Faculty Opinions recommendation of Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour.

2015 ◽  
Author(s):  
Peter Holzer
Keyword(s):  
Gut Microbiota ◽  
Magnesium Deficiency ◽  
Dietary Magnesium

Dietary magnesium deficiency affects gut microbiota and anxiety-like behaviour in C57BL/6N mice

2015 ◽  
Vol 27 (5) ◽  
pp. 307-311 ◽  
Author(s):  
Bettina Pyndt Jørgensen ◽  
Gudrun Winther ◽  
Pernille Kihl ◽  
Dennis S. Nielsen ◽  
Gregers Wegener ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Magnesium Deficiency ◽  
Standard Diet ◽  
Microbiota Composition ◽  
Deficient Diet ◽  
Anxiety Test ◽  
Dietary Magnesium ◽  
Gradient Gel Electrophoresis ◽  
The Impact ◽  
Gut Microbiota Composition

ObjectiveMagnesium deficiency has been associated with anxiety in humans, and rodent studies have demonstrated the gut microbiota to impact behaviour.MethodsWe investigated the impact of 6 weeks of dietary magnesium deficiency on gut microbiota composition and anxiety-like behaviour and whether there was a link between the two. A total of 20 C57BL/6 mice, fed either a standard diet or a magnesium-deficient diet for 6 weeks, were tested using the light-dark box anxiety test. Gut microbiota composition was analysed by denaturation gradient gel electrophoresis.ResultsWe demonstrated that the gut microbiota composition correlated significantly with the behaviour of dietary unchallenged mice. A magnesium-deficient diet altered the gut microbiota, and was associated with altered anxiety-like behaviour, measured by decreased latency to enter the light box.ConclusionMagnesium deficiency altered behavior. The duration of magnesium deficiency is suggested to influence behaviour in the evaluated test.

Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour

2015 ◽  
Vol 27 (3) ◽  
pp. 168-176 ◽  
Author(s):  
Gudrun Winther ◽  
Betina M Pyndt Jørgensen ◽  
Betina Elfving ◽  
Denis Sandris Nielsen ◽  
Pernille Kihl ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Magnesium Deficiency ◽  
Forced Swim Test ◽  
Tolerance Test ◽  
Standard Diet ◽  
Restricted Diet ◽  
Microbial Composition ◽  
Deficient Diet ◽  
Significant Difference ◽  
Dietary Magnesium

ObjectiveGut microbiota (GM) has previously been associated with alterations in rodent behaviour, and since the GM is affected by the diet, the composition of the diet may be an important factor contributing to behavioural changes. Interestingly, a magnesium restricted diet has been shown to induce anxiety and depressive-like behaviour in humans and rodents, and it could be suggested that magnesium deficiency may mediate the effects through an altered GM.MethodsThe present study therefore fed C57BL/6 mice with a standard diet or a magnesium deficient diet (MgD) for 6 weeks, followed by behavioural testing in the forced swim test (FST) to evaluate depressive-like behaviour. An intraperitoneal glucose tolerance test (GTT) was performed 2 day after the FST to assess metabolic alterations. Neuroinflammatory markers were analysed from hippocampus. GM composition was analysed and correlated to the behaviour and hippocampal markers.ResultsIt was found that mice exposed to MgD for 6 weeks were more immobile than control mice in the FST, suggesting an increased depressive-like behaviour. No significant difference was detected in the GTT. GM composition correlated positively with the behaviour of undisturbed C57BL/6 mice, feeding MgD diet altered the microbial composition. The altered GM correlated positively to the hippocampal interleukin-6.ConclusionIn conclusion, we hypothesise that imbalances of the microbiota–gut–brain axis induced by consuming a MgD diet, contributes to the development of depressive-like behaviour.

Risk of dietary magnesium deficiency is low in most African countries based on food supply data

2012 ◽  
Vol 368 (1-2) ◽  
pp. 129-137 ◽  
Author(s):  
Edward J. M. Joy ◽  
Scott D. Young ◽  
Colin R. Black ◽  
E. Louise Ander ◽  
Michael J. Watts ◽  
...  
Keyword(s):  
Food Supply ◽  
Magnesium Deficiency ◽  
African Countries ◽  
Dietary Magnesium

Low gut microbiota diversity and dietary magnesium intake are associated with the development of PPI‐induced hypomagnesemia

2019 ◽  
Vol 33 (10) ◽  
pp. 11235-11246 ◽  
Author(s):  
Lisanne M. M. Gommers ◽  
Thomas H. A. Ederveen ◽  
Jenny Wijst ◽  
Caro Overmars-Bos ◽  
Guus A. M. Kortman ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Magnesium Intake ◽  
Dietary Magnesium ◽  
Microbiota Diversity

scholarly journals Erythrocyte membrane plaques from rats with magnesium deficiency

Blood ◽  
1977 ◽  
Vol 49 (4) ◽  
pp. 657-664 ◽  
Author(s):  
RJ Elin ◽  
HK Tan
Keyword(s):  
Erythrocyte Membrane ◽  
Plasma Membranes ◽  
Magnesium Deficiency ◽  
Freeze Fracture ◽  
Deficient Diet ◽  
White Rats ◽  
Dietary Magnesium ◽  
Freeze Fracture Electron Microscopy ◽  
And Control ◽  
Fracture Electron

