range of nanomaterials of interest in the biomedical and biotechnology fields.

scholarly journals CALCIUM SALTS OF AMINO ACIDS FOR THE TREATMENT OF OSTEOPOROSIS IN ANIMALS

2018 ◽  
Vol 54 (3) ◽  
pp. 314-318
Author(s):  
D. V. Lopatik ◽  
U. D. Kovalenko ◽  
Z. I. Kuvaeva ◽  
E. A. Manchik
Keyword(s):  
Amino Acids ◽  
Calcium Carbonate ◽  
Bone Tissue ◽  
Therapeutic Effect ◽  
Test Substance ◽  
Calcium Salts ◽  
Treatment Of Osteoporosis ◽  
Prevention And Treatment ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Results of the study of the drug from calcium salts of amino acids (calcium diglycinate, calcium di-L-prolinate) on the model of osteoporosis in animals are described. The test substance was found to have better therapeutic effect in the regeneration of bone tissue in comparison with the drug containing calcium carbonate. The drug containing calcium salts of glycine and L-proline can be used for prevention and treatment of osteoporosis.

scholarly journals SYNTHESIS AND INVESTIGATION OF BIOMIMETIC HYDROXYAPATITES DOPED BY SILICATE AND CARBONATE ANIONS IN THE PRESENCE OF CITRATE IONS

2020 ◽  
pp. 106-113 ◽  
Author(s):  
M. Troubitsin ◽  
Viet Hung Hoang ◽  
L. Furda
Keyword(s):  
Single Phase ◽  
Maximum Yield ◽  
Physiological Saline ◽  
Average Crystallite Size ◽  
Chemical Precipitation ◽  
Degree Of Crystallinity ◽  
Regeneration Of Bone Tissue ◽  
Biomimetic Hydroxyapatite ◽  
Regeneration Of Bone ◽  
Citrate Ions

In the present work, biomimetic hydroxyapatite (BHAP) doped with silicate and carbonate anions in the presence of citrate ions are synthesized by chemical precipitation from aqueous solutions. According to the results of X-ray phase analysis (XRD), all the obtained materials are single-phase. Scanning electron microscopy (SEM) demonstrates that BHAP powders are a collection of agglomerated particles with similar morphology. Dynamic light scattering confirms that the synthesized BHAPs consist of agglomerates 1–4μm in size. For all samples, with an increase in the number of introduced citrate ions, decreases in the average crystallite size and degree of crystallinity are observed. With an increase in the concentration of citrate ions, the content of agglomerate fractions of 1–2μm in size increases from 70.16 to 75.43%. The solubility of hydroxyapatite samples in physiological saline (ω(NaCl) = 0.9%) at temperatures of 22°C and 37°C is studied. It is revealed that for all synthesized BHAPs, the amount of released Ca2+ ions into the liquid phase increases. The maximum yield of Ca2+ ions in physiological saline is recorded in BHAP with the highest content of citrate ions. The obtained results allow to consider the synthesized BHAP as a promising medical biomaterial for the regeneration of bone tissue.

scholarly journals Synthetic Three-Dimensional Scaffold for Application in the Regeneration of Bone Tissue

2018 ◽  
Vol 09 (04) ◽  
pp. 277-289
Author(s):  
Dante Jesus Coletta ◽  
Liliana Raquel Missana ◽  
Talita Martins ◽  
Maria Victoria Jammal ◽  
Luciano Andrés García ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Three Dimensional ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

scholarly journals INFLUENCE OF DISTURBED CONDITIONS OF REPARATIVE REGENERATION OF BONE TISSUE ON THE DYNAMICS OF THYROID HORMONES

2016 ◽  
Vol 1 (4) ◽  
pp. 109-114 ◽  
Author(s):  
Курганский ◽  
Ilya Kurganskiy ◽  
Родионова ◽  
Lyubov Rodionova ◽  
Зарицкая ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Normal Values ◽  
Gradual Increase ◽  
Reparative Regeneration ◽  
Bone Tissue Regeneration ◽  
Regeneration Of Bone Tissue ◽  
Peripheral Conversion ◽  
Regeneration Of Bone

Managing bone tissue regeneration is a key problem in traumatology and orthopedics. The researches proved that thyroid hormones affect hemostasis and reparative regeneration of bone tissue favorably and promote osteogenesis and bone consolidation.The aim of this research is to study the influence of disturbed reparative regeneration on the concentration of thyroid hormones in blood in the dynamics. Experimental research on rabbits (n=12) with modelling of disturbed reparative regeneration revealed disorder in thyroid hormones synthesis and different directions of T3 and unbound T3 production on the 35th day when the maxi-mum decrease of T3 (2times) and unbound T3 (1.5times) compared to normal values was registered. The analysis of production of T4 and unbound T4 revealed suppression of the values from the 1st to 50th day and gradual increase in unbound T4 from the 50th day. The most significant manifestation of thyroid gland reaction on the disturbed reparative regeneration of shin bones was the decrease in T3 and peripheral conversion of thyroid hormones up to 50th day with formation of false joint in these terms.

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