scholarly journals Ischiocavernosus Muscle Release for Urethral Obstruction Treatment after Pelvic Symphyseal Distraction Osteotomy in a Cat with Pelvic Stenosis

2021 ◽  
Vol 8 (10) ◽  
pp. 225
Author(s):  
Yoon-Ho Roh ◽  
Jeong-Nam Kim ◽  
Pill-Moo Byun ◽  
Dae-Hyun Kim ◽  
Seong-Mok Jeong ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Positive Contrast ◽  
Reference Intervals ◽  
Diameter Ratio ◽  
Functional Restoration ◽  
Urethral Obstruction ◽  
Uneventful Recovery ◽  
Maximal Diameter ◽  
Canal Diameter ◽  
Ischiocavernosus Muscle

Symphyseal distraction osteotomy (SDO) with a polymethyl methacrylate (PMMA) spacer is an effective surgical treatment for cats with pelvic stenosis. This study reports the successful treatment of urethral obstruction due to ischiocavernosus muscle (IM) tension after SDO with a PMMA spacer. A 2-year-old castrated male Korean domestic shorthair feline had megacolon and pelvic canal stenosis. The ratio of the maximal diameter of the colon to the L5 length and the pelvic canal diameter ratio were 1.6 and 0.45, respectively. Pelvic SDO was performed with a PMMA spacer, leading to pelvic canal enlargement (pelvic canal diameter ratio: 0.73). Two days after surgery, dysuria was identified immediately after removing the preoperatively placed urinary catheter. Complete blood counts and serum biochemical profiles were within the reference intervals, and a positive contrast retrograde urethrogram confirmed urethral obstruction at the level of the membranous–pelvic urethra region. Increased tension of the IM leading to a narrowed urethra was suspected as the cause of urethral obstruction. After IM release at the level of origin on the ischium, the patient had an uneventful recovery with spontaneous urination. Muscle release resulted in excellent functional restoration, with no intraoperative or postoperative complications reported during the 12-month long-term follow-up. Therefore, SDO with IM release could be a feasible therapeutic option for severe pelvic stenosis without complications, such as urethral obstruction, in cats.

Efficient retrovirus-mediated PIG-A gene transfer and stable restoration of GPI-anchored protein expression in cells with the PNH phenotype

Blood ◽  
2001 ◽  
Vol 97 (10) ◽  
pp. 3004-3010 ◽  
Author(s):  
Jun-ichi Nishimura ◽  
Ken L. Phillips ◽  
Russell E. Ware ◽  
Sharon Hall ◽  
Lee Wilson ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Line ◽  
Mononuclear Cells ◽  
Therapeutic Option ◽  
Growth Factor Receptor ◽  
Functional Restoration ◽  
Normal Donor ◽  
Erythroid Cells ◽  
Entry Site ◽  
Hematopoietic Stem

Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal hematopoietic stem cell disorder characterized by complement-mediated hemolysis due to deficiencies of glycosylphosphatidylinositol-anchored proteins (GPI-APs) in subpopulations of blood cells. Acquired mutations in the X-linked phosphatidylinositol glycan–class A (PIG-A) gene appear to be the characteristic and pathogenetic cause of PNH. To develop a gene therapy approach for PNH, a retroviral vector construct, termed MPIN, was made containing the PIG-A complementary DNA along with an internal ribosome entry site and the nerve growth factor receptor (NGFR) as a selectable marker. MPIN transduction led to efficient and stable PIG-A and NGFR gene expression in a PIG-A–deficient B-cell line (JY5), a PIG-A–deficient K562 cell line, an Epstein-Barr virus–transformed B-cell line (TK-14−) established from a patient with PNH, as well as peripheral blood (PB) mononuclear cells from a patient with PNH. PIG-A expression in these cell lines stably restored GPI-AP expression. MPIN was transduced into bone marrow mononuclear cells from a patient with PNH, and myeloid/erythroid colonies and erythroid cells were derived. These transduced erythroid cells restored surface expression of GPI-APs and resistance to hemolysis. These results indicate that MPIN is capable of efficient and stable functional restoration of GPI-APs in a variety of PIG-A–deficient hematopoietic cell types. Furthermore, MPIN also transduced into PB CD34+ cells from a normal donor, indicating that MPIN can transduce primitive human progenitors. These findings set the stage for determining whether MPIN can restore PIG-A function in multipotential stem cells, thereby providing a potential new therapeutic option in PNH.

