scholarly journals Improving Medication Regimen Recommendation for Parkinson’s Disease Using Sensor Technology

Sensors ◽  
2021 ◽  
Vol 21 (10) ◽  
pp. 3553
Author(s):  
Jeremy Watts ◽  
Anahita Khojandi ◽  
Rama Vasudevan ◽  
Fatta B. Nahab ◽  
Ritesh A. Ramdhani
Keyword(s):  
Parkinson’S Disease ◽  
Time Series ◽  
Parkinson's Disease ◽  
Random Forest ◽  
Treatment Planning ◽  
Time Series Data ◽  
Classification Model ◽  
Series Data ◽  
Demographic Information ◽  
Subjective Data

Parkinson’s disease medication treatment planning is generally based on subjective data obtained through clinical, physician-patient interactions. The Personal KinetiGraph™ (PKG) and similar wearable sensors have shown promise in enabling objective, continuous remote health monitoring for Parkinson’s patients. In this proof-of-concept study, we propose to use objective sensor data from the PKG and apply machine learning to cluster patients based on levodopa regimens and response. The resulting clusters are then used to enhance treatment planning by providing improved initial treatment estimates to supplement a physician’s initial assessment. We apply k-means clustering to a dataset of within-subject Parkinson’s medication changes—clinically assessed by the MDS-Unified Parkinson’s Disease Rating Scale-III (MDS-UPDRS-III) and the PKG sensor for movement staging. A random forest classification model was then used to predict patients’ cluster allocation based on their respective demographic information, MDS-UPDRS-III scores, and PKG time-series data. Clinically relevant clusters were partitioned by levodopa dose, medication administration frequency, and total levodopa equivalent daily dose—with the PKG providing similar symptomatic assessments to physician MDS-UPDRS-III scores. A random forest classifier trained on demographic information, MDS-UPDRS-III scores, and PKG time-series data was able to accurately classify subjects of the two most demographically similar clusters with an accuracy of 86.9%, an F1 score of 90.7%, and an AUC of 0.871. A model that relied solely on demographic information and PKG time-series data provided the next best performance with an accuracy of 83.8%, an F1 score of 88.5%, and an AUC of 0.831, hence further enabling fully remote assessments. These computational methods demonstrate the feasibility of using sensor-based data to cluster patients based on their medication responses with further potential to assist with medication recommendations.

scholarly journals Predicting Parkinson’s Disease Medication Regimen Using Sensor Technology

2021 ◽  
Author(s):  
Jeremy Watts ◽  
Anahita Khojandi ◽  
Rama Vasudevan ◽  
Fatta B. Nahab ◽  
Ritesh Ramdhani
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Random Forest ◽  
Classification Model ◽  
Sensor Data ◽  
Sensor Technology ◽  
Medication Regimen ◽  
Levodopa Dose ◽  
Subjective Data ◽  
Random Forest Classification

Abstract Parkinson’s disease (PD) medication treatment planning is generally based on subjective data through in-office, physicianpatient interactions. The Personal KinetiGraphTM (PKG) has shown promise in enabling objective, continuous remote health monitoring for Parkinson’s patients. In this proof-of-concept study, we propose to use objective sensor data from the PKG and apply machine learning to subtype patients based on levodopa regimens and response. We apply k-means clustering to a dataset of with-in-subject Parkinson’s medication changes—clinically assessed by the PKG and Hoehn & Yahr (H&Y) staging. A random forest classification model was then used to predict patients’ cluster allocation based on their respective PKG data and demographic information. Clinically relevant clusters were developed based on longitudinal dopaminergic regimens—partitioned by levodopa dose, administration frequency, and total levodopa equivalent daily dose—with the PKG increasing cluster granularity compared to the H&Y staging. A random forest classifier was able to accurately classify subjects of the two most demographically similar clusters with an accuracy of 87:9 ±1:3

scholarly journals Understanding Collective Human Mobility Spatiotemporal Patterns on Weekdays from Taxi Origin-Destination Point Data

