Global scaling for semi-quantitative analysis in FP-CIT SPECT

2014 ◽  
Vol 53 (06) ◽  
pp. 234-241 ◽  
Author(s):  
C. Lange ◽  
G. Ulrich ◽  
H. Amthauer ◽  
W. Brenner ◽  
D. Kupitz ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Single Photon ◽  
Photon Emission ◽  
Statistical Parametric Mapping ◽  
Performance Measure ◽  
Emission Computed Tomography ◽  
Reference Region ◽  
Whole Brain ◽  
Custom Made ◽  
The Mean

SummarySemi-quantitative characterization of dopamine transporter availability from single photon emission computed tomography (SPECT) with 123I-ioflupane (FP-CIT) is based on uptake ratios relative to a reference region. The aim of this study was to evaluate the whole brain as reference region for semiquantitative analysis of FP-CIT SPECT. The rationale was that this might reduce statistical noise associated with the estimation of non-displaceable FP-CIT uptake. Patients, methods: 150 FP-CIT SPECTs were categorized as neurodegenerative or non-neurode- generative by an expert. Semi-quantitative analysis of specific binding ratios (SBR) was performed with a custom-made tool based on the Statistical Parametric Mapping software package using predefined regions of interest (ROIs) in the anatomical space of the Montreal Neurological Institute. The following reference regions were compared: predefined ROIs for frontal and occipital lobe and whole brain (without striata, thalamus and brainstem). Tracer uptake in the reference region was characterized by the mean, median or 75th percentile of its voxel intensities. The area (AUC) under the receiver operating characteristic curve was used as performance measure. Results: The highest AUC of 0.973 was achieved by the SBR of the putamen with the 75th percentile in the whole brain as reference. The lowest AUC for the putamen SBR of 0.937 was obtained with the mean in the frontal lobe as reference. Conclusion: We recommend the 75th percentile in the whole brain as reference for semi-quantitative analysis in FP-CIT SPECT. This combination provided the best agreement of the semi-quantitative analysis with visual evaluation of the SPECT images by an expert and, therefore, is appropriate to support less experienced physicians.

123I-FP-CIT SPECT imaging of the dopaminergic state

2012 ◽  
Vol 51 (06) ◽  
pp. 244-251 ◽  
Author(s):  
C. Eggers ◽  
A. Holstein ◽  
C. Schneider ◽  
D. J. Pedrosa ◽  
M. Dietlein ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Single Photon ◽  
Photon Emission ◽  
Visual Assessment ◽  
Emission Computed Tomography ◽  
Rater Agreement ◽  
Automated Method ◽  
Atypical Parkinsonian Syndrome ◽  
Study Results ◽  
Dopaminergic Degeneration

Summary123I-N-ω-fluoropropyl-2β-carbomethoxy-3β- (4-iodophenyl)nortropan (123I-FP-CIT) single photon emission computed tomography (SPECT) can be evaluated by both visual assessment and quantitative analysis to assess the striatal dopamine state in vivo. The aim of our study was to investigate if visual assessment according to a predefined image grading scale reflects the results of quantitative assessment techniques. Patients, methods: 195 patients with a clinical diagnosis of idiopathic Parkinson's disease (n = 134), atypical parkinsonian syndrome (n = 47) or essential tremor (n = 14) were examined with 123I-FP-CIT SPECT and included in this retrospective study. Results were analysed according to predefined visual patterns of dopaminergic degeneration and graded as normal (grade 5) or abnormal (grade 1–4) independently by three raters. Quantitative two-dimensional (2D) operator-dependent, manual and three-dimensional (3D) operator- independent, automated approaches were used for quantitative analysis of the specific 123I-FP-CIT tracer binding ratio (SBR) for caudate and putamen. Results: Sensitivity, specificity, PPV, NPV and diagnostic accuracy of visual assessment of 123I-FP-CIT SPECT for the diagnosis of a neuro degenerative Parkinson's syndrome were 99%, 86%, 99%, 86% and 98%, respectively. Visual assessment and quantitative analysis agreed well in evaluating the degree of dopaminergic degeneration. Significant differences (p < 0.001) were found between degeneration patterns. Only between the so-called eagle wing degeneration and the normal pattern no significant differences in SBR caudate and putamen were found, neither by the quantitative manual (p = 1.00; p = 0.196) nor by the quantitative automated method (p = 1.0; p = 0.785). Inter-rater agreement for visual assessment was substantial for all possible pairs of the three raters (κ = 0.70 to 0.74). Strong correlations were observed between the quantitative manual and quantitative automated methods for quantification of SBR caudatum (r = 0.920, r2 = 0.846, p < 0.001) and SBR putamen (r = 0.908, r2 = 0.824, p < 0.001). Conclusion: Visual assessment was highly consistent with the results obtained by quantitative analysis and showed a substantial inter-rater agreement between experienced and inexperienced raters. Our findings indicate that visual assessment might be a reliable analysis approach for clinical routine.

