Knowledge of some aspects of the influence of antiepileptic drugs in patients with epilepsy

2020 ◽  
pp. 32-46
Author(s):  
Marina Bortyash ◽  
Marina Khanieva
Keyword(s):  
Side Effects ◽  
Antiepileptic Drugs ◽  
Drug Dependency ◽  
Toxic Impact ◽  
Therapeutic Results ◽  
Patients With Epilepsy

Substantial intensity of side effects and low tolerance of drugs are reflected directly on the quality of patients' lives. In common with positive therapeutic results, antiepileptic drugs have a toxic impact on an organism of human including drug dependency and they can lead to fatality in different conditions (in case of overdose, drugs abuse, heightened sensitivity of organism).

scholarly journals Perspective: Therapeutic Potential of Flavonoids as Alternative Medicines in Epilepsy

2019 ◽  
Vol 10 (5) ◽  
pp. 778-790 ◽  
Author(s):  
Jae Young Kwon ◽  
Min-Tae Jeon ◽  
Un Ju Jung ◽  
Dong Woon Kim ◽  
Gyeong Joon Moon ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Therapeutic Potential ◽  
Double Vision ◽  
Beneficial Effects ◽  
Medical Needs ◽  
Treatment Of Epilepsy ◽  
Alternative Medicines ◽  
Patients With Epilepsy

ABSTRACTEpilepsy is a chronic neurological disorder that affects many people worldwide. Temporal lobe epilepsy is the most common and most studied type of epilepsy, but the pathological mechanisms underlying this condition are poorly understood. More than 20 antiepileptic drugs (AEDs) have been developed and used for the treatment of epilepsy; however, 30% of patients still experience uncontrolled epilepsy and associated comorbidities, which impair their quality of life. In addition, various side effects have been reported for AEDs, such as drowsiness, unsteadiness, dizziness, blurred or double vision, tremor (shakiness), greater risk of infections, bruising, and bleeding. Thus, critical medical needs remain unmet for patients with uncontrolled epilepsy. Flavonoids belong to a subclass of polyphenols that are widely present in fruits, vegetables, and certain beverages. Recently, many studies have reported that some flavonoids elicit various beneficial effects in patients with epilepsy without causing the side effects associated with conventional medical therapies. Moreover, flavonoids may have a property of regulating microRNA expression associated with inflammation and cell survival. These findings suggest that flavonoids, which are more effective but impose fewer adverse effects than conventional AEDs, could be used in the treatment of epilepsy.

scholarly journals Interchangeability among therapeutic equivalents of lamotrigine: evaluation of quality of life

2012 ◽  
Vol 48 (1) ◽  
pp. 95-102 ◽  
Author(s):  
Beatriz Maria Pereira Girolineto ◽  
Veriano Alexandre Junior ◽  
Américo Ceiki Sakamoto ◽  
Leonardo Régis Leira Pereira
Keyword(s):  
Quality Of Life ◽  
Side Effects ◽  
Deleterious Effect ◽  
Reference Product ◽  
Plasma Concentrations ◽  
Product Formulation ◽  
Epileptic Patients ◽  
The Mean ◽  
Patients With Epilepsy

Epilepsy is the most common serious neurological disorder worldwide. Approximately 70% of patients with epilepsy have their seizures controlled by clinical and pharmacological treatment. This research evaluated the possible influence of interchangeability among therapeutic equivalents of LTG on the clinical condition and quality of life of refractory epileptic patients. The study was divided into three periods of 42 days, and an equivalent therapeutic LTG randomly dispensed for each period (two similars - formulations A and B, and the reference product - formulation C). The mean dose of LTG was 5.5 mg/kg/day. The presence of side effects tends to have a greater deleterious effect on quality of life of refractory epileptics compared to variations in number of seizures or changes in plasma concentrations. The results showed that independently of the drug prescribed, interchangeability among therapeutic equivalents can negatively impact epilepsy control.

Association of non-adherence to antiepileptic drugs and seizures, quality of life, and productivity: Survey of patients with epilepsy and physicians

2008 ◽  
Vol 13 (2) ◽  
pp. 316-322 ◽  
Author(s):  
Collin A. Hovinga ◽  
Miya R. Asato ◽  
Ranjani Manjunath ◽  
James W. Wheless ◽  
Stephanie J. Phelps ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Antiepileptic Drugs ◽  
Patients With Epilepsy

scholarly journals The effect of depression and side effects of antiepileptic drugs on injuries in patients with epilepsy

2017 ◽  
Vol 24 (9) ◽  
pp. 1135-1139 ◽  
Author(s):  
S. Gur-Ozmen ◽  
M. Mula ◽  
N. Agrawal ◽  
H. R. Cock ◽  
D. Lozsadi ◽  
...  
Keyword(s):  
Side Effects ◽  
Antiepileptic Drugs ◽  
Patients With Epilepsy

scholarly journals Psychosocial Problems and Physical Activity at Different Ages in Patients with Epilepsy