Closed reduction and percutaneous fixation of sacroiliac luxations in cats using 2.4 mm cannulated screws – a cadaveric study

2012 ◽  
Vol 25 (01) ◽  
pp. 22-27 ◽  
Author(s):  
E. Binder ◽  
U. Reif ◽  
M. Biel ◽  
J. Bokemeyer ◽  
M. Kramer ◽  
...  
Keyword(s):  
Closed Reduction ◽  
Diameter Ratio ◽  
Width Ratio ◽  
Percutaneous Fixation ◽  
Cannulated Screws ◽  
Pelvic Anatomy ◽  
Surgical Time ◽  
Computed Tomographic ◽  
Canal Diameter ◽  
Canal Width

SummaryObjectives: To describe fluoroscopically assisted percutaneous placement of 2.4 mm cannulated screws for fixation of artificially induced sacroiliac luxations in cats, and to evaluate the success of this technique in restoration of normal pelvic anatomy.Methods: Fluoroscopically assisted closed reduction and percutaneous fixation of sacroiliac luxations using 2.4 mm cannulated screws was performed in cadavers of 12 cats. Pre- and postoperative radiographs and postoperative computed tomographic scans were used to evaluate screw placement, screw purchase within the sacral body, reduction of the sacroiliac joint, pelvic canal diameter ratio, and hemipelvic canal width ratio.Results: Mean total surgical time was 6 minutes and 10 seconds ± 53 seconds and mean total time of fluoroscopic screening for each procedure was 44 seconds ± 6 seconds. Mean percent of reduction was 98.33% and mean screw purchase within the sacral body was 73%. Eleven out of 12 screws were placed in a satisfactory location in the sacral body. Pelvic canal diameter ratio and hemipelvic canal width ratio indicated successful restoration of the pelvic anatomy.Clinical significance: Our results confirm that fluoroscopically assisted percutaneous placement of 2.4 mm cannulated screws is a feasible technique for fixation of sacroiliac luxations in cats. Mechanical properties of this fixation technique need to be evaluated before the use in clinical patients.

Endovascular repair of an abdominal aortic aneurysm in the presence of a hydronephrotic horseshoe kidney

Vascular ◽  
2012 ◽  
Vol 20 (1) ◽  
pp. 54-56 ◽  
Author(s):  
Lian Krivoshei ◽  
Yemi Akin-Olugbade ◽  
Glen Mcwilliams ◽  
Moshe Halak ◽  
Daniel Silverberg
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Therapeutic Option ◽  
Endovascular Aneurysm Repair ◽  
Horseshoe Kidney ◽  
Uneventful Recovery ◽  
Endovascular Stent Graft ◽  
Abdominal Aortic ◽  
Aneurysm Repair ◽  
Accessory Renal Arteries

The aim of this paper is to report an unusual case of a patient with an abdominal aortic aneurysm (AAA) and a hydronephrotic horseshoe kidney (HSK) that was repaired by endovascular means. An 81-year-old male patient with a known HSK was found to have hydronephrosis and an AAA. The patient's aneurysm was treated with an endovascular stent graft which required the covering of accessory renal arteries. He had an uneventful recovery with complete resolution of the hydronephrosis evident on a computed tomography scan performed seven months after the surgery. In conclusion, endovascular aneurysm repair is a feasible therapeutic option for an AAA coexisting with an HSK and may be considered as a valid alternative to open repair when concomitant hydronephrosis is present.