scholarly journals Quantitation of rCBF by 99mTc-Hexamethylpropyleneamine Oxime Single Photon Emission Computed Tomography Combined with 133Xe CBF

1994 ◽  
Vol 14 (2) ◽  
pp. 353-357 ◽  
Author(s):  
Yoshinari Isaka ◽  
Yoshihito Itoi ◽  
Masatoshi Imaizumi ◽  
Keiichi Ashida ◽  
Masaya Okamoto ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Mean Flow ◽  
Single Photon Emission ◽  
Whole Brain ◽  
Emission Computed ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

A simple, noninvasive method of measuring CBF that uses single photon emission computed tomography (SPECT) of 99mTc-hexamethylpropyleneamine oxime (99mTc-HMPAO) and whole-brain CBF obtained by 133Xe clearance technique was developed. SPECT data were normalized to the count density of HMPAO uptake in the whole brain and then converted to the absolute units of CBF by multiplying average CBF in the whole brain obtained by 133Xe. Mean CBF values in healthy volunteers (n = 12) were 49 ± 7 and 30 ± 5 ml 100 g−1 min−1 for gray matter and white matter, respectively, with a global flow value of 45 ± 5 ml 100 g−1 min−1. The mean flow value was 19 ± 7 ml 100g−1 min−1 for the core of the infarct and 31 ± 5 ml 100 g−1 min−1 for the contralateral region (n = 13). CBF values were reproducible for all brain regions. The method was convenient to use and suitable for the routine measurement of regional CBF in normal and pathologic states.

scholarly journals Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain

2011 ◽  
Vol 32 (1) ◽  
pp. 190-198 ◽  
Author(s):  
Benjamin H Brinkmann ◽  
David T Jones ◽  
Matt Stead ◽  
Noojan Kazemi ◽  
Terence J O'Brien ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Statistical Parametric Mapping ◽  
Emission Computed Tomography ◽  
Normal Brain ◽  
Neurologic Disease ◽  
Parametric Mapping ◽  
Hmpao Spect ◽  
Neurologic Disorders ◽  
History Of

Tc-99m ethyl cysteinate diethylester (ECD) and Tc-99m hexamethyl propylene amine oxime (HMPAO) are commonly used for single-photon emission computed tomography (SPECT) studies of a variety of neurologic disorders. Although these tracers have been very helpful in diagnosing and guiding treatment of neurologic disease, data describing the distribution and laterality of these tracers in normal resting brain are limited. Advances in quantitative functional imaging have demonstrated the value of using resting studies from control populations as a baseline to account for physiologic fluctuations in cerebral perfusion. Here, we report results from 30 resting Tc-99m ECD SPECT scans and 14 resting Tc-99m HMPAO scans of normal volunteers with no history of neurologic disease. Scans were analyzed with regions of interest and with statistical parametric mapping, with comparisons performed laterally (left vs. right), as well as for age, gender, and handedness. The results show regions of significant asymmetry in the normal controls affecting widespread areas in the cerebral hemispheres, but most marked in superior parietotemporal region and frontal lobes. The results have important implications for the use of normal control SPECT images in the evaluation of patients with neurologic disease.

scholarly journals Frontal assessment battery and brain perfusion imaging in Alzheimer's disease

2012 ◽  
Vol 24 (6) ◽  
pp. 994-1001 ◽  
Author(s):  
Etsuko Oshima ◽  
Seishi Terada ◽  
Shuhei Sato ◽  
Chikako Ikeda ◽  
Shigeto Nagao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Single Photon ◽  
Photon Emission ◽  
Statistical Parametric Mapping ◽  
Brain Perfusion ◽  
University Hospital ◽  
Emission Computed Tomography ◽  
Frontal Assessment Battery ◽  
Assessment Battery

