Analisis Hubungan Polifarmasi Dan Interaksi Obat Pada Pasien Rawat Jalan Yang Mendapat Obat Hipertensi  Di Rsp. Dr. Ario Wirawan Periode Januari-Maret 2019

Hipertensi merupakan masalah kesehatan masyarakat yang umum di negara berkembang. Riskesdas tahun 2013 menyatakan bahwa prevalensi hipertensi secara umum diindonesia sebesar 26,5% dengan proporsi serbesar berada di Jawa Tengah yaitu 57,89%. Polifarmasi secara signifikan bisa meningkatkan resiko interaksi obat dimana interaksi obat merupakan salah satu faktor penting dalam drug related problem yang dapat mempengaruhi outcome terapi pasien. Interaksi obat merupakan satu dari delapan kategori masalah terkait obat (drug-related problem) yang dapat mempengaruhi outcome klinis pasien, dengan meningkatnya kompleksitas obat-obat yang digunakan dalam pengobatan saat ini dan kecenderungan terjadinya praktik polifarmasi, maka kemungkinan terjadinya interaksi obat semakin besar. Tujuan dari penelitian ini adalah untuk mengetahui hubungan interaksi obat dalam resep polifarmasi pada pasien yang mendapat terapi obat antihipertensi di instalasi farmasi RSP dr. Ario Wirawan Salatiga. Penelitian ini dilakukan secara retrospektif dengan menggunakan resep pasien hipertensi rawat jalan di Rumah Sakit Paru Ario Wirawan Salatiga periode Januari-Maret 2019 sebanyak 72 sampel yang termasuk ke dalam kriteria inklusi. Data dianalisis secara deskriptif menggunakan Drug Interaction Facts dan di analisis dengan Spearman test. Diperoleh data bahwa jumlah interaksi obat-obat yang terjadi (51,39%). Pola mekanisme yang terbanyak adalah farmakokinetik (53,97%) dengan tingkat keparahan yang terbanyak adalah minor (42,86%). Hasil menunjukkan adanya korelasi antara jumlah obat dengan kejadian interaksi (r=0,986, p=000) adanya hubungan yang sangat signifikan.Kata kunci : Interaksi Obat, polifarmasi, terapi obat hipertensi.Hypertension is a common problem in developing countries. Based on the basic health research in 2013, the prevalence of hypertension in Indonesia was 26.5% with a large proportion in Central Java at 57.89%. Polypharmacy can significantly increase the risk of drug interactions where drug interactions are an important factor in drug related problems that can affect the outcome of patient therapy. Drug interaction is one of eight categories of drug-related problems that can affect a patient's clinical outcome. Increasing complexity of the drugs used in current treatment will raise the tendency for polypharmacy to occur, resulting higher chance for the drug interaction possibility.This study is aimed to find relationship of drug interactions with polypharmacy prescriptions by patients receiving antihypertensive drug therapy in Dr. Ario Wirawan Hospital. This study was conducted retrospectively using the outpatient prescription that entered the inclusion criteria at Dr. Ario Wirawan Hospital Salatiga. A total of 72 samples that included in the inclusion criteria. Data were analyzed descriptively using Drug Interaction Facts and analyzed by Spearman test. Result showed that the number of drug interactions that occurred (51,39%). The most mechanism pattern of the drug interaction was pharmacokinetics (53,97%) with the highest severity level being minor (42,86%). This study showed that there is a a very significant correlation between the number of drugs and interactions (r = 0.986, p = 000).Keywords : Drug interactions, polypharmacy, hypertension drug therapy

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IDENTIFIKASI DRUG RELATED PROBLEMS PADA PASIEN AUTIS DI RUMAH SAKIT X KOTA YOGYAKARTA

Jurnal Kefarmasian Akfarindo ◽

10.37089/jofar.v0i0.52 ◽

2019 ◽

pp. 30-40

Author(s):

Ruri Renggani Sandra ◽

Della Midi Wardhani ◽

Woro Supadmi

Keyword(s):

