Faculty Opinions recommendation of Arabidopsis interdigitating cell growth requires two antagonistic pathways with opposing action on cell morphogenesis.

2005 ◽  
Author(s):  
Jaideep Mathur
Keyword(s):  
Cell Growth ◽  
Cell Morphogenesis ◽  
Interdigitating Cell

scholarly journals Arabidopsis Interdigitating Cell Growth Requires Two Antagonistic Pathways with Opposing Action on Cell Morphogenesis

Cell ◽  
2005 ◽  
Vol 120 (5) ◽  
pp. 687-700 ◽  
Author(s):  
Ying Fu ◽  
Ying Gu ◽  
Zhiliang Zheng ◽  
Geoffrey Wasteneys ◽  
Zhenbiao Yang
Keyword(s):  
Cell Growth ◽  
Cell Morphogenesis ◽  
Interdigitating Cell

Cell morphogenesis of trichomes in Arabidopsis: differential control of primary and secondary branching by branch initiation regulators and cell growth

Development ◽  
1997 ◽  
Vol 124 (19) ◽  
pp. 3779-3786 ◽  
Author(s):  
U. Folkers ◽  
J. Berger ◽  
M. Hulskamp
Keyword(s):  
Cell Growth ◽  
Cell Shape ◽  
Normal Development ◽  
Branching Pattern ◽  
Cell Morphogenesis ◽  
Negative Regulators ◽  
Branch Number ◽  
Underlying Mechanisms ◽  
Differential Control ◽  
Trichome Cell

Cell morphogenesis, i.e. the acquisition of a particular cell shape, can be examined genetically in the three-branched trichomes that differentiate from single epidermal cells on the leaves of Arabidopsis thaliana. In normal development, the growing trichome cell undergoes two successive branching events, resulting in a proximal side stem and a distal main stem which subsequently splits in two branches. Using new and previously described trichome mutants, we have analyzed the branching pattern in single and double mutants affecting branch number or cell size in order to determine underlying mechanisms. Our results suggest that primary branching is genetically distinct from subsequent branching events and that the latter, secondary events are initiated in response to positive and negative regulators of branching as well as subject to control by cell growth. We propose a model of how trichome cell morphogenesis is regulated during normal development.

scholarly journals A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.

1992 ◽  
Vol 12 (3) ◽  
pp. 1162-1178 ◽  
Author(s):  
C Costigan ◽  
S Gehrung ◽  
M Snyder
Keyword(s):  
Cell Growth ◽  
Vegetative Growth ◽  
Sequence Similarity ◽  
Growth Control ◽  
Cell Morphogenesis ◽  
Wild Type ◽  
Extra Copy ◽  
Synthetic Lethal ◽  
Cell Biol ◽  
Regulatory Link

The Saccharomyces cerevisiae SPA2 protein localizes at sites involved in polarized cell growth in budding cells and mating cells. spa2 mutants have defects in projection formation during mating but are healthy during vegetative growth. A synthetic lethal screen was devised to identify mutants that require the SPA2 gene for vegetative growth. One mutant, called slk-1 (for synthetic lethal kinase), has been characterized extensively. The SLK1 gene has been cloned, and sequence analysis predicts that the SLK1 protein is 1,478 amino acid residues in length. Approximately 300 amino acids at the carboxy terminus exhibit sequence similarity with the catalytic domains of protein kinases. Disruption mutations have been constructed in the SLK1 gene. slk1 null mutants cannot grow at 37 degrees C, but many cells can grow at 30, 24, and 17 degrees C. Dead slk1 mutant cells usually have aberrant cell morphologies, and many cells are very small, approximately one-half the diameter of wild-type cells. Surviving slk1 cells also exhibit morphogenic defects; these cells are impaired in their ability to form projections upon exposure to mating pheromones. During vegetative growth, a higher fraction of slk1 cells are unbudded compared with wild-type cells, and under nutrient limiting conditions, slk1 cells exhibit defects in cell cycle arrest. The different slk1 mutant defects are partially rescued by an extra copy of the SSD1/SRK1 gene. SSD1/SRK1 has been independently isolated as a suppressor of mutations in genes involved in growth control, sit4, pde2, bcy1, and ins1 (A. Sutton, D. Immanuel, and K.T. Arnat, Mol. Cell. Biol. 11:2133-2148, 1991; R.B. Wilson, A.A. Brenner, T.B. White, M.J. Engler, J.P. Gaughran, and K. Tatchell, Mol. Cell. Biol. 11:3369-3373, 1991). These data suggest that SLK1 plays a role in both cell morphogenesis and the control of cell growth. We speculate that SLK1 may be a regulatory link for these two cellular processes.

