scholarly journals COMPARATIVE ANALYSIS OF THE RESULTS RECEIVED IN THE PAIN EFFECTS SCALE IN WOMEN WITH MULTIPLE SCULPROSIS

2018 ◽  
Vol 28 (2) ◽  
pp. 519-523
Author(s):  
Inna Mincheva Ivanova
Keyword(s):  
Multiple Sclerosis ◽  
Statistical Significance ◽  
Pain Syndrome ◽  
Chronic Fatigue ◽  
The Body ◽  
Final Study ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
The Individual ◽  
Multiple Sclerosis Patients

Multiple sclerosis (MS) is one of the most common diseases of the central nervous system (CNS), one of the biggest puzzles in medicine. A number of drugs and therapies have been developed that affect the symptoms or change the severity and frequency of the seizures. Multiple sclerosis is of great social and economic importance to the world, due to the great invasion at early age. It affects the "young adults" in their creatively active period - between 10 and 50 years of age. Contrary to most allegations that pain is absent in MS patients, this is not the case. In the first periods of the disease, pain is almost absent, apart from the periodic manifestation of cramps, perceptions and all types of pain in the body, which at night interfere with sleep, provoke chronic fatigue and irritability (as they themselves have other mechanisms leading to the event their). However, some studies show that pain persists more frequently in women than in men. In most cases, disabling and immobilizing patients is exalted by their attempts to avoid pain. Physiotherapy is a basic tool for maintaining and improving the general condition of the patient. The study involved 22 patients with relapsing-remitting MS. The survey was conducted on the territory of Sofia - NSA "Vasil Levski", in the period from 01.09.2013 to 30.10.2015. The pain syndrome was evaluated in multiple sclerosis patients, at the beginning, the 10th procedure and the last procedure. For each patient in the experimental group, 20 procedures were performed within 10 weeks. The duration of the individual activity was 1 hour. The procedures for hippotherapy were a total of 16, each lasting 30 minutes. After the completion of the 10-week Physiotherapy program, each of the patients continues the hippotherapy courses on the Khan Asparuh horse base. The therapeutic program we have prepared and tested includes the following: Exercise with a large therapeutic ball (fitball); proprioceptive neuromuscular facilitation (PNF); myofascial techniques (MFT); autogenous training (AT); hippo therapy (HT). During the study, the subsequent results showed a significant decrease in pain in the tested group. At the end of the study, the improvement of the indicators from the initial to the final study were seen. The statistical significance is less than or equal to 0.01, with the possibility of error being minimal. From the conclusions, it can be said that the methodology thus performed brings great positives in terms of pain reduction in women with multiple sclerosis who participated in the study.

COMPARATIVE ANALYSIS OF THE RESULTS RECEIVED IN THE PAIN EFFECTS SCALE IN MEN WITH MULTIPLE SCULPROSIS

2018 ◽  
Vol 28 (2) ◽  
pp. 525-530
Author(s):  
Inna Mincheva Ivanova
Keyword(s):  
Multiple Sclerosis ◽  
Statistical Significance ◽  
Pain Syndrome ◽  
Chronic Fatigue ◽  
The Body ◽  
Final Study ◽  
The Central Nervous System ◽  
Male Patients ◽  
The Individual ◽  
Multiple Sclerosis Patients

