scholarly journals Pengaruh Pemberian Salep Fraksi Etil Asetat Daun Jambu Biji (Psidium guajava) terhadap Luka Bakar Pada Mencit Putih (Mus musculus L.)

2021 ◽  
Vol 3 (1) ◽  
pp. 23-34
Author(s):  
M. Eko Pranoto
Keyword(s):  
Mus Musculus ◽  
Psidium Guajava

Jambu biji (Psidium guajava L.) merupakan salah satu bahan alam yang banyak tersebar. Daun jambu biji diteliti memiliki khasiat terhadap percepatan penyembuhan luka. Fraksi etil asetat kstrak daun jambu biji terbukti memiliki aktivitas penyembuhan luka yang lebih baik dibandingkan fraksi air, fraksi etanol maupun n-heksan. Etil asetat sebagai pelarut semi polar diasumsikan mampu menarik senyawa yang sifatnya relative polar maupun non polar. Ekstrak yang potensial perlu untuk diformulasikan menjadi bentuk sediaan yang mudah untuk diaplikasikan, memberikan efek perlindungan dan menstabilkan senyawa. Salep diformulasikan menggunakan basis adeps lanae dan vaselin album. Efek penyembuhan luka diujikan terhadap luka bakar pada mencit yang diberi perlakuan salep 5%, 10%, kontrol negatif dan kontrol positif. Pengujian dilakukan selama 14 hari dengan mengukur pengurangan diameter pada luka. Data hasil pengujian diolah menggunakan ANOVA dan menunjukkan adanya perbedaan yang berarti diantara kelompok pengujian (nilai p=0,003). Pengolahan data menggunakan DUNCAN menunjukkan kelompok perlakuan yang diberi salep dengan konsentrasi 10% memberikan hasil yang setara dengan kelompok perlakuan kontrol positif.

scholarly journals UJI AKTIVITAS JUS BUAH JAMBU BIJI BERDAGING MERAH (Psidium guajava L.) TERHADAP PENINGKATAN TROMBOSIT PADA MENCIT (Mus musculus L.) YANG DIINDUKSI KLORAMFENIKOL

2018 ◽  
Vol 10 (2) ◽  
pp. 170-178
Author(s):  
Cindy Trie Permatasari Hosea ◽  
Abdul Wahid Jamaluddin ◽  
Yuko Mulyono Adikurniawan
Keyword(s):  
Mus Musculus ◽  
Psidium Guajava ◽  
Thrombocyte Count ◽  
Guava Fruit ◽  
Life Threatening ◽  
Post Hoc ◽  
One Way Anova ◽  
Hemostatic Disorder

Thrombocytopenia is the most common hemostatic disorder acquired in dogs and can be a life-threatening. Guava fruit and leaves extract are believed to improve thrombocyte counts. The purpose of this study was to prove that administration of guava juice could improve  thrombocyte count in mice that have thrombocytopenia after induced by chloramphenicol. We were used 24 mice as samples divided into 4 groups : KS group (given aquades for 12 days), KN group (induced by chloramphenicol for 7 days, then aquades on next 5 days), group P1 (induced by chloramphenicol for 7 days then guava juice 5 g/ml concentration on 5 next day); and group P2 (induced by chloramphenicol for 7 days then guava juice 10 g/ml concentration on the next 5 days). Thrombocyte count was measured three times, before treatment (day 0), after chloramphenicol induction (day 7), and after guava juice (day 12). Data of thrombocyte count was analyzed using one way Anova and Post Hoc LSD test. The results showed that the guava juice (Psidium guajava L.) concentration of 5 g/ml and 10 g/ml had significant effect (p <0,05) to increase platelet numbers  in mice after induced by chlorampenicol dose 30mg/30grBW.

scholarly journals UJI AKTIVITAS JUS BUAH JAMBU BIJI BERDAGING MERAH (Psidium guajava L.) TERHADAP PENINGKATAN TROMBOSIT PADA MENCIT (Mus musculus L.) YANG DIINDUKSI KLORAMFENIKOL

