scholarly journals A Review of Nephrotoxicity of Microcystins

Toxins ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 693
Author(s):  
Shuaishuai Xu ◽  
Xiping Yi ◽  
Wenya Liu ◽  
Chengcheng Zhang ◽  
Isaac Yaw Massey ◽  
...  
Keyword(s):  
Public Health ◽  
Target Organ ◽  
Cyanobacterial Blooms ◽  
Public Health Issue ◽  
Oxygen Species ◽  
Global Public Health ◽  
Potential Threat ◽  
Toxic Metabolites ◽  
Health Studies ◽  
Cytoskeleton Disruption

Cyanobacterial blooms triggered by eutrophication and climate change have become a global public health issue. The toxic metabolites microcystins (MCs) generated by cyanobacteria can accumulate in food chain and contaminate water, thus posing a potential threat to human and animals health. Studies have suggested that aside liver, the kidney may be another target organ of MCs intoxication. Therefore, this review provides various evidences on the nephrotoxicity of MCs. The review concludes that nephrotoxicity of MCs may be related to inhibition of protein phosphatases and excessive production of reactive oxygen species, cytoskeleton disruption, endoplasmic reticulum stress, DNA damage and cell apoptosis. To protect human from MCs toxic consequences, this paper also puts forward some directions for further research.

Genomic background of a colistin-resistant and highly virulent MCR-1-positive Escherichia coli ST6395 from a broiler chicken in Pakistan

2019 ◽  
Vol 77 (7) ◽  
Author(s):  
Mashkoor Mohsin ◽  
Mariya Azam ◽  
Sajjad ur Rahman ◽  
Fernanda Esposito ◽  
Fábio P Sellera ◽  
...  
Keyword(s):  
Public Health ◽  
Escherichia Coli ◽  
Galleria Mellonella ◽  
Public Health Issue ◽  
Infection Model ◽  
Global Public Health ◽  
Potential Threat ◽  
In Vivo Experiments ◽  
Antimicrobial Resistance Genes

ABSTRACT The convergence of high virulence and multidrug resistance (MDR) in Gram-negative pathogens circulating at the human–animal interface is a critical public health issue. We hereby report the genomic characteristics and virulent behavior of a colistin-resistant Escherichia coli, serotype ONT:H26, belonging to ST6395, isolated from a healthy broiler in Pakistan. This strain harbored multiple antimicrobial resistance genes, including mcr-1.1 and blaCARB-2, besides cma (colicin M) and astA [heat-stable enterotoxin 1 (EAST1) toxin] virulence genes. In vivo experiments carried out with the Galleria mellonella infection model revealed that MCR-1-positive E. coli ST6395 killed 96.4% of the larvae at 18 hour post-infection. Interplay between resistance and virulence in clinically important pathogens could be a potential threat, representing a serious challenge to global public health.

scholarly journals Policies for tackling health inequities in migrants in an irregular situation: learning from Italy

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
F Sesti ◽  
A Rosano ◽  
D Ingleby ◽  
G Baglio ◽  
R Bell ◽  
...  
Keyword(s):  
Public Health ◽  
Health Care ◽  
Health Policies ◽  
Public Health Issue ◽  
Global Public Health ◽  
Integration Policy ◽  
Access To Health Services ◽  
Human Right ◽  
Access To Health

Abstract Issue With increasing of numbers of people moving in Europe and around the world, the health of migrants has become a key global public-health issue. Migrants in an irregular situation (MIS) represent an important part of the migration phenomenon, whether they have become irregular by entering a country without authorisation or by overstaying a visa, including whose applied unsuccessfully for asylum. Description of the problem Overstaying of visas is not unusual in EU countries and during 2015 and 2016 in particular, many countries experienced a large number of unauthorised entrants. Health policies for MIS are increasingly a matter of concern. Using the 2015 Migrant Integration Policy Index Health strand (MIPEX HS) it is possible to conduct an analysis of health policies, focusing on access to health services by MIS. Results Among the 34 European countries covered by the MIPEX HS, Italy’s overall score of 65 is exceeded only by Switzerland (70) and Norway (67). Averaging the indicators of access for MIS, Italy obtains the highest score (83), followed by Denmark, France, the Netherlands, Romania, Spain, Sweden and Switzerland with 67. Its score for legal entitlements to health care is 75 (the same as Sweden), while reporting of MIS to the immigration authorities is prohibited and there are no sanctions against helping them. However, legislation introduced by the new government in 2018 has restricted some of their rights. Lessons Current migration to Europe requires dealing with short-term health needs as well as strengthening public health and health systems in the long term. This presentation will discuss the lessons that can be learned from the comparative analysis of health policies for MIS using the MIPEX HS. Key messages Affordable health care is a human right, which should not be denied to any migrant. Policy analysis plays a key role in identifying interventions for promoting health equity.

