Faculty Opinions recommendation of Restoration of anterior regeneration in a planarian with limited regenerative ability.

2013 ◽  
Author(s):  
Harukazu Nakamura
Keyword(s):  
Regenerative Ability ◽  
Anterior Regeneration

scholarly journals Restoration of anterior regeneration in a planarian with limited regenerative ability

Nature ◽  
2013 ◽  
Vol 500 (7460) ◽  
pp. 77-80 ◽  
Author(s):  
James M. Sikes ◽  
Phillip A. Newmark
Keyword(s):  
Regenerative Ability ◽  
Anterior Regeneration

A morphological and histological investigation of the regeneration in Myxicola infundibulum (Montagu, 1808) (Sabellida, Annelida)

2017 ◽  
Vol 97 (5) ◽  
pp. 1155-1165 ◽  
Author(s):  
Nancy K. Prentiss ◽  
Mary S. Tyler ◽  
David Dean
Keyword(s):  
Cartilage Tissue ◽  
Histological Investigation ◽  
Regenerative Ability ◽  
Anterior Regeneration

Anterior regeneration of the annelid polychaete, Myxicola infundibulum (Montagu, 1808) is described from histological and SEM perspectives. This article provides additional evidence that anterior and posterior regeneration of isolated worm pieces does occur in this species, but that regenerative ability is restricted to abdominal pieces obtained from small individuals (less than 5 mm in thorax diameter and 10–20 mm in length). New cartilage tissue forms within the regenerating crown, but thoracic regeneration is limited to three segments. Anterior and posterior regeneration occurred within isolated pieces excised from the abdomen, resulting in the formation of 13 clones, with up to five individuals per clone.

scholarly journals Potential Implantable Nanofibrous Biomaterials Combined with Stem Cells for Subchondral Bone Regeneration

Materials ◽  
2020 ◽  
Vol 13 (14) ◽  
pp. 3087
Author(s):  
Rana Smaida ◽  
Luc Pijnenburg ◽  
Silvia Irusta ◽  
Erico Himawan ◽  
Gracia Mendoza ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Regeneration ◽  
Subchondral Bone ◽  
Therapeutic Potential ◽  
Sodium Hyaluronate ◽  
Vinyl Pyrrolidone ◽  
Regenerative Ability ◽  
Poly Vinyl Pyrrolidone

The treatment of osteochondral defects remains a challenge. Four scaffolds were produced using Food and Drug Administration (FDA)-approved polymers to investigate their therapeutic potential for the regeneration of the osteochondral unit. Polycaprolactone (PCL) and poly(vinyl-pyrrolidone) (PVP) scaffolds were made by electrohydrodynamic techniques. Hydroxyapatite (HAp) and/or sodium hyaluronate (HA) can be then loaded to PCL nanofibers and/or PVP particles. The purpose of adding hydroxyapatite and sodium hyaluronate into PCL/PVP scaffolds is to increase the regenerative ability for subchondral bone and joint cartilage, respectively. Human bone marrow-derived mesenchymal stem cells (hBM-MSCs) were seeded on these biomaterials. The biocompatibility of these biomaterials in vitro and in vivo, as well as their potential to support MSC differentiation under specific chondrogenic or osteogenic conditions, were evaluated. We show here that hBM-MSCs could proliferate and differentiate both in vitro and in vivo on these biomaterials. In addition, the PCL-HAp could effectively increase the mineralization and induce the differentiation of MSCs into osteoblasts in an osteogenic condition. These results indicate that PCL-HAp biomaterials combined with MSCs could be a beneficial candidate for subchondral bone regeneration.

scholarly journals The fate of fetal and adult B-cell progenitors grafted into immunodeficient CBA/N mice.

