SALIVA CRYSTALLIZATION IN PATIENTS WITH COMBINED GASTROENTEROLOGICAL AND CARDIOVASCULAR PATHOLOGY

The purpose of this study was to estimate the specifity of saliva crystallization in comorbid pathology of digestive and cardiovascular systems. We collected saliva from 35 patients with coronary artery disease, 48 patients - with ulcer disease and 112 patients - with their combination. The features of self and initiated crystallization in the patients of all groups were evaluated using a specialized system of semi-quantitative parameters. It was stated that the crystallograms of comorbid patients are characterized by a clearly visible predominance of single-crystal elements over dendritic ones. The total density of structures in the facias is significantly reduced in comparison with both healthy people and patients of other groups.

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Diagnostic accuracy of rest-exercise first pass ventriculography with a fast single crystal gamma camera in detecting coronary artery disease

European Journal of Nuclear Medicine ◽

10.1007/bf00252595 ◽

1987 ◽

Vol 13 (5) ◽

pp. 213-220 ◽

Cited By ~ 2

Author(s):

Raffaele Giubbini ◽

Marco Metra ◽

Paolo Guerra ◽

Giovanni La Canna ◽

Giovanni Bissoli ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Diagnostic Accuracy ◽

Single Crystal ◽

Gamma Camera ◽

First Pass ◽

Artery Disease

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Relationship between Semi-Quantitative Parameters of Thallium-201 Myocardial Perfusion Imaging and Coronary Artery Disease

Diagnostics ◽

10.3390/diagnostics10100772 ◽

2020 ◽

Vol 10 (10) ◽

pp. 772

Author(s):

Chin-Chuan Chang ◽

Ming-Hui Yang ◽

Chih-Ting Liu ◽

Hsiu-Lan Chu ◽

Chia-Yang Lin ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Myocardial Perfusion Imaging ◽

Myocardial Perfusion ◽

Sensitivity And Specificity ◽

Thallium 201 ◽

Optimal Cutoff ◽

Cutoff Value ◽

Quantitative Parameters ◽

Artery Disease

This study aimed to investigate the diagnostic performance of semi-quantitative parameters of thallium-201 myocardial perfusion imaging (MPI) for coronary artery disease (CAD). From January to December 2017, patients were enrolled who had undergone Tl-201 MPI and received cardiac catheterization for coronary artery disease within three months of MPI. Receiver operating characteristics (ROC) analysis was used to determine the optimal cutoff values of semi-quantitative parameters. A comparison of the sensitivity and specificity of these parameters based on different subgroupings was further performed. A total of 130 patients were enrolled for further analysis. Among the collected parameters, the stress total perfusion deficit (sTPD) had the highest value of the area under curve (0.813) under the optimal cutoff value of 3.5%, with a sensitivity and specificity of 73.5% and 74.5%, respectively (p = 0.0000), for the diagnosis of CAD. With further subgrouping analysis based on history of diabetes or dyslipidemia, the sensitivity and specificity showed similar results. Based on the currently collected data and image acquisition conditions, the sTPD parameter has a clinical role for the diagnosis of CAD with a cutoff value of 3.5%.

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Noncalcified Coronary Plaque Volumes in Healthy People With a Family History of Early Onset Coronary Artery Disease

Circulation Cardiovascular Imaging ◽

10.1161/circimaging.113.000980 ◽

2014 ◽

Vol 7 (3) ◽

pp. 446-453 ◽

Cited By ~ 23

Author(s):

Brian G. Kral ◽

Lewis C. Becker ◽

Dhananjay Vaidya ◽

Lisa R. Yanek ◽

Rehan Qayyum ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Family History ◽

Early Onset ◽

Coronary Plaque ◽

Healthy People ◽

History Of ◽

Artery Disease

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Conventional risk factors and arterial bed parameters in patients with coronary artery disease younger and older than 50 years