ABSTRACTBackground: The frontal assessment battery (FAB) is reported to be a useful tool for assessing frontal dysfunction. However, the neural substrates involved in patients with Alzheimer's disease (AD) remain to be elucidated. The aim of the present study was to identify the regional perfusion patterns of the brain associated with performance scores on the FAB of patients with AD using brain perfusion assessed by single photon emission computed tomography (SPECT).Methods: Twenty-four AD patients with high scores and 24 age- and sex-matched AD patients with low scores on the FAB were selected from 470 consecutive Japanese patients of the Memory Clinic of Okayama University Hospital. All 48 participants underwent brain SPECT with 99mTc-ethylcysteinate dimer, and the SPECT images were analyzed by statistical parametric mapping.Results: No significant differences were found between high and low FAB scoring groups with respect to Addenbrooke's Cognitive Examination scores, Mini-Mental State Examination scores, or the depression score of the Neuropsychiatric Inventory subscale. Compared with patients with high scores on the FAB, AD patients with low scores showed significant hypoperfusion in the left middle frontal gyrus (MFG) and the right superior frontal gyrus (SFG) extending to the left SFG.Conclusion: Our results suggest that functional activity of the SFG and MFG is closely related to the FAB score. The FAB might be a promising strategy to detect early stages of AD with low SFG and MFG function.

scholarly journals Estimation of Cerebral Perfusion Reserve by Blood Oxygenation Level—Dependent Imaging: Comparison with Single-Photon Emission Computed Tomography

2003 ◽  
Vol 23 (1) ◽  
pp. 121-135 ◽  
Author(s):  
Akihiko Shiino ◽  
Yasuo Morita ◽  
Atsushi Tsuji ◽  
Kengo Maeda ◽  
Ryuta Ito ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Blood Oxygenation ◽  
Reserve Capacity ◽  
Emission Computed Tomography ◽  
Cerebrovascular Reserve ◽  
Oxygenation Level ◽  
The Mean ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Measurement of cerebrovascular reserve capacity predicts the risk of ischemic insult in patients with major vessel occlusion. Blood oxygenation level-dependent (BOLD) imaging has the potential to estimate reserve capacity of the cerebral circulation noninvasively based on changes in the signal that reflect differences in the magnetic susceptibility of intravascular oxyhemoglobin and deoxyhemoglobin. The authors examined the feasibility of using the BOLD technique to assess cerebrovascular reserve capacity in patients with cerebrovascular occlusive disease by comparing results with an established method of measuring CBF. Ten patients with severe or complete occlusion of the internal carotid artery were compared with 17 healthy subjects to evaluate regional differences and identify variables that indicate a change in the BOLD signal. Dilation of cerebral vessels was induced by breath holding, and the R2* change was examined with gradient-echo, echo-planar imaging. Before measuring the regional change in the BOLD signal, actual timing of “activated” and “rest” periods was corrected by shifting the phase of a sine-wave template to obtain the largest correlation coefficient. Percent signal change was calculated on a pixel-by-pixel basis and was compared with CBF measured by single-photon emission computed tomography (SPECT) before and after acetazolamide challenge. The degree of impairment and the distribution of impaired areas detected by the BOLD study correlated with the results of SPECT. Overall sensitivity and specificity of the BOLD technique by visual inspection were 100% and 98.4%, respectively. A negative response (decreased CBF) frequently was observed in areas of exhausted reserve capacity, suggesting that a “steal” phenomenon exists. The percent change and the ΔCBF were well correlated ( P < 0.01). The mean percent change in most areas of impaired reserve capacity was more than 2 SD below the mean values in healthy subjects. The present method of semiquantitative BOLD analysis can be used to create a map of the cerebral hemodynamic state. Furthermore, the development of reliable, generally accessible techniques for evaluating cerebral hemodynamics opens the door for clinical studies to monitor and treat patients with compromised reserve. This study is an attempt to develop such analysis.

scholarly journals Quantitative analysis of gated myocardial perfusion SPECT

2018 ◽  
pp. 220-227
Author(s):  
Victor Ploskikh ◽  
Elena Kotina
Keyword(s):  
Quantitative Analysis ◽  
Myocardial Perfusion ◽  
Data Processing ◽  
Single Photon ◽  
Photon Emission ◽  
Myocardial Perfusion Spect ◽  
Mathematical Representation ◽  
Emission Computed Tomography ◽  
Gated Myocardial Perfusion Spect ◽  
Perfusion Spect

The paper considers the problem of gated myocardial perfusion single photon emission computed tomography (SPECT) data processing. An approach to the quantitative analysis of gated myocardial perfusion SPECT data used in software developed in the SPbSU is presented. The article presents and formalizes the complete data processing workflow. All the main tasks of the data processing are considered. Mathematical representation of problem domain objects is presented. A detailed algorithm of the data processing is given. The algorithmis implemented as component of the data processing software suite.

