Faculty Opinions recommendation of Postoperative mortality in parathyroid surgery in Sweden during five decades: improved outcome despite older patients.

Author(s):  
John Wass
2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 600-600
Author(s):  
Noha Rashad ◽  
Arielle Lutterman Heeke ◽  
Hussein Mustafa Khaled ◽  
Nelly Ali El din ◽  
Gamal Abd El Motaal ◽  
...  

600 Background: The incidence of early onset CRC is rising. Little is known about the clinicopathological differences between younger and older Egyptian (EGY) adults with CRC. Herein we explore these differences. Methods: A retrospective review of younger EGY adult (YA; ≤ 46 years) and older EGY adult (OA; > 65 years) patients (pts) with CRC was performed. T and Fisher’s exact tests were used for comparative analyses. Kaplan-Meier methodology estimated survival. Results: In total, 997 EGY pts with CRC were studied, including 443 YA (median age 35 years; range 15-46) and 153 OA pts (median 70 years range 65-84).There were no statistically significant differences with respect to gender, degree of tumor differentiation, extracolonic extension, stage at presentation, or patterns of metastasis between the two groups. YA pts had more rectal primaries compared with OA pts (49% vs. 31%, p < 0.001), whereas older pts had more colon primaries (69% vs. 51%, p < 0.001). Additionally YA pts had more left-sided tumors (78% vs. 62%, p < 0.001) compared with OA pts, whereas older pts had more right-sided tumors (32% vs. 17%, p < 0.001). YA pts were more likely to have mucin-producing tumors (40% vs. 23%, p = 0.003). Although there were no differences in the proportion of pts presenting with metastatic disease (28% [YA] vs. 32% [OA], p = 0.615), or the pattern of metastasis to the liver, lung, or peritoneum (40% vs. 50%, p = 0.288; 5% vs. 6%, p = 1.00, 16% vs. 17%, p = 1.00), YA were more likely to have CRC-related lymph node (LN) involvement (mean: 3.2 vs. 1.6, p = 0.006). There were no differences in PFS (Median: 12 months for YA vs. 13 months for OA) or OS (median: 76 months for YA vs. not reached for OA) between the two groups. However male YA pts had a better OS that female pts (median OS not reached in males, 72 months in females). Conclusions: Significant differences were evident between YA and OA pts with CRC, notably locations of primary tumors. Male had improved outcome compared to female YA patients. Additional evaluation of the molecular features of CRC in young and older patients in Egypt is warranted.


2021 ◽  
Vol 67 (5) ◽  
pp. 5
Author(s):  
S.I. Shlyafer ◽  
◽  
I.B. Shikina ◽  

Significance: Population ageing challanges the majority of the world including the Russian Federation. Older people are more subject to operative interventions, including high tech interventions. The purpose of the study is to analyze indicators characterizing the level of surgical care deivery to older patients in the Russian hospitals in 2011-2019. Material and methods. Indicators characterising surgical care delivery in hospitals were analyzed including: the number of patients operated; the number of operations performed, including high tech interventions; the number of deaths after surgery, including after high tech interventions; frequency of postoperative complications; postoperative mortality among older patients (women - 55 years and older, men - 60 years and older). The authors used data of the federal statistical observation form No. 14 "Information onabout performance of units of medical organizations providing inpatient medical care" for the period from 2011 to 2019. Statistical (calculations of extensive and intensive indicators) and analytical methods were applied. Results. The share of older patients out of all patients operated in 2019 in the Russian hospitals equalled to 35.2% (vs 23.1% in 2011), including high tech interventions (18.9% of all operations). Conclusion: among older patients the study has identified: an 18.8% increse in the number of patients discharged from hospitals; a 5.6% increase in the number of patients operated; a 63.5% increase in the number of operations in the hospital, including a 2.6 fold increase in the number of operations using high technologies; a 73.4 % increase in the number of operated patients who died in the hospital; including a 3.8 fold increase in the number of patients died after operations using high technologies; postoperative mortality rate of patients increased from 2.21 to 2.39%. The rate of postoperative complications associated with all operations decreased from 1.06 to 0.64%, including decrease from 1.74 to 0.97% in postoperative complications associated with operations using high technologies.


2014 ◽  
Vol 17 (3) ◽  
pp. 178
Author(s):  
Edward Ansari ◽  
Alexander Blehm ◽  
Udo Boeken ◽  
Arthur Lichtenberg

Surgical repair in older patients with acute type A aortic dissection (ATAAD) evokes a higher peri- and postoperative mortality, it therefore remains controversial in nonagenarians. The authors present a case of a surgically managed ATAAD in a nonagenerian, a 94-year-old man presented with an uncomplicated ATAAD, necessitating emergency surgical repair. The subsequent postoperative course was uneventful, and the patient was discharged after uncomplicated recovery. Aggressive surgical approach should be feasable in select nonagenarian patients with ATAAD, depending on the clinical presention and prior patient history.


2009 ◽  
Vol 160 (2) ◽  
pp. 295-299 ◽  
Author(s):  
S Norenstedt ◽  
A Ekbom ◽  
L Brandt ◽  
J Zedenius ◽  
I-L Nilsson

ObjectivePrimary hyperparathyroidism (pHPT) is a common endocrine disorder. In Europe, pHPT has been associated with premature death in cardiovascular disorders. Our question was whether the risk of postoperative death has been affected by the increased proportion of elderly patients referred for parathyroid surgery.MethodsThe nationwide Cancer Registry and Causes-of-Death Registry were used to analyze mortality among 14 635 Swedish patients subjected to parathyroid adenomectomy (PTx) during 1961–2004. Standard mortality ratios (SMR) and the 95% confidence intervals (CI) were calculated with the entire Swedish population as control, standardized for age, gender and calendar year.ResultsThe observation period was more than 166 000 person-years. The overall perioperative (30-day) mortality rate was 1.3% (185/14 635; SMR 7.9; CI 6.82–9.15); 1.1% for women (132/11 500; SMR 7.56; CI 6.32–8.96), and 1.7% for men (53/3135; SMR 9.01; CI 6.75–11.78). Cardiovascular disorder was the dominant cause of death in both sexes and in all the investigated age groups (age 15–54 years; SMR 29.0; CI 9.42–67.71, age 55–74 years; SMR 6.12; CI 3.96–9.03, age 75 years: SMR 5.26; CI 3.74–7.19). The SMR decreased over the calendar year period notwithstanding a rising proportion of elderly individuals. In the most recent period, 1997–2004, the perioperative mortality rate was only 0.5%, which represents a normalization of the excess mortality risk during the first post-PTx year (SMR 1.17; CI 0.92–1.46).ConclusionPTx is a safe procedure, regardless of patient age. Today, the perioperative mortality risk is not a reason for excluding elderly patients from parathyroid surgery.


2016 ◽  
Vol 29 (S1) ◽  
pp. 121-126 ◽  
Author(s):  
Renata Tabola ◽  
George Mantese ◽  
Roberto Cirocchi ◽  
Alessandro Gemini ◽  
Veronica Grassi ◽  
...  

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