Abstract This study investigated the anemia of dietary magnesium deficiency in inbred Fisher white rats using freeze-fracture electron microscopy. The plasma membranes of erythrocytes from animals receiving two different magnesium-deficient and control diets were observed at weekly or biweekly intervals for 6 wk. The earliest changes were small plaques on the external surface (ES) and fracture face (PF) of erythrocyte plasma membranes, which occurred after 2 wk of either magnesium-deficient diet. These plaques persisted and increased in size with progressive magnesium deficiency. When fully developed, the plaques consisted of round or oval elevations approximately 30–50 nm in diameter outlined by a narrow raised border. The surface of the plaques was smooth and devoid of intramembranous particles. Incubation of erythrocytes from magnesium-deficient rats in a physiologic solution containing 2 meq/liter magnesium for 1 hr at 37degrees C did not alter the appearance of the plaques. Erythrocytes from control rats, obtained during the same time periods, showed no plaques. Thus, a deficiency of magnesium in rats altered erythrocyte membrane structure.

scholarly journals Effect of Dietary Magnesium Content on Intestinal Microbiota of Rats

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2889
Author(s):  
Arantxa García-Legorreta ◽  
Luis Alfonso Soriano-Pérez ◽  
Aline Mariana Flores-Buendía ◽  
Omar Noel Medina-Campos ◽  
Lilia G. Noriega ◽  
...  
Keyword(s):  
Intestinal Microbiota ◽  
Magnesium Deficiency ◽  
Control Diet ◽  
Hypervariable Region ◽  
Magnesium Content ◽  
Fecal Microbiota ◽  
Male Rats ◽  
Physiological Processes ◽  
Intestinal Dysbiosis ◽  
Dietary Magnesium

Background: Magnesium is a mineral that modulates several physiological processes. However, its relationship with intestinal microbiota has been scarcely studied. Therefore, this study aimed to assess the role of dietary magnesium content to modulate the intestinal microbiota of Wistar male rats. Methods: Rats were randomly assigned one of three diets: a control diet (C-Mg; 1000 mg/kg), a low magnesium content diet (L-Mg; 60 mg/kg), and a high magnesium content diet (H-Mg; 6000 mg/kg), for two weeks. After treatment, fecal samples were collected. Microbiota composition was assessed by sequencing the V3–V4 hypervariable region. Results: The C-Mg and L-Mg groups had more diversity than H-Mg group. CF231, SMB53, Dorea, Lactobacillus and Turibacter were enriched in the L-Mg group. In contrast, the phyla Proteobacteria, Parabacteroides, Butyricimonas, and Victivallis were overrepresented in the H-Mg group. PICRUSt analysis indicated that fecal microbiota of the L-Mg group were encoded with an increased abundance of metabolic pathways involving carbohydrate metabolism and butanoate metabolism. Conclusion: Dietary magnesium supplementation can result in intestinal dysbiosis development in a situation where there is no magnesium deficiency. Conversely, low dietary magnesium consumption is associated with microbiota with a higher capacity to harvest energy from the diet.

Use of Synthetic Diets and Biochemical Criteria in the Assessment of Nutrient Requirements of Fish

1976 ◽  
Vol 33 (4) ◽  
pp. 1040-1045 ◽  
Author(s):  
C. B. Cowey
Keyword(s):  
Fatty Acids ◽  
Rainbow Trout ◽  
Magnesium Deficiency ◽  
Scophthalmus Maximus ◽  
Salmo Gairdneri ◽  
Response Curves ◽  
Dietary Magnesium ◽  
Carbon Acids ◽  
Acid Status ◽  
Turbot Scophthalmus Maximus

Dietary allowances of nutrients have been formulated mainly from growth–response curves. The use of other criteria, especially those which exploit the biochemical role of nutrients, is discussed by reference to three different nutrients, namely thiamin, magnesium, and essential fatty acids.It is shown that erythrocyte transketolase activity provides a nutritional index of thiamin status in turbot (Scophthalmus maximus). The enzyme is saturated with coenzyme (thiamin pyrophosphate) at a dietary thiamin level of 2.6 mg/kg.Assessment of mineral requirements is shown to present special problems because complex interrelationships exist between some dietary minerals. It is shown that dietary magnesium deficiency (4 mg magnesium/100 g diet) leads to renal calcification in rainbow trout (Salmo gairdneri) at dietary calcium levels of 2.7 g/100 g (Ca: P ratio 1: 1). Elevation of dietary magnesium to 100 mg/100 g under these conditions gave freedom from pathology and enhanced growth.Ratios of certain fatty acids in the tissue phospholipids of rainbow trout are known to provide a useful index of essential fatty acid status. These ratios cannot be applied to turbot as this species does not chain elongate and desaturate 18-carbon acids at appreciable rates. Long chain polyunsaturated fatty acids of the ω3 series must be supplied preformed in the diet of turbot.

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