Multiple sclerosis (MS) is one of the most common diseases of the central nervous system (CNS), one of the biggest puzzles in medicine. A number of drugs and therapies have been developed that affect the symptoms or change the severity and frequency of the seizures. Multiple sclerosis is of great social and economic importance to the world, due to the great invasion at early age. It affects the "young adults" in their creatively active period - between 10 and 50 years of age. Contrary to most allegations that pain is absent in MS patients, this is not the case. In the first periods of the disease, pain is almost absent, apart from the periodic manifestation of cramps, perceptions and all types of pain in the body, which at night interfere with sleep, provoke chronic fatigue and irritability (as they themselves have other mechanisms leading to the event their). However, some studies show that pain persists more frequently in women than in men. In most cases, disabling and immobilizing patients is exalted by their attempts to avoid pain. Physiotherapy is a basic tool for maintaining and improving the general condition of the patient. The study involved 18 male patients with relapsing-remitting MS. The survey was conducted on the territory of Sofia - NSA "Vasil Levski", in the period from 01.09.2013 to 30.10.2015. The pain syndrome was evaluated in multiple sclerosis patients, at the beginning, the 10th procedure and the last procedure. For each patient in the experimental group, 20 procedures were performed within 10 weeks. The duration of the individual activity was 1 hour. The procedures for hippotherapy were a total of 16, each lasting 30 minutes. After the completion of the 10-week Physiotherapy program, each of the patients continues the hippotherapy courses on the Khan Asparuh horse base. The therapeutic program we have prepared and tested includes the following: Exercise with a large therapeutic ball (fitball); proprioceptive neuromuscular facilitation (PNF); myofascial techniques (MFT); autogenous training (AT); hippo therapy (HT). During the study, the subsequent results showed a significant decrease in pain in the tested group. At the end of the study, the improvement of the indicators from the initial to the final study were seen. The statistical significance is less than or equal to 0.01, with the possibility of error being minimal. From the conclusions, it can be said that the methodology thus performed brings great positives in terms of pain reduction in women with multiple sclerosis who participated in the study.

Cold-induced reactivity in multiple sclerosis patients

2017 ◽  
pp. 56-62 ◽  
Author(s):  
Л.И. Герасимова-Мейгал ◽  
И.М. Сиренев
Keyword(s):  
Multiple Sclerosis ◽  
Cold Test ◽  
Typical Feature ◽  
Humid Climate ◽  
Ssr Analysis ◽  
Epidemiological Surveys ◽  
The Central Nervous System ◽  
The Individual ◽  
Hands And Feet ◽  
Multiple Sclerosis Patients

Цель исследования - изучение особенностей восприимчивости пациентов с рассеянным склерозом (РС) к холодовому воздействию с помощью функциональных тестов, характеризующих функцию терморегуляции. Как известно, РС - хроническое прогрессирующее аутоиммунное заболевание центральной нервной системы мультифакториальной природы, более часто встречающееся в регионах с холодным и влажным климатом. Нарушения терморегуляции вследствие автономной дисфункции являются характерным признаком РС, вместе с тем участию холодового фактора в развитии заболевания не придается существенного значения. Методика. Обследовано 32 пациента (17 мужчин и 15 женщин, средний возраст 29,6 ± 4,2 года) с установленным диагнозом: РС ремиттирующе-рецидивирующая форма течения (средняя продолжительность заболевания - 4,2 ± 2,7 года) и 18 практически здоровых лиц группы сравнения. Восприятие холода оценивали с помощью визуально-аналоговой шкалы. Продолжительность холод-индуцированной вазоконстрикции после локального холодового теста изучали по данным инфракрасной термометрии. Вегетативную регуляцию вазомоторных реакций оценивали по результатам анализа вызванных кожных вегетативных потенциалов (ВКВП). Результаты. На основе анализа самооценки восприятия холода у пациентов с РС показана низкая переносимость холодового фактора. При проведении локального холодового теста отмечено замедление восстановления температуры кожи кисти, что характерно для усиления холод-индуцированной вазоконстрикции. В группе пациентов с РС выявлено снижение параметров ВКВП ладоней и стоп, свидетельствующее о дефиците нейрогенного контроля терморегуляционных сосудистых реакций. Заключение. У пациентов с РС выявлены нарушения механизмов терморегуляции при действии холода, что обусловливает высокую индивидуальную восприимчивость к холоду у данной категории лиц. Сопоставление результатов анализа механизмов индивидуальной холод-индуцированной реактивности у пациентов с РС с данными эпидемиологических исследований приводит к заключению о потенциальном модулирующем влиянии холодового фактора на течение РС. The purpose of the present study was focused on the evaluation of the sensitivity to cold in multiple sclerosis (MS) patients by means of functional thermoregulatory based tests. MS is known to be a chronic autoimmune progressive disease of the central nervous system of multifactor origin that is very common in regions with cold and humid climate. Disorder of thermoregulation caused by autonomic dysfunction is a typical feature of MS, however the role of the cold in the disease development is still underestimated. Methods. Thirty two MS patients (17 males, 15 females, mean age 29,6 ± 4,2 years) with the remittent form of the disease (mean disease duration 4,2 ± 2,7 years) and 18 age-matched healthy controls volunteered to participate in this study. Susceptibility to cold was analyzed with the use of visual-analogous scale. The duration of cold-induced vasoconstriction after local cold test was estimated using by infrared thermometry. Autonomic regulation of vasomotor reactions was investigated with the help of the skin sympathetic response (SSR) analysis. Results. The analysis of self-reported perception of the cold in MS patients showed their low tolerance to cold. Slow recovery of the skin temperature of the hand in the local cold test observed in MS patients was considered as the aggravated cold-induced vasoconstriction. The decreased SSR in the hands and feet in MS patients was found that indicates the deficit of the neurogenic control of thermoregulatory vasomotor reactions. Conclusion. The results obtained demonstrate the impairment of thermoregulation under cold in MS patients that leads to higher individual susceptibility to cold of this group. Comparing of the data found in this study on the mechanisms of the individual cold-induced reactivity in MS patients with epidemiological surveys enable to conclude that cold environment has potential modulating effect of on the course of MS.