Sensors ◽  
2019 ◽  
Vol 19 (12) ◽  
pp. 2812 ◽  
Author(s):  
Jing Yang ◽  
Yizhong Sun ◽  
Bowen Shang ◽  
Lei Wang ◽  
Jie Zhu
Keyword(s):  
Time Series ◽  
Time Series Data ◽  
Human Mobility ◽  
Spatiotemporal Patterns ◽  
Classification Model ◽  
Series Data ◽  
Similarity Measurement ◽  
Mobility Patterns ◽  
Point Data ◽  
Destination Point

With the availability of large geospatial datasets, the study of collective human mobility spatiotemporal patterns provides a new way to explore urban spatial environments from the perspective of residents. In this paper, we constructed a classification model for mobility patterns that is suitable for taxi OD (Origin-Destination) point data, and it is comprised of three parts. First, a new aggregate unit, which uses a road intersection as the constraint condition, is designed for the analysis of the taxi OD point data. Second, the time series similarity measurement is improved by adding a normalization procedure and time windows to address the particular characteristics of the taxi time series data. Finally, the DBSCAN algorithm is used to classify the time series into different mobility patterns based on a proximity index that is calculated using the improved similarity measurement. In addition, we used the random forest algorithm to establish a correlation model between the mobility patterns and the regional functional characteristics. Based on the taxi OD point data from Nanjing, we delimited seven mobility patterns and illustrated that the regional functions have obvious driving effects on these mobility patterns. These findings are applicable to urban planning, traffic management and planning, and land use analyses in the future.

scholarly journals Positive Unlabelled Learning for Satellite Images’Time Series Analysis: An Application to Cereal and Forest Mapping

2021 ◽  
Vol 14 (1) ◽  
pp. 140
Author(s):  
Johann Desloires ◽  
Dino Ienco ◽  
Antoine Botrel ◽  
Nicolas Ranc
Keyword(s):  
Time Series ◽  
Land Cover ◽  
Prediction Models ◽  
Time Series Data ◽  
Binary Classification ◽  
Satellite Image ◽  
Classification Model ◽  
Series Data ◽  
Remotely Sensed Data ◽  
Land Type

Applications in which researchers aim to extract a single land type from remotely sensed data are quite common in practical scenarios: extract the urban footprint to make connections with socio-economic factors; map the forest extent to subsequently retrieve biophysical variables and detect a particular crop type to successively calibrate and deploy yield prediction models. In this scenario, the (positive) targeted class is well defined, while the negative class is difficult to describe. This one-class classification setting is also referred to as positive unlabelled learning (PUL) in the general field of machine learning. To deal with this challenging setting, when satellite image time series data are available, we propose a new framework named positive and unlabelled learning of satellite image time series (PUL-SITS). PUL-SITS involves two different stages: In the first one, a recurrent neural network autoencoder is trained to reconstruct only positive samples with the aim to higight reliable negative ones. In the second stage, both labelled and unlabelled samples are exploited in a semi-supervised manner to build the final binary classification model. To assess the quality of our approach, experiments were carried out on a real-world benchmark, namely Haute-Garonne, located in the southwest area of France. From this study site, we considered two different scenarios: a first one in which the process has the objective to map Cereals/Oilseeds cover versus the rest of the land cover classes and a second one in which the class of interest is the Forest land cover. The evaluation was carried out by comparing the proposed approach with recent competitors to deal with the considered positive and unlabelled learning scenarios.

scholarly journals An IoT Time Series Data Security Model for Adversarial Attack Based on Thermometer Encoding

2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Zhongguo Yang ◽  
Irshad Ahmed Abbasi ◽  
Fahad Algarni ◽  
Sikandar Ali ◽  
Mingzhu Zhang
Keyword(s):  
Time Series ◽  
Deep Learning ◽  
Time Series Data ◽  
Data Classification ◽  
Classification Model ◽  
Series Data ◽  
Security Model ◽  
Learning Methods ◽  
Model Based ◽  
Adversarial Attack