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2020-2541 ◽

2020 ◽

Vol 19 (4) ◽

pp. 2541

Author(s):

A. A. Khromova ◽

L. I. Salyamova ◽

O. G. Kvasova ◽

V. E. Oleinikov

Keyword(s):

Risk Factors ◽

Cardiovascular Disease ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Healthy People ◽

Stiffness Index ◽

Non Invasive ◽

History Of ◽

Artery Disease ◽

Conventional Risk Factors

Aim. To study conventional risk factors and arterial stiffness parameters to identify non-invasive markers of coronary atherosclerosis in patients with and without history of cardiovascular disease, with premature and physiological vascular aging.Material and methods. The study included 198 patients with coronary artery disease (CAD) and 57 healthy people. The subjects were divided into two cohorts: younger and older than 50 years. Each group included patients with newly diagnosed acute coronary syndrome with/without history of cardiovascular disease (CAD and/or hypertension). Conventional risk factors were analyzed in all subjects. Ultrasound radiofrequency of common carotid arteries (CCA), applanation tonometry, volume sphygmography were performed.Results. Analysis of arterial parameters in individuals <50 years old revealed differences between healthy people and patients with CAD. In the subgroup of patients without a history of cardiovascular disease compared with healthy people, CCA were damaged in 77% (p<0,05), aorta — in 13%, muscular arteries — in 29% (p<0,05); in patients with a history of cardiovascular disease, in 71% (p<0,05), 5% and 34% (p<0,05), respectively. In the older age group of patients with and without history of cardiovascular disease, CCA were damaged in 84% and 94% (p<0,05), aorta — in 92% and 87% (p<0,05), muscular arteries — in 42-44% (p<0,05), respectively. According to the ROC analysis, in patients <50 years old, the area under the curve (AUC) for the intima-media thickness (IMT) was 0,830, the threshold — 622,3 (p=0,000); for the beta stiffness index — 0,850, threshold — 7,01 (p=0,002); for L-/CAVI1 — 0,742, threshold — 7,3 (p=0,000). In patients >50 years of age, AUC for the IMT was 0,948, threshold — 607,5 (p=0,000); for the beta stiffness index — 0,740, threshold — 8,84 (p=0,000); for L-/CAVI1 — 0,861, threshold — 8,4 (p=0,000).Conclusion. Timely identification of atherosclerotic markers using noninvasive techniques can improve the prediction of cardiovascular events. A comprehensive non-invasive examination of the arteries with determination of IMT, beta stiffness index, and L-/CAVI1 will probably identify young people with an unfavorable absolute cardiovascular risk. .

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Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population

Gastroenterology Research and Practice ◽

10.1155/2019/6069870 ◽

2019 ◽

Vol 2019 ◽

pp. 1-7 ◽

Cited By ~ 3

Author(s):

Yingyu Xu ◽

Zhenzhen Zhao ◽

Shousheng Liu ◽

Yingpu Xiao ◽

Mengyuan Miao ◽

...

Keyword(s):

Coronary Artery Disease ◽

Liver Disease ◽

Coronary Artery ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Healthy People ◽

