State of central hemodynamics and myocardial contractility in vibration disease

2020 ◽  
pp. 62-73
Author(s):  
Sergey Babanov
Keyword(s):  
Myocardial Contractility ◽  
Central Hemodynamics ◽  
Hemodynamic Changes ◽  
Vibration Disease ◽  
Regional Center ◽  
Severity Of The Disease ◽  
Degrees Of Severity

The article describes the peculiarities of Central hemodynamics and myocardial contractility in patients with vibration disease, various forms and degrees of severity with the help of echocardiography of the Department of pathology of the regional center of occupational pathology of SBME "Samara mediko-a sanitary part of № 5 of Kirov district". It was found that patients with vibration disease are characterized by the formation of a phase syndrome of myocardial hyperdynamics and a hyperkinetic variant of Central hemodynamics, while hemodynamic changes depend on the form of vibration disease, the severity of the disease, and the length of work in contact with vibration.

Vibration disease from exposure to general vibration: methodology of diagnosis and place of electroneuromyography

2021 ◽  
pp. 7-16
Author(s):  
S.A. Babanov
Keyword(s):  
The State ◽  
Functional Mobility ◽  
Sensorimotor System ◽  
Vibration Disease ◽  
Regional Center ◽  
Neuromuscular Apparatus ◽  
Degrees Of Severity ◽  
Sensory Polyneuropathy

The article describes the features of the state of the neuromuscular apparatus in vibration diseases of various degrees of severity using electroneuromyographic research on the basis of the department of occupational Pathology of the regional center of Occupational Pathology of the Samara Medical and Sanitary Unit No. 5 of the Kirov district. It was found that patients with vibration disease are characterized by changes in the excitability and functional mobility of the sensorimotor system, the formation of vegetative-sensory polyneuropathy, depending on the severity of the vibration disease, the length of work in contact with vibration.

State of neuromuscular transmission in vibration disease, according to electroneuromyographic test

2020 ◽  
pp. 55-68
Author(s):  
Sergey Babanov
Keyword(s):  
Neuromuscular Transmission ◽  
System Development ◽  
Disease Type ◽  
Functional Mobility ◽  
Sensorimotor System ◽  
Muscular System ◽  
Vibration Disease ◽  
Regional Center ◽  
Occupational Disorders ◽  
Sensory Polyneuropathy

The article covers the particular features of the neuro-muscular system in vibration disease of various types and severity by electroneuromyographical tests at the Department of Occupational Disorders, Regional Center for Occupational Disorders, Samara Medical and Sanitary Unit № 5 of the Kirov Region (State Budgetary Healthcare Institution of the Samara Region). Changes in excitability and functional mobility of the sensorimotor system, development of vegetative-sensory polyneuropathy depending on the vibration disease type, severity, and the length of exposure to vibration at work are found in vibration disease patients.

Central hemodynamics during progressive upper- and lower-body exercise and recovery

1984 ◽  
Vol 57 (2) ◽  
pp. 366-370 ◽  
Author(s):  
D. S. Miles ◽  
M. N. Sawka ◽  
D. E. Hanpeter ◽  
J. E. Foster ◽  
B. M. Doerr ◽  
...  
Keyword(s):  
Myocardial Contractility ◽  
Impedance Cardiography ◽  
Recovery Period ◽  
Peripheral Resistance ◽  
Cycle Ergometer ◽  
Lower Body ◽  
Central Hemodynamics ◽  
Rest Periods ◽  
Ergometer Exercise ◽  
Contractility Indices

The purpose of this study was to compare stroke volume (SV) and myocardial contractility responses during and immediately after upper- and lower-body exercise. Nine men (mean 28 yr, 78 kg) completed progressive intensity discontinuous tests on both an arm crank and cycle ergometer. Exercise for each power output (PO) was 7 min with 20-min rest periods interspersed. Impedance cardiography was used to measure cardiac output (Q), SV, and contractility on a beat-by-beat basis during exercise and a 15-s recovery period. Q increased linearly, and total peripheral resistance decreased exponentially with increasing PO levels. During recovery from exercise, the Q and heart rate (HR) values decreased immediately at all PO levels. When the exercise VO2 exceeded 1.0 1 X min-1, SV fell significantly during recovery for both exercise modes. In general, the recovery myocardial contractility indices remained similar to exercise values. It was concluded that immediately after low intensities of exercise, Q decreases because of a fall in HR. After moderate- and high-intensity exercise, Q decreases because of a fall in both HR and SV.

EFFECTS OF S-METHYL-ISOTHIOUREA ON THE MYOCARDIAL CONTRACTILITY AND THE HEMODYNAMIC CHANGES IN HYPERDYNAMIC ENDOTOXEMIA.