Biological markers in body fluids for activity and progression in multiple sclerosis

1999 ◽  
Vol 5 (4) ◽  
pp. 287-290
Author(s):  
Per Soelberg Sùrensen
Keyword(s):  
Multiple Sclerosis ◽  
Disease Activity ◽  
Biological Markers ◽  
Body Fluids ◽  
Therapeutic Effects ◽  
Therapeutic Decisions ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
The Individual ◽  
Relapsing Remitting Multiple Sclerosis

Reliable biological markers in body fluids for disease activity and progression are important for our understanding of the pathophysiology and therapeutic decisions in various subtypes of multiple sclerosis. Sampling from body fluids such as cerebrospinal fluid, blood, and urine constitutes the problem that the local immuno-inflammatory process takes place in the central nervous system whereas the disease activity is only to some extent reflected in the systemic immune compartment. Promising results have been obtained in studies of adhesion molecules, pro-inflammatory cytokines, co-stimulatory molecules and neopterin as markers of disease activity in relapsing-remitting multiple sclerosis. However, these results apply to groups of patients but not necessarily to individual patients. Currently no single body fluid marker is sufficiently correlated to disease activity to be used in the individual patient in monitoring disease activity, progression, or therapeutic effects.

scholarly journals Fingolimod Regulates BDNF-AS and HOTAIR Expression in Multiple Sclerosis Patients

2021 ◽  
Author(s):  
Fatemeh khani Habibabadi ◽  
Mohammad Ali Sahraian ◽  
Mohammad Javan ◽  
Mehrdad Behmanesh
Keyword(s):  
Multiple Sclerosis ◽  
Antisense Rna ◽  
In Silico ◽  
Bdnf Expression ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
Remitting Multiple Sclerosis ◽  
Multiple Sclerosis Patients ◽  
Regulatory Functions ◽  
Relapsing Remitting Multiple Sclerosis

