Faculty Opinions recommendation of Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.

Author(s):  
Mohamed Sayegh ◽  
Jessamyn Bagley
Author(s):  
Shabir Ahmad Mir

: Listeria monocytogenes, a facultative intracellular gram-positive pathogen, is the causative agent of the disease listeriosis. The virulence of this intracellular bacterium is dependent on the coordinated activity of various bacterial factors, which are in turn tightly controlled by a specific set of regulators. The arsenal of virulence factors employed by L. monocytogenes for its infection cycle is available in the literature. Although the internalins of L. monocytogenes have been studied in detail their structural details are currently scattered and fragmented. Therefore, in the current review, we provide a brief account of the existing knowledge on structural details of the key internalins of L. monocytogenes and also highlight the recent advances in their functional aspects.


Gene ◽  
1992 ◽  
Vol 118 (1) ◽  
pp. 121-125 ◽  
Author(s):  
Klaus Brehm ◽  
Albert Haas ◽  
Werner Goebel ◽  
Jürgen Kreft

1991 ◽  
Vol 174 (3) ◽  
pp. 741-744 ◽  
Author(s):  
J W Conlan ◽  
R J North

The rate of growth of Listeria monocytogenes in the livers of mice infected intravenously with a lethal or sublethal inoculum of this facultative intracellular bacterium is greatly increased if neutrophils and other host cells are prevented from accumulating at foci of infection during the first 24 h by treatment with a monoclonal antibody (5C6) specific for the type 3 complement receptor of myelomonocytic cells. A histological examination of the livers of control mice showed that the accumulation of neutrophils at infectious foci resulted in the focal destruction of infected hepatocytes. In contrast, failure of neutrophils to accumulate at these sites in 5C6-treated mice allowed Listeria to multiply extensively in hepatocytes without destroying them. The results indicate that neutrophils play an important role in early defense against listeriosis in the liver by destroying infected hepatocytes, thereby reducing the opportunity for Listeria to multiply in permissive cells. In this way, neutrophils serve to break the chain of cell-to-cell spread of infection.


1992 ◽  
Vol 26 (3) ◽  
pp. 200-205 ◽  
Author(s):  
A. J. Marco ◽  
M. Domingo ◽  
J. Ruberte ◽  
A. Carretero ◽  
V. Briones ◽  
...  

The lymphatic drainage of the peritoneal cavity has been investigated by intraperitoneal inoculation of an intracellular bacterium ( Listeria monocytogenes) and an inert marker (Indian ink). The results reveal that both agents are transported, either after phagocytosis by intraperitoneal macro phages or in suspension in the lymph, towards the cranial sternal lymph nodes ( Lymphonodi sternales craniales) of the ventral thoracic Iymphocentrum ( Lymphocentrum thoracicum ventrale) and to the lymph nodes of the mediastinal lymphocentrum ( Lymphocentrum mediastinale), prior to systemic dissemination. This mechanism of peritoneal lymph drainage has relevance on experimental studies involving the inoculation of pathogens, and on the investigation of metastatic diffusion of neoplasms from the peritoneum.


2017 ◽  
Vol 5 ◽  
pp. 1104-1107
Author(s):  
Anna Zadernowska ◽  
Wioleta ChajÄ™cka-Wierzchowska ◽  
Arkadiusz Zakrzewski

Listeria monocytogenes is a Gram-positive intracellular bacterium, which causes foodborne listeriosis. This organism can be introduced through many routes to food-processing environments and may become established on food-processing equipment. Examination of 130 meat samples was conducted and the Listeria monocytogenes prevalence was determined by using an ISO culture method and PCR method. The isolated strains’ ability to form a biofilm was determined with the microplate (MP) method. Out of 130 meat samples examined, 22 (17%) contained L. monocytogenes. The majority (n=13; 59%) of the strains were characterized by a no biofilm producer. Four of the of Listeria monocytogenes strains (18,2%) showed strong and five of them (22,7%) moderate ability to form biofilm


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