Redefining Optimal Nail to Medullary Canal Diameter Ratio in Stainless Steel Flexible Intramedullary Nailing of Pediatric Femur Fractures

2017 ◽  
Vol 37 (7) ◽  
pp. e398-e402 ◽  
Author(s):  
James S. Shaha ◽  
Jason M. Cage ◽  
Sheena R. Black ◽  
Robert L. Wimberly ◽  
Steven H. Shaha ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Intramedullary Nailing ◽  
Medullary Canal ◽  
Diameter Ratio ◽  
Femur Fractures ◽  
Flexible Intramedullary Nailing ◽  
Canal Diameter

Two Years follow up of a Patient with Renal Fibrosis: from Renal Transplantation to Normal Functional Restoration Following the Use of Ammi visnaga and Urtica pillulefera

2020 ◽  
Vol 3 (2) ◽  
pp. 01-03
Author(s):  
Ahed J Alkhatib
Keyword(s):  
Kidney Transplantation ◽  
Therapeutic Option ◽  
Functional Restoration ◽  
Kidney Fibrosis ◽  
Ammi Visnaga ◽  
Physiological Limits ◽  
Appropriate Treatment ◽  
Normal Functional ◽  
Immunological Reactions ◽  
End Stage

Kidney transplantation is the appropriate treatment for patients with end stage kidney disease. Although it offers survival and quality of life, it is still costing and has its complications such as transplantation failure mainly due to immunological reactions. The main objective of the present study is to describe a case study of a patient with renal failure and kidney fibrosis. Kidney transplantation was recommended. The patient and his family asked for possible alternative therapeutic options. The patient was male, 26 years age. The therapeutic option was a combination of the crude extract of Ammi visnaga and the powder of dried leaves of Urtica pillulifera mixed with honey. This regimen was applied for 21 days. At the end of the regimen, both creatinine and urea were restored to their physiological limits. Taken together, it is possible to use herbs of medical importance to replace kidney transplantation.

An Efficient Statistic for Determining the Diameter of Thin Sectioned Uniform Spheres from Measurements of Biological Samples

1974 ◽  
Vol 32 ◽  
pp. 114-115
Author(s):  
W. R. Schucany ◽  
G. H. Kelsoe ◽  
V. F. Allison
Keyword(s):  
Biological Samples ◽  
Traditional Method ◽  
Cell Types ◽  
Accurate Estimation ◽  
Morphological Identification ◽  
Sectioned Material ◽  
Maximal Diameter ◽  
Similar Cell

Accurate estimation of the size of spheroid organelles from thin sectioned material is often necessary, as uniquely homogenous populations of organelles such as vessicles, granules, or nuclei often are critically important in the morphological identification of similar cell types. However, the difficulty in obtaining accurate diameter measurements of thin sectioned organelles is well known. This difficulty is due to the extreme tenuity of the sectioned material as compared to the size of the intact organelle. In populations where low variance is suspected the traditional method of diameter estimation has been to measure literally hundreds of profiles and to describe the “largest” as representative of the “approximate maximal diameter”.

Echocardiography in Saanen-goats: Normal findings, reference intervals in awake goats, and the effect of general anesthesia

2011 ◽  
Vol 153 (12) ◽  
pp. 553-564 ◽  
Author(s):  
K. Steininger ◽  
A.-S. J. Berli ◽  
R. Jud ◽  
C. C. Schwarzwald
Keyword(s):  
General Anesthesia ◽  
Reference Intervals

Influence of preoperative statins and aspirin administration on biological and magnetic resonance imaging properties in patients with abdominal aortic aneurysm

VASA ◽  
2020 ◽  
pp. 1-9
Author(s):  
Milos Sladojevic ◽  
Petar Zlatanovic ◽  
Zeljka Stanojevic ◽  
Igor Koncar ◽  
Sasenka Vidicevic ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Abdominal Aortic Aneurysm ◽  
Magnetic Resonance ◽  
Aortic Aneurysm ◽  
Signal Intensity ◽  
Psoas Muscle ◽  
Resonance Imaging ◽  
Maximal Diameter ◽  
Aneurysm Wall ◽  
Abdominal Aortic

