STUDY THE CHANGE OF HIGH-SENSITIVE TROPONIN T CONCENTRATION IN CHILDREN SEPSIS AT BINH DINH GENERAL HOSPITAL

2014 ◽  
pp. 39-45
Author(s):  
Dinh Hieu Le ◽  
Hung Viet Phan
Keyword(s):  
Blood Culture ◽  
General Hospital ◽  
Positive Blood Culture ◽  
Pediatric Patients ◽  
Troponin T ◽  
High Sensitivity ◽  
Significant Difference ◽  
High Sensitivity Troponin T ◽  
The Relationship ◽  
High Sensitive Troponin

Objective: Determining the relationship between the change of high-sensitivity Troponin T concentration with the degree of infection, mortality, and positive blood culture in sepsis. Patients and Methods: based on 39 pediatric patients who were diagnosed sepsis at Pediatric department of Binh Dinh General Hospital, from 4/2012 -7/2013. Results: Hs-Troponin T concentrations increased in 84.6% of patients with a median of 29.9 pg/ml and quartile is 17.9 to 112.9. There isn’t significant difference statistically hs-Troponin T levels according to age of patients with p >0.05. There is a moderate positive relationship between the hs-Troponin T concentration with the severity of sepsis (rs = 0.39, p <0.05). There is a statistically significant correlation between increased hs-Troponin T levels with mortality of sepsis with p <0.01. There is a statistically significant correlation between increased hs-Troponin T levels with positive blood culture in sepsis with p<0.05. Conclusion: There is statistically significant relationship between the hs-Troponin T concentration with the degree of of infection, mortality, and positive blood culture in sepsis. Key words: Troponin T, sepsis

STUDY THE CHANGE OF HIGH-SENSITIVE TROPONIN T CONCENTRATION IN CHILDREN HEART FAILURE AT PEDIATRIC DEPARTMENT OF BINH DINH GENERAL HOSPITAL

2014 ◽  
pp. 48-54
Author(s):  
Van Khanh Luong ◽  
Hung Viet Phan
Keyword(s):  
Heart Failure ◽  
General Hospital ◽  
Troponin T ◽  
High Sensitivity ◽  
Ventricular Dilatation ◽  
Pediatric Department ◽  
X Ray ◽  
Significant Difference ◽  
Chest X Ray ◽  
High Sensitivity Troponin T

Objective: Search the relationship between concentration of high-sensitivity Troponin T with the degree of heart failure, and some changes on chest X-ray and echocardiography. Patients and Methods: based on 44 pediatric patients who were diagnosed heart failure at Pediatric Department of Binh Dinh General Hospital, from 4/2012 -3/2013. Results: Hs-Troponin T concentrations increased in 79.5% of patients had heart failure with a median of 30.2 pg/ml and quartile is 14.6 to 64.5. There is significant difference statistically hs-Troponin T levels according to age of patients with p<0.01. There is a very closely positive relationship between the hs-Troponin T concentration with the degree of heart failure (rs = 0.80, p<0.01). There is a moderate positive correlation between the hs-Troponin T concentration with ventricular dilatation (rs = 0.34, p<0.05). There is no correlation between the hs-Troponin T concentration with changes on chest X-ray. Conclusion: There is statistically significant relationship between the hs-Troponin T concentration with the degree of heart failure and ventricular dilatation on echocardiography. Key words: Troponin T, heart failure, echocardiography

scholarly journals The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome

2020 ◽  
Author(s):  
Alessandro Mengozzi ◽  
Georgios Georgiopoulos ◽  
Marco Falcone ◽  
Giusy Tiseo ◽  
Nicola Riccardo Pugliese ◽  
...  
Keyword(s):  
Troponin T ◽  
Strong Predictor ◽  
Cardiac Injury ◽  
High Sensitivity ◽  
Strong Relationship ◽  
High Sensitivity Troponin T ◽  
The Relationship ◽  
D Dimer ◽  
Related Mortality

Abstract Introduction: High sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). We then explored the relevance of these pathways in defining mortality and complications risk and the potential effects of the treatments to attenuate such risk.Methods: In this single-center, prospective, observational study we enrolled 266 consecutive patients hospitalized for SARS-CoV-2 pneumonia. Primary endpoint was in-hospital COVID-19 mortality. Results: hsTnT, even after adjustment for confounders, was associated with mortality. D-dimer and CRP presented stronger associations with hsTnT than PaO2. Changes of hsTnT, D-dimer and CRP were related but only D-dimer was associated with mortality. Moreover, low molecular weight heparin showed attenuation of the mortality in the whole population, particularly in subjects with higher hsTnT.Conclusions: D-dimer possessed a strong relationship with hsTnT and mortality. Anticoagulation treatment showed greater benefits with regard to mortality. These findings suggest a major role of SARS-CoV-2 coagulopathy in hsTnT elevation and its related mortality in COVID-19. A better understanding of the mechanisms related to COVID-19 might pave the way to therapy tailoring in these high-risk individuals.

