scholarly journals Herpetic Keratitis Preceded by COVID-19 Vaccination

Vaccines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1394
Author(s):  
Saiqun Li ◽  
Xiuhua Jia ◽  
Fei Yu ◽  
Qian Wang ◽  
Tingting Zhang ◽  
...  
Keyword(s):  
Vaccine Development ◽  
Large Population ◽  
Safety Data ◽  
Vaccine Safety ◽  
Herpetic Keratitis ◽  
Virus Reactivation ◽  
Varicella Zoster ◽  
Corneal Scarring ◽  
Ocular Herpes ◽  
One Year

The global Coronavirus Disease 2019 (COVID-19) pandemic has accelerated vaccine development at an unprecedented rate. A large population of people have received COVID-19 vaccines, while the vaccine safety data are limited. Here, we reported two cases of herpetic keratitis that occurred soon after receiving the inactivated COVID-19 vaccines. Case 1 was a 60-year-old woman who underwent penetrating keratoplasty (PKP) one year ago for corneal scarring caused by herpes simplex keratitis (HSK), and case 2 was a 51-year-old man with an unremarkable medical history. Both patients developed herpetic keratitis (HSK and varicella-zoster virus corneal endotheliitis, respectively) soon after receiving the inactivated COVID-19 vaccines (Sinovac). Herpetic keratitis was treated successfully with topical or plus oral antiviral ganciclovir. The short latency time in these two cases suggested that an inactivated COVID-19 vaccine may have a risk of triggering ocular herpes virus reactivation. Both clinicians and patients should be aware of this phenomenon. However, a causal relationship awaits confirmation.

scholarly journals Faster than warp speed: early attention to COVD-19 by anti-vaccine groups on Facebook

2021 ◽  
Author(s):  
Seth C Kalichman ◽  
Lisa A Eaton ◽  
Valerie A Earnshaw ◽  
Natalie Brousseau
Keyword(s):  
Social Media ◽  
Vaccine Development ◽  
Rapid Development ◽  
Development Program ◽  
Vaccine Safety ◽  
Vaccine Hesitancy ◽  
Conspiracy Theories ◽  
The Us ◽  
Us Government ◽  
Vaccine Information

Abstract Background The unprecedented rapid development of COVID-19 vaccines has faced SARS-CoV- (COVID-19) vaccine hesitancy, which is partially fueled by the misinformation and conspiracy theories propagated by anti-vaccine groups on social media. Research is needed to better understand the early COVID-19 anti-vaccine activities on social media. Methods This study chronicles the social media posts concerning COVID-19 and COVID-19 vaccines by leading anti-vaccine groups (Dr Tenpenny on Vaccines, the National Vaccine Information Center [NVIC] the Vaccination Information Network [VINE]) and Vaccine Machine in the early months of the COVID-19 pandemic (February–May 2020). Results Analysis of 2060 Facebook posts showed that anti-vaccine groups were discussing COVID-19 in the first week of February 2020 and were specifically discussing COVID-19 vaccines by mid-February 2020. COVID-19 posts by NVIC were more widely disseminated and showed greater influence than non-COVID-19 posts. Early COVID-19 posts concerned mistrust of vaccine safety and conspiracy theories. Conclusion Major anti-vaccine groups were sowing seeds of doubt on Facebook weeks before the US government launched its vaccine development program ‘Operation Warp Speed’. Early anti-vaccine misinformation campaigns outpaced public health messaging and hampered the rollout of COVID-19 vaccines.

scholarly journals COVID-19 Vaccine Safety in Cancer Patients: A Single Centre Experience

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3573
Author(s):  
Alfred Chung Pui So ◽  
Harriet McGrath ◽  
Jonathan Ting ◽  
Krishnie Srikandarajah ◽  
Styliani Germanou ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Safety Data ◽  
Vaccine Safety ◽  
Phase Iii ◽  
Solid Malignancy ◽  
Common Grade ◽  
Phase Iii Trials ◽  
Oncology Care ◽  
Grade 3 ◽  
Oncology Centre

