Faculty Opinions recommendation of The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition.

2009 ◽  
Author(s):  
Piero Vernia
Keyword(s):  
Intestinal Microbiota ◽  
Microbiota Composition ◽  
Human Intestinal Microbiota ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Effect Of Age

The effect of age and non-steroidal anti-inflammatory drugs on human intestinal microbiota composition

2009 ◽  
Vol 103 (2) ◽  
pp. 227-234 ◽  
Author(s):  
Harri Mäkivuokko ◽  
Kirsti Tiihonen ◽  
Soile Tynkkynen ◽  
Lars Paulin ◽  
Nina Rautonen
Keyword(s):  
Young Adults ◽  
16S Rdna ◽  
Intestinal Microbiota ◽  
The Elderly ◽  
Elderly Subjects ◽  
16S Rdna Sequencing ◽  
Human Intestinal Microbiota ◽  
Rdna Sequencing ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Ageing has been suggested to cause changes in the intestinal microbial community. In the present study, the microbiota of a previously well-defined group of elderly subjects aged between 70 and 85 years, both non-steroidal anti-inflammatory drugs (NSAID) users (n9) and non-users (n9), were further compared with young adults (n14) with a mean age of 28 years, by two DNA-based techniques: percentage guanine+cytosine (%G+C) profiling and 16S rDNA sequencing. Remarkable changes in microbiota were described with both methods: compared with young adults a significant reduction in overall numbers of microbes in both elderly groups was measured. Moreover, the total number of microbes in elderly NSAID users was higher than in elderly without NSAID. In 16S rDNA sequencing, shifts in all major microbial phyla, such as lower numbers of Firmicutes and an increase in numbers of Bacteroidetes in the elderly were monitored. On the genus level an interesting link between reductions in the proportion of known butyrate producers belonging toClostridiumcluster XIVa, such asRoseburiaandRuminococcus, could be demonstrated in the elderly. Moreover, in the Actinobacteria group, lower numbers ofCollinsellaspp. were evident in the elderly subjects with NSAID compared both with young adults and the elderly without NSAID, suggesting that the use of NSAID along with age may also influence the composition of intestinal microbiota. Furthermore, relatively high numbers ofLactobacillusappeared only in the elderly subjects without NSAID. In general, the lowered numbers of microbial members in the major phyla, Firmicutes, together with changes in the epithelial layer functions can have a significant effect on the colon health of the elderly.

scholarly journals The human intestinal microbiota of constipated-predominant irritable bowel syndrome patients exhibits anti-inflammatory properties

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Alain P. Gobert ◽  
Giulia Sagrestani ◽  
Eve Delmas ◽  
Keith T. Wilson ◽  
Thomas G. Verriere ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microbiota ◽  
Human Intestinal Microbiota ◽  
Anti Inflammatory ◽  
Irritable Bowel

scholarly journals Associations between Pro- and Anti-Inflammatory Gastro-Intestinal Microbiota, Diet, and Cognitive Functioning in Dutch Healthy Older Adults: The NU-AGE Study

Nutrients ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3471
Author(s):  
Annick P. M. van Soest ◽  
Gerben D. A. Hermes ◽  
Agnes A. M. Berendsen ◽  
Ondine van de Rest ◽  
Erwin G. Zoetendal ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Functioning ◽  
Intestinal Microbiota ◽  
Alpha Diversity ◽  
Cognitive Test ◽  
Processed Meat ◽  
Microbiota Composition ◽  
Healthy Older Adults ◽  
Age Related ◽  
Anti Inflammatory

Dietary modulation of the gastro-intestinal microbiota is a potential target in improving healthy ageing and age-related functional outcomes, including cognitive decline. We explored the association between diet, gastro-intestinal microbiota and cognition in Dutch healthy older adults of the ‘New dietary strategies addressing the specific needs of the elderly population for healthy aging in Europe’ (NU-AGE) study. The microbiota profile of 452 fecal samples from 226 subjects was determined using a 16S ribosomal RNA gene-targeted microarray. Dietary intake was assessed by 7-day food records. Cognitive functioning was measured with an extensive cognitive test battery. We observed a dietary and microbial pro- to anti-inflammatory gradient associated with diets richer in animal- or plant-based foods. Fresh fruits, nuts, seeds and peanuts, red and processed meat and grain products were most strongly associated to microbiota composition. Plant-rich diets containing fresh fruits, nuts, seeds and peanuts were positively correlated with alpha-diversity, various taxa from the Bacteroidetes phylum and anti-inflammatory species, including those related to Faecalibacterium prausnitzii and Eubacterium rectale and E. biforme. Animal product-rich diets associated with pro-inflammatory species, including those related to Ruminococcus gnavus and Collinsella spp.. Cognition was neither associated with microbiota composition nor alpha-diversity. In conclusion, diets richer in animal- and plant-based foods were related to a pro- and anti-inflammatory microbial profile, while cognition was associated with neither.

