scholarly journals Relationship between Smoking and Concentrations of Some Biochemical Parameters in Blood of Young Smokers

2019 ◽  
pp. 65-70
Author(s):  
Khalid Shaalan Sahab
Keyword(s):  
Cigarette Smoking ◽  
Total Cholesterol ◽  
Biochemical Parameters ◽  
Low Density Lipoprotein ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Total Serum ◽  
Control Group ◽  
Low Density ◽  
Young Smokers

Cigarette smoking is main cause of lung cancer and one of the major causes for cardiovascular problems. Smoking causes changes to some blood contents. The study aimed to identifying the influence of cigarette smoking on concentrations of glucose, total cholesterol, triglycerides, high density lipoprotein (HDL-C), glucose, low density lipoprotein (LDL-C) and bilirubin in blood of young smokers. The study conducted among 30 subjects of young smokers and compared with 20 non-smoker volunteers as control group. The biochemical parameters of blood among all subjects have been determined by using available commercial kits. The results have been showed that the mean of the total serum bilirubin levels were lower in smokers when compared with controls but with significant (P > 0.05). Serum fasting blood glucose (FBG) and total cholesterol (TC) levels were found to be higher in smokers as compared to controls (P ≤ 0.05). The comparison between the estimated levels of triglycerides (TG) and low density lipoprotein-c (LDL-C) in smokers and healthy controls subjects showed no significant increased (P > 0.05). Also there are no significant decrease in levels of HDL-C in smoking subjects as compared to controls Conclusion: The conclusion from results, that smoke of cigarette can influence on biochemical parameters such as glucose, total cholesterol and bilirubin in early stages of smoking and produce a problems to cardiovascular system in early ages.

scholarly journals A study on correlation of lipid profile with body mass index in young adults (18-20 years)

2020 ◽  
Vol 11 (SPL2) ◽  
pp. 102-107
Author(s):  
Gurupavan Kumar Ganta ◽  
Divya D ◽  
Kedari G S R
Keyword(s):  
Physical Activity ◽  
Body Mass Index ◽  
Young Adults ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Biochemical Parameters ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Overweight And Obesity ◽  
Low Density

Overweight and obesity in youth is a worldwide public health problem. Predisposition to obesity starts during the first or second decade of life. Overweight and obesity in adolescents have a substantial effect upon many systems, resulting in clinical conditions such as metabolic syndrome, early atherosclerosis, dyslipidaemia, hypertension and type 2 diabetes mellitus. Our study was done to find the relation between body mass index (BMI) and lipid profile in young adults (18-20 years) and for the correlation between the various parameters. 150 young adults between 18-20 years of age, who gave written voluntary consent were included in the study. BMI was calculated after measuring height and weight along with fasting blood samples for estimation of blood glucose and lipid profile [Total cholesterol, High density lipoprotein (HDL), Low density lipoprotein (LDL), Very low density lipoprotein (VLDL) and triacylglycerol (TGL)] were measured. The data collected was analysed using Statistical package for the social sciences (SPSS) statistics software version 20. A linear correlation regression analysis was done to know the correlation between the anthropometric measurements and biochemical parameters. ANOVA test was performed to know the significance and a p value of < 0.01 was taken as significant. All the biochemical parameters showed a positive correlation with BMI. Total cholesterol had the highest positive correlation with BMI. There was a prevalence of 39.3% overweight/obesity as per BMI cut-off. Individuals who were in the obese category had a higher prevalence of abnormal lipid profile especially total cholesterol. Stress and lack of physical activity have a detrimental effect on health and are a major risk factor for development of obesity. 90% of the students in this study did not have any regular physical activity. Educating the students about effects of obesity and dyslipidaemia on quality of health can help in bringing life style modifications which can help them in the long run.

scholarly journals Blood lipid associations in 18 year-old men

1992 ◽  
Vol 26 (5) ◽  
pp. 316-320 ◽  
Author(s):  
Leonor Poletto ◽  
Stella Pezzotto ◽  
Julio Morini
Keyword(s):  
Physical Activity ◽  
Social Class ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Smoking Habit ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Total Serum ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol

The association of cigarette smoking, physical activity at work, and social class with total cholesterol and with high and low density lipoprotein cholesterol were examined in a random sample of 238 males, of 18 years of age, of Rosario, Argerntina. The mean (mg/dl) total serum cholesterol of the whole sample was 174.7, the high density lipoprotein cholesterol 52.8, and the low density lipoprotein cholesterol 121.5. Black tobacco consumers, evenly distributed by social class, had higher levels of total and low density lipoprotein cholesterol. Total cholesterol was higher in the high social class, differently from what smokers' distribution by social class, would lead one to expect. While a highly negative association was found between social class and physical activity at work, there were no significant diferences in lipoprotein levels between manual and non-manual workers. It is possible that the nutritional differences by social class still prevail over the smoking habit in their influence on the lipoprotein levels in these subjects.

scholarly journals Effect of Magnetic Water on Some Physiological Aspects of Adult Male Rabbits

2012 ◽  
Vol 36 (0E) ◽  
pp. 120-126
Author(s):  
Khalisa Kadim Khudiar
Keyword(s):  
Lipid Profile ◽  
Adult Male ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Total Serum ◽  
Control Group ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Magnetic Water

The present study was undertaken to search out thebeneficial effect of magnetized water on serumantioxidant, lipid profile and total protein of adult male rabbits. Twenty adult male rabbits were randomly divided into two equal groups and were treated daily for 60 days as follows:Group C:Rabbits of this group were allowed to ad libitumsupplyofdrinking water (control group),Group MG:Rabbits of this group were allowed to ad libitum supply of magnetic water.Fasting blood (for 8-12 hrs) samples were drawn by cardiac puncture technique at different times 0, 30 and 60 days of experiment for measuring the following parameters. Serum glutathione concentration (GSH), lipid profile including serum triacylglycerol (TAG), total cholesterol - (TC), high density lipoprotein - cholesterol (HDL-C), low density lipoprotein - cholesterol (LDL-C) and very low density lipoprotein cholesterol - (VLDL-C), total serum protein concentrations (TSP). The result revealed that drinking of magnetic water had beneficial effect on some physiological aspects manifested by a significant elevation in serum GSH, HDL-C and total serum proteins concentration. In addition to significant suppression in serums TC, TAG, LDL-C, and VLDL-C concentrations .In conclusion the results of this study pointed to the prevalence of magnetic water upon normal drinking water in all measures issued.

scholarly journals Dyslipidemia in Psoriasis: A Case - Controlled Study

2021 ◽  
Vol 19 (2) ◽  
pp. 39-43
Author(s):  
Monique Kafle ◽  
Madhu Gyawlee ◽  
Amit Amatya ◽  
Bhaskar Mohan Meher Kayastha ◽  
Smarika Upadhyaya
Keyword(s):  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
High Density ◽  
Controlled Study ◽  
Control Group ◽  
Low Density ◽  
Chronic Inflammatory Condition

INTRODUCTION:  Psoriasis is a chronic inflammatory condition of skin which can be associated with other ailments including dyslipidemia which is an abnormal serum lipid profile. OBJECTIVE: The aim of present study was to determine correlation between dyslipidemia and Psoriasis of patients visiting the Out-patient Department of Patan Hospital METHODS: Ninety patients were selected for study. Among them 30 patients with psoriasis were taken as cases and 60 patients that matched for age and sex with Psoriasis patients were taken as controls. The lipid profile that comprised four parameters: serum High-density Lipoprotein, Low-density Lipoprotein, Total Cholesterol and Triglyceride were determined and compared for both case and control groups. RESULTS: More than 95% of the psoriatic patients had dyslipidemia. The odds of dyslipidemia among Psoriatic patients were 1.709 times higher compared to control group (p <0.001). Among the parameters, results showed High-density lipoprotein was significantly lower while Triglyceride was significantly higher among the cases compared to controls with p value of 0.012 and 0.001 respectively. The risk factors like smoking and alcohol were present in higher proportions among the patients with dyslipidemia but it failed to reach statistical significance. With increase in duration of Psoriasis and PASI scores, lipid parameters i.e., Total cholesterol, triglyceride and Low-density lipoprotein increased while High density lipoprotein decreased but this correlation was insignificant. CONCLUSION: This study showed Dyslipidemia is significantly higher among patients with Psoriasis especially lipid profile parameters Triglyceride and total cholesterol. Thus, timely screening and management of dyslipidemia among Psoriatic patients might be helpful in prevention of future cardiovascular events.

scholarly journals Association of Dyslipidemia and Hyperhomocysteinemia in epileptic patients on carbamazepine monotherapy.

