scholarly journals PERAN KELENJAR SEBASEA PADA ALOPESIA ANDROGENIK

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Rahma M Fahruddin ◽  
Sonny J R Kalangi ◽  
Taufiq F Pasiak
Keyword(s):  
Hair Growth ◽  
Sebaceous Gland ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Phase Growth ◽  
Androgenic Alopecia ◽  
Men And Women ◽  
Common Cause ◽  
Three Phase ◽  
Hair Shafts

Abstract: In the scalp there are about 100,000 hair shafts, made of dead keratinized tissues and hair follicles. Each hair follicle has a three-phase growth cycle: anagen, catagen, and telogen. Due to these, human hair grows discontinuously, with phases of growth followed by phases of rest, and does not fall simultanously, called mosaic growth pattern. Androgenic alopecia is the most common cause of hair loss and thinning in humans, which affects men and women. The sebaceous gland has an important role in the occurrence of androgenic alopecia. Recent advances in studies of hair growth show that selective and high safety drugs are needed in the management of androgenic alopecia. Substances that can be used are as follows: growth stimulators, DHT inhibitors, anti-inflammatory, anti-androgen, and super oxide dismuse substances.Key words: hair, hair folicle, androgenic alopecia, sebacceous gland.Abstrak: Pada kulit kepala terdapat sekitar 100.000 batang rambut yang terbuat dari jaringan tanduk mati dan folikel tempat tumbuh rambut. Setiap folikel rambut memiliki tiga tahap periode pertumbuhan, yaitu anagen, katagen, dan telogen. Adanya ketiga tahap ini menyebabkan pertumbuhan rambut „mozaik‟ dimana rambut tidak memanjang sekaligus dan rontok secara bersamaan. Alopesia androgenik merupakan penyebab paling umum kehilangan dan menipisnya rambut baik pada laki-laki maupun perempuan. Kelenjar sebasea berperan penting pada proses terjadinya alopesia androgenik. Dengan kemajuan terbaru dalam studi pertumbuhan rambut, pemilihan obat yang selektif dan aman menjadi pemecahan masalah utama bagi alopesia androgenik. Obat-obat yang dapat digunakan yaitu growth stimulator, DHT inhibitor, anti-inflamasi, anti-androgen, dan super oxide dismuse.Kata kunci: rambut, folilkel rambut, alopesia androgenik, kelenjar sebasea.

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

The skin and hair of the southern elephant seal, Mirounga leonina (Linn.). IV. Annual cycle of pelage follicle activity and moult

2012 ◽  
Vol 60 (4) ◽  
pp. 259 ◽  
Author(s):  
John K. Ling
Keyword(s):  
Hair Growth ◽  
Growth Cycle ◽  
Elephant Seal ◽  
Hair Follicles ◽  
Southern Elephant Seal ◽  
Growth Stages ◽  
Adult Males ◽  
Mirounga Leonina ◽  
Complete Replacement ◽  
Adult Females

Hair growth stages, anagen, catagen and telogen, were diagnosed histologically in skin samples taken at Macquarie Island from 103 southern elephant seals – 11 pups, 56 immatures, 23 adult females and 13 adult males – in order to correlate hair follicle activity with field observations of this species’ unusual type of moult. The duration of the hair growth cycle in fully developed follicles is ~12 weeks. Hair follicles are active for 2–3 months before, during and after the moult haul-out and are resting at other times of the year. A high proportion of adult females appear to commence hair growth between 4 January and 2 February. While implantation of the blastocyst may be triggered by some astral event, such as daylength, it does not depend on completion of the moult, as suggested by previous authors. The pelage cycle is possibly controlled by an endogenous rhythm established during follicle development and subsequent growth and shedding of the natal coat, but the timing and duration of the moult haul-out may depend on the nutritional status of seals within each particular age–sex class. In adult seals this will be governed by terrestrial activities that involve fasting during the breeding and moulting seasons, whereas immature seals haul out and fast, not only to moult but some also come ashore and rest during winter. There may also be metabolic demands for materials for the complete replacement of the pelage, and much of the stratum corneum.

