scholarly journals Are We Facing a New Colposcopic Practice in the HPV Vaccination Era? Opportunities, Challenges, and New Perspectives

Vaccines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1081
Author(s):  
Ankica Lukic ◽  
Rosa De Vincenzo ◽  
Andrea Ciavattini ◽  
Caterina Ricci ◽  
Roberto Senatori ◽  
...  
Keyword(s):  
Risk Stratification ◽  
Diagnostic Accuracy ◽  
Hpv Vaccination ◽  
Vaccination Status ◽  
Human Papillomavirus Vaccine ◽  
Test Results ◽  
Referral Pattern ◽  
Primary And Secondary Prevention ◽  
Vaccine Type ◽  
Papillomavirus Vaccine

The combination of primary and secondary prevention has already influenced the colposcopic practice by reduction in HPV (human papillomavirus) vaccine-type HSIL (HIGH-GRADE SIL), colposcopy referral numbers, colposcopic positive predictive value (PPV) for CIN2+, and by modification of referral pattern, colposcopic performance, and procedures. Different strategies, both isolated and combined, have been proposed in order to maintain the diagnostic accuracy of colposcopy: patient risk stratification based on immediate or future risk of CIN3+ or on HPV genotyping after a positive screening test. Data are needed to support alternative colposcopic strategies based on vaccination status and on the application of artificial intelligence where the patient’s risk stratification is implicit in precision medicine which involves the transition from an operator-dependent morphology-based to a less-operator dependent, more biomolecular management. The patient’s risk stratification based on any combination of “history” and “test results” to decrease colposcopy workload further reduce colposcopic and histologic morphological approaches, while adding genotyping to the risk stratification paradigm means less cytologic morphologic diagnosis. In Italy, there is a strong colposcopic tradition and there is currently no immediate need to reduce the number of colposcopies. Instead, there is a need for more accredited colposcopists to maintain the diagnostic accuracy of colposcopy in the vaccination era.

Attitudes about human papillomavirus vaccine in young women

2003 ◽  
Vol 14 (5) ◽  
pp. 300-306 ◽  
Author(s):  
Jessica A Kahn ◽  
Susan L Rosenthal ◽  
Tara Hamann ◽  
David I Bernstein
Keyword(s):  
Human Papillomavirus ◽  
Young Women ◽  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Human Papillomavirus Vaccine ◽  
Chi Square ◽  
Positive Attitudes ◽  
Number Of Sexual Partners ◽  
Papillomavirus Vaccine ◽  
To Receive

Human papillomavirus (HPV) vaccines are under investigation, but little is known about attitudes regarding vaccination. The aims of this study were to identify attitudes about and intention to receive an HPV vaccine in young women using a theory-based model. Young women ( n=52, mean age 25 years, range 18-30 years, 35% Black/Non-Hispanic) completed a survey assessing knowledge, attitudes about HPV vaccination, and risk behaviours. Associations between attitudes and intention to receive the vaccine were assessed using Mann-Whitney U or chi-square tests. Subjects reported positive attitudes about receiving an HPV vaccine and high intention to receive the vaccine both for themselves and their daughters. Variables associated significantly with intention included knowledge ( P=0.004), personal beliefs about vaccination ( P=0.004), belief that others would approve of vaccination ( P=0.005), and higher number of sexual partners ( P=0.028). Information on attitudes about HPV vaccination and predictors of intention to receive a vaccine may guide immunization initiatives for young adults.

scholarly journals Effectiveness of 1, 2, and 3 Doses of Human Papillomavirus Vaccine Against High-Grade Cervical Lesions Positive for Human Papillomavirus 16 or 18

2019 ◽  
Vol 189 (4) ◽  
pp. 265-276
Author(s):  
Michelle L Johnson Jones ◽  
Julia Warner Gargano ◽  
Melissa Powell ◽  
Ina U Park ◽  
Linda M Niccolai ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Hpv Vaccine ◽  
Hpv Vaccination ◽  
Intraepithelial Neoplasia ◽  
Dose Schedule ◽  
Adenocarcinoma In Situ ◽  
Human Papillomavirus Vaccine ◽  
Cervical Lesions ◽  
Hpv 16 ◽  
Vaccine Type