2018 ◽  
Vol 10 (2) ◽  
pp. 170-178
Author(s):  
Cindy Trie Permatasari Hosea ◽  
Abdul Wahid Jamaluddin ◽  
Yuko Mulyono Adikurniawan
Keyword(s):  
Mus Musculus ◽  
Psidium Guajava ◽  
Thrombocyte Count ◽  
Guava Fruit ◽  
Life Threatening ◽  
Post Hoc ◽  
One Way Anova ◽  
Hemostatic Disorder

Thrombocytopenia is the most common hemostatic disorder acquired in dogs and can be a life-threatening. Guava fruit and leaves extract are believed to improve thrombocyte counts. The purpose of this study was to prove that administration of guava juice could improve  thrombocyte count in mice that have thrombocytopenia after induced by chloramphenicol. We were used 24 mice as samples divided into 4 groups : KS group (given aquades for 12 days), KN group (induced by chloramphenicol for 7 days, then aquades on next 5 days), group P1 (induced by chloramphenicol for 7 days then guava juice 5 g/ml concentration on 5 next day); and group P2 (induced by chloramphenicol for 7 days then guava juice 10 g/ml concentration on the next 5 days). Thrombocyte count was measured three times, before treatment (day 0), after chloramphenicol induction (day 7), and after guava juice (day 12). Data of thrombocyte count was analyzed using one way Anova and Post Hoc LSD test. The results showed that the guava juice (Psidium guajava L.) concentration of 5 g/ml and 10 g/ml had significant effect (p <0,05) to increase platelet numbers  in mice after induced by chlorampenicol dose 30mg/30grBW.

scholarly journals PENGARUH DOSIS EKSTRAK JAMBU BIJI (PSIDIUM GUAJAVA. L) DAN TABLET Fe TERHADAP PERUBAHAN KADAR HEMOGLOBIN PADA MENCIT (MUS MUSCULUS)

2018 ◽  
Vol 10 (3) ◽  
pp. 102-107
Author(s):  
Yusnaini Yusnaini
Keyword(s):  
Mus Musculus ◽  
Experimental Studies ◽  
Psidium Guajava ◽  
Control Group ◽  
Control Group Design ◽  
Laboratory Design ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Post Hoc

According to the WHO 40% of maternal deaths in developing countries related to anemia in pregnancy and is most commonly caused by iron deficiency and acute bleeding, even less so the two interact. This study aims to determine the effect of doses of extracts of Guava (Psidium Guajava. L) and Tablet Fe to changes in hemoglobin levels in mice (Mus musculus). Type True Experimental studies in laboratory design nonrandomized design Pretest-Posttest Control Group Design. Samples were mice (Mus musculus) as many as 20 birds were divided into four groups with each group number as many as five tails. Group A was given a tablet Fe as much as 0.126 mg / kg / day, group B was given a tablet Fe as much as 0.126 mg / KgBW / day coupled with extracts of Guava as much as 10 mg / kg / day, group C was given tablets Fe as much as 0.126 mg / kg / day coupled with guava extract as much as 20 mg / kg / day, group D was given tablets as much as 0.126 mg Fe / KgBW / day plus guava extract as much as 30 mg / kg / day. The data collection was conducted from June 5 s / d July 20, 2015. Data were analyzed using Paired T-Test continued with Test and One Way ANOVA Post Hoc Test namely LSD test. Results showed that there was no significant difference in hemoglobin levels between the groups in which the value of P = 0634> 0.05.. Based on the results of this study concluded that there was no effect of dose of extract of guava (Psidium Guajava. L) and Tablet Fe to changes in hemoglobin levels in mice (Mus musculus), but the effect on the number of erythrocytes of mice (Mus musculus)

scholarly journals UJI EFEKTIVITAS SEDIAAN GEL FRAKSI ETIL ASETAT DAUN JAMBU BIJI (Psidium guajava Linn) TERHADAP PENYEMBUHAN LUKA TERBUKA PADA MENCIT (Mus musculus)

