scholarly journals Armillifer Infections in Humans: A Systematic Review

2019 ◽  
Vol 4 (2) ◽  
pp. 80 ◽  
Author(s):  
Petros Ioannou ◽  
Rodanthi Vamvoukaki
Keyword(s):  
Systematic Review ◽  
Abdominal Pain ◽  
Hepatic Encephalopathy ◽  
Human Disease ◽  
Human Infection ◽  
Ocular Infection ◽  
Obligate Parasites ◽  
Permanent Loss ◽  
Treatment Data ◽  
Undercooked Meat

Armillifer is a genus of obligate parasites belonging to the Pentastomida subclass that was first described as a cause of human disease in 1847. Human infection by Armillifer is rare and not widely known. These parasites are transmitted to humans by handling or eating undercooked meat from infected snakes, which are the definitive hosts, or oral uptake of environmental ova. The aim of this systematic review was to record all available evidence regarding infections by Armillifer in humans. A systematic review of PubMed (through 21 December 2018) for studies providing epidemiological, clinical, microbiological, as well as treatment data and outcomes of Armillifer infections was conducted. A total of 26 studies, containing data of 40 patients, were eventually included in the analysis. The most common sites of infection were the peritoneal cavity, the liver, the lower respiratory and the abdominal tract. The commonest infecting species was A. armillatus and most patients were asymptomatic; however, when symptoms occurred, the commonest was abdominal pain, even though unusual presentations occurred, such as hepatic encephalopathy or neurologic symptoms. Most cases were diagnosed at surgery or by imaging, and most patients were not treated. Mortality was low, but the majority of the cases with ocular infection lead to permanent loss of vision.

scholarly journals A Systematic Review of Human Infections by Pseudomonas mendocina

2020 ◽  
Vol 5 (2) ◽  
pp. 71
Author(s):  
Petros Ioannou ◽  
Georgios Vougiouklakis
Keyword(s):  
Systematic Review ◽  
Human Infection ◽  
Fourth Generation ◽  
Aerobic Bacterium ◽  
Pseudomonas Mendocina ◽  
The Family ◽  
Treatment Data ◽  
Severe Infections ◽  
Infection Types ◽  
Human Infections

Pseudomonas mendocina is a Gram-negative, rod-shaped, aerobic bacterium that belongs in the family Pseudomonadaceae and has been isolated from water and soil. Even though it is thought to cause infections quite rarely in humans, it can cause severe infections even in immunocompetent individuals. The aim of this study was to systemically review all cases of human infection by P. mendocina in the literature and describe their epidemiology, microbiology, antimicrobial susceptibility, treatment and outcomes. Thus, a systematic review of PubMed for studies providing epidemiological, clinical, microbiological as well as treatment data and outcomes of Pseudomonas mendocina infections was conducted. In total, 12 studies, containing data of 16 patients, were included. The commonest P. mendocina infections were infective endocarditis, central nervous system infections and skin and soft tissue infections (SSTIs). Fever was the main presenting symptom, while sepsis was evident in almost half the patients. Pseudomonas mendocina was susceptible to most antibiotics tested. Mortality was low in all different infection types. Third or fourth generation cephalosporins and quinolones are the commonest agents used for treatment, irrespectively of the infection site.

scholarly journals Intestinal barrier dysfunction in irritable bowel syndrome: a systematic review

2021 ◽  
Vol 14 ◽  
pp. 175628482199358
Author(s):  
Nikita Hanning ◽  
Adam L. Edwinson ◽  
Hannah Ceuleers ◽  
Stephanie A. Peters ◽  
Joris G. De Man ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Systematic Review ◽  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Barrier Function ◽  
Significant Proportion ◽  
Healthy Controls ◽  
Barrier Dysfunction ◽  
Irritable Bowel

Background and Aim: Irritable bowel syndrome (IBS) is a complex and heterogeneous disorder. Sensory, motor and barrier dysfunctions are the key physiological endophenotypes of IBS. Our aim is to review studies evaluating barrier dysfunction in adults and children with IBS, as well as to link those changes with IBS symptomatology and quality of life. Methods: A comprehensive and systematic review of multiple databases was performed up to March 2020 to identify studies comparing intestinal permeability in IBS patients with healthy controls. Both in vivo and in vitro studies were considered. Results: We identified 66 studies, of which 27 used intestinal probes to quantify barrier function. The prevalence of barrier dysfunction differed between PI-IBS (17–50%), IBS-D (37–62%) and IBS-C (4–25%). At a group level, permeability was increased compared with healthy controls in IBS-D (9/13 studies) and PI-IBS (4/4 studies), but only a minority of IBS-C (2/7 studies) and not in the only IBS-M study. All four studies in children with IBS demonstrated loss of barrier function. A heterogeneous set of tight junction genes were found to be altered in small and large intestines of adults with IBS, but these have not been evaluated in children. Positive associations were identified between barrier dysfunction and bowel disturbances (6/9 studies), abdominal pain (9/13 studies), overall symptom severity (1/6 studies), depression and anxiety (1/1 study) and quality of life (1/4 studies). Fecal slurry or supernatants of IBS patients were found to induce barrier disruption in animal models (5/6 studies). Conclusions: Barrier dysfunction is present in a significant proportion of adult and all pediatric IBS studies, especially in the IBS-D and PI-IBS subtype. The majority of studies indicated a positive association between loss of barrier function and symptoms such as abdominal pain and changes in the bowel function.