Nowadays, an Internet of Things (IoT) device consists of algorithms, datasets, and models. Due to good performance of deep learning methods, many devices integrated well-trained models in them. IoT empowers users to communicate and control physical devices to achieve vital information. However, these models are vulnerable to adversarial attacks, which largely bring potential risks to the normal application of deep learning methods. For instance, very little changes even one point in the IoT time-series data could lead to unreliable or wrong decisions. Moreover, these changes could be deliberately generated by following an adversarial attack strategy. We propose a robust IoT data classification model based on an encode-decode joint training model. Furthermore, thermometer encoding is taken as a nonlinear transformation to the original training examples that are used to reconstruct original time series examples through the encode-decode model. The trained ResNet model based on reconstruction examples is more robust to the adversarial attack. Experiments show that the trained model can successfully resist to fast gradient sign method attack to some extent and improve the security of the time series data classification model.

scholarly journals Anode Effect Prediction in Hall-Héroult Cells Using Time Series Characteristics

2020 ◽  
Vol 10 (24) ◽  
pp. 9050
Author(s):  
Ron Kremser ◽  
Niclas Grabowski ◽  
Roman Düssel ◽  
Albert Mulder ◽  
Dietmar Tutsch
Keyword(s):  
Time Series ◽  
Energy Efficient ◽  
Time Series Data ◽  
High Energy ◽  
Anode Effect ◽  
Classification Model ◽  
Series Data ◽  
Aluminium Production ◽  
Oxide Ions ◽  
Practical Implications

In aluminium production, anode effects occur when the alumina content in the bath is so low that normal fused salt electrolysis cannot be maintained. This is followed by a rapid increase of pot voltage from about 4.3 V to values in the range from 10 to 80 V. As a result of a local depletion of oxide ions, the cryolite decomposes and forms climate-relevant perfluorocarbon (PFC) gases. The high pot voltage also causes a high energy input, which dissipates as heat. In order to ensure energy-efficient and climate-friendly operation, it is important to predict anode effects in advance so that they can be prevented by prophylactic actions like alumina feeding or beam downward movements. In this paper a classification model is trained with aggregated time series data from TRIMET Aluminium SE Essen (TAE) that is able to predict anode effects at least 1 min in advance. Due to a high imbalance in the class distribution of normal state and labeled anode effect state as well as possible model’s weaknesses the final F1 score of 32.4% is comparatively low. Nevertheless, the prediction provides an indication of possible anode effects and the process control system may react on it. Consequent practical implications will be discussed.

scholarly journals Sentinel-1 and 2 Time-Series for Vegetation Mapping Using Random Forest Classification: A Case Study of Northern Croatia

2021 ◽  
Vol 13 (12) ◽  
pp. 2321
Author(s):  
Dino Dobrinić ◽  
Mateo Gašparović ◽  
Damir Medak
Keyword(s):  
Time Series ◽  
Random Forest ◽  
Digital Elevation Model ◽  
Large Scale ◽  
Time Series Data ◽  
Vegetation Mapping ◽  
Series Data ◽  
Reference Dataset ◽  
Digital Elevation ◽  
Elevation Model

Land-cover (LC) mapping in a morphologically heterogeneous landscape area is a challenging task since various LC classes (e.g., crop types in agricultural areas) are spectrally similar. Most research is still mostly relying on optical satellite imagery for these tasks, whereas synthetic aperture radar (SAR) imagery is often neglected. Therefore, this research assessed the classification accuracy using the recent Sentinel-1 (S1) SAR and Sentinel-2 (S2) time-series data for LC mapping, especially vegetation classes. Additionally, ancillary data, such as texture features, spectral indices from S1 and S2, respectively, as well as digital elevation model (DEM), were used in different classification scenarios. Random Forest (RF) was used for classification tasks using a proposed hybrid reference dataset derived from European Land Use and Coverage Area Frame Survey (LUCAS), CORINE, and Land Parcel Identification Systems (LPIS) LC database. Based on the RF variable selection using Mean Decrease Accuracy (MDA), the combination of S1 and S2 data yielded the highest overall accuracy (OA) of 91.78%, with a total disagreement of 8.22%. The most pertinent features for vegetation mapping were GLCM Mean and Variance for S1, NDVI, along with Red and SWIR band for S2, whereas the digital elevation model produced major classification enhancement as an input feature. The results of this study demonstrated that the aforementioned approach (i.e., RF using a hybrid reference dataset) is well-suited for vegetation mapping using Sentinel imagery, which can be applied for large-scale LC classifications.

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