2018 ◽  
Vol 2 (89) ◽  
Author(s):  
Elvyra Grinienė ◽  
Viktorija Pečinina
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Antiepileptic Drugs ◽  
Physical Inactivity ◽  
Age Groups ◽  
Psychosocial Problems ◽  
Health Problems ◽  
Activity Levels ◽  
Patients With Epilepsy

Research background and hypothesis. Physical inactivity of patients with epilepsy is associated with the course of the disease, treatment, preconceived attitudes and myths that their physical activity might be dangerous and cause seizures (Steinhoff et al., 1996; Nakken, 2001 ).The aim of our research was to examine the links between the psychosocial problems of patients’ with epilepsy, their hysical activity, self-reported quality of life as well as their connection with patients’ age. Research  methods.  The  participants  were  209  patients  with  epilepsy  from  three  different  regions  (Šiauliai, Panevėžys and Pasvalys) of Lithuania. The subjects were selected with the help of quantitative closed-type survey – QOLIE-89 and IPAQ international questionnaire. The research findings were compared between two age groups: younger (20–39 years of age) and senior (40–59 years of age) subjects. Research results. The main psychosocial problems for patients with epilepsy were concerns about possible injuries during the seizures, experience of shame and other social restraint, health problems that might occur as a result of taking antiepileptic drugs for a long period of time, negative effects of antiepileptic drugs and memory impairments. These problems were more common among younger respondents (p < 0.05). Physical activity levels in patients with epilepsy were inadequate and different. The main factor that contributed to these differences was patients’ age. Younger respondents trained more in their leisure time, while seniors spent more time reading or sleeping (p = 0.002).Younger patients lacked knowledge about the most appropriate types of physical activities, senior  respondents  were  inactive  were  to  the  disapproval  of  medical  professionals  and  their  health  problems  (p = 0.006). Younger respondents evaluated their lifestyle as good enough more often than seniors. Discussion  and  conclusion.  Psychosocial  problems  and  physical  inactivity  of  patients  with  epilepsy  were connected with their age. Younger respondents more often than seniors were physically active and their self-reported quality of life was good.Keywords: age of patients with epilepsy, social problems, physical activity, evaluation of lifestyle.

A review on cost effective analysis of antiepileptic drugs

2017 ◽  
Vol 6 (9) ◽  
pp. 5507 ◽  
Author(s):  
Uthara S.S. ◽  
Mohammed Basheer ◽  
Anil Babu A.
Keyword(s):  
Quality Of Life ◽  
Developing Countries ◽  
Antiepileptic Drugs ◽  
Low Cost ◽  
Cost Effective ◽  
Global Burden ◽  
Patients With Epilepsy ◽  
Effective Analysis

80% of the epilepsy patients were resides in developing countries. 12 million patients with epilepsy were in India that is One-sixth of the global burden is due to epilepsy. Those diseases were treated properly there is a greater reduction in seizure and people may leads to proper life, if untreated that may become a large increase in burden. Drugs are the main treatment for epilepsy. As compared with conventional AEDs newer drugs are much expensive some newer drugs were 10 to 20 times costlier than older drugs. if those expensive drugs reduce the seizure events, improves the quality of life and with lesser ADRs then the benefit justify the higher cost of the drug. The epilepsy burden can be reduced mainly by giving epilepsy care at low cost, given the lack of expertise in the management of epilepsy in poor areas.

scholarly journals Cognitive and Psychological Side Effects of Antiepileptic Drugs

2020 ◽  
Author(s):  
Katja Eva Brückner
Keyword(s):  
Side Effects ◽  
Medical Treatment ◽  
Antiepileptic Drugs ◽  
Severe Side Effect ◽  
Side Effect Profile ◽  
Profound Impact ◽  
Treatment Of Epilepsy ◽  
In The Beginning ◽  
And Behavior

Among well-known side effects such as dizziness, nausea, headache and diplopia medical treatment of epilepsy may cause side effects on cognition, mood and behavior. In special constellations this can profoundly affect compliance with the medication as well as quality of life. Some patients are more vulnerable to side effects than others. Side effects can have profound impact on the development and future life of a patient. Some antiepileptic drugs (e.g. topiramate, zonisamide) show a more severe side effect profile than others (e.g. lamotrigine, levetiracetam). Thus, in the treatment of epilepsy, it is crucial to consider such possible side effects – especially in the beginning of or while changing the medical treatment. Specific neuropsychological examinations can monitor side effects on cognitive functions like concentration, memory or speech function. If this is not possible in an ambulant setting, specific screening instruments and repeated and precise interviews of patients and/or relatives can help to discover potential side effects. Because most side effects can be reversible, dosage modification or drug replacement is required as soon as incompatibilities are discovered.

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