Emergency approval of vaccines against COVID-19 provides an opportunity for us to return to pre-pandemic oncology care. However, safety data in cancer patients is lacking due to their exclusion from most phase III trials. We included all patients aged less than 65 years who received a COVID-19 vaccine from 8 December 2020 to 28 February 2021 at our London tertiary oncology centre. Solicited and unsolicited vaccine-related adverse events (VRAEs) were collected using telephone or face-to-face consultation. Within the study period, 373 patients received their first dose of vaccine: Pfizer/BioNTech (75.1%), Oxford/AstraZeneca (23.6%), Moderna (0.3%), and unknown (1.1%). Median follow-up was 25 days (5–85). Median age was 56 years (19–65). Of the patients, 94.9% had a solid malignancy and 76.7% were stage 3–4. The most common cancers were breast (34.0%), lung (13.4%), colorectal (10.2%), and gynaecological (10.2%). Of the patients, 88.5% were receiving anti-cancer treatment (36.2% parenteral chemotherapy and 15.3% immunotherapy), 76.1% developed any grade VRAE of which 2.1% were grade 3. No grade 4/5 or anaphylaxis were observed. The most common VRAEs within 7 days post-vaccination were sore arm (61.7%), fatigue (18.2%), and headaches (12.1%). Most common grade 3 VRAE was fatigue (1.1%). Our results demonstrate that COVID-19 vaccines in oncology patients have mild reactogenicity.

scholarly journals Review of COVID-19 mRNA Vaccines: BNT162b2 and mRNA-1273

2021 ◽  
pp. 089719002110096
Author(s):  
Shyh Poh Teo
Keyword(s):  
Vaccine Development ◽  
Safety Data ◽  
The United States ◽  
Virus Infections ◽  
Phase 3 ◽  
Vaccination Programs ◽  
Safety Surveillance ◽  
Mass Immunization ◽  
United States Food ◽  
States Food

The United States Food and Drug Administration recently issued emergency use authorization for 2 mRNA vaccines for preventing COVID-19 disease caused by SARS-CoV-2 virus infections. BNT162b2 from Pfizer-BioNTech and mRNA-1273 by Moderna are planned for use in mass-immunization programs to curb the pandemic. A brief overview of COVID-19 mRNA vaccines is provided, describing the SARS-CoV-2 RNA, how mRNA vaccines work and the advantages of mRNA over other vaccine platforms. The Pfizer-BioNTech collaboration journey to short-list mRNA vaccine candidates and finally selecting BNT162b2 based on safety data is outlined, followed by the Phase 3 study of BNT162b2 demonstrating 95% efficacy in preventing COVID-19 infections. Studies regarding mRNA-1273 (Moderna) are described, including extended immunogenicity data up to 119 days. The Phase 3 COVE study of mRNA-1273 eventually showed vaccine efficacy of 94.5%. Recommendations for future mRNA vaccine development are provided, including ongoing safety surveillance, evaluation in under-represented groups in previous studies and improving mRNA vaccine thermostability. Finally, further logistical considerations are required for manufacturing, storing, distribution and implementing mass vaccination programs to curb the pandemic.

scholarly journals Analysis of T Cell Responses during Active Varicella-Zoster Virus Reactivation in Human Ganglia

2013 ◽  
Vol 88 (5) ◽  
pp. 2704-2716 ◽  
Author(s):  
M. Steain ◽  
J. P. Sutherland ◽  
M. Rodriguez ◽  
A. L. Cunningham ◽  
B. Slobedman ◽  
...  
Keyword(s):  
T Cell ◽  
Varicella Zoster Virus ◽  
T Cell Responses ◽  
Virus Reactivation ◽  
Varicella Zoster ◽  
Cell Responses

Understanding Online Conversation about COVID-19 Vaccine on Twitter: Data Mining Approach (Preprint)

2021 ◽  
Author(s):  
Ekaterina Malova
Keyword(s):  
Online Social Networks ◽  
Information Seeking ◽  
Information Dissemination ◽  
Vaccine Development ◽  
Online Communication ◽  
Vaccine Safety ◽  
Interaction Patterns ◽  
Twitter Users ◽  
The Government ◽  
Online Conversation