Shock ◽  
1996 ◽  
Vol 5 ◽  
pp. 60
Author(s):  
J. Kaszaki ◽  
C. Szabó ◽  
A. Wolfard ◽  
Z. Balogh ◽  
S. Nagy
Keyword(s):  
Myocardial Contractility ◽  
Hemodynamic Changes

scholarly journals Expression of Ki-67, PCNA markers and the apoptotic index in the inflammatory bowel disease in dogs and its diagnostic values

2017 ◽  
Vol 73 (9) ◽  
pp. 567-571
Author(s):  
Andrzej Rychlik ◽  
Marcin Nowicki ◽  
Marta Szweda ◽  
Ewa Kaczmar
Keyword(s):  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Apoptotic Index ◽  
Control Group ◽  
Ki 67 ◽  
Proliferation Markers ◽  
Diagnostic Values ◽  
Inflammatory Bowel ◽  
Severity Of The Disease ◽  
Degrees Of Severity

The aim of this study was to determine the expression of Ki-67 and PCNA proliferative antigens and the apoptotic index in dogs with various degrees of severity of inflammatory bowel disease (IBD), and to evaluate the applicability of these markers in diagnosing the disease. The study was performed on 28 dogs of different breeds, both sexes, with body weights of 10 to 20 kg, aged 2 to 10 years. The animals diagnosed with IBD were divided into four groups of 7 dogs each, including three groups characterized by various degrees of severity of IBD and a control group. The expression of Ki-67 and PCNA antigens was determined immunohistochemically, and the apoptotic index was expressed as the number of TUNEL-positive lamina propria cells in the duodenum, jejunum and the colon. Regardless of its form, IBD affected the expression of the analyzed proliferation markers and apoptosis in duodenal, jejunal and colonic mucosa, but most of the analyzed parameters were not correlated with the severity of the disease. The severity of IBD was correlated only with the expression of Ki-67 in duodenal villi. The results of the study point to the limited applicability PCNA and the apoptotic index in differentiating and evaluating the progression of IBD in dogs. The estimation of Ki-67 expression may be useful in the evaluation of the severity of IBD in dogs.

scholarly journals THE PECULIARITIES OF THE IMMUNOLOGICAL DISORDERS AT VIBRATION DISEASE

2016 ◽  
Vol 1 (4) ◽  
pp. 41-46
Author(s):  
SA A Babanov ◽  
TA A Azovskova ◽  
RA A Baraeva
Keyword(s):  
Statistical Processing ◽  
Cytokine Profile ◽  
Control Group ◽  
Functional Screening ◽  
Immunological Study ◽  
Necrosis Factor Alpha ◽  
Vibration Disease ◽  
Inflammatory Processes ◽  
Complete Physical Examination ◽  
Severity Of The Disease

Aim - to study the state of cellular immunity and cytokine profile at vibration disease due to exposure to local and general vibration, taking into account the severity of the disease. Assessing the role of immunological changes in the pathogenesis of vibration disease. Material and methods. The study involved 84 patients with various forms and severity of vibration disease due to exposure to local and general vibration. The control group included 30 people who did not have contact with occupational hazards at work and who were recognized as healthy according to a complete physical examination. Diagnosis was based on occupational history, sanitary characteristics of working conditions (work in contact with local or general vibration, the vibration levels excessing maximum acceptable level for more than 15 years), full clinical functional screening and instrumental examination of patients. Methods of immunological study included determination of subpopulations of lymphocytes, levels of cytokines IL-ф, IL-4, IL-8, tumor necrosis factor alpha (TNF-а) in serum by ELISA. Statistical processing of the data was performed using SPSS software package 21. Results. The study revealed a significant decrease in helper (CD4+) and suppressor (CD8+) subpopulations of lymphocytes, increase of concentration of pro-inflammatory cytokines IL-ф, IL-8, TNF-а; reduction in anti-inflammatory cytokine IL-4 in patients with vibration disease compared with the control group, regardless of the type of vibration, but more pronounced at the second degree of vibration disease due to general vibration. Revealed changes are indicative of the activation of inflammatory processes, violation of immunological reactivity, the presence of cytokine imbalance as the effect of exposure to occupational vibration. Conclusion. The study of the immunological profile (cellular link, cytokine profile) at vibration disease opens up prospects for rehabilitation and treatment of patients with this pathology, and also elaborates our knowledge of the pathogenesis of this disease.

scholarly journals Comparative Analysis of 95 Patients with Different Severity in the Early Outbreak of COVID-19 in Wuhan, China

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Fang He ◽  
Xue-feng Ding ◽  
Meng Cao ◽  
Hai-ying Gong ◽  
Xiang-zhen Fu ◽  
...  
Keyword(s):  
Red Cross ◽  
Laboratory Findings ◽  
Reactive Protein ◽  
Abnormal Chest ◽  
Treatment Measures ◽  
Critical Patients ◽  
Severity Of The Disease ◽  
Degrees Of Severity ◽  
Transmission Speed ◽  
Fast Transmission