Abstract Before 2016, human papillomavirus (HPV) vaccination was recommended on a 3-dose schedule. However, many vaccine-eligible US females received fewer than 3 doses, which provided an opportunity to evaluate the real-world vaccine effectiveness (VE) of 1, 2, and 3 doses. We analyzed data on cervical intraepithelial neoplasia (CIN) grades 2–3 and adenocarcinoma in situ (designated CIN2+) from the HPV Vaccine Impact Monitoring Project (HPV-IMPACT; 2008–2014). Archived tissue from CIN2+ lesions was tested for 37 types of HPV. Women were classified by number of doses received ≥24 months before CIN2+ detection. Using a test-negative design, VE was estimated as 1 minus the adjusted odds ratio from a logistic regression model that compared vaccination history for women whose lesions tested positive for HPV-16/18 (vaccine-type cases) with that for women who had all other CIN2+ lesions (controls). Among 3,300 women with available data on CIN2+, typing results, and vaccine history, 1,561 (47%) were HPV-16/18–positive, 136 (4%) received 1 dose of HPV vaccine, 108 (3%) received 2 doses, and 325 (10%) received 3 doses. Adjusted odds ratios for vaccination with 1, 2, and 3 doses were 0.53 (95% confidence interval (CI): 0.37, 0.76; VE = 47%), 0.45 (95% CI: 0.30, 0.69; VE = 55%), and 0.26 (95% CI: 0.20, 0.35; VE = 74%), respectively. We found significant VE against vaccine-type CIN2+ after 3 doses of HPV vaccine and lower but significant VE with 1 or 2 doses.

scholarly journals Impact of Pharmacist Delivered Education on Early Parent Awareness and Perceptions Regarding Human Papillomavirus (HPV) Vaccination in the Community Pharmacy Setting in West Virginia

2018 ◽  
Vol 9 (3) ◽  
pp. 8
Author(s):  
Jennifer A Wick ◽  
Betsy M Elswick
Keyword(s):  
Human Papillomavirus ◽  
West Virginia ◽  
Hpv Vaccination ◽  
Community Pharmacies ◽  
Human Papillomavirus Vaccine ◽  
Convenience Sample ◽  
Immunization Services ◽  
Early Parent ◽  
Vaccine Availability ◽  
Papillomavirus Vaccine

ABSTRACT Objectives: (1) Define parental perceptions of the Human Papillomavirus Vaccine and of vaccine administration at community pharmacies (2) Describe parental intentions to have children vaccinated against HPV (3) Describe reasoning behind parental vaccination intentions (4) Assess effectiveness of pharmacist-led education on these perceptions and intentions Methods: This was a prospective pretest, posttest study with a convenience sample conducted at parenting groups throughout northern West Virginia in 2018.  Participants, a total of 34 parents/guardians, attended an educational session regarding Human Papillomavirus (HPV) vaccination with immediate pre/post survey.  The survey included questions about demographics, vaccination status, vaccination intentions, and decision-making. Results: Following intervention, intention to vaccinate according to the Advisory Committee on Immunization Practices (ACIP) recommendations increased from 35% (n=12) to 44% (n=15).  The percentage of participants against vaccinating decreased from 23% (n=8) to 12% (n=4).  Participants demonstrated increased awareness of HPV vaccine availability at community pharmacies, with awareness increasing from 32% (n=11) to 100% (n=34). Conclusions: Pharmacist delivered education may be useful in increasing parent/legal guardian awareness of immunization services as well as intention to vaccinate their child.

scholarly journals Adverse events following school-based vaccination of girls with quadrivalent human papillomavirus vaccine in Slovenia, 2009 to 2013

2016 ◽  
Vol 21 (14) ◽  
Author(s):  
Maja Šubelj ◽  
Veronika Učakar ◽  
Alenka Kraigher ◽  
Irena Klavs
Keyword(s):  
Human Papillomavirus ◽  
Adverse Events ◽  
Vaccination Programme ◽  
Hpv Vaccination ◽  
Monitoring And Evaluation ◽  
Human Papillomavirus Vaccine ◽  
School Based ◽  
Annual Reporting ◽  
Reporting Rates ◽  
Papillomavirus Vaccine

Adverse events following immunisation (AEFIs) with qHPV reported to the Slovenian AEFI Registry for the first four school years of the vaccination programme were analysed. We calculated annual reporting rates for 11–14 year-old vaccinees with AEFIs, using the number of qHPV doses distributed within the school-based vaccination programme as the denominator. Between September 2009 and August 2013, 211 AEFIs that occurred in 89 vaccinees were reported, a rate of 149.5 vaccinees with AEFI per 100,000 qHPV doses distributed. For five vaccinees, serious AEFIs (8.4 per 100,000 doses distributed) were reported. The highest reporting rates were for fatigue, headache, and fever (≥ 38.0⁰) (53.8, 40.3, and 35.3 per 100,000 qHPV doses distributed, respectively). As no AEFI resulted in permanent sequelae and they all were categorised as serious only due to the criterion of a minimum of one day of hospitalisation, this provides reassurance for the safety of our school-based HPV vaccination programme. Further AEFI surveillance is warranted to provide data for HPV vaccination programme monitoring and evaluation of its safety.

