scholarly journals Recent Trends in Assessment of Cellulose Derivatives in Designing Novel and Nanoparticulate-Based Drug Delivery Systems for Improvement of Oral Health

Polymers ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 92
Author(s):  
Khaled M. Hosny ◽  
Hala M. Alkhalidi ◽  
Waleed S. Alharbi ◽  
Shadab Md ◽  
Amal M. Sindi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Health ◽  
Dosage Forms ◽  
Cellulose Derivatives ◽  
Natural Polymers ◽  
Formulation Development ◽  
Drug Release Rate ◽  
Pharmaceutical Dosage Forms ◽  
Low Toxicity ◽  
Recent Trends

Natural polymers are revolutionizing current pharmaceutical dosage forms design as excipient and gained huge importance because of significant influence in formulation development and drug delivery. Oral health refers to the health of the teeth, gums, and the entire oral-facial system that allows us to smile, speak, and chew. Since years, biopolymers stand out due to their biocompatibility, biodegradability, low toxicity, and stability. Polysaccharides such as cellulose and their derivatives possess properties like novel mechanical robustness and hydrophilicity that can be easily fabricated into controlled-release dosage forms. Cellulose attracts the dosage design attention because of constant drug release rate from the precursor nanoparticles. This review discusses the origin, extraction, preparation of cellulose derivatives and their use in formulation development of nanoparticles having multidisciplinary applications as pharmaceutical excipient and in drug delivery, as bacterial and plant cellulose have great potential for application in the biomedical area, including dentistry, protein and peptide delivery, colorectal cancer treatment, and in 3D printable dosage forms.

An Overview of Excipients Classification and Their Use in Pharmaceuticals

2020 ◽  
Vol 16 ◽  
Author(s):  
Cansel Kose Ozkan ◽  
Ozgur Esim ◽  
Ayhan Savaser ◽  
Yalcin Ozkan
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Dosage Form ◽  
Dosage Forms ◽  
Design Development ◽  
Pharmaceutical Dosage Form ◽  
Pharmaceutical Dosage Forms ◽  
Product Identification ◽  
Direct Administration ◽  
Active Substances

: The content and the application of pharmaceutical dosage forms must meet several basic requirements to ensure and maintain efficiency, safety and quality. A large number of active substances have limited ability to direct administration. Excipients are generally used to overcome the limitation of direct administration of these active substances. However, the function, behavior and composition of the excipients need to be well known in the design, development and production of pharmaceutical dosage forms. In this review, excipients used to assist in any pharmaceutical dosage form production processes of drugs, to preserve, promote or increase stability, bioavailability and patient compliance, to assist in product identification / separation, or to enhance overall safety and effectiveness of the drug delivery system during storage or use are explained. Moreover, the use of these excipients in drug delivery systems are identified. Excipient toxicity, which is an issue discussed in the light of current studies, also discussed in this review.

Bora Rice: Natural Polymer for Drug Delivery

2021 ◽  
Vol 7 (1) ◽  
pp. 2
Author(s):  
Kalyani Pathak ◽  
Ratna Jyoti Das ◽  
Riya Saikia ◽  
Aparoop Das ◽  
Mohammad Zaki Ahmad
Keyword(s):  
Drug Delivery ◽  
Cold Water ◽  
Food Additives ◽  
Physical Stability ◽  
Colloidal Dispersion ◽  
Delivery Systems ◽  
Rice Starch ◽  
Cancer Drug ◽  
Natural Polymers ◽  
Pharmaceutical Dosage Forms

Natural polymers play a vital part in the formulation of pharmaceutical dosage forms due to their use as excipients. Synthetic polymers have been introduced into drug delivery recently; the usage of natural polymers in drug delivery research continues to rise. It is not surprising that applications other than its caloric value have been found for starch. Various natural sources of the polymer have been investigated for delivery systems; among them, Assam Bora rice starch seems to be a promising candidate due to its interesting properties such as being non-toxic, biocompatible, biodegradable, mucoadhesive, and non-immunogenic. Assam Bora rice, locally known as Bora Chaul, was first introduced in Assam, India, from Thailand or Myanmar by Thai-Ahom, now widely cultivated throughout the Assam. The starch obtained from Assam Bora rice is characterized by its high amylopectin content (i.e., >95%) with a branched, waxy polymer which shows physical stability and resistance towards enzymatic action. Assam Bora rice starch hydrates and swells in cold water, forming viscous colloidal dispersion or sols responsible for its bioadhesive nature. Moreover, it is degraded by colonic bacteria but remains undigested in the upper GIT. Due to the excellent adhesion and gelling capability, it is often selected as a mucoadhesive matrix in a controlled release drug delivery system. Carboxymethyl Assam Bora rice starch has also been applied for SPIONs stabilization and, further, it can effectively bind and load cationic anti-cancer drug molecule, Doxorubicin hydrochloride (DOX), via electrostatic interaction. This article provides a critical assessment of Assam Bora rice literature and shows how the rice can be used in many ways, from food additives to drug delivery systems.

