scholarly journals Kontribusi hiperglikemia dan hipoalbuminemia terhadap multiple organ dysfunction syndrome (MODS) pada pasien multitrauma

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Hendri . ◽  
Heber B. Sapan ◽  
Harsali F. Lampus
Keyword(s):  
Blood Glucose ◽  
Serum Albumin ◽  
Injury Severity Score ◽  
Blood Glucose Level ◽  
Sequential Organ Failure Assessment ◽  
Severity Score ◽  
Injury Severity ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Failure Assessment

Abstract: Recent randomized prospective data suggest that early hyperglycemia and hypoalbuminemia are associated with MODS in multitrauma patients. This study was aimed to determine the contribution of early blood glucose elevation and decreased serum albumin in Trauma Emergency Department or ICU patients. We prospectively collected multitrauma patients with Injury Severity Score (ISS) ≥18, blood glucose, serum albumin, aged 14-81 years old, admitted to level I Trauma Centre at Prof. Dr. R. D. Kandou General Hospital Manado from September 2015 through July 2016. Sequential Organ Failure Assessment (SOFA) score was used to determine MODS during hospitalization. The X2 (Fisher exact) test was used to determine the level of significance and odd ratio was used to determine the risk estimation. There were 51 multitrauma patients in this study. The mean age was 31.73 years old; 41 males (80.4%) and 10 females (19.6%); blood glucose level >126 mg/dl occurred in 34 patients (66.7%) and ≤ 126 mg/dL occurred in 17 patients (33.3%). Serum albumin level <3.5 gr/dL occurred in 31 patients (60.8%) and ≥3,5 gr/dl occurred in 20 patients (39.2%). Conclusion: Early hyperglycemia (blood glucose level >126 mg/dL) and hypoalbuminemia (serum albumin <3.5 gr/dL) were associated with significantly higher MODS rates in multitrauma patients independently of injury characteristics. The present of early hyperglycemia and hypoalbuminemia may allow early identification of trauma patients who are at risk for MODS.Keywords: multitrauma, hyperglycemia, hypoalbuminemia, MODSAbstrak: Data prospektif secara random menunjukkan bahwa adanya hiperglikemia dan hipoalbuminemia dapat berisiko terhadap terjadinya MODS pada pasien dengan multitrauma. Penelitian ini bertujuan untuk menentukan kontribusi hiperglikemia dan hipoalbuminemia pada pasien yang dirawat di Instalasi Gawat Darurat maupun di ICU. Data diambil secara prospektif pada pasien multitrauma dengan Injury Severity Score (ISS) ≥18, kadar gula darah dan serum albumin, usia 14-81 tahun yang datang ke Pusat Trauma RSUP Prof Dr. R. D. Kandou Manado selama 11 bulan (September 2015 s/d Juli 2016). Digunakan Sequential Organ Failure Assessment (SOFA) skor untuk menentukan MODS selama dirawat. Data dianalisis dengan X2 atau Fisher exact test untuk tingkat signifikansi dan odd ratio untuk menentukan perkiraan tingkat kesalahan. Hasil penelitian mendapatkan total 51 pasien yang termasuk dalam kriteria inklusi. Rerata usia 31,73 tahun, laki-laki 41 pasien (80,4%) dan perempuan 10 pasien (19,6%). Kadar gula darah >126 mg/dl sebanyak 34 pasien (66,7%) dan kadar gula darah ≤126 mg/dl sebanyak 17 pasien (33,3%). Kadar albumin <3,5 gr/dl sebanyak 31 pasien (60,8%) dan kadar albumin ≥3,5 gr/dl sebanyak 20 pasien (39,2%). Simpulan: Hiperglikemia dengan kadar gula darah >126 mg/dl dan hipoalbuminemia dengan kadar albumin <3,5 gr/dl sangat berisiko untuk terjadi MODS pada pasien-pasien trauma namun tergantung dari beratnya cedera yang dialami. Adanya hiperglikemia dan hipoalbuminemia merupakan tanda awal terhadap risiko terjadinya MODS pada pasien multitrauma.Kata kunci: multitrauma, hiperglikemia, hipoalbuminemia, MODS

scholarly journals Skor prediksi sindrom disfungsi multi-organ pada pasien multitrauma