The relationship between two laboratory assays: High sensitivity troponin T and N-terminal pro-brain natriuretic peptide

2020 ◽  
Vol 38 (12) ◽  
pp. 2750-2751
Author(s):  
Navkiranjot Kaur ◽  
Andrew Singletary ◽  
Rakesh Engineer ◽  
Amy S. Nowacki ◽  
Baruch S. Fertel ◽  
...  
Keyword(s):  
Brain Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Troponin T ◽  
High Sensitivity ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T ◽  
The Relationship

scholarly journals High Sensitivity Troponin T as Complementary Modality for Determining Doxorubicin Regimen Cardiotoxicity in Non-Hodgkin Lymphoma Patients

2020 ◽  
Author(s):  
Ami Ashariati Prayogo ◽  
Satriyo Dwi Suryantoro ◽  
Merlyna Savitri ◽  
Winona May Hendrata ◽  
Andi Yasmin Wijaya ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Troponin T ◽  
High Sensitivity ◽  
Left Ventricular ◽  
Cellular Damage ◽  
Left Ventricular Ejection ◽  
Non Hodgkin Lymphoma ◽  
High Sensitivity Troponin ◽  
Significant Difference ◽  
High Sensitivity Troponin T

Purpose: This study aims to evaluate the role of high-sensitivity troponin T (hsTnT) as a complementary tool for determining cardiotoxicity in non-Hodgkin lymphoma (NHL) patients receiving cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) regimen chemotherapy. Methods: We included 35 patients diagnosed with NHL who received CHOP chemotherapy. Left ventricular ejection fraction (LVEF) and hsTnT were measured at two time points: before the first cycle (pre-test) and after the fourth cycle (post-test). The LVEF and hsTnT were analysed using IBM SPSS version 24 through the paired-sample T-test, Wilcoxon signed-rank test, Pearson’s correlation and Spearman’s correlation. Results: There was a significant difference in both LVEF and hsTnT between pre-chemotherapy and post-4th chemotherapy cycles (p = 0.001). However, more contrast difference from the baseline value of hsTnT compared to LVEF could be observed. LVEF did not detect any deterioration in myocardial function. However, 10 out of 35 subjects exhibit hsTnT higher than the 99th percentile of the population (>14 pg/ml), suggesting that myocardial injury (MI) could be detected. There was no correlation between LVEF and hsTnT (p > 0.05). Conclusion: HsTnT, together with LVEF, could complement each other and offer better coverage for detecting cardiotoxicity during the administration of CHOP in NHL patients. An insignificant correlation between hsTnT and LVEF showed that cardiotoxicity existed in a broad spectrum including cellular damage and functional impairment, as hsTnT represents cellular damage, and LVEF reflects heart functional capacity.

scholarly journals The relationship between cardiac injury, inflammation and coagulation in predicting COVID-19 outcome

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Alessandro Mengozzi ◽  
◽  
Georgios Georgiopoulos ◽  
Marco Falcone ◽  
Giusy Tiseo ◽  
...  
Keyword(s):  
Troponin T ◽  
Strong Predictor ◽  
Cardiac Injury ◽  
High Sensitivity ◽  
Strong Relationship ◽  
High Sensitivity Troponin T ◽  
The Relationship ◽  
D Dimer ◽  
Related Mortality

AbstractHigh sensitivity troponin T (hsTnT) is a strong predictor of adverse outcome during SARS-CoV-2 infection. However, its determinants remain partially unknown. We aimed to assess the relationship between severity of inflammatory response/coagulation abnormalities and hsTnT in Coronavirus Disease 2019 (COVID-19). We then explored the relevance of these pathways in defining mortality and complications risk and the potential effects of the treatments to attenuate such risk. In this single-center, prospective, observational study we enrolled 266 consecutive patients hospitalized for SARS-CoV-2 pneumonia. Primary endpoint was in-hospital COVID-19 mortality. hsTnT, even after adjustment for confounders, was associated with mortality. D-dimer and CRP presented stronger associations with hsTnT than PaO2. Changes of hsTnT, D-dimer and CRP were related; but only D-dimer was associated with mortality. Moreover, low molecular weight heparin showed attenuation of the mortality in the whole population, particularly in subjects with higher hsTnT. D-dimer possessed a strong relationship with hsTnT and mortality. Anticoagulation treatment showed greater benefits with regard to mortality. These findings suggest a major role of SARS-CoV-2 coagulopathy in hsTnT elevation and its related mortality in COVID-19. A better understanding of the mechanisms related to COVID-19 might pave the way to therapy tailoring in these high-risk individuals.