scholarly journals Materials for Pharmaceutical Dosage Forms: Molecular Pharmaceutics and Controlled Release Drug Delivery Aspects

2010 ◽  
Vol 11 (9) ◽  
pp. 3298-3322 ◽  
Author(s):  
Heidi M. Mansour ◽  
MinJi Sohn ◽  
Abeer Al-Ghananeem ◽  
Patrick P. DeLuca
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Release Drug

scholarly journals Recently Investigated Natural Gums and Mucilages as Pharmaceutical Excipients: An Overview

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Pritam Dinesh Choudhary ◽  
Harshal Ashok Pawar
Keyword(s):  
Drug Delivery ◽  
Drug Absorption ◽  
Drug Delivery Systems ◽  
Chemical Constituents ◽  
Dosage Forms ◽  
Polymeric Compounds ◽  
Recent Trends ◽  
Natural Drugs ◽  
Novel Drug ◽  
Delivery Technology

Due to advances in drug delivery technology, currently, excipients are included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug release and drug absorption. Recent trends towards use of plant based and natural products demand the replacement of synthetic additives with natural ones. Today, the whole world is increasingly interested in natural drugs and excipients. These natural materials have many advantages over synthetic ones as they are chemically inert, nontoxic, less expensive, biodegradable, and widely available. This review discusses majority of the plant-derived polymeric compounds (gums and mucilage’s), their sources, chemical constituents, uses, and some recent investigations as excipients in novel drug delivery systems.

scholarly journals Polysaccharide 3D Printing for Drug Delivery Applications

Pharmaceutics ◽  
2022 ◽  
Vol 14 (1) ◽  
pp. 145
Author(s):  
Alexandra Zamboulis ◽  
Georgia Michailidou ◽  
Ioanna Koumentakou ◽  
Dimitrios N. Bikiaris
Keyword(s):  
Drug Delivery ◽  
Additive Manufacturing ◽  
3D Printing ◽  
Fused Deposition Modeling ◽  
Large Family ◽  
Cellulose Derivatives ◽  
Natural Polymers ◽  
Fused Deposition ◽  
Deposition Modeling ◽  
Drug Delivery Applications

3D printing, or additive manufacturing, has gained considerable interest due to its versatility regarding design as well as in the large choice of materials. It is a powerful tool in the field of personalized pharmaceutical treatment, particularly crucial for pediatric and geriatric patients. Polysaccharides are abundant and inexpensive natural polymers, that are already widely used in the food industry and as excipients in pharmaceutical and cosmetic formulations. Due to their intrinsic properties, such as biocompatibility, biodegradability, non-immunogenicity, etc., polysaccharides are largely investigated as matrices for drug delivery. Although an increasing number of interesting reviews on additive manufacturing and drug delivery are being published, there is a gap concerning the printing of polysaccharides. In this article, we will review recent advances in the 3D printing of polysaccharides focused on drug delivery applications. Among the large family of polysaccharides, the present review will particularly focus on cellulose and cellulose derivatives, chitosan and sodium alginate, printed by fused deposition modeling and extrusion-based printing.

scholarly journals A Comprehensive Review On Pelletization Technology: A Novel Strategy For Formulation Development

2021 ◽  
Vol 001 (03) ◽  
Author(s):  
Akshay Parihar ◽  
Bhupendra Prajapati ◽  
Himanshu Paliwal
Keyword(s):  
Drug Delivery ◽  
Oral Drug Delivery ◽  
Dosage Forms ◽  
Oral Drug ◽  
The Novel ◽  
Formulation Development ◽  
Oral Drug Delivery System ◽  
Bioactive Agents ◽  
Novel Strategy ◽  
Novel Drug

Pelletization technology is gaining very much attention in present times as it has provided a competent pathway for the oral drug delivery system manufacturing. Pellets offers many biopharmaceuticals as well as technological recompenses over the conventional dosage forms. Pellets offer required strength for dose which can be blended for the delivery of incompatible bioactive agents and helps in providing different release profiles. In this review we will be discussing the extensively used techniques of pelletization, extrusion and spheronization in detail with their methods and applications in the field of pharmacy as a competent pathway for the novel drug delivery systems.

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