Objective: Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, is expressed by neurons and glial cells in the central nervous system (CNS). In the CNS, BDNF is responsible for neuroprotection and neurogenesis. Recent studies showed that the Fingolimod, the first oral medicine for relapsing-remitting multiple sclerosis (RR-MS), induces BDNF expression. Besides, It is well demonstrated that long noncoding RNAs (lncRNAs) have a pivotal role in gene regulation. This study is mainly focused on how Fingolimod treatment plays role in BDNF regulation in coordination with lncRNAs. Methods: An in-silico study was performed to predict BDNF-regulatory candidate lncRNAs using online tools. Then, the expression of BDNF-related lncRNAs was analyzed in patients with relapsing-remitting multiple sclerosis (RRMS) at baseline and after three months of Fingolimod treatment. Results: Based on in silico results, two lncRNAs with potential regulatory functions on the BDNF including, Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) and HOX Transcript Antisense RNA (HOTAIR), and also natural antisense of BDNF were selected. Fingolimod treatment increased the expression of HOTAIR lncRNA; however, the BDNF antisense RNA (BDNF-AS) expression was reduced dramatically. Furthermore, the results indicate a positive correlation between HOTAIR and MALAT1 lncRNAs and BDNF. Also, after Fingolimod treatment, the patients' EDSS scores were declined or remained unchanged, indicating disease hindrance by Fingolimod therapy. Conclusion: Altogether, fingolimod exerts protective roles in RRMS patients probably by the mediation of HOTIAR and BDNF-AS lncRNAs.

An MRI study of Chlamydia pneumoniae infection in Italian multiple sclerosis patients

2003 ◽  
Vol 9 (5) ◽  
pp. 467-471 ◽  
Author(s):  
L ME Grimaldi ◽  
A Pincherle ◽  
F Martinelli-Boneschi ◽  
M Filippi ◽  
F Patti ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Chlamydia Pneumoniae ◽  
Neurological Diseases ◽  
Disease Onset ◽  
Progressive Multiple Sclerosis ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
Magnetic Resonance Imaging Mri ◽  
Multiple Sclerosis Patients ◽  
Mri Study

We amplified sequences of the Chlamydia pneumoniae (C P) major-outer membrane protein in the cerebrospinal fluid (CSF) from 23 of 107 (21.5%) relapsing-remitting or secondary progressive multiple sclerosis (MS) patients and two of 77 (2.6%) patients with other neurological diseases (OND) (P =0.00022). C P+ patients showed magnetic resonance imaging (MRI) evidence of more active disease (P =0.02) compared to CP-MS patients and tended to have an anticipation of age at disease onset (32.39-12 versus 28.59-10 years; P =ns) causing a longer disease duration (7.59-5 versus 4.49-4 years; P =0.016) at the time of clinical evaluation. These findings, although indirectly, suggest that C P infection of the central nervous system (C NS) might affect disease course in a subgroup of MS patients.

scholarly journals Visual Field Changes in Multiple Sclerosis

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
D E A Mansour ◽  
A M E Abdelhamid ◽  
S S M Fahmy
Keyword(s):  
Multiple Sclerosis ◽  
Visual Field ◽  
Demyelinating Disease ◽  
Visual Field Loss ◽  
University Hospitals ◽  
Mcdonald Criteria ◽  
International Panel ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
Multiple Sclerosis Patients

Abstract Background multiple sclerosis (MS) is a demyelinating disease of the central nervous system and the leading cause of disability in young adults. Afferent pregeniculate visual pathways (retina, optic nerves, chiasm, and tracts) are preferential targets of inflammation, demyelination, and axonal degeneration. Aim of the Work in our study was to find and correlate visual field findings in multiple sclerosis patients with clinical data. Patients and Methods this study included 30 eyes of 17 patients previously diagnosed as multiple sclerosis according to the international panel on diagnosis of MS (McDonald criteria 2001) and its revision by Polman etal 2005. All our cases were from both sexes and of different age group ranging from 18 years old to 51 years old. there were subtypes of MS included in our study which were relapsing remitting (RR), and secondary progressive (SP). All cases were from Ain-shams university hospitals, outpatient clinics. Results this study was conducted in Ain-shams university hospitals out-patient clinics, it included 17 patients previously diagnosed as MS. The age in our study was ranging from 18 to 51 years old with mean age of 33.67± 9.37.Our cases were from both sex with prevelance of female patients. Conclusion these findings illustrate the role of perimetry in detecting both clinically overt & and clinically occult optic nerve involvement in patients with MS. It quantifies the depth of visual field loss, identifies atypical cases of optic neuritis, aids in counseling patients about prognosis.