Summary: Background: Main objective of this study was to evaluate the influence of statins and/or acetylsalicylic acid on biochemical characteristics of abdominal aortic aneurysm (AAA) wall and intraluminal thrombus (ILT). Patients and methods: Fifty patients with asymptomatic infrarenal AAA were analyzed using magnetic resonance imaging on T1w sequence. Relative ILT signal intensity (SI) was determined as a ratio between ILT and psoas muscle SI. Samples containing the full ILT thickness and aneurysm wall were harvested from the anterior surface at the level of the maximal diameter. The concentration of enzymes such as matrix metalloproteinase (MMP) 9, MMP2 and neutrophil elastase (NE/ELA) were analyzed in ILT and AAA wall; while collagen type III, elastin and proteoglycan 4 were analyzed in harvested AAA wall. Oxidative stress in the AAA wall was assessed by catalase and malondialdehyde activity in tissue samples. Results: Relative ILT signal intensity (1.09 ± 0.41 vs 0.89 ± 0.21, p = 0.013) were higher in non-statin than in statin group. Patients who were taking aspirin had lower relative ILT area (0.89 ± 0.19 vs 1.13. ± 0.44, p = 0.016), and lower relative ILT signal intensity (0.85 [0.73–1.07] vs 1.01 [0.84–1.19], p = 0.021) compared to non-aspirin group. There were higher concentrations of elastin in AAA wall among patients taking both of aspirin and statins (1.21 [0.77–3.02] vs 0.78 (0.49–1.05) ng/ml, p = 0.044) than in patients who did not take both of these drugs. Conclusions: Relative ILT SI was lower in patients taking statin and aspirin. Combination of antiplatelet therapy and statins was associated with higher elastin concentrations in AAA wall.

COVID-19 complicated by pulmonary embolism treated with catheter directed thrombectomy

VASA ◽  
2020 ◽  
Vol 49 (4) ◽  
pp. 333-337 ◽  
Author(s):  
Francisco Leonardo Galastri ◽  
Leonardo Guedes Moreira Valle ◽  
Breno Boueri Affonso ◽  
Marcela Juliano Silva ◽  
Rodrigo Gobbo Garcia ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
High Risk ◽  
Dynamic Process ◽  
Therapeutic Option ◽  
Massive Pulmonary Embolism ◽  
Percutaneous Intervention ◽  
Thromboembolic Events ◽  
Emergency Center ◽  
Catheter Directed Thrombolysis

Summary: COVID-19 is a recently identified illness that is associated with thromboembolic events. We report a case of pulmonary embolism in a patient with COVID-19, treated by catheter directed thrombectomy. A 57 year old patient presented to the emergency center with severe COVID-19 symptoms and developed massive pulmonary embolism. The patient was treated with catheter directed thrombolysis (CDT) and recovered completely. Coagulopathy associated with COVID-19 is present in all severe cases and is a dynamic process. We describe a case of massive/high risk pulmonary embolism, in a patient with COVID-19 receiving full anticoagulation, who was treated by percutaneous intervention. CDT can be an additional therapeutic option in patients with COVID-19 and pulmonary embolism that present with rapid clinical collapse.

Endovascular repair of a spontaneous ilio-iliac fistula presenting as pulmonary embolism

VASA ◽  
2011 ◽  
Vol 40 (3) ◽  
pp. 246-250 ◽  
Author(s):  
Melas ◽  
Saratzis ◽  
Abbas ◽  
Sarris ◽  
Saratzis ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Endovascular Repair ◽  
Therapeutic Option ◽  
Artery Aneurysm ◽  
Iliac Vein ◽  
Massive Pulmonary Embolism ◽  
Long Term Results ◽  
Common Iliac Vein ◽  
Iliac Artery Aneurysm ◽  
Common Iliac Artery Aneurysm

Spontaneous rupture of a common iliac artery aneurysm into the common iliac vein is a rare phenomenon. We report the case of a 68 year old man admitted with acute cardiac failure and massive pulmonary embolism as a complication of a spontaneous ilio-iliac fistula, secondary to aneurysmal rupture. The aneurysm was successfully excluded using an aorto-uni-iliac stent graft. No complications were noted at 9 months follow-up. Arteriovenous fistulae should be considered in patients with aortic or iliac aneurysms who develop a pulmonary embolism or symptoms of venous congestion. Endovascular repair of these pathologies is a feasible therapeutic option; however long term results remain unknown.

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