scholarly journals Endocarditis in Liver Transplant Recipients: A Systematic Review

2021 ◽  
Vol 10 (12) ◽  
pp. 2660
Author(s):  
Petros Ioannou ◽  
Konstantinos Alexakis ◽  
Diamantis P. Kofteridis
Keyword(s):  
Systematic Review ◽  
Liver Transplant ◽  
Pulmonary Valve ◽  
Cochrane Library ◽  
Transplant Recipients ◽  
Treatment Data ◽  
Liver Transplant Recipients ◽  
Culture Negative ◽  
Overall Mortality ◽  
Significant Mortality

Infective Endocarditis (IE) is associated with significant mortality. Interestingly, IE in patients with liver transplantation has not been adequately described. The aim of this review was to systematically review all published cases of IE in liver transplant recipients and describe their epidemiology, microbiology, clinical characteristics, treatment and outcomes. A systematic review of PubMed, Scopus and Cochrane Library (through 2nd January 2021) for studies providing epidemiological, clinical, microbiological, treatment data and outcomes of IE in liver transplant recipients was conducted. A total of 39 studies, containing data for 62 patients, were included in the analysis. The most common causative pathogens were gram-positive microorganisms in 69.4%, fungi in 25.8%, and gram-negative microorganisms in 9.7% of cases, while in 9.3% IE was culture-negative. The aortic valve was the most commonly infected valve followed by mitral, tricuspid and the pulmonary valve. Aminoglycosides, vancomycin and aminopenicillins were the most commonly used antimicrobials, and surgical management was performed in half of the cases. Clinical cure was noted in 57.4%, while overall mortality was 43.5%. To conclude, this systematic review thoroughly describes IE in liver transplant recipients and provides information on epidemiology, clinical presentation, treatment and outcomes.

scholarly journals Serological evidence of human infection with SARS-CoV-2: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Xinhua Chen ◽  
Zhiyuan Chen ◽  
Andrew S Azman ◽  
Xiaowei Deng ◽  
Ruijia Sun ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Human Infection ◽  
Serological Evidence

scholarly journals The saga of scrub typhus with a note on the outbreaks in Mizoram

2018 ◽  
Vol 18 (2) ◽  
pp. 50-57
Author(s):  
K. Lalchhandama
Keyword(s):  
Infectious Disease ◽  
Opportunistic Infection ◽  
Scrub Typhus ◽  
Emerging Infectious Disease ◽  
Human Infection ◽  
Bacterial Disease ◽  
Orientia Tsutsugamushi ◽  
Obligate Parasites ◽  
Serious Disease ◽  
Collective Information

Scrub typhus is one the most important re-emerging infectious disease, and perhaps, the most important bacterial disease. Caused by Orientia tsutsugamushi, it is transmitted through the bite of mites belonging to the genus Leptotrombidium, in which the bacteria are obligate parasites. Though the mites are natural ectoparasites of rodents and other animals, in which there is no disease, opportunistic infection to humans gives rise to a serious disease. Known to Japanese physicians as tsutsugamushi (insect disease), human infection is caused by the larvae of trombiculid mites, the fact established by Mataro Nagayo and co-workers established in 1917. The pathogen was discovered by Naosuke Hayashi in 1920. In Mizoram, the disease has been rampant since 2011. This paper summarises available data on the prevalence of the infection in different districts base on collective information from various sources. Records between 2012 and 2018 show that over a thousand people had been infected and 35 people had died of the disease.

scholarly journals Symptomatic manifestations of the disease caused by coronavirus (COVID-19) in adults: systematic review

2021 ◽  
Vol 42 (spe) ◽  
Author(s):  
Antonio Rosa de Sousa Neto ◽  
Ana Raquel Batista de Carvalho ◽  
Erika Morganna Neves de Oliveira ◽  
Rosilane de Lima Brito Magalhães ◽  
Maria Eliete Batista Moura ◽  
...  
Keyword(s):  
Systematic Review ◽  
Abdominal Pain ◽  
Chest Pain ◽  
Web Of Science ◽  
Scientific Literature ◽  
Nasal Congestion ◽  
Research Question ◽  
Clinical Manifestations ◽  
Runny Nose ◽  
Cough Headache

ABSTRACT Objective To identify symptoms of COVID-19 in adults in the scientific literature. Method Systematic review of studies published from December 1, 2019 to April 21, 2020 from the Scopus, Web of Science and PubMed databases, in order to answer the following research question: “What are the symptoms caused by COVID-19 in adults?” using the keywords “Symptoms”, “Clinical Manifestations”, “Coronavirus”, “COVID-19”. Results Of the total 105 references, 13 references that addressed the symptoms of COVID-19 were selected. Fever and normal or dry cough were symptoms present in all studies. Conclusion The symptoms identified in adult patients were fever, normal or dry cough, headache, pharyngalgia, dyspnea, diarrhea, myalgia, vomiting, sputum or expectoration, anxiety or chest pain, fatigue, nausea, anorexia, abdominal pain, rhinorrhea, runny nose or nasal congestion, dizziness, chills, systemic pain, mental confusion, hemoptysis, asthma, taste disorder, smell disorder, belching and tachycardia.

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