2016 ◽  
Vol 8 (2) ◽  
Author(s):  
Leo Rendy ◽  
Heber B. Sapan ◽  
Laurens T. B. Kalesaran ◽  
Julius H. Lolombulan
Keyword(s):  
At Risk ◽  
Emergency Department ◽  
Injury Severity Score ◽  
Sequential Organ Failure Assessment ◽  
Organ Failure ◽  
Risk Score ◽  
Severity Score ◽  
Injury Severity ◽  
Failure Assessment ◽  
The Mean

Abstract: Multiple organ dysfunction syndrome (MODS) in patients with major trauma remains to be frequent and devastating complication during clinical course in emergency department and intensive care unit (ICU). The ability to easily and accurately identify patients at risk for MODS postinjury especially in multitrauma cases would be very valuable. This study aimed to construct an instrument for prediction of the development of MODS in adult multitrauma patients using clinical and laboratory data available in the first day at prahospital and emergency department (hospital) setting. This was a prospective study. Samples were adult multitrauma patients with Injury Severity Score (ISS) ≥16, aged 16-65 years old, admitted to 4 academic Level-I trauma center from September 2014 to September 2015. Sequential organ failure assessment (SOFA) score was used to determine MODS during hospitalization. A risk score created from the final regression model consisted of significant variables as MODS predictor. The results showed that there were 98 multitrauma patients as samples. The mean age was 35.2 years old; mostly male (85.71%); the mean of ISS was 23.6; mostly (76.53%) were caused by blunt injury mechanism. MODS was encountered in 43 patients (43.87%). The prediction risk score consists of Revised Trauma Score (RTS) (<7.25) and serum lactate level ≥2 mmol/L. This study also verified several independent risk factors for post multitrauma MODS, such as ISS >25, presence of SIRS, shock grade 2 or more, and white blood cell count >12,000/mm3. Conclusion: We derived a novel, simple, and applicable instrument to predict MODS in adult following multitrauma. The use of this scoring system may allow early identification of multitrauma patients who are at risk for MODS and result in more aggressive targeted resuscitation and better referral allocation based on regional trauma system.Keywords: MODS, multitrauma, emergency department, MODS prediction scoreAbstrak: Sindrom disfungsi multi-organ (MODS) merupakan komplikasi buruk yang sering terjadi sepanjang perjalanan klinis pasien trauma mayor di Unit Gawat Darurat (UGD) maupun di ruang perawatan intensif. Suatu nilai patokan yang dapat memprediksi MODS pascatrauma secara akurat sejak dini tentunya sangat berharga bagi tatalaksana pasien terutama pada kasus multitrauma. Penelitian ini bertujuan untuk membuat suatu instrumen yang dapat memrediksi perkembangan MODS pada pasien dewasa multitrauma dengan menggunakan data klinis dan laboratorium yang tersedia pada 24 jam pertama pasca trauma pada seting fase prahospital maupun di fase hospital sejak di UGD. Jenis penelitian ini prospektif, mengumpulkan pasien multitrauma dengan Injury Severity Score (ISS) ≥16, rentang usia 16-65 tahun, di 4 pusat trauma level-1 rumah sakit pendidikan selama 1 tahun (September 2014-2015). Dilakukan pencatatan data klinis dan laboratorium sesuai perkembangan pasien. Skor sequential organ failure assessment (SOFA) digunakan untuk menentukan adanya MODS selama perawatan. Skor prediksi dibuat dengan membangun model regresi logistik yang signifikan untuk memrediksi terjadinya MODS pasca multitrauma. Hasil penelitian mendapatkan 98 sampel multitrauma yang memenuhi kriteria inklusi dengan rerata usia 35,2 tahun, sebagian besar laki-laki (85,71%) dengan rerata ISS 23,6, dan disebabkan oleh trauma tumpul (76,53%). MODS terjadi pada 43 pasien (43,87%). Skor prediksi terdiri dari RTS dengan (cut off point 7,25) dan kadar laktat serum (cut off point 3,44 mmol/mL). Penelitian ini juga memverifikasi beberapa faktor risiko individual terjadinya MODS pasca multitrauma yaitu ISS>25, adanya SIRS, syok derajat 2 atau lebih, dan leukositosis >12.000. Simpulan: Kami melaporkan instrumen baru yang praktis untuk memrediksi MODS pada pasien multitrauma dewasa. Skor ini memungkinkan identifikasi dini pasien trauma yang berisiko akan mengalami MODS sehingga dapat menjadi tanda alarm dilakukannya resusitasi yang lebih agresif dan tepat serta alokasi rujukan pasien yang lebih efisien berdasarkan sistem trauma regional.Kata kunci: MODS, multitrauma, UGD, skor prediksi MODS

Is Blood Sugar the Next Lactate?