scholarly journals Altered cortical phase- and amplitude-coupling in Multiple Sclerosis

2021 ◽  
Author(s):  
Marcus Siems ◽  
Johannes Tünnerhoff ◽  
Ulf Ziemann ◽  
Markus Siegel
Keyword(s):  
Multiple Sclerosis ◽  
Large Scale ◽  
Demyelinating Disease ◽  
Disease Stage ◽  
Functional Changes ◽  
Non Invasive ◽  
Relapsing Remitting ◽  
The Central Nervous System ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis

AbstractMultiple Sclerosis is a demyelinating disease of the central nervous system that can result in cognitive decline and physical disability. However, related functional changes in large-scale brain interactions remain poorly understood and corresponding non-invasive biomarkers are sparse. Here, we measured magnetoencephalography in 17 relapsing-remitting Multiple Sclerosis patients at an early disease stage (median EDSS = 1.5, range 0 to 3.5) and 17 healthy controls to investigate brain-wide phase- and amplitude-coupling of frequency specific neuronal activity. We developed a new analysis approach that combines dimensionality reduction, bootstrap aggregating and multivariate classification to identify changes of brain-wide coupling in Multiple Sclerosis. We identified systematic and non-redundant changes of both phase- and amplitude-coupling. Changes included both, increased and decreased neuronal coupling in wide-spread, bilateral neuronal networks across a broad range of frequencies. These changes allowed to successfully classify patients and controls with an accuracy of 84%. Furthermore, classification confidence predicted behavioral scores of disease severity. Our results unravel systematic changes of large-scale neuronal coupling in Multiple Sclerosis and suggest non-invasive electrophysiological coupling measures as powerful biomarkers of Multiple Sclerosis.

The norepinephrine level is decreased in the lymphocytes of long-term interferon-beta-treated multiple sclerosis patients

2006 ◽  
Vol 12 (3) ◽  
pp. 265-270 ◽  
Author(s):  
C Rajda ◽  
K Bencsik ◽  
J Füvesi ◽  
E Seres ◽  
L Vécsei ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Peripheral Blood Lymphocytes ◽  
Stable Phase ◽  
Norepinephrine Level ◽  
Group Interactions ◽  
Relapsing Remitting ◽  
The Individual ◽  
Multiple Sclerosis Patients ◽  
Relapsing Remitting Multiple Sclerosis

The mutual involvement of dopamine and its metabolites in the nervous and immune systems has the potential to provide information on the interaction of these two systems. During a 24-hour period, we used capillary electrophoresis with electrochemical detection to repeatedly measure the intracellular catecholamine concentrations in the peripheral blood lymphocytes of relapsing-remitting multiple sclerosis (RRMS) patients receiving interferon (IFN)-beta-1b ( n = 13), and those of IFN-naïve RRMS patients receiving their first IFN-beta-1a injection ( n = 19) during this study, and compared them with the levels in healthy controls ( n = 12). At baseline, the norepinephrine level was significantly decreased ( P = 0.003) in the long-term IFN MS patients compared with the controls. The Time × Group interactions for dopamine ( P= 0.5854) and norepinephrine ( P = 0.6192) were not significant. The group effects for the individual drugs were P = 0.3529 and 0.1282, respectively. The lower norepinephrine level at baseline in the long-term IFN MS group suggests an immunologically stable phase, in line with our previous findings. This is the first report of the effects of IFN-beta administration on intracellular catecholamines in MS patients. Further studies are necessary to elucidate the immune reactions affected by the catecholamines in MS and to evaluate the roles of these potential immunotransmitters.

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