BACKGROUND Timely vaccination against COVID-19 can prevent a large number of people from getting infected. However, given the disease novelty and fast vaccine development, some people are hesitant to vaccinate. Online social networks like Twitter produce huge amounts of public health information and impact peoples' vaccination decisions. Hence, it is important to understand the conversation around the COVID-19 vaccination through the lens of social media. OBJECTIVE The present study aimed to define the nature of a larger Twitter conversation around the COVID-19 vaccine and explored interaction patterns between Twitter users engaged in such a conversation. METHODS Data collection took place in November 2020 on the wave of the news about the COVID-19 vaccine breakthrough. In total, 9600 Twitter posts were analyzed using a combination of text and network analysis. RESULTS Results of this study show that mixed-emotions reactions and discussions about potential side effects and vaccine safety dominated the online conversation. Twitter was primarily used for two purposes: information dissemination and opinion expression. Overall, the communication network was sparse, non-reciprocal, decentralized, and highly modular. Four main network clusters highlighted different groups of conversation stakeholders. CONCLUSIONS This study provides important insights into public sentiments, information-seeking behaviors, and online communication patterns during a major COVID-19 crisis. Given the popularity of Twitter among different types of communities and its power for rapid information dissemination, it can be an effective tool for vaccination promotion. Thus, it should be actively used to promote safe and effective vaccination through major stakeholders in the government, science, and health sectors.

Acyclovir in general practice

1992 ◽  
Vol 30 (26) ◽  
pp. 101-104 ◽  
Keyword(s):  
General Practice ◽  
Herpes Simplex ◽  
Early Treatment ◽  
Systemic Treatment ◽  
Systemic Infection ◽  
Herpes Viruses ◽  
Important Advance ◽  
Varicella Zoster ◽  
Ocular Herpes ◽  
The Cost

Acyclovir (Zovirax; Wellcome) is now widely prescribed for the treatment of herpes infections. In 1984 we hailed acyclovir as an important advance for the “early treatment of primary skin and ocular herpes simplex infections and for varicella-zoster infections requiring systemic treatment”, but warned against using it “indiscriminately in view of the cost, the lack of data on toxicity and the increasing number of acyclovir-resistant herpes viruses being reported.”1 In this article we appraise the place of acyclovir in general practice and so for the treatment of patients likely to be immunocompetent and without severe systemic infection.

scholarly journals Sleep problems increase the risk of musculoskeletal pain in boys but not girls: a prospective cohort study

2020 ◽  
Vol 179 (11) ◽  
pp. 1711-1719
Author(s):  
Alessandro Andreucci ◽  
Paul Campbell ◽  
Lisa K Mundy ◽  
Susan M Sawyer ◽  
Silja Kosola ◽  
...  
Keyword(s):  
Cohort Study ◽  
Musculoskeletal Pain ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Sleep Problems ◽  
Large Population ◽  
Population Based ◽  
School Aged Children ◽  
Increased Risk ◽  
One Year

Abstract Adults with sleep problems are at higher risk for onset of musculoskeletal pain, but the evidence is less clear for children. This prospective cohort study investigated whether children with sleep problems are at higher risk for onset of musculoskeletal pain and explored whether sex is a modifier of this association. In a prospective cohort study of Australian schoolchildren (n = 1239, mean age 9 years), the associations between sleep problems at baseline and new onset of both musculoskeletal pain and persistent musculoskeletal pain (pain lasting > 3 months) 1 year later were investigated using logistic regression. The potential modifying effect of sex was also assessed. One-year incidence proportion for musculoskeletal pain onset is 43% and 7% for persistent musculoskeletal pain. Sleep problems were associated with musculoskeletal pain onset and persistent musculoskeletal pain onset in boys, odds ratio 2.80 (95% CI 1.39, 5.62) and OR 3.70 (1.30, 10.54), respectively, but not girls OR 0.58 (0.28, 1.19) and OR 1.43 (0.41, 4.95), respectively. Conclusions: Rates of musculoskeletal pain are high in children. Boys with sleep problems are at greater risk of onset of musculoskeletal pain, but girls do not appear to have higher risk. Consideration of sleep health may help prevent persistent musculoskeletal pain in children. What is Known:• Sleep problems are associated with the onset of musculoskeletal pain in adults.• It is not clear if the association between sleep problems and the onset of musculoskeletal pain is present also in children and if sex plays a role in this association. What is New:• This is the first large population-based study that has prospectively investigated the relationship between sleep problems and onset of musculoskeletal pain in school-aged children.• Children, especially boys with sleep problems, were at increased risk for the development of persistent musculoskeletal pain.

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