Chinese Han ◽

Nonalcoholic Fatty Liver ◽

Han Population ◽

Artery Disease

Background. Nonalcoholic fatty liver disease (NAFLD) patients are often prone to coronary artery disease (CAD), and CAD is found to be the main cause of death in NAFLD patients. The purpose of this study was to investigate the association between fatty acid desaturase 2 (FADS2) rs3834458 polymorphism and serum FADS2 level with NAFLD and CAD in Chinese Han population. Materials and Methods. The serum level of FADS2 was detected by enzyme-linked immunosorbent assay (ELISA) in healthy people, NAFLD patients, and NAFLD patients combined with CAD (NAFLD+CAD). Polymerase chain reaction (PCR) was used to detect the genotypes of FADS2 rs3834458 in the three groups. Results. Body mass index (BMI), glucose (GLU), total cholesterol (TC), and low-density lipoprotein cholesterol (LDL-C) of the NAFLD group and the NAFLD+CAD group were higher than those of the healthy control group (P<0.05); the HDL-C of the NAFLD+CAD group was significantly lower than that of the healthy people and the NAFLD group (P<0.05). The serum FADS2 concentration in the NAFLD+CAD group was significantly higher than that in the NAFLD group (P<0.05) and the healthy people (P<0.05). There was no significant difference in genotype distribution (χ2=5.347, P<0.497) and allele frequency (χ2=3.322, P=0.345) between the three groups. Logistic regression analysis showed that the T allele was not an independent risk factor for CAD with NAFLD (OR=1.62, 95% CI: 0.422-6.180). Conclusions. Serum FADS2 concentration was positively correlated with the susceptibility of NAFLD with CAD, while the polymorphism of rs3834458 was not associated with NAFLD with CAD.

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Evaluation of visual and quantitative parameters of MPS SPECT in MINOCA patients in one year after acute coronary syndrome: comparison with CMR

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jeab111.050 ◽

2021 ◽

Vol 22 (Supplement_3) ◽

Author(s):

A Mochula ◽

O Mochula ◽

A Maltseva ◽

D Vorobyeva ◽

V Ryabov ◽

...

Keyword(s):

Myocardial Infarction ◽

Coronary Artery Disease ◽

Acute Myocardial Infarction ◽

Coronary Artery ◽

Myocardial Perfusion ◽

Obstructive Coronary Artery Disease ◽

Quantitative Parameters ◽

Artery Disease ◽

One Year ◽

Type Of Injury

Abstract Funding Acknowledgements Type of funding sources: None. Background. In recent years a group of patients with acute myocardial infarction without obstructive coronary artery disease (MINOCA) is of interest. In this group of patients, there is a lack of information related to myocardial perfusion, blood flow and reserve, which could be important in term of risk and prognosis assessment. Purpose. To assess the visual and quantitative MPS SPECT parameters in MINOCA patients compared to cardiac magnetic resonance (CMR) data. Methods. In the period from 2017 to 2018 were examined 18 (8 male, mean 62.9 ± 10.7years) consecutive patients with acute myocardial infarction without obstructive coronary artery disease (MINOCA). Within 7-10 days after admission to the hospital and one year later all patients underwent SPECT myocardial perfusion scintigraphy (MPS) with the assessment of standard indices (SSS, SRS, SDS) and quantitative parameters: rest MBF (rMBF), stress MBF (sMBF) and CFR (on CZT gamma-camera). Also, all patients underwent CMR. Based on CMR data all patient were divided into two groups: 1) patients with non-ischemic type of injury and 2) patients with ischemic type of injury. Results. We found out significant correlation between regional quantitative SPECT indices and transmural extent of myocardial infarction evaluated by CMR: r=–0.4 for sMBF; r=–0.35 for CFR (p < 0.05). In the first hospitalization this groups of patient didn`t have of any differences, according visual and quantitative data by SPECT. However, in one year, visual analysis showed that SSS and SDS were significantly (p < 0.001) lower in patient with ischemic type of injury by CMR data: 2 (2; 3) vs 5.5 (4; 9) and 2 (1; 3) vs 4.5 (2; 5), respectively. According to the quantitative MPS data analysis, global and CFR values were significantly lower in patients with non-ischemic type of injury 1.30 (1.14; 1.75) vs 1.71 (1.34; 1.81). Conclusion. The analysis of quantitative MPS SPECT parameters showed that such approach allows identifying MBF and CFR disturbances. These results showed that MINOCA patients are heterogeneous group and require more strong investigation, observation and treatment.