Design study of a Laue lens for nuclear medicine

2015 ◽  
Vol 48 (1) ◽  
pp. 125-137 ◽  
Author(s):  
Gianfranco Paternò ◽  
Valerio Bellucci ◽  
Riccardo Camattari ◽  
Vincenzo Guidi
Keyword(s):  
Nuclear Medicine ◽  
Single Photon ◽  
Photon Emission ◽  
Emission Computed Tomography ◽  
Monte Carlo Code ◽  
Laue Lens ◽  
Transmission Geometry ◽  
Custom Made ◽  
Restricted Region ◽  
Photon Emission Computed Tomography

A Laue lens is an ensemble of crystals capable of focusing, through diffraction in transmission geometry, a fraction of the photons emitted by an X- or γ-ray source onto a small area of a detector. The present study facilitates a thorough understanding of the effect of each system parameter on the efficiency, the resolution and the field of view of the lens. In this way, the structure and the size of the crystals can be set to achieve a compact lens capable of providing a high-resolution image of the radioactivity distribution lying inside a restricted region of a patient's body. As an application, a Laue lens optimized at 140.5 keV, the γ-line emitted by99mTc, has been designed. The lens is composed of ten rings of Ge crystals with curved diffracting planes and focuses the photons onto a detector 50 cm apart from the source with 1.16 × 10−5efficiency and 0.2 mm resolution. The combination of these two important figures of merit makes the proposed device better performing than pinhole single photon emission computed tomography, which is the technique employed for top-resolution images in nuclear medicine. Finally, the imaging capability of the designed lens has been tested through simulations performed with a custom-made Monte Carlo code.

scholarly journals Striatal dopamine D2/3 receptors in medication-naïve schizophrenia: an [123I] IBZM SPECT study

2021 ◽  
pp. 1-9
Author(s):  
Kao Chin Chen ◽  
Yen Kuang Yang ◽  
Oliver D. Howes ◽  
I Hui Lee ◽  
Tzung Lieh Yeh ◽  
...  
Keyword(s):  
Single Photon ◽  
Imaging Techniques ◽  
Photon Emission ◽  
Striatal Dopamine ◽  
Dopamine Synthesis ◽  
Emission Computed Tomography ◽  
Healthy Controls ◽  
Recent Onset ◽  
Significant Difference ◽  
The Mean

Abstract Background The hyper-function of the striatal dopamine system has been suggested to underlie key pathophysiological mechanisms in schizophrenia. Moreover, patients have been observed to present a significant elevation of dopamine receptor availability compared to healthy controls. Although it is difficult to measure dopamine levels directly in humans, neurochemical imaging techniques such as single-photon emission computed tomography (SPECT) provide indirect indices of in vivo dopamine synthesis and release, and putative synaptic levels. Methods We focused on the role of dopamine postsynaptic regulation using [123I] iodobenzamide (IBZM) SPECT. We compared D2/3 receptor availability between 53 healthy controls and 21 medication-naive patients with recent-onset schizophrenia. Result The mean specific striatal binding showed no significant difference between patients and controls (estimated difference = 0.001; 95% CI −0.11 to 0.11; F = 0.00, df = 1, 69; p = 0.99). There was a highly significant effect of age whereby IBZM binding declined with advancing age [estimated change per decade of age = −0.01(binding ratio); 95% CI −0.01 to −0.004; F = 11.5, df = 1, 69; p = 0.001]. No significant correlations were found between the mean specific striatal binding and psychopathological or cognitive rating scores. Conclusions Medication-naïve patients with recent-onset schizophrenia have similar D2/3 receptor availability to healthy controls. We suggest that, rather than focusing exclusively on postsynaptic receptors, future treatments should target the presynaptic control of dopamine synthesis and release.

Sign in / Sign up

Export Citation Format

Share Document