2020 ◽  
Vol 27 (02) ◽  
pp. 230-236 ◽  
Author(s):  
Shazia Bano ◽  
Syed Munawar Alam ◽  
Saima Iram
Keyword(s):  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Carbamazepine Therapy ◽  
Epileptic Patients

Objectives: To observe the association between dyslipidemia and homocysteine level in epileptic patients; especially on carbamazepine monotherapy. Study Design: Cross sectional study. Setting: Neurology Department and Epilepsy Centre of Jinnah Post Graduate Medical Centre, Karachi. Period: From January 2015 – January 2016. Material & Methods: Total 300 subjects, aged more than 15 years were included and divided into three groups.  Group A (100 healthy individuals) was control group, Group B (100 newly diagnosed epileptic patients without antiepileptic therapy), Group C (100 epileptic patients on Carbamazepine therapy, which was further subdivided into C-I (n=33) had epileptic patients on Carbamazepine therapy less than 1 year, C-II (n=33) comprised of epileptic patients on Carbamazepine therapy 1-2 years and C-III (n=33) had epileptic patients on Carbamazepine therapy more than 2 years. Serum lipid profile and homocysteine levels were measured. Results: In patients with different durations of carbamazepine monotherapy; a noteworthy incremental trend in the levels of homocysteine, total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol was observed. Homocysteine was found positively correlated with total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol. Conclusion: In our study dyslipidemia was associated with hyperhomocysteinemia, which in turn was correlated with atherosclerosis in CBZ treated epileptic patients.

scholarly journals PCSK9 immunization using nanoliposomes: preventive efficacy against hypercholesterolemia and atherosclerosis

2021 ◽  
Vol 17 (5) ◽  
pp. 1365-1377
Author(s):  
Amir Abbas Momtazi-Borojeni ◽  
Mahmoud Reza Jaafari ◽  
Mohammad Afshar ◽  
Maciej Banach ◽  
Amirhossein Sahebkar
Keyword(s):  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Th2 Cells ◽  
Control Group ◽  
Low Density ◽  
Humoral Immune ◽  
Novel Approach ◽  
Density Lipoprotein Receptor

IntroductionThe aim of the study was to study a nanoliposomal anti-PCSK9 vaccine as a novel approach for cholesterol lowering via PCSK9 inhibition.Material and methodsAn immunogenic peptide construct termed immunogenic fused PCSK9-tetanus (IFPT) was displayed on the surface of liposome nanoparticles (L-IFPT) and mixed into alum adjuvant (L-IFPTA+). The manufactured vaccine formulations IFPT, L-IFPT, L-IFPTA+, IFPTA+, and free nanoliposomes were subcutaneously injected four times with bi-weekly intervals in C57BL/6 mice on a severe atherogenic protocol.ResultsAmong the formulations, L-IFPTA+ vaccine was found to elicit the highest IgG response against PCSK9 peptide. The induced PCSK9 antibodies inhibited PCSK9-LDLR interaction through binding to PCSK9 in vaccinated mice. Liver low-density lipoprotein receptor (LDLR) protein was increased in vaccinated mice. L-IFPTA+, L-IFPT and IFPTA+ vaccines reduced total cholesterol by up to –38.13 ±3.8% (p = 0.006), –23 ±4.1% (p = 0.027) and –19.12 ±3% (p = 0.038), and low-density lipoprotein cholesterol (LDL-C) by up to –57 ±7.7% (p = 0.0003), –41.67 ±4.2% (p = 0.03) and –36.11 ±5% (p = 0.02) in hypercholesterolemic mice, respectively, versus control mice after 8 weeks. Long-term assessment indicated that the vaccine formulations could stimulate a long-lasting humoral immune response against PCSK9 peptide, which was associated with a marked reduction of total cholesterol in L-IFPTA+, L-IFPT and IFPTA+ vaccine groups by up to –82.5 ±7.3% (p = 0.002), –70.54 ±6.2% (p = 0.013) and –72.02 ±8.7% (p = 0.004), respectively, and LDL-C by up to –88.14 ±5.6% (p = 0.002), –55.92 ±8.3% (p = 0.003) and 54.81 ±9.3% (p = 0.003), respectively, versus the pre-vaccination time point adjusted to the control group. Anti-inflammatory Th2 cells and IL-4 cytokine were considerably increased in splenocytes of vaccinated mice.ConclusionsL-IFPTA+ vaccine can induce long-lasting, functional and safe PCSK9-specific antibodies in hypercholesterolemic C57BL/6 mice, providing a long-term protective impact on dyslipidemia and atherosclerosis.