1979 ◽  
Vol 150 (3) ◽  
pp. 548-563 ◽  
Author(s):  
C J Paige ◽  
P W Kincade ◽  
M A Moore ◽  
G Lee
Keyword(s):  
B Cells ◽  
B Cell ◽  
Fetal Liver ◽  
Cell Cloning ◽  
Generate Functional ◽  
Self Renewal ◽  
Relative Ability ◽  
Cloning Assay ◽  
Regenerative Ability

The relative ability of various precursors to generate functional B cells in vivo was assessed by transferring normal, chromosomally-marked CBA/H-T6T6 cells to irradiated or unirradiated immunodeficient CBA/N mice. Emergence of donor-derived B cells was monitored by means of a B-cell cloning assay (in which CBA/N cells are inactive), and by karyotpic analysis of lymphoid, myeloid, and stem cell metaphases. Grafts of lymph node, spleen, anti-mu surface immunoglobin suppressed bone marrow, sIg+ cell-depleted marrow, normal marrow, fetal liver, and yolk sac suggest: (a) there is little self-renewal of sIg+ B cells in these models; (b) pre-committed cells have extensive proliferative/differentiative potential and at least initially contribute most of the newly-formed B cells; (c) populations or pre-B cells obtained from various sources differ in their regenerative ability; (d) CBA/N mice are deficient in a category of pre-B cells which are found in fetal liver; and (e) selective B-cell chimerism results from grafting of unirradiated CBA/N mice.

Anterior regeneration in the polychaeteMarenzelleria viridis(Annelida: Spionidae)

2016 ◽  
Vol 135 (4) ◽  
pp. 357-369
Author(s):  
Tracy A. Whitford ◽  
Jason D. Williams
Keyword(s):  
Anterior Regeneration

Urolithin A improves muscle function by inducing mitophagy in muscular dystrophy

2021 ◽  
Vol 13 (588) ◽  
pp. eabb0319
Author(s):  
Peiling Luan ◽  
Davide D’Amico ◽  
Pénélope A. Andreux ◽  
Pirkka-Pekka Laurila ◽  
Martin Wohlwend ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscular Dystrophy ◽  
Mitochondrial Dysfunction ◽  
Muscle Function ◽  
Experimental Models ◽  
Muscle Stem Cells ◽  
Expression Of Genes ◽  
Primary Myoblasts ◽  
Urolithin A ◽  
Regenerative Ability

Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy, and despite advances in genetic and pharmacological disease-modifying treatments, its management remains a major challenge. Mitochondrial dysfunction contributes to DMD, yet the mechanisms by which this occurs remain elusive. Our data in experimental models and patients with DMD show that reduced expression of genes involved in mitochondrial autophagy, or mitophagy, contributes to mitochondrial dysfunction. Mitophagy markers were reduced in skeletal muscle and in muscle stem cells (MuSCs) of a mouse model of DMD. Administration of the mitophagy activator urolithin A (UA) rescued mitophagy in DMD worms and mice and in primary myoblasts from patients with DMD, increased skeletal muscle respiratory capacity, and improved MuSCs’ regenerative ability, resulting in the recovery of muscle function and increased survival in DMD mouse models. These data indicate that restoration of mitophagy alleviates symptoms of DMD and suggest that UA may have potential therapeutic applications for muscular dystrophies.

Fluctuations of adenylate cyclase activity during anterior regeneration in Owenia fusiformis (Polychaete Annelid)

Development ◽  
1978 ◽  
Vol 48 (1) ◽  
pp. 73-78
Author(s):  
Josiane Coulon ◽  
Monique Marilley
Keyword(s):  
Cell Cycle ◽  
Cyclic Amp ◽  
Adenylate Cyclase ◽  
Cyclase Activity ◽  
Adenylate Cyclase Activity ◽  
Biochemical Assays ◽  
Strong Stimulation ◽  
Periodic Fluctuations ◽  
Early Phases ◽  
Anterior Regeneration

Biochemical assays of adenylate cyclase activity were performed during the early phases of regeneration in Owenia fusiformis (Polychaete Annelid). The results indicate the existence of a strong stimulation in an early phase following trauma. This stimulation is then followed by periodic fluctuations exhibiting a diurnal rhythm correlated with the cell cycle. Adenylate cyclase activity is also shown to be neurotransmitter-dependent. In this paper it is proposed that neurotransmitters might participate in the regulation of cyclic AMP formation, by means of adenylate cyclase acting on target blastema cells, undergoing the cell cycle.

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