Analysis of the human intestinal microbiota from 92 volunteers after ingestion of identical meals

2013 ◽  
Vol 4 (2) ◽  
pp. 187-193 ◽  
Author(s):  
J.S. Jin ◽  
M. Touyama ◽  
R. Kibe ◽  
Y. Tanaka ◽  
Y. Benno ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Restriction Fragment Length Polymorphism ◽  
Intestinal Microbiota ◽  
Fragment Length Polymorphism ◽  
Microbiota Composition ◽  
Key Factors ◽  
Enzyme Systems ◽  
Human Intestinal Microbiota ◽  
Faecal Samples ◽  
Restriction Fragment Length

The intestinal microbiota composition of 92 volunteers living in Japan was identified following the consumption of ‘identical meals’ (1,879 kcal/day) for 3 days. When faecal samples were analysed by terminal restriction fragment length polymorphism with several primer-restriction enzyme systems and then clustered, the patterns could be divided into 2 clusters. Contribution tests and partition modelling showed that OTU211 of the 35f-MspI system and OTU237 of the 35f-AluI system were key factors in the distribution of these groups. However, significant differences among these groups in terms of body mass index and age were not observed.

scholarly journals Human intestinal microbiota composition is associated with local and systemic inflammation in obesity

Obesity ◽  
2013 ◽  
Vol 21 (12) ◽  
pp. E607-E615 ◽  
Author(s):  
Froukje J. Verdam ◽  
Susana Fuentes ◽  
Charlotte de Jonge ◽  
Erwin G. Zoetendal ◽  
Runi Erbil ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Systemic Inflammation ◽  
Microbiota Composition ◽  
Human Intestinal Microbiota

Long-term monitoring of the human intestinal microbiota composition

2013 ◽  
Vol 15 (4) ◽  
pp. 1146-1159 ◽  
Author(s):  
Mirjana Rajilić-Stojanović ◽  
Hans G. H. J. Heilig ◽  
Sebastian Tims ◽  
Erwin G. Zoetendal ◽  
Willem M. de Vos
Keyword(s):  
Intestinal Microbiota ◽  
Microbiota Composition ◽  
Human Intestinal Microbiota ◽  
Long Term Monitoring ◽  
Term Monitoring

scholarly journals Association between the ABO blood group and the human intestinal microbiota composition

2012 ◽  
Vol 12 (1) ◽  
pp. 94 ◽  
Author(s):  
Harri Mäkivuokko ◽  
Sampo J Lahtinen ◽  
Pirjo Wacklin ◽  
Elina Tuovinen ◽  
Heli Tenkanen ◽  
...  
Keyword(s):  
Blood Group ◽  
Intestinal Microbiota ◽  
Abo Blood Group ◽  
Microbiota Composition ◽  
Human Intestinal Microbiota

High-throughput analysis of the impact of antibiotics on the human intestinal microbiota composition

2013 ◽  
Vol 92 (3) ◽  
pp. 387-397 ◽  
Author(s):  
S.E. Ladirat ◽  
H.A. Schols ◽  
A. Nauta ◽  
M.H.C. Schoterman ◽  
B.J.F. Keijser ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
High Throughput ◽  
Microbiota Composition ◽  
High Throughput Analysis ◽  
Throughput Analysis ◽  
Human Intestinal Microbiota ◽  
The Impact

scholarly journals The Host-Specific Intestinal Microbiota Composition Impacts Campylobacter coli Infection in a Clinical Mouse Model of Campylobacteriosis

Pathogens ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 804
Author(s):  
Markus M. Heimesaat ◽  
Claudia Genger ◽  
Sigri Kløve ◽  
Dennis Weschka ◽  
Soraya Mousavi ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Molecular Mechanisms ◽  
Immune Cell ◽  
Inflammatory Responses ◽  
Fecal Microbiota Transplantation ◽  
Campylobacter Coli ◽  
Microbiota Composition ◽  
Mesenteric Lymph Nodes ◽  
Human Intestinal Microbiota ◽  
The Impact

Human Campylobacter-infections are progressively rising globally. However, the molecular mechanisms underlying C. coli–host interactions are incompletely understood. In this study, we surveyed the impact of the host-specific intestinal microbiota composition during peroral C. coli infection applying an established murine campylobacteriosis model. Therefore, microbiota-depleted IL-10−/− mice were subjected to peroral fecal microbiota transplantation from murine versus human donors and infected with C. coli one week later by gavage. Irrespective of the microbiota, C. coli stably colonized the murine gastrointestinal tract until day 21 post-infection. Throughout the survey, C. coli-infected mice with a human intestinal microbiota displayed more frequently fecal blood as their murine counterparts. Intestinal inflammatory sequelae of C. coli-infection could exclusively be observed in mice with a human intestinal microbiota, as indicated by increased colonic numbers of apoptotic epithelial cells and innate as well as adaptive immune cell subsets, which were accompanied by more pronounced pro-inflammatory cytokine secretion in the colon and mesenteric lymph nodes versus mock controls. However, in extra-intestinal, including systemic compartments, pro-inflammatory responses upon pathogen challenge could be assessed in mice with either microbiota. In conclusion, the host-specific intestinal microbiota composition has a profound effect on intestinal and systemic pro-inflammatory immune responses during C. coli infection.

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