Objective. To explore the clinical characteristics of patients with different severity in the early outbreak of COVID-19, hoping to provide reference for clinical diagnosis and treatment. Methods. We retrospectively analyzed the clinical data of 95 COVID-19 patients in Wuhan Red Cross Hospital of China from January 17 to February 13, 2020. All patients were investigated with epidemiological questionnaires. Outcomes were followed up until April 1, 2020. Results. There were 53 males and 42 females, aged 22–84 years (mean 57.3 years). Clinical classification included 54 cases of common type, 27 cases of severe type, and 14 cases of critical type. Six patients had been exposed to the local Huanan seafood market. There were 38 clusters of COVID-19, including 27 family clusters and 11 work unit clusters. Common symptoms included fever (86 (90.5%) of 95), cough (73 (76.8%)), and fatigue (50 (52.6%)). Laboratory findings showed that the most common abnormalities were lymphopenia (75 (78.9%)), elevated D-dimer (60 (63.2%)), and elevated C-reactive protein (56 (58.9%)) on admission. All patients had abnormal chest computed tomography, showing patchy shadows or ground-glass opacities. Severe and critical cases were older, more likely to have shortness of breath, more likely to have underlying comorbidities, and more likely to have abnormal laboratory findings than common cases. The prognosis of patients with different degrees of severity was significantly different. All common and severe patients (100%) were cured and discharged from the hospital, while 10 (71.4%) of 14 critical patients died. Conclusions. COVID-19 has fast transmission speed and high pathogenicity. We must assess the severity of the disease and take corresponding treatment measures as early as possible.

REFERENCE VALUES OF SHORT-CELLULAR FATTY ACIDS IN SALIVA IN INTENSIVE CARE UNIT PATIENTS WITHOUT RESPIRATORY PATHOLOGY

2019 ◽  
Vol 64 (3) ◽  
pp. 153-157 ◽  
Author(s):  
Alexander Mikhaylovich Zatevalov ◽  
N. V. Gudova ◽  
A. S. Oganesyan ◽  
E. P. Selkova ◽  
A. Yu. Mironov ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Fatty Acids ◽  
Intensive Care ◽  
Reference Values ◽  
Area Under The Curve ◽  
Short Chain Fatty Acids ◽  
Gas Liquid Chromatography ◽  
Respiratory Pathology ◽  
Severity Of The Disease ◽  
Degrees Of Severity

Biochemical indicators of saliva were studied in 47 patients of the intensive care unit and intensive care unit of a neurosurgical hospital with varying degrees of severity of the disease. The method of gas-liquid chromatography of the acidified substrate of the saliva filtrate determined the concentrations of short-chain fatty acids (SCFA) and their reference values for patients without respiratory tract diseases. The threshold values of the concentrations of SCFA and the values of their calculated indices were determined by ROC analysis with the construction of the ROC curve, calculation of the area under the curve (AUC) and the cutoff threshold CutOff. The method of determining reference values of HFA in saliva developed as a result of the study makes it possible to assess the risks of developing an unfavorable course of the disease, optimize treatment tactics and improve the prognosis of the disease.

Correlation between cardiac performance and plasma catecholamine levels in conscious dogs

1985 ◽  
Vol 248 (1) ◽  
pp. H82-H88 ◽  
Author(s):  
M. A. Young ◽  
T. H. Hintze ◽  
S. F. Vatner
Keyword(s):  
Plasma Levels ◽  
Myocardial Contractility ◽  
Treadmill Exercise ◽  
Left Ventricular ◽  
Conscious Dogs ◽  
Lv Function ◽  
Plasma Catecholamine ◽  
Hemodynamic Changes ◽  
Marked Disparity ◽  
Inotropic Stimulation

We correlated levels of circulating norepinephrine (NE) and epinephrine (Epi) induced by 1) infusions, 2) treadmill exercise, and 3) hemorrhage with left ventricular (LV) function in conscious dogs instrumented for the measurement of LV and arterial pressures, LV diameter, and calculations of indexes of myocardial contractility. With infusions of NE, significant hemodynamic changes were observed only when plasma levels of NE exceeded 1,000 pg/ml. While statistically significant, the increase in rate of rise of LV pressure (LV dP/dt) at these levels was relatively slight, i.e., 8 +/- 2.3%. With further increases in catecholamines (greater than 1,000 pg/ml) good correlations were observed with increases in arterial pressure and myocardial contractility. Similar results occurred with infusions of Epi. Moderate treadmill exercise doubled LV dP/dt, while NE and Epi rose by only 563 +/- 128 and 292 +/- 50 pg/ml, respectively. Hemorrhage (30 ml/kg) decreased all indexes of contractility but increased plasma NE by 1,108 +/- 206 pg/ml and Epi by 1,475 +/- 266 pg/ml. Despite arterial NE and Epi levels 10-20 times those during exercise, infusions were unable to reproduce the peak changes in contractility seen with exercise. Infusions of NE or Epi to equal the plasma levels during exercise increased contractility by only 5-10%. In view of the marked disparity between levels of circulating catecholamines and LV function during exercise, hemorrhage, and catecholamine infusion, we conclude that circulating catecholamines do not adequately reflect the degree of inotropic stimulation to the myocardium.(ABSTRACT TRUNCATED AT 250 WORDS)

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