Autism Spectrum Disorders ◽

Drug Interaction ◽

Related Problem ◽

Drug Information ◽

Autism Spectrum ◽

Drug Related Problems ◽

Drug Reactions ◽

Drug Related Problem ◽

Spectrum Disorders ◽

Drugs Interaction

Autism spectrum disorders (ASD) adalah gangguan perkembangan saraf dengan penyebab yang kompleks dari banyak fakor Penggunaan obat pada pasien autis harus dimonitoring untuk mencegah terjadinya drug related problems. Intervensi farmasis dengan mengidentifikasi kejadian drug related problem adalah kegiatan pelayanan asuhan kefarmasian untuk meningkatkan keberhasilan terapi. Penelitian ini adalah observasional dengan pengumpulan data secara retrospektif berdasarkan data rekam medik. Evaluasi kejadian drug related problems meliputi indikasi yang tidak diterapi, terapi tanpa indikasi, pemilihan obat yang tidak tepat, overdosis, under dosis, adverse drug reactions dan interaksi obat. Literatur yang digunakan sebagai acuan adalah Drug Information Handbook, 18thed, Stockley Drug Interaction, Drugs Interaction Facts 2001, dan Pharmacotherapy A Pathophysiologic Approach 2005 dan jurnal yang relevan. Hasil penelitian diperoleh pasien dengan jenis kelamin laki-laki 20 pasien (77%), perempuan 6 pasien (23%). Usia antara 6-11 tahun yaitu 15 pasien (58%), 1-5 tahun terdapat 9 pasien (34%), usia <1 tahun dan 12-17 tahun masing-masing sebanyak 1 pasien (4%). Penyakit penyerta ISPA merupakan kasus yang paling banyak terjadi, terbanyak kedua adalah epilepsi dan gastroenteritis akut (GEA). Kejadian DRPs Indikasi tidak diterapi 9%, Terapi tanpa indikasi 9%, Pemilihan obat tidak tepat 9%, Over dosis 31%, Under dosis 33% dan interaksi obat 9%. Terdapat 24 pasien ( 92,3%) yang mengalami DRPs potensial dan 2 pasien (7,7%) yang tidak mengalami. Kriteria DRPs dengan persentase tertinggi adalah under dosis sebanyak 33% dan over dosis sebanyak 31%.

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IDENTIFIKASI DRPs (DRUG RELATED PROBLEMs) PENDERITA ISPA PASIEN PEDIATRIK DI INSTALASI FARMASI RUMAH SAKIT

WARTA FARMASI ◽

10.46356/wfarmasi.v6i1.70 ◽

2017 ◽

Vol 6 (1) ◽

pp. 37-49

Author(s):

Musdalipah Musdalipah ◽

Eny Nurhikma ◽

Sartika Sartika

Keyword(s):

Drug Interaction ◽

Respiratory Infection ◽

Acute Respiratory Infection ◽

Related Problem ◽

Dose Interval ◽

Drug Related Problems ◽

Cross Sectional ◽

Drug Related Problem ◽

Descriptive Method ◽

Random Method

ABSTRAK Drug Related Problem (DRP) atau masalah terkait obat adalah bagian dari asuhan kefarmasian (parmaceutical care) yang menggambarkan suatu keadaan, dimana profesional kesehatan (apoteker) menilai adanya ketidaksesuaian pengobatan dalam mencapai terapi yang sesungguhnya. Tujuan penelitian adalah untuk mengidentifikasi DRPs penderita ISPA (Infeksi Saluran Pernafasan Akut) di Instalasi Farmasi Rumah Sakit kota Kendari dengan kategori polifarmasi, interaksi obat dan interval dosis. Penelitian ini menggunakan metode deskriptif dengan pendekatan Cross Sectional, sampel dalam penelitian ini adalah resep pasien pediatrik yang menderita ISPA. Pengambilan sampel menggunakan metode acak sederhana. Data diolah secara deskriptif dan di jabarkan dalam bentuk narasi. Hasil penelitian ini menunjukkan identifikasi DRPs (Drug Related Problems) dari 30 pasien penderita ISPA di temukan 11 (36,66%) pasien (43,33%) mengalami DRPs kategori polifarmasi, dan 4 pasien (13,33%) mengalami DRPs kategori interval dosis dan tidak di temukan DPRs kategori interaksi obat. Kata Kunci : DRPs, Peresepan, ISPA, Pediatrik ABSTRACT Drug Related Problem (DRP) is a part of pharmaceutical care that describes a situation in which the health professional (pharmacist) assesses a treatment discrepancy in achieving actual therapy. The purpose of this research was identification patient of ISPA (Acute Respiratory Infection) at Pharmacy Installation of Kendari Hospital with Polifarmacy category, drug interaction and dose interval. This research uses descriptive method with Cross Sectional approach, the sample in this research is recipe of pediatric patient suffering from ARI. Sampling using simple random method. Data is processed descriptively and described in the form of narration. The results of this study indicate that based on the identification of DRPs (Drug Related Problems) it can be concluded that from 30 patients with respiratory infection found 11 patients (36.66%) experienced DRPs polifarmation category, and 4 patients (13.33%) experienced DRPs category interval Dose and not found DPRs drug interaction category. Keywords : DRPs, Prescribing, ISPA, Child