scholarly journals Clinical Leadership and Management Perceptions of Inpatients with Obesity: An Interpretative Phenomenological Analysis

2020 ◽  
Vol 17 (21) ◽  
pp. 8123
Author(s):  
Danielle Hitch ◽  
Fiona Pazsa ◽  
Alison Qvist
Keyword(s):  
Public Health ◽  
Interpretative Phenomenological Analysis ◽  
Phenomenological Analysis ◽  
Public Health Issue ◽  
Global Public Health ◽  
Perceptions And Attitudes ◽  
Potential Impact ◽  
Personal Understanding ◽  
Professional Perceptions ◽  
Perceptions Of Care

While obesity is recognized as a key global public health issue, there has been no research to date on the perceptions of care for people with this condition held by individuals in positions of organizational power. The aim of this study was therefore to describe the perceptions and experiences of clinical leaders and managers of providing care to inpatients with obesity at a metropolitan public health service. This study applied an interpretative phenomenological analysis (IPA) approach to qualitative research, conducting interviews with 17 participants. Their perceptions of care for inpatients with obesity encompassed both their personal understanding as an individual, and their observations about the organizational, patient and carer perspectives. Three overall themes were identified: (1) the problem of inpatients with obesity, (2) inpatients with obesity as sources of risk and (3) personal and professional perceptions of inpatients with obesity. While clinical leaders and managers were aware of the potential impact of stigma and weight bias on care given to this cohort, elements of implicit bias, stereotyping, “othering” and ambivalence were frequently present in the data. Ongoing efforts to improve care for patients with obesity must therefore include efforts to address perceptions and attitudes at all organisational levels of the workforce.

scholarly journals The prevention of female genital mutilation in England: what can be done?

2018 ◽  
Vol 41 (3) ◽  
pp. e261-e266 ◽  
Author(s):  
E Plugge ◽  
S Adam ◽  
L El Hindi ◽  
J Gitau ◽  
N Shodunke ◽  
...  
Keyword(s):  
Public Health ◽  
Female Genital Mutilation ◽  
Public Health Issue ◽  
Global Public Health ◽  
Criminal Offence ◽  
Genital Mutilation ◽  
Awareness Raising ◽  
The Uk ◽  
The Impact ◽  
Female Genital

Abstract Background Female genital mutilation (FGM) is a global public health issue. Women in the UK are at risk of FGM and its adverse health consequences but little is known about its practice. Since 1985 it has been a criminal offence to perform FGM in the UK and further legislation has tightened the law but FGM continues. Methods Four community researchers from the Kenyan, Nigerian, Somalian and Sudanese communities in Oxford conducted focus groups and interviews with 53 people to understand the communities’ beliefs about how best to prevent FGM. Results Participants believed that the current UK legislation alone was not sufficient to tackle FGM and might in fact be counterproductive by alienating communities through its perceived imposition. They felt that there had been insufficient consultation with affected communities, awareness raising and education about the legislation. Community-led solutions were the most effective way to tackle FGM. Conclusions FGM adversely affects communities globally. In the UK, researchers from affected communities gathered data demonstrating the feasibility and importance of involving communities in FGM prevention work. Further research is needed to understand how best to prevent FGM in affected communities and, very importantly, to examine the impact of the UK legislation relating to FGM.

scholarly journals Clinical Leadership and Management Perceptions of Inpatients with Obesity: An Interpretative Phenomenological Analysis

2020 ◽  
Author(s):  
Danielle Hitch ◽  
Fiona Pazsa ◽  
Alison Qvist
Keyword(s):  
Public Health ◽  
Interpretative Phenomenological Analysis ◽  
Phenomenological Analysis ◽  
Public Health Issue ◽  
Global Public Health ◽  
Perceptions And Attitudes ◽  
Potential Impact ◽  
Personal Understanding ◽  
Professional Perceptions ◽  
Perceptions Of Care

While obesity is recognized as a key global public health issue, there has been no research to date on the perceptions of care for people with this condition held by individuals in positions of organizational power. The aim of this study was therefore to describe the perceptions and experiences of clinical leaders and managers of providing care to inpatients with obesity at a metropolitan public health service. This study applied an interpretative phenomenological analysis (IPA) approach to qualitative research, conducting interviews with 17 participants. Their perceptions of care for inpatients with obesity encompassed both their personal understanding as an individual, and their observations about the organizational, patient and carer perspectives. Three overall themes were identified: 1) The problem of inpatients with obesity, 2) Inpatients with obesity as sources of risk and 3) Personal and professional perceptions of inpatients with obesity. While clinical leaders and managers were aware of potential impact of stigma and weight bias on the care given to this cohort, elements of implicit bias, stereotyping, ‘othering’ and ambivalence were frequently present in the data. Ongoing efforts to improve care for patients with obesity must therefore include efforts to address perceptions and attitudes at all organisational levels of the workforce.

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