scholarly journals Association of Dyslipidemia and Hyperhomocysteinemia in epileptic patients on carbamazepine monotherapy.

2020 ◽  
Vol 27 (02) ◽  
pp. 230-236
Author(s):  
Shazia Bano ◽  
Syed Munawar Alam ◽  
Saima Iram
Keyword(s):  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Carbamazepine Therapy ◽  
Epileptic Patients

Objectives: To observe the association between dyslipidemia and homocysteine level in epileptic patients; especially on carbamazepine monotherapy. Study Design: Cross sectional study. Setting: Neurology Department and Epilepsy Centre of Jinnah Post Graduate Medical Centre, Karachi. Period: From January 2015 – January 2016. Material & Methods: Total 300 subjects, aged more than 15 years were included and divided into three groups.  Group A (100 healthy individuals) was control group, Group B (100 newly diagnosed epileptic patients without antiepileptic therapy), Group C (100 epileptic patients on Carbamazepine therapy, which was further subdivided into C-I (n=33) had epileptic patients on Carbamazepine therapy less than 1 year, C-II (n=33) comprised of epileptic patients on Carbamazepine therapy 1-2 years and C-III (n=33) had epileptic patients on Carbamazepine therapy more than 2 years. Serum lipid profile and homocysteine levels were measured. Results: In patients with different durations of carbamazepine monotherapy; a noteworthy incremental trend in the levels of homocysteine, total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol was observed. Homocysteine was found positively correlated with total cholesterol, triglyceride, low density lipoprotein cholesterol, very low density lipoprotein cholesterol. Conclusion: In our study dyslipidemia was associated with hyperhomocysteinemia, which in turn was correlated with atherosclerosis in CBZ treated epileptic patients.

Cholesterol Ester Transfer Protein in Children on Peritoneal Dialysis

2004 ◽  
Vol 24 (3) ◽  
pp. 281-286 ◽  
Author(s):  
Yuriko Tanaka ◽  
Takeshi Matsuyama ◽  
Kenji Ishikura ◽  
Hiroshi Hataya ◽  
Masahiro Ikeda ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Serum Albumin ◽  
Total Cholesterol ◽  
Patient Group ◽  
Cholesterol Ester ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Transfer Protein