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Assessment of Drug Related Problems among Type 2 Diabetic Patients on Follow up at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia

10.21203/rs.2.13882/v2 ◽

2019 ◽

Author(s):

Haymen Abdulmalik ◽

Yohannes Tadiwos ◽

Nanati Legesse

Keyword(s):

Drug Therapy ◽

Related Problem ◽

University Hospital ◽

Key Words Diabetes Mellitus ◽

Diabetic Patients ◽

Key Words Diabetes ◽

Drug Related Problems ◽

Eastern Ethiopia ◽

Drug Related Problem

Abstract Objectives: To assess drug related problem among patients with type 2 diabetes at Hiwot Fana Specialized University Hospital Results: In this study, a total of 148 patient medication records were included. More than half, 83(57.4%) were males and the rest 65(42.6%) were females. The mean age of the study participant’s was 51.26 ± 7.08. Around one third (74.3%) of the participants had urban residency. A total of 127 drug related problems were identified, of which dosage too low was the most common type of DRP encountered, 47(37%), followed by unnecessary drug therapy, 25(19.7%) and ineffective drug therapy, 25(19.7%). 95(64.2%) of the patients had at least one drug related problem. Among patients with DRP, more than half of them, 59 (62.1%) had a single DRP. Out of the total participants, 85(57.4%) of them were taking one anti-diabetic medication and 63(42.6%) of them dual anti-diabetic medications. Only half of the patients have attained the desired FBG level. There was no patient who had experienced more than two types of drug related problems at a time. Less than 10% of patients were taking five or more drugs at a time. Key Words: Diabetes mellitus, Drug therapy problem, Hiwot fana specialized university hospital.

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Occurrence of possible drug related interactions in medical patients in out-patient departments of Pakistan

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20204086 ◽

2020 ◽

Vol 9 (10) ◽

pp. 1503

Author(s):

Hammad A. Butt ◽

Ammara Khan ◽

Naveed Suleman

Keyword(s):

Drug Interaction ◽

Drug Interactions ◽

Related Problem ◽

Potential Drug ◽

Medical Patients ◽

Interaction Detection ◽

Drug Related Problem ◽

Detection Program ◽

Background Data ◽

Potential Interactions

Background: Data regarding occurrence of drug-drug interactions in Pakistan is rare. In the current study, we have tried to find out the clinical adversity and frequency witnessed in prescriptions of a medical outpatient department.Methods: Patient prescriptions were analyzed for potential drug-drug interactions. A sample of 364 patients, visited outpatient department who were being prescribed at least two drugs simultaneously using a drug interaction program website.Results: The 364 patients (72.8% male, mean age 57.9±15.2 years) were prescribed a median of six drugs (range 2-13) at OPD visit. Three hundred forty nine patients (95.8%) had at least one potentially interacting drug combination. 2636 potential interactions were seen in the visiting patients. Out of these 124 (4.7%) were of major severity, 1730 (65.6%) moderate and 515 (19.5%). Out of 124 patients with a potential DDI with major severity, no patient was re-hospitalized within 2 months after discharge due to a probable drug-related problem associated with the potential DDI.Conclusions: A large percentage of patients were detected having one or more potential drug-drug interactions, using drug interaction detection program. However, the percentage of patients having clinically adverse consequences due to drug-drug interactions appears to be very low.