2006 ◽  
Vol 72 (7) ◽  
pp. 613-618 ◽  
Author(s):  
TherÈSe M. Duane ◽  
Tracey Dechert ◽  
Nicholas Dalesio ◽  
Luke G. Wolfe ◽  
Nicholas Dalesio ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Injury Severity Score ◽  
Blood Glucose Level ◽  
Blood Sugar ◽  
Severity Score ◽  
Injury Severity ◽  
Trauma Patients ◽  
Severely Injured ◽  
Infection Rates ◽  
Initial Blood

This study evaluates whether an initial blood glucose level is similarly predictive of injury severity and outcome as admission lactate in trauma patients. Between February 2004 and June 2005, we prospectively compared patients with presenting blood sugars of ≤150 mg/dL (LBS) with those with blood sugars >150 mg/dL (HBS). Fifty patients had BS above 150 mg/dL, whereas 176 patients were ≤150 mg/dL. These groups had similar demographics except for age. Injury Severity Score (ISS) of ≥15 was seen in 56.0 per cent of HBS patients versus 28.4 per cent of LBS patients (P = 0.0006). HBS patients had similar infection rates (12.0% HBS vs. 5.7% LBS, P = 0.13) but a higher mortality (30.0% HBS vs. 5.7% LBS, P < 0.0001). There was a linear relationship between ISS and BS (r2 = 0.18, P < 0.0001) and ISS and lactate (r2 = 0.17, P < 0.0001). Blood sugar trended with the lactate (r = 0.25, P = 0.0001). Hyperglycemic patients were more severely injured with higher mortality. BS correlated with lactate, and because it is easily obtainable, it may serve as a readily available predictor of injury severity and prognosis.

scholarly journals Microbiological Study of Etiological Pathogen in Early Infection of Open Fracture in Orthopedics

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Tai Ken Meng ◽  
Ahmad Fadzli Bin Sulong ◽  
Nazri Bin Mohd. Yusof
Keyword(s):  
Injury Severity Score ◽  
Severity Score ◽  
Open Fracture ◽  
Injury Severity ◽  
Cross Sectional Study ◽  
Early Infection ◽  
High Rate ◽  
Cross Sectional ◽  
Gram Negative ◽  
Exact Test

Introduction: Infection is a dreaded complication of open fracture in the field of orthopaedics. This study was conducted to evaluate the susceptibility of microorganism involved in early infection of open fractures to current prophylactic antibiotics practice and determine the association of various characteristics to the resistance of such microorganisms. Materials and Methods: This cross sectional study was conducted from January 2015 to December 2017 in Hospital Tengku Ampuan Afzan, Kuantan, Malaysia. A total of 179 cases were collected from the operating record with 110 cases fulfilling the inclusion and exclusion criteria. The patients underwent routine debridement where culture and sensitivity were followed up. Previous notes were traced to identify the various risk factors involved and evaluated against resistance of microorganism. Statistical analysis was done with SPSS version 23 applying Pearson chi-square tests and Fisher's exact test. Results: Admission to intensive care unit, blood transfusion, antibiotic regime and duration, fracture grade, injury severity score and duration of admission were all significantly associated with resistance of microorganism (p < 0.0001). This study also demonstrated 65.9% predominance of Gram-negative microorganisms. These gram-negative microorganisms were seen more in higher fracture grades, injury severity score, and longer duration of admission or antibiotics prescribed. The overall resistance to cefuroxime and gentamicin were 68.6% and 36.9% respectively. Conclusion: The shift of microorganism species to gram-negative and the high rate of resistance suggested that current antibiotic guidelines and regime needed to be fine-tuned to achieve optimal results in managing open fracture.

