scholarly journals Faculty Opinions recommendation of Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype.

2019 ◽  
Author(s):  
Paul R Walker ◽  
Stoyan Tankov
Keyword(s):  
Tumor Cell ◽  
Macrophage Phenotype ◽  
Tumor Associated Macrophage ◽  
Apoptotic Tumor Cell

scholarly journals Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Ann-Christin Frank ◽  
Stefanie Ebersberger ◽  
Annika F. Fink ◽  
Sebastian Lampe ◽  
Andreas Weigert ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Macrophage Phenotype ◽  
Tumor Associated Macrophage ◽  
Apoptotic Tumor Cell

scholarly journals Pan-cancer analysis reveals tumor-associated macrophage communication in the tumor microenvironment

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Linbang Wang ◽  
Tao He ◽  
Jingkun Liu ◽  
Jiaojiao Tai ◽  
Bing Wang ◽  
...  
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Cell ◽  
Hub Genes ◽  
Tumor Associated Macrophage ◽  
Molecular Features ◽  
Receptor Interactions ◽  
Tumor Types ◽  
Pan Cancer

Abstract Background Tumor-associated macrophages (TAMs) are abundant in the tumor microenvironment (TME). However, their contribution to the immunosuppressive status of the TME remains unclear. Methods We integrated single-cell sequencing and transcriptome data from different tumor types to uncover the molecular features of TAMs. In vitro experiments and prospective clinical tests confirmed the results of these analysis. Results We first detected intra- and inter-tumoral heterogeneities between TAM subpopulations and their functions, with CD86+ TAMs playing a crucial role in tumor progression. Next, we focused on the ligand-receptor interactions between TAMs and tumor cells in different TME phenotypes and discovered that aberrant expressions of six hub genes, including FLI1, are involved in this process. A TAM-tumor cell co-culture experiment proved that FLI1 was involved in tumor cell invasion, and FLI1 also showed a unique pattern in patients. Finally, TAMs were discovered to communicate with immune and stromal cells. Conclusion We determined the role of TAMs in the TME by focusing on their communication pattern with other TME components. Additionally, the screening of hub genes revealed potential therapeutic targets.

scholarly journals Reprogramming Tumor Associated Macrophage Phenotype by a Polysaccharide from Ilex asprella for Sarcoma Immunotherapy

2018 ◽  
Vol 19 (12) ◽  
pp. 3816 ◽  
Author(s):  
Qiu Li ◽  
Zhihui Hao ◽  
Yeting Hong ◽  
Wei He ◽  
Wenwen Zhao
Keyword(s):  
Survival Rate ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Signal Transducer ◽  
Macrophage Phenotype ◽  
Therapeutic Tool ◽  
Acidic Polysaccharide ◽  
Tumor Associated Macrophage ◽  
Animal Survival ◽  
Anti Tumor Activity

We report here the discovery of an acidic polysaccharide, namely IAPS-2, from the root of Ilex asprella, with anti-tumor activity via a repolarizing tumor associated macrophages (TAMs) phenotype. We obtained IAPS-2 polysaccharide from this herb based on acidity and found that IAPS-2 expressed the activity of promoting the secretion of anti-tumor cytokines in macrophages. Furthermore, we evaluated its anti-tumor effect on TAM cells, through the activation of nuclear factor-κB (NF-κB) and signal transducer and activator of transcription (STAT) signaling. In particular, in the tumor murine model, IAPS-2 demonstrated that it could significantly inhibit the growth of tumors via modulating the function of TAMs and increase the animal survival rate. In summary, IAPS-2, with a clearly illustrated chemical composition, potent anti-tumor activity, and a solid mechanism of action, may be developed into a valuable therapeutic tool for cancer immunotherapy.

Apoptotic tumor-cell death in response to cell proliferation is influenced by p53 status in resected non-small cell lung cancer

Lung Cancer ◽  
2002 ◽  
Vol 36 (1) ◽  
pp. 27-32 ◽  
Author(s):  
Fumihiro Tanaka ◽  
Tetsuya Takata ◽  
Tomoko Yamada ◽  
Kazuhiro Yanagihara ◽  
Yosuke Otake ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cell Death ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Tumor Cell Death ◽  
Apoptotic Tumor Cell ◽  
P53 Status

Apoptotic tumor cell death under the influence of the cytotoxic complex Tag7–Hsp70 is induced by interaction with the TNFR1 receptor

2016 ◽  
Vol 466 (1) ◽  
pp. 48-50 ◽  
Author(s):  
O. K. Ivanova ◽  
T. N. Sharapova ◽  
E. A. Romanova ◽  
L. P. Sashchenko ◽  
N. V. Gnuchev ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Tumor Cell Death ◽  
Apoptotic Tumor Cell ◽  
Tnfr1 Receptor

Distinct mathematical behavior of apoptotic versus non-apoptotic tumor cell death

1999 ◽  
Vol 43 (3) ◽  
pp. 601-605 ◽  
Author(s):  
Patricia Harrigan Hardenbergh ◽  
Philip Hahnfeldt ◽  
Lynn Hlatky ◽  
Clifford Takemoto ◽  
Akiko Shimamura ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Tumor Cell Death ◽  
Apoptotic Tumor Cell ◽  
Mathematical Behavior

Polarization of tumor-associated macrophage phenotype via porous hollow iron nanoparticles for tumor immunotherapy in vivo

Nanoscale ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 130-144 ◽  
Author(s):  
Ke Li ◽  
Lu Lu ◽  
Chencheng Xue ◽  
Ju Liu ◽  
Ye He ◽  
...  
Keyword(s):  
Immune Response ◽  
Tumor Growth ◽  
Iron Nanoparticles ◽  
Tumor Immunotherapy ◽  
Macrophage Phenotype ◽  
Tumor Associated Macrophage ◽  
Immunosuppressive Microenvironment ◽  
M1 Type

PHNPs and 3-MA re-polarize TAMs to M1-type by activating the protein of NF-κB p65 and then remodelling the immunosuppressive microenvironment, thus activating immune response and inhibiting tumor growth.

scholarly journals CIB1 prevents nuclear GAPDH accumulation and non-apoptotic tumor cell death via AKT and ERK signaling

Oncogene ◽  
2012 ◽  
Vol 32 (34) ◽  
pp. 4017-4027 ◽  
Author(s):  
T M Leisner ◽  
C Moran ◽  
S P Holly ◽  
L V Parise
Keyword(s):  
Cell Death ◽  
Tumor Cell ◽  
Erk Signaling ◽  
Tumor Cell Death ◽  
Apoptotic Tumor Cell
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