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Assessment of Drug Related Problems among Type 2 Diabetic Patients on Follow up at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia

10.21203/rs.2.13882/v1 ◽

2019 ◽

Author(s):

Haymen Abdulmalik ◽

Yohannes Tadiwos ◽

Nanati Legesse

Keyword(s):

Drug Therapy ◽

Related Problem ◽

University Hospital ◽

Key Words Diabetes Mellitus ◽

Diabetic Patients ◽

Key Words Diabetes ◽

Drug Related Problems ◽

Eastern Ethiopia ◽

Drug Related Problem

Abstract Objectives: To assess drug related problem among patients with type 2 diabetes at Hiwot Fana Specialized University HospitalResults: In this study, a total of 148 patient medication records were included. More than half, 83(57.4%) were males and the rest 65(42.6%) were females. The mean age of the study participant’s was 51.26 ± 7.08. Around one third (74.3%) of the participants had urban residency. A total of 127 drug related problems were identified, of which dosage too low was the most common type of DRP encountered, 47(37%), followed by unnecessary drug therapy, 25(19.7%) and ineffective drug therapy, 25(19.7%). 95(64.2%) of the patients had at least one drug related problem. Among patients with DRP, more than half of them, 59 (62.1%) had a single DRP. Out of the total participants, 85(57.4%) of them were taking one anti-diabetic medication and 63(42.6%) of them dual anti-diabetic medications. Only half of the patients have attained the desired FBG level. There was no patient who had experienced more than two types of drug related problems at a time. Less than 10% of patients were taking five or more drugs at a time. Key Words: Diabetes mellitus, Drug therapy problem, Hiwot fana specialized university hospital.

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Assessment of Drug-Related Problems among Type 2 Diabetic Patients on Follow up at Hiwot Fana Specialized University Hospital, Harar, Eastern Ethiopia

10.21203/rs.2.13882/v3 ◽

2019 ◽

Author(s):

Haymen Abdulmalik ◽

Yohannes Tadiwos ◽

Nanati Legesse

Keyword(s):

Drug Therapy ◽

Related Problem ◽

University Hospital ◽

Key Words Diabetes Mellitus ◽

Diabetic Patients ◽

Key Words Diabetes ◽

Drug Related Problems ◽

Eastern Ethiopia ◽

Drug Related Problem

Abstract Objectives: To assess the drug-related problem among patients with type 2 diabetes at Hiwot Fana Specialized University Hospital Results: In this study, a total of 148 patient medication records were included. More than half, 83(57.4%) were men and the rest 65(42.6%) were women. The mean age of the study participants was 51.26 ± 7.08. Around one third (74.3%) of the participants had urban residency. A total of 127 drug-related problems were identified, of which dosage too low was the most common type of DRP encountered, 46(36.2%), followed by unnecessary drug therapy, 25(19.7%) and ineffective drug therapy, 25(19.7%). 95(64.2%) of the patients had at least one drug-related problem. Among patients with DRP, more than half of them, 59 (62.1%) had a single DRP. Out of the total participants, 85(57.4%) of them were taking one anti-diabetic medication and 63(42.6%) of them dual anti-diabetic medications. Only half of the patients have attained the desired FBG level. There was no patient who had experienced more than two types of drug-related problems at a time. Less than 10% of patients were taking five or more drugs at a time. Key Words: Diabetes mellitus, Drug therapy problem, Hiwot Fana specialized university hospital.

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Review of Impact and Handling of Potential Antihypertensive Drug Interactions in Chronic Kidney Disease Patients

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) ◽

10.22487/j24428744.2021.v7.i1.15332 ◽

2021 ◽

Vol 7 (1) ◽

pp. 39-53

Author(s):

Ni Made Susilawati ◽

Eli Halimah ◽

Siti Saidah

Keyword(s):

Drug Interaction ◽

Drug Interactions ◽

Heart Function ◽

Mortality Rates ◽

Morbidity And Mortality ◽

Potential Drug ◽

Analysis Program ◽

Drug Related Problems ◽

Related Effect ◽

Complete Knowledge

Drug interaction is a type of Drug-Related Problems (DRPs) that caneventually increase morbidity and mortality rates. CKD patients have asignificant risk of developing polypharmacy due to comorbid diseases andpharmacokinetics' alteration. The literature review was conducted byexploring all of the articles related to the drug interaction using druginteraction analysis program in CKD patients, which obtained from threedatabases, namely Google Scholar, PubMed, and Science Direct, usingseveral keywords combination. Based on the comprehensive reviewsconducted, it is known that the most common effects of antihypertensivedrug interactions in CKD patients are decreasing effects of antihypertensivedrugs, hypotension, and hyperkalemia. Handling management used for theemergence of potential drug interactions is based on the severity of the druginteractions and complete knowledge of the patients' clinical condition. Themanagement of drug interaction by monitoring blood pressure, diuresis, andpotassium levels; Monitor the related effect symptoms; Monitor the fluidand body weight; Monitor the kidney and heart function. On the conditionwhere the handling management of potential drug interactions is not carriedout, elevated morbidity and mortality rates are the risks of complicationsarising from the drug interactions.