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Features of metabolic disorders in the patients with diseases associated with atherosclerosis, on the background of functional bile outflow abnormalities

The Scientific Notes of the I P Pavlov St Petersburg State Medical University ◽

10.24884/1607-4181-2014-21-1-45-48 ◽

2014 ◽

Vol 21 (1) ◽

pp. 45-48 ◽

Cited By ~ 1

Author(s):

I. A. Gorbacheva ◽

Yu. A. Sycheva ◽

P. S. Shabak-Spassky ◽

L. A. Nikolaeva ◽

L. G. Vladimirova

Keyword(s):

Coronary Artery Disease ◽

Risk Factor ◽

Coronary Artery ◽

Metabolic Disorders ◽

Chronic Coronary Artery Disease ◽

Cardiovascular Pathology ◽

Atherosclerosis Progression ◽

Prevention And Treatment ◽

Integrated Approaches ◽

Artery Disease

The paper presents the results of evaluation of the pathogenetic relationship between atherosclerosis and functional abnormalities of the bile outflow. The main group included 54 patients with cardiovascular pathology and biliary dyskinesia. The group of comparison consisted of 20 patients with chronic coronary artery disease. The results suggest that the functional bile outflow abnormality is a risk factor of atherosclerosis progression leading to hypercholesterolemia and dyslipidemia, and should be considered in the development of integrated approaches to prevention and treatment of the diseases caused by atherosclerosis.

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The current profile of the patient with atrial fibrillation

International Archives of Medicine ◽

10.3823/2572 ◽

2018 ◽

Vol 11 ◽

Author(s):

Iuliana Ardeleanu ◽

Liviu Macovei ◽

Larisa Anghel ◽

Ana Tanasa ◽

Mircea Balasanian ◽

...

Keyword(s):

Atrial Fibrillation ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Cardiovascular Diseases ◽

Sinus Rhythm ◽

Anticoagulant Therapy ◽

Current Profile ◽

Cardiovascular Pathology ◽

Ischemic Coronary Artery Disease ◽

Artery Disease

Abstract: Atrial fibrillation (AF) is the most common supraventricular arrhythmia, characterized by an irregular and extremely rapid atrial electrical activation that causes loss of atrial mechanical function and important hemodynamic consequences. AF classification is important in both the therapeutic approach and the prognosis. Several classifications based on the ECG patch, epicardial or endocavitary records have been performed over time, but no classification can take into account all the characteristics of AF and especially associated diseases, which may be both the cause and consequence of arrhythmia. Aim: The aim of the study is to establish the current profile of the patient with atrial fibrillation in the new era of oral anticoagulant therapy and sinus rhythm restoration. Material and methods: The trial was conducted on patients with atrial fibrillation hospitalized between 01.10.2014-31.03.2015 at Institute of Cardiovascular Diseases ”Prof. Dr. G. Georgescu”, Iasi. Patients included in the study were analyzed according to age and sex, criteria for the clinical and paraclinic definition for atrial fibrillation. Results: Atrial fibrillation is an extremely common cardiovascular pathology and is present in about one-third of patients admitted to our clinic. Cardiovascular diseases such as hypertension, ischemic coronary artery disease, and valvulopathy are common in patients with AF. Patients with AF are usually elderly patients with many associated diseases in whom sinus rhythm restoration treatment and anticoagulant therapy are difficult to establish. AF is one of the most common arrhythmias that complicates the evolution of acute myocardial infarction, association between dual antiplatelet therapy and anticoagulation treatment, increasing the risk of bleeding complications. Conclusions: Atrial fibrillation is an extremely common cardiovascular pathology and is present in about one-third of patients admitted to our hospital. The data obtained revealed that this arrhythmia occurs in a small number of cases as the only pathology of the patient, usually associated with numerous comorbidities. Cardiovascular diseases such as hypertension, ischemic coronary artery disease, valvulopathy are common in our practice. Patient with AF is a patient who requires long-term anticoagulant therapy and in whom sinus rhythm recovery therapy is dependent on the precocity of presentation to the physician, as well as on the therapeutic resources of current medicine.

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