Faculty Opinions recommendation of Baseline characteristics and treatment-emergent risk factors associated with cerebrovascular event and death with risperidone in dementia patients.

144 Background: Denosumab is a monoclonal antibody that neutralizes RANKL preventing osteoclast activation. It has been shown to be superior to zoledronic acid in preventing skeletal-related events in breast cancer with bone metastases. Hypocalcemia has been reported as a common side effect. The aim is to evaluate the risk factors associated with denosumab induce hypocalcemia. Methods: Retrospective study in which 144 charts were reviewed. Baseline characteristics: age, gender, race, type of cancer, calcium, phosphate, vitamin D, PTH, creatinine levels, GFR and corrected calcium were obtained. Tumors were classified in hormone sensitive versus non-sensitive. Charts were reviewed to evaluate for the development and severity of hypocalcemia as defined by the international review criteria. A multivariant analysis to evaluate the relationship between hypocalcemia and the variables of interest was done. Results: Hypocalcemia was observed in 71 of 144 patients. Grade 2 hypocalcemia was the most common. Significantly lower levels of GFR at baseline were detected in patients withhypocalcemia. Hormone responsive tumors were significantly less likely to develop hypocalcemia. Conclusions: Despite adequate supplementation of vitamin D and calcium, hypocalcemia is a common side effect of Denosumab. Careful monitoring of calcium levels is necessary especially in chronic kidney disease and hormone insensitive tumors. [Table: see text]

Download Full-text

Intensive Care Utilization during Hospital Admission for Delivery

Anesthesiology ◽

10.1097/00000542-200006000-00009 ◽

2000 ◽

Vol 92 (6) ◽

pp. 1537-1544 ◽

Cited By ~ 71

Author(s):

Sumedha Panchal ◽

Amelia M. Arria ◽

Andrew P. Harris

Keyword(s):

Risk Factors ◽

Intensive Care ◽

Hospital Admission ◽

Hospital Setting ◽

Mortality Rates ◽

Cerebrovascular Event ◽

Icu Mortality ◽

Factors Associated ◽

Icu Admission ◽

Common Risk Factors

Background During childbirth, the maternal need for intensive care unit (ICU) services is not well-defined. This information could influence the decision whether to incorporate ICU services into the labor and delivery suite. Methods This study reports (1) ICU use and mortality rates in a statewide population of obstetric patients during their hospital admission for childbirth, and (2) the risk factors associated with ICU admission and mortality. A case-control design using patient records from a state-maintained anonymous database for the years 1984-1997 was used. Outcome variables included ICU use and mortality rates. Results Of the 822,591 hospital admissions for delivery of neonates during the study period, there were 1,023 ICU admissions (0.12%) and 34 ICU deaths (3.3%). Age, race, hospital type, volume of deliveries, and source of admission independently and in combination were associated with ICU admission (P < 0.05). The most common risk factors associated with ICU admission included cesarean section, preeclampsia or eclampsia, and postpartum hemorrhage (P < 0.001). Black race, high hospital volume of deliveries, and longer duration of ICU stay were associated with ICU mortality (P < 0.05). The most common risk factors associated with ICU mortality included pulmonary complications, shock, cerebrovascular event, and drug dependence (P < 0.05). Conclusions This study shows that ICU use and mortality rate during hospital admission for delivery of a neonate is low. These results may influence the location of perinatal ICU services in the hospital setting.

Download Full-text

Factors associated with non-prescription of oral anticoagulant treatment in non-valvular atrial fibrillation patients with dementia: a CPRD–HES study

Age and Ageing ◽

10.1093/ageing/afaa045 ◽

2020 ◽

Vol 49 (4) ◽

pp. 679-682 ◽

Cited By ~ 1

Author(s):

Megan Besford ◽

Sophie Graham ◽

Cormac Sammon ◽

Faisal Mehmud ◽

Victoria Allan ◽

...

Keyword(s):

Risk Factors ◽

Atrial Fibrillation ◽

Oral Anticoagulant ◽

Treatment Guidelines ◽

Bleeding Risk ◽

Practice Research ◽

Clinical Practice Research Datalink ◽

Newly Diagnosed ◽

Factors Associated ◽

Dementia Patients

Abstract Dementia is a common comorbidity in patients with atrial fibrillation (AF) and treatment guidelines recommend oral anticoagulant (OAC) therapy for AF patients with dementia unless concordance cannot be ensured by the caregiver. Despite this, the literature reports a low prescribing of OAC treatment in these patients. This study investigated possible factors associated with non-prescribing of OAC treatment in dementia patients newly diagnosed with non-valvular atrial fibrillation (NVAF) at age ≥ 65 years between 2013 and 2017 using the Clinical Practice Research Datalink and Hospital Episodes Statistics databases. Of 1090 dementia patients newly diagnosed with NVAF, 693 (63.6%) patients did not have a prescription for an OAC in the year following their diagnosis. The likelihood of experiencing a thromboembolic event was high, with 97% of the population having a CHA2DS2-VASc score > 2; however, little difference in the presence of stroke risk factors was observed between the prescribed and non-prescribed groups. The presence of bleeding risk factors was high; only 28 (2.6%) of patients did not have a previous fall or a HAS-BLED bleeding risk factor. A history of falls [OR = 0.76, 95% confidence intervals (CIs) (0.58, 0.98)], previous major bleed [OR = 0.56, 95% CI (0.43, 0.73)] and care home residence [OR = 0.47, 95% CI (0.30, 0.74)] were associated with not having an OAC prescription. The results suggest that dementia patients with NVAF and certain risk bleeding risk factors are less likely to be prescribed an OAC. Further work is needed to establish possible relationships between bleeding risk factors and other potential drivers of OAC prescribing.

Download Full-text

Risk factors associated with substance use

PsycEXTRA Dataset ◽

10.1037/e553882014-001 ◽

2014 ◽

Author(s):

Ariel M. Barber ◽

Alexandra Crouch ◽

Stephen Campbell

Keyword(s):

Risk Factors ◽

Substance Use ◽

Factors Associated

Download Full-text

A Six Year Prospective Study of Fibrinogen and Other Risk Factors Associated with Mortality in Stable Claudicants

Thrombosis and Haemostasis ◽

10.1055/s-0038-1656361 ◽

1992 ◽

Vol 68 (03) ◽

pp. 261-263 ◽

Cited By ~ 71

Author(s):

A K Banerjee ◽

J Pearson ◽

E L Gilliland ◽

D Goss ◽

J D Lewis ◽

...

Keyword(s):

Risk Factors ◽

Intermittent Claudication ◽

Fibrinogen Level ◽

Past History ◽

Fold Increase ◽

Arterial Disease ◽

Plasma Fibrinogen ◽

Plasma Fibrinogen Level ◽

Factors Associated ◽

Probability Of Death

SummaryA total of 333 patients with stable intermittent claudication at recruitment were followed up for 6 years to determine risk factors associated with subsequent mortality. Cardiovascular diseases were the underlying cause of death in 78% of the 114 patients who died. The strongest independent predictor of death during the follow-up period was the plasma fibrinogen level, an increase of 1 g/l being associated with a nearly two-fold increase in the probability of death within the next 6 years. Age, low ankle/brachial pressure index and a past history of myocardial infarction also increased the probability of death during the study period. The plasma fibrinogen level is a valuable index of those patients with stable intermittent claudication at high risk of early mortality. The results also provide further evidence for the involvement of fibrinogen in the pathogenesis of arterial disease.

Download Full-text