2016 ◽  
Vol 16 (2) ◽  
pp. 23-32
Author(s):  
Lydia Septa Desiyana ◽  
Muhammad Ali Husni ◽  
Seila Zhafira
Keyword(s):  
Wound Healing ◽  
Ethyl Acetate ◽  
Mus Musculus ◽  
Healing Process ◽  
Ethyl Acetate Fraction ◽  
Psidium Guajava ◽  
Positive Control ◽  
Negative Control ◽  
Wound Healing Process ◽  
Guava Leaf

Guava leaf has various benefits, one of them is accelerating the healing process of a wound. This study aims to formulate the ethyl acetate fraction into a gel form and test the effectiveness of gel formulation toward open wounds in 16 male mices (Mus musculus) which made excision 1 cm circular full thickness wound on the back of mice parallel with Os. vetebra. The ethyl acetate fraction of guava leaf has been made into concentrations of 5% and 7% with base gel used as negative control and Bioplacenton as positive control. The evaluation towards ethyl acetate fraction gels showed the gels have green-yellow color, guava odor, homogenous, relevant pH to the skin 6,31-6,51, and spread over 2,8-3 cm (stiff gel). The gels were applied onto the wounds twice a day for about 21 days. The observation was conducted every day towards the scab formation day, scab chipped day, and wound healing day. The data were analyzed statistically using one way ANOVA then continued with Tukey test. The average day for scab formation, scab chipped, and wound healing process, successively are in the negative control i.e. 6,50 ; 13,50 ; 20,25, then positive control of  3,75 ; 11,00 ; 17,25, for gel with 5% concentration,  3,75 ; 9,75 ; 16,50, and gel with 7% concentration,  4,50 ; 12,00 ; 18,25. The statistical result showed that the ethyl acetats fraction  could accelerate the scab formation (p0,05) and the open-wound healing (p0,05) in mice than the control negative (p0,05), but not in the scab exfoliation (p0,05). Gel concentration 5% accelerated faster in forming the scab, flaking off the scab, and  healing the wound compared with the gel concentration of 7%. 

In vitro antioxidant potential of spray-dried Psidium guajava L. leaves extracts

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
MR Fernandes ◽  
CR Souza ◽  
ML Martinez ◽  
WP Oliveira
Keyword(s):  
Psidium Guajava ◽  
Antioxidant Potential ◽  
Spray Dried

Anthelmintic potential of Psidium guajava in sheep

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
R Rostirolla Debiage ◽  
FM Ferreira Gonçalves ◽  
A Rodriges Pereira ◽  
RM Gonçalvez da Silva ◽  
E Yoshihara ◽  
...  
Keyword(s):  
Psidium Guajava

Zwei Fallberichte einer disseminierten Toxoplasmose

2012 ◽  
Vol 40 (01) ◽  
pp. 64-69
Author(s):  
C. Kiesow ◽  
C. Ellenberger ◽  
B. Stief
Keyword(s):  
Mus Musculus ◽  
Ailurus Fulgens

ZusammenfassungEs werden die Fälle einer disseminierten letalen Toxoplasmose bei einer Farbmaus (Mus musculus) und einem Roten Panda (Ailurus fulgens) vorgestellt. Es handelte sich um eine als Haustier gehaltene Farbmaus und einen Roten Panda aus einem sächsischen zoologischen Garten. Die pathologische Untersuchung ergab bei beiden Tieren eine systemische Toxoplasmeninfektion. Eine hochgradige nekrotisierende Hepatitis stellte in beiden Fällen den histologischen Hauptbefund dar. Parasitenzysten fanden sich massenhaft in der Leber, in mäßiger Zahl im Gehirn und in geringer Zahl in anderen Organen. Mittels PAS-Reaktion waren diese Zysten bei der Farbmaus kaum darstellbar, beim Roten Panda dagegen sehr deutlich. PCR bzw. Immunhistologie bestätigten die Diagnose.

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