STUDY THE CHANGE OF HIGH-SENSITIVE TROPONIN T CONCENTRATION IN CHILDREN HEART FAILURE AT PEDIATRIC DEPARTMENT OF BINH DINH GENERAL HOSPITAL

2014 ◽  
pp. 48-54
Author(s):  
Van Khanh Luong ◽  
Hung Viet Phan
Keyword(s):  
Heart Failure ◽  
General Hospital ◽  
Troponin T ◽  
High Sensitivity ◽  
Ventricular Dilatation ◽  
Pediatric Department ◽  
X Ray ◽  
Significant Difference ◽  
Chest X Ray ◽  
High Sensitivity Troponin T

Objective: Search the relationship between concentration of high-sensitivity Troponin T with the degree of heart failure, and some changes on chest X-ray and echocardiography. Patients and Methods: based on 44 pediatric patients who were diagnosed heart failure at Pediatric Department of Binh Dinh General Hospital, from 4/2012 -3/2013. Results: Hs-Troponin T concentrations increased in 79.5% of patients had heart failure with a median of 30.2 pg/ml and quartile is 14.6 to 64.5. There is significant difference statistically hs-Troponin T levels according to age of patients with p<0.01. There is a very closely positive relationship between the hs-Troponin T concentration with the degree of heart failure (rs = 0.80, p<0.01). There is a moderate positive correlation between the hs-Troponin T concentration with ventricular dilatation (rs = 0.34, p<0.05). There is no correlation between the hs-Troponin T concentration with changes on chest X-ray. Conclusion: There is statistically significant relationship between the hs-Troponin T concentration with the degree of heart failure and ventricular dilatation on echocardiography. Key words: Troponin T, heart failure, echocardiography

STUDY THE CHANGE OF HIGH-SENSITIVE TROPONIN T CONCENTRATION IN CHILDREN SEPSIS AT BINH DINH GENERAL HOSPITAL

2014 ◽  
pp. 39-45
Author(s):  
Dinh Hieu Le ◽  
Hung Viet Phan
Keyword(s):  
Blood Culture ◽  
General Hospital ◽  
Positive Blood Culture ◽  
Pediatric Patients ◽  
Troponin T ◽  
High Sensitivity ◽  
Significant Difference ◽  
High Sensitivity Troponin T ◽  
The Relationship ◽  
High Sensitive Troponin

Objective: Determining the relationship between the change of high-sensitivity Troponin T concentration with the degree of infection, mortality, and positive blood culture in sepsis. Patients and Methods: based on 39 pediatric patients who were diagnosed sepsis at Pediatric department of Binh Dinh General Hospital, from 4/2012 -7/2013. Results: Hs-Troponin T concentrations increased in 84.6% of patients with a median of 29.9 pg/ml and quartile is 17.9 to 112.9. There isn’t significant difference statistically hs-Troponin T levels according to age of patients with p >0.05. There is a moderate positive relationship between the hs-Troponin T concentration with the severity of sepsis (rs = 0.39, p <0.05). There is a statistically significant correlation between increased hs-Troponin T levels with mortality of sepsis with p <0.01. There is a statistically significant correlation between increased hs-Troponin T levels with positive blood culture in sepsis with p<0.05. Conclusion: There is statistically significant relationship between the hs-Troponin T concentration with the degree of of infection, mortality, and positive blood culture in sepsis. Key words: Troponin T, sepsis

Abstract 12777: High Sensitivity Troponin T is Associated With Increased Heart Failure Risk in Metabolic Syndrome in the Atherosclerosis Risk in Communities (ARIC) Study

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Yashashwi Pokharel ◽  
Wensheng Sun ◽  
Dennis Villarael ◽  
Elizabeth Selvin ◽  
Salim Virani ◽  
...  
Keyword(s):  
Heart Failure ◽  
Metabolic Syndrome ◽  
Myocardial Injury ◽  
Troponin T ◽  
Cox Model ◽  
High Sensitivity ◽  
Cvd Risk ◽  
Chi Square ◽  
High Sensitivity Troponin ◽  
High Sensitivity Troponin T

Background: Metabolic syndrome (MS) is associated with higher CVD risk. High sensitivity troponin T (hsTnT) is a marker of myocardial injury and an emerging marker for heart failure (HF) risk prediction. We examined whether hsTnT is associated with increased HF risk in people with similar number of MS components present at baseline in 10316 ARIC participants without prevalent HF. Methods: We used Wald Chi-square test to assess the interaction between MS and hsTnT and Cox model for the association of incident HF hospitalization by hsTnT categories across groups created by the number of MS components after adjusting for risk factors and NT-proBNP (Table). Results: The mean age of the study population was 63 (SD, 6) years (56% women). Mean hsTnT levels were higher with increasing MS components (Table). There were 1353 HF hospitalizations over a median of 14 years. The interaction of MS with hsTnT for HF was borderline significant (p-interaction 0.059). Compared to individuals without MS and hsTnT<5 ng/L the HRs (95%CIs) were 1.7 (1.4-2.1) in those without MS and hsTnT≥5 ng/L; 1.7 (1.3-2.1) in MS and hsTnT<5 ng/L; and 3.6 (3.0-4.4) in MS and hsTnT≥5 ng/L. In groups with 1-5 MS components present, increasing hsTnT was significantly associated with higher hazards for HF in each group with the highest HR in those with all 5 MS components (Table). Conclusion: Presence of higher MS risk components was associated with increasing subclinical myocardial injury as assessed by higher hsTnT. The hazards for HF were numerically similar in individuals without MS but detectable hsTnT (>5 ng/L) as to those with MS but undetectable hsTnT. In people with similar number of MS components higher hsTnT levels were associated with increased HF hazards suggesting that in MS hsTnT could be a useful marker for identifying those at higher risk for incident HF.

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