Role of CaECM25 in cell morphogenesis, cell growth and virulence in Candida albicans

2008 ◽  
Vol 51 (4) ◽  
pp. 362-372 ◽  
Author(s):  
TingTing Zhang ◽  
WanJie Li ◽  
Di Li ◽  
Yue Wang ◽  
JianLi Sang
Keyword(s):  
Candida Albicans ◽  
Cell Growth ◽  
Cell Morphogenesis

scholarly journals Gradient in cytoplasmic pressure in germline cells controls overlying epithelial cell morphogenesis

PLoS Biology ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. e3000940
Author(s):  
Laurie-Anne Lamiré ◽  
Pascale Milani ◽  
Gaël Runel ◽  
Annamaria Kiss ◽  
Leticia Arias ◽  
...  
Keyword(s):  
Cell Growth ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Nurse Cell ◽  
Ovarian Follicle ◽  
Pressure Control ◽  
Nurse Cells ◽  
Cell Morphogenesis ◽  
Germline Cells

It is unknown how growth in one tissue impacts morphogenesis in a neighboring tissue. To address this, we used the Drosophila ovarian follicle, in which a cluster of 15 nurse cells and a posteriorly located oocyte are surrounded by a layer of epithelial cells. It is known that as the nurse cells grow, the overlying epithelial cells flatten in a wave that begins in the anterior. Here, we demonstrate that an anterior to posterior gradient of decreasing cytoplasmic pressure is present across the nurse cells and that this gradient acts through TGFβ to control both the triggering and the progression of the wave of epithelial cell flattening. Our data indicate that intrinsic nurse cell growth is important to control proper nurse cell pressure. Finally, we reveal that nurse cell pressure and subsequent TGFβ activity in the stretched cells combine to increase follicle elongation in the anterior, which is crucial for allowing nurse cell growth and pressure control. More generally, our results reveal that during development, inner cytoplasmic pressure in individual cells has an important role in shaping their neighbors.

A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth

1992 ◽  
Vol 12 (3) ◽  
pp. 1162-1178
Author(s):  
C Costigan ◽  
S Gehrung ◽  
M Snyder
Keyword(s):  
Cell Growth ◽  
Vegetative Growth ◽  
Sequence Similarity ◽  
Growth Control ◽  
Cell Morphogenesis ◽  
Wild Type ◽  
Extra Copy ◽  
Synthetic Lethal ◽  
Cell Biol ◽  
Regulatory Link

The Saccharomyces cerevisiae SPA2 protein localizes at sites involved in polarized cell growth in budding cells and mating cells. spa2 mutants have defects in projection formation during mating but are healthy during vegetative growth. A synthetic lethal screen was devised to identify mutants that require the SPA2 gene for vegetative growth. One mutant, called slk-1 (for synthetic lethal kinase), has been characterized extensively. The SLK1 gene has been cloned, and sequence analysis predicts that the SLK1 protein is 1,478 amino acid residues in length. Approximately 300 amino acids at the carboxy terminus exhibit sequence similarity with the catalytic domains of protein kinases. Disruption mutations have been constructed in the SLK1 gene. slk1 null mutants cannot grow at 37 degrees C, but many cells can grow at 30, 24, and 17 degrees C. Dead slk1 mutant cells usually have aberrant cell morphologies, and many cells are very small, approximately one-half the diameter of wild-type cells. Surviving slk1 cells also exhibit morphogenic defects; these cells are impaired in their ability to form projections upon exposure to mating pheromones. During vegetative growth, a higher fraction of slk1 cells are unbudded compared with wild-type cells, and under nutrient limiting conditions, slk1 cells exhibit defects in cell cycle arrest. The different slk1 mutant defects are partially rescued by an extra copy of the SSD1/SRK1 gene. SSD1/SRK1 has been independently isolated as a suppressor of mutations in genes involved in growth control, sit4, pde2, bcy1, and ins1 (A. Sutton, D. Immanuel, and K.T. Arnat, Mol. Cell. Biol. 11:2133-2148, 1991; R.B. Wilson, A.A. Brenner, T.B. White, M.J. Engler, J.P. Gaughran, and K. Tatchell, Mol. Cell. Biol. 11:3369-3373, 1991). These data suggest that SLK1 plays a role in both cell morphogenesis and the control of cell growth. We speculate that SLK1 may be a regulatory link for these two cellular processes.

scholarly journals Gradient in cytoplasmic pressure in the germline cells controls overlying epithelial cell morphogenesis

2018 ◽  
Author(s):  
Laurie-Anne Lamiré ◽  
Pascale Milani ◽  
Gaël Runel ◽  
Annamaria Kiss ◽  
Leticia Arias ◽  
...  
Keyword(s):  
Cell Growth ◽  
Epithelial Cell ◽  
Epithelial Cells ◽  
Nurse Cell ◽  
Shape Change ◽  
Ovarian Follicle ◽  
Pressure Control ◽  
Nurse Cells ◽  
Cell Morphogenesis ◽  
Cell Shape Change

AbstractIt is unknown how growth in one tissue impacts morphogenesis in a neighboring tissue. To address this, we used the Drosophila ovarian follicle, where a cluster of 15 nurse cells and a posteriorly located oocyte are surrounded by a layer of epithelial cells. It is known that as the nurse cells grow, the overlying epithelial cells flatten in a wave that begins in the anterior. Here, we demonstrate that an anterior to posterior gradient of decreasing cytoplasmic pressure is present across the nurse cells and that this gradient acts through TGFß to control both the triggering and the progression of the wave of epithelial cell flattening. Our data indicate that intrinsic nurse cell growth is important to control proper nurse cell pressure. Finally, we reveal that nurse cell pressure and subsequent TGFß activity in the StC combine to increase follicle elongation in the anterior, which is crucial for allowing nurse cell growth and pressure control. More generally, our results reveal that during development, inner cytoplasmic pressure in individual cells has an important role in shaping their neighbors.Impact StatementCell shape change depends on extrinsic forces exerted by cytoplasmic pressure in neighbouring cells.

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