Faculty Opinions recommendation of Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data.

2015 ◽  
Author(s):  
Andrea Semplicini
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Vitamin D ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Patient Data

scholarly journals Self-monitoring of Blood Pressure in Patients With Hypertension-Related Multi-morbidity: Systematic Review and Individual Patient Data Meta-analysis

2019 ◽  
Author(s):  
J P Sheppard ◽  
K L Tucker ◽  
W J Davison ◽  
R Stevens ◽  
W Aekplakorn ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
High Intensity ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Cochrane Library ◽  
Self Monitoring ◽  
Co Morbidity

Abstract BACKGROUND Studies have shown that self-monitoring of blood pressure (BP) is effective when combined with co-interventions, but its efficacy varies in the presence of some co-morbidities. This study examined whether self-monitoring can reduce clinic BP in patients with hypertension-related co-morbidity. METHODS A systematic review was conducted of articles published in Medline, Embase, and the Cochrane Library up to January 2018. Randomized controlled trials of self-monitoring of BP were selected and individual patient data (IPD) were requested. Contributing studies were prospectively categorized by whether they examined a low/high-intensity co-intervention. Change in BP and likelihood of uncontrolled BP at 12 months were examined according to number and type of hypertension-related co-morbidity in a one-stage IPD meta-analysis. RESULTS A total of 22 trials were eligible, 16 of which were able to provide IPD for the primary outcome, including 6,522 (89%) participants with follow-up data. Self-monitoring was associated with reduced clinic systolic BP compared to usual care at 12-month follow-up, regardless of the number of hypertension-related co-morbidities (−3.12 mm Hg, [95% confidence intervals −4.78, −1.46 mm Hg]; P value for interaction with number of morbidities = 0.260). Intense interventions were more effective than low-intensity interventions in patients with obesity (P < 0.001 for all outcomes), and possibly stroke (P < 0.004 for BP control outcome only), but this effect was not observed in patients with coronary heart disease, diabetes, or chronic kidney disease. CONCLUSIONS Self-monitoring lowers BP regardless of the number of hypertension-related co-morbidities, but may only be effective in conditions such obesity or stroke when combined with high-intensity co-interventions.

scholarly journals Effect of vitamin D supplementation on pain and physical function in patients with knee osteoarthritis (OA): an OA Trial Bank protocol for a systematic review and individual patient data (IPD) meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. e035302 ◽  
Author(s):  
Xingzhong Jin ◽  
Benny Antony ◽  
Xia Wang ◽  
Monica SM Persson ◽  
Timothy McAlindon ◽  
...  
Keyword(s):  
Vitamin D ◽  
Knee Osteoarthritis ◽  
Physical Function ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Clinical Signs ◽  
Vitamin D Supplementation ◽  
Patient Data ◽  
Knee Oa ◽  
Patient Reported

IntroductionObservational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, randomised controlled trials (RCTs) to date investigating the efficacy of vitamin D supplementation in knee OA have reported conflicting results. Further research is needed to clarify the effects of vitamin D on patient-reported outcomes and determine whether there are patient subgroups who may benefit from the supplementation. The aim of this individual patient data (IPD) meta-analysis is to identify patient-level predictors of treatment response to vitamin D supplementation on pain and physical function.Methods and analysisA systematic literature search will be conducted for RCTs of vitamin D supplementation on knee OA. Authors of original RCTs will be contacted to obtain the IPD. The primary outcomes will include long-term (≥12 months) pain and physical function. Secondary outcomes will include medium-term (≥6 months and <12 months) and short-term (<6 months) pain and physical function, as well as patient global assessment, quality of life and adverse events. Potential treatment effect modifiers to be examined in the subgroup analyses include age, gender, body mass index, baseline knee pain severity and physical function, baseline vitamin D level, radiographic stage, presence of bone marrow lesions on MRI, presence of clinical signs of local inflammation and concomitant depressive symptoms. Both one-step and two-step modelling methods will be used to determine the possible modifiable effect of each subgroup of interest.Ethics and disseminationResearch ethical or governance approval is exempt for this study as no new data are being collected. This study will be the first IPD meta-analysis to clarify the effect of vitamin D supplementation on clinical symptoms in different subgroups of patients with knee OA. The findings will be disseminated through peer-review publications and conference presentations.PROSPERO registration numberCRD42018107740.

scholarly journals Self-monitoring of blood pressure in hypertension: A systematic review and individual patient data meta-analysis

PLoS Medicine ◽  
2017 ◽  
Vol 14 (9) ◽  
pp. e1002389 ◽  
Author(s):  
Katherine L. Tucker ◽  
James P. Sheppard ◽  
Richard Stevens ◽  
Hayden B. Bosworth ◽  
Alfred Bove ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Self Monitoring

scholarly journals Does vitamin D supplementation improve bone density in vitamin D-deficient children? Protocol for an individual patient data meta-analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. e019584 ◽  
Author(s):  
Tania Winzenberg ◽  
Christel Lamberg-Allardt ◽  
Ghada El-Hajj Fuleihan ◽  
Christian Mølgaard ◽  
Kun Zhu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Density ◽  
Bone Mineral ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Vitamin D Supplementation ◽  
Patient Data ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Baseline Serum

IntroductionOur previous study-level (aggregate data) meta-analysis suggested that vitamin D supplements may be beneficial for bone density specifically in children with vitamin D deficiency. However, the misclassification of vitamin D status inherent in study-level data means that the results are not definitive and cannot provide an accurate assessment of the size of any effect. Therefore, we propose to undertake an individual patient data (IPD) meta-analysis to determine whether the effect of vitamin D supplementation on bone density in children differs according to baseline vitamin D status, and to specifically estimate the effect of vitamin D in children who are vitamin D deficient.Methods and analysisThis study has been designed to adhere to the Preferred Reporting Items for Systematic Review and Meta-Analyses of IPD statement. We will include randomised placebo-controlled trials of vitamin D supplementation reporting bone density outcomes at least 6 months after the study commenced in children and adolescents (aged <20 years) without coexistent medical conditions or treatments causing osteoporosis. We will update the search of the original review to cover the period 2009–2017, using the same methods as the original review. Fully anonymised data on all randomised patients will be requested. Outcomes will be femoral neck, total hip, lumbar spine and proximal and distal forearm bone mineral density, and total body bone mineral content. A two-stage IPD meta-analysis will be used to examine the effect of baseline serum 25-hydroxyvitamin D (25(OH)D) on treatment effect for each bone density outcome. Restricted maximum likelihood will be used to estimate the random-effects meta-analysis models, with 95% CI for summary effects. Heterogeneity will be assessed by I2and potential publication bias (small-study effects) and availability bias by funnel plots, Egger’s test and Peter’s test.Ethics and disseminationEthics approval will not be required as the data are to be used for the primary purpose for which they were collected and all original individual studies had ethics approval. Results of the IPD meta-analysis will be submitted for publication in a peer-reviewed journal.PROSPERO registration numberCRD42017068772.

109. Using blood pressure self-monitoring in pregnancy: A systematic review and individual patient data meta-analysis

2018 ◽  
Vol 13 ◽  
pp. S76
Author(s):  
Richard McManus ◽  
Katherine Tucker ◽  
Clare Bankhead ◽  
James Hodgkinson ◽  
Nia Roberts ◽  
...  
Keyword(s):  
Systematic Review ◽  
Blood Pressure ◽  
Individual Patient Data ◽  
Meta Analysis ◽  
Patient Data ◽  
Self Monitoring ◽  
In Pregnancy
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