scholarly journals Through thick and thin: Diagnosis of transthyretin cardiac amyloidosis through non-invasive multimodality imaging

2021 ◽  
pp. 201010582110061
Author(s):  
Raja Ezman Raja Shariff ◽  
Hafisyatul Aiza Zainal Abidin ◽  
Sazzli Kasim
Keyword(s):  
Cardiac Amyloidosis ◽  
Troponin T ◽  
Multimodality Imaging ◽  
High Sensitivity ◽  
Dark Blood ◽  
Non Invasive ◽  
Doppler Study ◽  
Alternative Means ◽  
High Sensitivity Troponin T

Cardiac amyloidosis is a severely underdiagnosed cause of heart failure with preserved ejection fraction. We report a case of highly probable transthyretin (ATTR) cardiac amyloidosis (ATTR-CA) diagnosed through the assistance of non-invasive multimodality imaging. An 81-year-old man presented with worsening dyspnoea, reduced effort tolerance and limb swelling. Examination and bedside investigations demonstrated congestive cardiac failure. On arrival, N-terminal-pro B-type natriuretic peptide was 2400 ng/L, and high-sensitivity troponin T was 78 mmol/L. Echocardiography showed severe left and right ventricular hypertrophy, and a Doppler study revealed diastolic dysfunction. Cardiac magnetic resonance imaging revealed on non-conventional dark blood sequence an abnormal inversion time for nulling myocardium suggestive of infiltrative disease, including amyloidosis. The patient was referred for nuclear-based studies involving technetium-99m pyrophosphate which demonstrated changes highly diagnostic of ATTR-CA. Early diagnosis of ATTR-CA remains paramount due to the increasing availability of disease-modifying therapies. Current guidelines recognise the role of multimodality imaging in confidently recognising the disease without the need for histological evidence in the appropriate context, providing an alternative means of diagnosis.

Increased serum level of high sensitivity troponin T even prior to surgery can predict adverse events during carotid endarterectomy

Vascular ◽  
2021 ◽  
pp. 170853812098629
Author(s):  
Bálint Nagy ◽  
Elettra Engblom ◽  
Marijana Matas ◽  
Péter Maróti ◽  
Tamás Kőszegi ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Matrix Metalloproteinase ◽  
Carotid Endarterectomy ◽  
Troponin T ◽  
High Sensitivity ◽  
Matrix Metalloproteinase 9 ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T ◽  
Metalloproteinase 9

Objectives Perioperative stress affects the outcome of carotid endarterectomy performed under regional anesthesia. Here we aimed to explore the temporal profile of the stress marker cortisol and its relationship to high-sensitivity troponin-T, matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and S100B as an indicator of blood–brain barrier alteration in the systemic circulation. Methods Prospective part of the study: a total of 31 patients with significant carotid stenosis scheduled for carotid endarterectomy in regional anesthesia were enrolled. Follow-up part of the study and retrospective analysis of the outcome: each patient was followed up to five years and morbidity as well as mortality data were collected from an electronic database. Blood samples from each patient were serially taken; prior to surgery (T1), at the time of reperfusion (T2), 24 h (T3) and 72 h later postoperatively (T4), then the plasma concentration of each biomarker was measured. Besides, the clinical and surgical factors and perioperative adverse events were recorded. Results More positive correlations were found between: the early change of S100B (T2–T1) and late change in plasma cortisol level (T4–T3) (r = 0.403; p < 0.05); the early change of cortisol (T2–T1) and the early postoperative change of plasma matrix metalloproteinase-9 level (T3–T2) (r = 0.432; p = 0.01); the plasma concentration of tissue inhibitor of metalloproteinase-1 at 24 postoperative hours and the late change in plasma high-sensitivity troponin-T level (T4–T3) (r = 0.705; p < 0.001). Five patients needed an intraoperative shunt in whom the high-sensitivity troponin-T was elevated even prior to surgery, but definitive stroke never occurred. Plasma matrix metalloproteinase-9 concentration at reperfusion independently predicted the five-year mortality with a cut-off value of 456 ng/ml (sensitivity: 86%, specificity: 84%, area 0.887, p = 0.002). Conclusions A higher intraoperative change in S100B level reflecting carotid endarterectomy induced acute silent brain ischemia was associated with more pronounced post-operative change of cortisol. An early elevation of cortisol was found to be associated with a delayed increase of matrix metalloproteinase-9. Importantly, an increased high-sensitivity troponin-T even prior to carotid endarterectomy may predict clamp intolerance, and elevated matrix metalloproteinase-9 at reperfusion suggests a poor outcome.

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