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Impact of Patient-Specific Drug Interaction Information on Physician Prescribing Patterns

Drug Intelligence & Clinical Pharmacy ◽

10.1177/106002808001400407 ◽

1980 ◽

Vol 14 (4) ◽

pp. 280-283

Author(s):

Thomas R. Adams ◽

William J. Murray ◽

J. Heyward Hull

Keyword(s):

Drug Interaction ◽

Drug Therapy ◽

Drug Interactions ◽

Prescribing Patterns ◽

Study Patient ◽

Patient Specific ◽

Utilization Review ◽

Control Groups ◽

Anticoagulant Drug ◽

Physician Prescribing

Patient exposure to potential anticoagulant drug interactions was identified by computerized drug-therapy surveillance, as part of a peer-review program. To evaluate the response of clinicians provided with data on the potential drug interactions, 119 “exposed” patients were randomly divided and assigned to study or control groups. Physicians prescribing for the 60 study patients were informed of the potential problem by letter and were furnished with information on the drug interaction, while the 59 control patients were only monitored. Physicians provided with the information made statistically more changes in drug therapy than those not informed ( p < 0.05). Over 75 percent of study-patient physicians responding to a questionnaire accompanying the drug interaction data indicated that the service was useful and should be expanded to other drugs. Application of methods similar to that used in this study should offer drug utilization review committees an effective approach to improving drug therapy.

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Drug Related Problems and Complications of Bacterial Meningitis Admitted to Pediatrics Ward in Developing Country

10.21203/rs.3.rs-957560/v1 ◽

2021 ◽

Author(s):

bezie Kebede ◽

abinet abebe

Keyword(s):

Cerebrospinal Fluid ◽

Bacterial Meningitis ◽

Related Problem ◽

Admission Diagnosis ◽

Drug Related Problems ◽

Related Complication ◽

Adequate Treatment ◽

Drug Related Problem ◽

Co Morbidity ◽

Cerebrospinal Fluid Protein

Abstract Background: Bacterial meningitis is considered a medical emergency and it is a life-threatening infection that requires immediate treatment. However, even with an early diagnostic approach and adequate treatment with effective antibiotics, death and different complications may occur.Objective: This study aimed to assess drug related problems and its association on bacterial meningitis related complication.Method: A prospective hospital-based observational study was conducted at the pediatric ward of Hiwot Fana Specialized teaching hospital, Harar. This study was conducted longitudinally for consecutive one year from December 30/2019-Juanuary 1/2021 admitted to pediatrics ward. All pediatrics admitted with the diagnosis of bacterial meningitis and fulfilled the inclusion criteria. To identify independent predictors of bacterial meningitis related complication, binary logistic regression model were used using STATA, version 14.2. Stastical significance was declared at p<0.05Result: After 1 year follow up, 384 children were included in this study with a response rate of 98.1%. Males(55.73%) outnumbered. The mean age and cerebrospinal fluid protein were 5.01±0.19 and 60.5±4.53 respectively. Nearly half of the child had co-morbidity in addition to admission diagnosis, meningitis. Two hundred twenty four(58.33%) patients exposed to at least one type of drug related problem. One hundred twenty one (31.51%) children were developed bacterial meningitis related complications. Drug related problem(AOR=6.26, 95%CI: 3.58-10.93), cerebrospinal fluid protein(AOR=9.38, 95%CI: 9.81.9-96), age(AOR=0.01, 95%CI: 0.13-0.19), duration of illness(AOR=) and co-morbidity(AOR=13.18, 95%CI: 1.81-5.6) were absolutely associated with the occurrence of complication. Conclusion: Drug related problem and associated complications were substantial among children admitted with meningitis. This study identified significant association between drug related problem and complication. Health professional shall prevent drug related problem to prevent associated complication.

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