scholarly journals Human TIMP-3 Is Expressed During Fetal Development, Hair Growth Cycle, and Cancer Progression

1998 ◽  
Vol 46 (4) ◽  
pp. 437-447 ◽  
Author(s):  
Kristiina Airola ◽  
Matti Ahonen ◽  
Nina Johansson ◽  
Päivi Heikkilä ◽  
Juha Kere ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Fetal Development ◽  
Hair Growth ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Outer Root Sheath ◽  
Outer Root Sheath Cells ◽  
Factor Α

We studied the expression and regulation of TIMP-3, a recently cloned member of the tissue inhibitor of the metalloproteinase family, during human fetal development and in various human tissues, with emphasis on epithelial structures. Expression of TIMP-3 mRNA was detected by in situ hybridization in developing bone, kidney, and various mesenchymal structures. At 16 weeks of gestation, ectoderm-derived cells of hair germs expressed TIMP-3 mRNA, and beginning from the twentieth week consistent expression was detected in epithelial outer root sheath cells of growing hair follicles. In normal adult human skin, expression of TIMP-3 mRNA was limited to hair follicles, starting at the early anagen (growing) phase and vanishing at the catagen (regressing) phase. TIMP-3 mRNA was not detected in benign hair follicle-derived tumors but was present in tumor cells of infiltrative basal cell carcinomas and in surrounding stromal cells in squamous cell carcinomas. Human primary keratinocytes in culture expressed TIMP-3 mRNAs, the levels of which were upregulated by transforming growth factor-β (TGF-β), whereas interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) had no effect. Our results suggest a role for TIMP-3 in connective tissue remodeling during fetal development, hair growth cycle, and cancer progression.

Ectopic expression of c-Myc in the skin affects the hair growth cycle and causes an enlargement of the sebaceous gland

2005 ◽  
Vol 152 (6) ◽  
pp. 1125-1133 ◽  
Author(s):  
J.J. Bull ◽  
S. Pelengaris ◽  
S. Hendrix ◽  
C.M.T. Chronnell ◽  
M. Khan ◽  
...  
Keyword(s):  
Hair Growth ◽  
Sebaceous Gland ◽  
Ectopic Expression ◽  
Growth Cycle

Studies on the biochemistry and morphology of freshly isolated and maintained rat hair follicles

1989 ◽  
Vol 93 (3) ◽  
pp. 409-418
Author(s):  
M. Philpott ◽  
M.R. Green ◽  
T. Kealey
Keyword(s):  
Electron Microscopy ◽  
Hair Growth ◽  
Adenine Nucleotide ◽  
Light And Electron Microscopy ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Large Numbers ◽  
Thymidine Autoradiography ◽  
Permeable Supports

We have already shown that shearing can be used to yield large numbers of viable intact hair follicles. We now show that these follicles can be viably maintained on permeable supports for 7 days in vitro as determined by their adenine nucleotide contents, rates of [methyl-3H]thymidine and [U-14C]leucine uptake, [methyl-3H]thymidine autoradiography, patterns of keratin synthesis and light and electron microscopy. These studies, however, show that after 7 days maintenance the morphology of maintained follicles shows a closer resemblance to the telogen rather than the anagen follicle. We therefore conclude that the failure of previous attempts at maintaining hair growth in culture is due to hair follicles prematurely entering the resting stage of their hair growth cycle, possibly as a response to isolation.

scholarly journals Trps1-deficient transplanted skin gave rise to a substantial amount of hair: Trps1 is unnecessary for hair development

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Yingzhe Zhang ◽  
Tomoyuki Nakamura ◽  
Fukumi Furukawa ◽  
Yasuteru Muragaki
Keyword(s):  
Hair Growth ◽  
Mouse Skin ◽  
Hair Shaft ◽  
Hair Follicles ◽  
Newborn Mouse ◽  
Newborn Mice ◽  
Significant Difference ◽  
Normal Hair ◽  
Hair Development ◽  
Hair Shafts