Disseminierte intravasale Gerinnung und Fibrinolyse in der Frühphase nach Polytrauma

1995 ◽  
Vol 15 (02) ◽  
pp. 79-86
Author(s):  
L. Lampl ◽  
M. Helm ◽  
M. Tisch ◽  
K. H. Bock ◽  
E. Seifried
Keyword(s):  
Injury Severity Score ◽  
Severity Score ◽  
Injury Severity ◽  
Tissue Type ◽  
Disseminierte Intravasale Gerinnung

ZusammenfassungGerinnungsstörungen nach einem Polytrauma werden eine große Bedeutung für die weitere Prognose der Patienten beigemessen. In einer prospektiv angelegten Studie wurden bei 20 polytraumatisierten Patienten Gerinnungsund Fibrinolyseparameter analysiert, um deren Veränderungen während der präklinischen Phase zu definieren. Die Blutentnahmen wurden zum frühestmöglichen Zeitpunkt am Unfallort und bei Klinikübergabe durchgeführt. Die gewonnenen Proben wurden mit Hilfe eines speziell konzipierten »Kleinlabors« noch vor Ort verarbeitet, um möglichst native Meßwerte zu erhalten. Die Patienten wurden dem Schweregrad der Verletzung entsprechend kategorisiert und hatten einen Verletzungsschweregrad nach NACA > IV und einen Injury Severity Score (ISS) > 20. Die Ergebnisse zeigen, daß bereits in der sehr frühen Phase nach Eintritt des Traumas schwerwiegende Veränderungen des Gerinnungsund Fibrinolysesystems eintreten. Die frühzeitige Thrombingenerierung führt zu einer Verbrauchskoagulopathie und reaktiven Hyperfibrinolyse. Zusätzlich erzeugt die Freisetzung von endothelständigem Tissue-type-Plasminogenaktivator eine primäre Hyperfibrinolyse. Die Veränderungen des Gerinnungsund Fibrinolysesystems in der frühen präklinischen Phase nach Polytrauma können zu schwerwiegenden klinischen Komplikationen wie Blutungen, thromboembolischen Komplikationen und zur Ausbildung von Schockorganen führen.

Non-Selective Thoracic Computed Tomography in Trauma Patients Results in Injury Severity Score Inflation

2021 ◽  
pp. 000313482110249
Author(s):  
Leonardo Alaniz ◽  
Omaer Muttalib ◽  
Juan Hoyos ◽  
Cesar Figueroa ◽  
Cristobal Barrios
Keyword(s):  
Computed Tomography ◽  
Injury Severity Score ◽  
Severity Score ◽  
Injury Severity ◽  
Treatment Plan ◽  
Mortality Prediction ◽  
Trauma Patients ◽  
Mortality Benefit ◽  
Severity Scores ◽  
Score Inflation

Introduction Extensive research relying on Injury Severity Scores (ISS) reports a mortality benefit from routine non-selective thoracic CTs (an integral part of pan-computed tomography (pan-CT)s). Recent research suggests this mortality benefit may be artifact. We hypothesized that the use of pan-CTs inflates ISS categorization in patients, artificially affecting admission rates and apparent mortality benefit. Methods Eight hundred and eleven patients were identified with an ISS >15 with significant findings in the chest area. Patient charts were reviewed and scores were adjusted to exclude only occult injuries that did not affect treatment plan. Pearson chi-square tests and multivariable logistic regression were used to compare adjusted cases vs non-adjusted cases. Results After adjusting for inflation, 388 (47.8%) patients remained in the same ISS category, 378 (46.6%) were reclassified into 1 lower ISS category, and 45 (5.6%) patients were reclassified into 2 lower ISS categories. Patients reclassified by 1 category had a lower rate of mortality ( P < 0.001), lower median total hospital LOS ( P < .001), ICU days ( P < .001), and ventilator days ( P = 0.008), compared to those that remained in the same ISS category. Conclusion Injury Severity Score inflation artificially increases survival rate, perpetuating the increased use of pan-CTs. This artifact has been propagated by outdated mortality prediction calculation methods. Thus, prospective evaluations of algorithms for more selective CT scanning are warranted.

INJURY SEVERITY SCORE, HEAD INJURY, AND PATIENT WAIT DAYS

1992 ◽  
Vol 33 (2) ◽  
pp. 219-220 ◽  
Author(s):  
James Andersen ◽  
William Sharkey ◽  
Michael L. Schwartz ◽  
Barry A. McLellan
Keyword(s):  
Head Injury ◽  
Injury Severity Score ◽  
Severity Score ◽  
Injury Severity
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