Potential impact of the human papillomavirus vaccine on the incidence proportion of genital warts in French women (EFFICAE study): a multicentric prospective observational study

Sexual Health ◽  
2016 ◽  
Vol 13 (1) ◽  
pp. 49
Author(s):  
Philippe Judlin ◽  
Anne-Carole Jacquard ◽  
Xavier Carcopino ◽  
François Aubin ◽  
André Dahlab ◽  
...  
Keyword(s):  
Genital Herpes ◽  
Prospective Observational Study ◽  
Vaccine Coverage ◽  
Hpv Vaccination ◽  
Genital Warts ◽  
Vaccination Program ◽  
Human Papillomavirus Vaccine ◽  
Incidence Proportion ◽  
Potential Impact ◽  
Papillomavirus Vaccine

Background The objective was to evaluate the effect of a HPV vaccination program on the incidence proportion of a proxy, genital warts (GW), in women in France. Methods: The number of primary GW cases was prospectively recorded over two 4-month periods before (T0: Dec 2008 to March 2009) and after (T1: Dec 2011 to March 2012) a HPV vaccination program. A total of 160 gynaecologists participated in T0 and 189 in T1. Primary genital herpes (HSV) infection was used as a control. Results: During T0, 39 190 15- to 26 year-old women were seen, of whom 176 were diagnosed with GW (incidence proportion: 0.45%) and 155 with primary HSV infection (incidence proportion: 0.39%). During T1, 45 628 females were seen [229 with GW (incidence proportion: 0.50%) and 202 with HSV (incidence proportion: 0.44%)]. In the 15–20 years age category, the incidence proportion of primary GW decreased from 0.41% to 0.30% (P = 0.128) between T0 and T1, and the proportion of women newly diagnosed with primary genital herpes diseases slightly increased from 0.34% to 0.38% (P = 0.620). In the 15–18 years age group, this decrease became significant (0.34% to 0.18%; P = 0.048). Conclusions: A trend for a non-significant decreased incidence proportion of GW was observed in young women below 20 years who are more frequently vaccinated. This may be the result of HPV vaccination and suggests that a substantial increase in vaccine coverage could lead to a more pronounced decreased incidence proportion of GW in the future.

scholarly journals Human Papillomavirus Vaccination Status and Parental Endorsement Intentions among Undergraduate Student Nurses

2021 ◽  
Vol 18 (6) ◽  
pp. 3232
Author(s):  
Ashley Hollins ◽  
Diane Wardell ◽  
Maria E. Fernandez ◽  
Christine Markham ◽  
Vincent Guilamo-Ramos ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Undergraduate Student ◽  
Hpv Vaccination ◽  
Student Nurses ◽  
Vaccination Status ◽  
Human Papillomavirus Vaccine ◽  
Human Papillomavirus Vaccination ◽  
Vaccination Rates ◽  
Factors Associated ◽  
Chi Squared

We identified factors associated with student nurses’ Human Papillomavirus Vaccine (HPV) vaccination status and their intention to counsel parents on HPV vaccination. Undergraduate student nurses (N = 153) from a large university in the south participated. Descriptive statistics, chi-squared tests, and independent t-tests (p ≤ 0.05) were used to characterize the students’ vaccination status. Logistic regression was used to identify factors associated with vaccination status. HPV vaccination rates were low. Students who were older and married or living with a partner were less likely to have completed the HPV vaccine series. The most commonly cited reason for non-initiation and non-completion was the lack of provider endorsement. Vaccination status did not differ significantly according to race/ethnicity, religion, skills, or intention to counsel parents. While intentions to counsel parents on HPV vaccination are high among student nurses, interventions to improve vaccination rates among student nurses are needed.

scholarly journals Declines in Prevalence of Human Papillomavirus Vaccine-Type Infection Among Females after Introduction of Vaccine — United States, 2003–2018

2021 ◽  
Vol 70 (12) ◽  
pp. 415-420
Author(s):  
Hannah G. Rosenblum ◽  
Rayleen M. Lewis ◽  
Julia W. Gargano ◽  
Troy D. Querec ◽  
Elizabeth R. Unger ◽  
...  
Keyword(s):  
United States ◽  
Human Papillomavirus ◽  
Human Papillomavirus Vaccine ◽  
Vaccine Type ◽  
Papillomavirus Vaccine ◽  
Type Infection
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