Trps1 is considered as an important gene involved in the interactions between the epithelial and mesenchymal cells during hair follicle morphogenesis. The number of hair follicles in Trps1 Knockout (KO) newborn mouse skin was significantly lower than that in wild-type (WT) newborn skin. To gain insight into the functional role of Trps1 in hair development, we transplanted Trps1 KO newborn mouse skin on the backs of nude mice and examined hair growth at day 42 after transplantation. Surprisingly, transplanted skin from Trps1 KO newborn mice gave rise to a substantial amount of hair, although the hair was softer than that of WT mice. Histological examination revealed that the diameter of both hair follicles and hair shafts were significantly lower, whereas the density of hair follicles showed no significant difference between the Trps1 KO and WT mice. We introduce mouse hair follicles as a fascinating model to study the functions of Trps1 in mouse hair growth and pathology. This model suggests that the function of Trps1 is unnecessary for the development of normal hair follicles and hair shafts, although the loss of Trps1 affects the diameters of hair follicles and hair shaft.

The Frequency and Antiquity of Prehistoric Coca-Leaf-Chewing Practices in Northern Chile: Radioimmunoassay of a Cocaine Metabolite in Human-Mummy Hair

1991 ◽  
Vol 2 (3) ◽  
pp. 260-268 ◽  
Author(s):  
Larry W. Cartmell ◽  
Arthur C. Aufderheide ◽  
Angela Springfield ◽  
Cheryl Weems ◽  
Bernardo Arriaza
Keyword(s):  
Hair Follicles ◽  
Northern Chile ◽  
Cultural Groups ◽  
Men And Women ◽  
Adult Men ◽  
The Past ◽  
Hair Samples ◽  
Human Mummy ◽  
Different Cultures ◽  
Hair Shafts

Coca-leaf chewing results in absorption of part of its cocaine content. Following absorption, cocaine and/or its stable metabolic product benzoylecgonine (BZE) may enter the chewer's hair follicles and subsequently be incorporated into the hair shafts. This article reports that a recently developed radioimmunoassay is capable of detecting BZE in hair samples from ancient, spontaneously mummified human remains. Results are provided from tests on hair samples of 163 individuals, representatives of populations from seven different cultures living at coastal and low valley sites in northern Chile during the past 4,000 years. These indicate that coca-leaf-chewing practices began in this area about 2,000 years ago. The practice seems to have been common in several subsequent cultural groups. In one of these—Maitas Chiribaya—the majority of both adult men and women indulged in this practice. Coca-leaf-chewing women probably transferred BZE to their fetuses and nursing infants.

Disorders of Hair

2013 ◽  
Author(s):  
James Q Del Rosso
Keyword(s):  
Hair Loss ◽  
Alopecia Areata ◽  
Hair Growth ◽  
Growth Cycle ◽  
Hair Follicles ◽  
Common Type ◽  
Diagnosis And Treatment ◽  
Basic Knowledge ◽  
Androgenetic Alopecia ◽  
Broad Overview

A basic knowledge of the hair growth cycle is needed to evaluate disorders of hair growth. This chapter presents a broad overview of the physiology and evaluation of hair growth, as well as discussions of specific types of alopecia. The epidemiology, pathogenesis, diagnosis, and treatment of androgenetic alopecia, the most common type of nonscarring hair loss, are covered. Diffuse hair shedding is generalized hair loss over the entire scalp. Diagnosis and treatment of telogen effluvium, anagen arrest (anagen effluvium), and other causes of diffuse hair shedding are covered in detail. Alopecia areata, typically characterized by patchy hair loss; cicatricial alopecia, which results from permanent scarring of the hair follicles; and miscellaneous causes of hair loss are also discussed. Tables list the causes of diffuse and cicatricial alopecia, telogen effluvium, and miscellaneous chemicals and categories of drugs that can cause alopecia, as well as miscellaneous causes of hair loss. Included is an algorithm outlining the approach to diagnosing nonscarring alopecia, as well as a variety of clinical photographs. This review contains 9 highly rendered figures, 6 tables, and 42 references.

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