Objectives To examine whether cholesterol ester transfer protein (CETP) activity and mass contribute to dyslipidemia in children on peritoneal dialysis (PD), and to determine whether CETP activity or mass is responsible for severer hyperlipidemia in smaller (younger) patients. Study Design 27 patients (18 males, 9 females; mean age 11.8 ± 6.1 years) were enrolled. Each patient had been receiving PD for more than 6 months. Fasting blood samples were drawn and CETP activity, CETP mass, total cholesterol, triglyceride, β-lipoprotein profiles, lipoprotein lipid profiles (cholesterol and triglyceride in lipoproteins), apoprotein profile, and serum albumin levels were measured. The results were then compared, using Student's t-test, with those for a control group. In the patient group, the relationships between CETP activity and each factor were examined using simple and multiple regression analyses. Results Total cholesterol, triglyceride, low-density lipoprotein (LDL), very low-density lipoprotein (VLDL), chylomicron, and ApoB levels were significantly higher in the patient group. Mean CETP activity levels were 106% ± 24% in the patient group and 111% ± 21% in the control group. No significant difference in CETP activity was seen between the two groups, but CETP mass was lower in the patient group than in the control group (2.2 ± 0.6 μL/dL for the patient group vs 2.8 ± 0.9 μL/dL for the control group, p = 0.01). As a result, specific CETP activity (activity/protein mass ratio) was significantly higher in the patient group ( p < 0.0001). CETP activity was positively related to LDL and other atherogenic factors and negatively related to serum albumin level. No relationship between CETP activity and patient body weight was seen. Conclusion Specific CETP activity was higher in the patient group compared with that in the control group, and strong correlations were found between CETP activity and atherogenic factors in the patient group. Therefore, CETP seems to be associated with lipid abnormalities in children on PD but is not responsible for the severer hyperlipidemia seen in smaller children.

scholarly journals Lipid Profile and Electrolyte Imbalance are Associated with Diabetic Retinopathy in Bangladeshi Population

2020 ◽  
Vol 8 (3) ◽  
Author(s):  
Md. Golam Kabir ◽  
Deaniel Hossain ◽  
Suman Mohajan ◽  
Monsor Rahman
Keyword(s):  
Risk Factors ◽  
Diabetic Retinopathy ◽  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Electrolyte Imbalance ◽  
Control Group ◽  
Low Density

Background: Diabetic retinopathy (DR) is a micro-vascular complication which is the main cause of blindness among people with Diabetes Mellitus. Identification and mitigation of the risk factors associated with DR will help to reduce the visual disability in diabetic subjects. Aims and objective: The study has been undertaken to explore the association of lipids profile and electrolytes with the diabetic retinopathy in Bangladeshi type 2 diabetic subjects. Material and methods: In the present study, 63 people diabetic with retinopathy (DR) and 80 people diabetic without retinopathy (DWR) were studied along with 92 healthy controls without family history diabetes and prediabetes. Anthropometric parameters, glucose, triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, glycosylated haemoglobin (HbA1c) and electrolytes Na+, K+, Cl-, HCO3- were measured by standard methods.   Results: HbA1c of DWR group and DR group were 8.60±1.17 and 11.80±1.63 respectively. Total cholesterol, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c) were significantly higher (p<0.001) in both DWR and DR group compared to the healthy control. Triglyceride was significantly (p<0.001) higher in the DR group but no difference was found in DWR compared to the control group. K+ was significantly increased in the DR group. Na+, Cl-, HCO3- were significantly decreased in the DR group compared to control group. Conclusion: These results indicate that diabetic retinopathy patients exhibit dyslipidemia and electrolyte imbalance. Hypertriglyceridemia along with electrolyte imbalance is one the major risk factors toward the progression of diabetic retinopathy.

Effect of Turmeric and Ginger on Lipid Profile in Male Rats Exposed to Oxidative Stress

2019 ◽  
Vol 10 (01) ◽  
Author(s):  
Eman A. Al-Rekabi ◽  
Dheyaa K. Alomer ◽  
Rana Talib Al-Muswie ◽  
Khalid G. Al-Fartosi
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Drinking Water ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Male Rats ◽  
Control Group ◽  
Very Low Density Lipoprotein ◽  
Low Density

The present study aimed to investigate the effect of turmeric and ginger on lipid profile of male rats exposed to oxidative stress induced by hydrogen peroxide H2O2 at a concentration of 1% given with consumed drinking water to male rats. Methods: 200 mg/kg from turmeric and ginger were used, and the animals were treatment for 30 days. Results: the results showed a significant increase in cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipoprotein (VLDL), whereas it explained a significant decrease in high density lipoprotein (HDL) of male rats exposed to oxidative stress when compared with control group. the results showed a significant decrease in cholesterol, triglycerides, (LDL), (VLDL), whereas it explained a significant increase in (HDL) of rats treated with turmeric and ginger at dose 200 mg/kg when compared with male rats exposed to oxidative stress.

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