scholarly journals Uji Aktivitas Immunomodulator Berbagai Tanaman Famili Piperaceae pada Mencit Galur Balb/C dengan Metode Carbon Clearance

2019 ◽  
Vol 17 (2) ◽  
pp. 255
Author(s):  
Mohammad Roseno ◽  
Yayat Sudaryat ◽  
Widyastiwi Widyastiwi
Keyword(s):  
Carbon Clearance ◽  
Piper Retrofractum ◽  
Piper Aduncum

Tanaman keluarga Piperaceae tersebar luas di daerah tropis dan telah banyak digunakan sebagai tanaman obat, diantaranya adalah kemukus (Piper cubeba), kiseureuh (Piper aduncum), dan cabe jawa (Piper retrofractum). Tujuan penelitian adalah untuk mengevaluasi aktivitas imunomodulator ekstrak etanol beberapa tanaman dari keluarga Piperaceae pada mencit jantan galur Balb/c dengan metode carbon clearance. Penelitian dilakukan dengan membagi hewan coba menjadi 12 kelompok, yaitu kelompok kontrol normal, pembanding imunosupresan, pembanding imunostimulan, serta masing-masing tiga kelompok variasi dosis kemukus, kiseureuh, dan cabe jawa. Parameter aktivitas imunomodulator ditinjau dari indeks fagositosis, kadar leukosit darah tepi, dan kadar leukosit limpa. Hasil penelitian menunjukkan Ekstrak etanol kemukus (Piper cubeba) memiliki aktivitas imunomodulator sebagai imunosupresan, peningkatan dosis meningkatkan efek imunosupresan. Ekstrak etanol kiseureh (Piper aduncum) dosis rendah memiliki aktivitas imunomodulator sebagai imunosupresan, sedangkan pada dosis sedang dan tinggi memiliki kecenderungan sebagai imunostimulan. Ekstrak etanol cabe jawa (Piper retrofractum) memiliki aktivitas imunomodulator sebagai imunostimulan, dengan aktivitas tertinggi dicapai pada dosis sedang. Ekstrak etanol kemukus (Piper cubeba), kiseureh (Piper aduncum), dan cabe jawa (Piper retrofractum) mempengaruhi jumlah komponen granulosit darah tepi, dimana peningkatan neutrofil mempengaruhi peningkatan efek fagositosis. Ekstrak etanol kemukus (Piper cubeba), kiseureh (Piper aduncum), dan cabe jawa (Piper retrofractum) tidak mempengaruhi jumlah komponen granulosit limpa.

New cytotoxic and antifungal amides from the fruit of Piper retrofractum

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
R Muharini ◽  
Z Liu ◽  
L Wenhan ◽  
P Proksch
Keyword(s):  
Piper Retrofractum

Reticuloendothelial Function and Blood Coagulation in Rats

1969 ◽  
Vol 22 (03) ◽  
pp. 508-512
Author(s):  
L Pechet ◽  
Giselle S. Pechet ◽  
R. A MacDonald
Keyword(s):  
Blood Coagulation ◽  
Free Carbon ◽  
Colloidal Iron ◽  
Intravascular Coagulation ◽  
India Ink ◽  
Carbon Clearance

SummaryIntravascular coagulation and its possible effect on carbon clearance was studied in rats following the injection of commercial india ink containing shellac; a shellac-free carbon preparation; gelatin; heat denatured albumin; colloidal iron; and heparin. No relationship was found between activation of coagulation and RES function as measured by clearance of intravenously injected carbon.

Accumulation of Macromolecular Particles in the Reticuloendothelial System (RES) Mediated by Platelet Aggregation and Disaggregation

1969 ◽  
Vol 22 (03) ◽  
pp. 496-507 ◽  
Author(s):  
W.G van Aken ◽  
J Vreeken
Keyword(s):  
Platelet Aggregation ◽  
Degradation Products ◽  
Reticuloendothelial System ◽  
Caproic Acid ◽  
Carbon Particles ◽  
Carbon Clearance ◽  
Aggregation And Disaggregation ◽  
Platelet Aggregates

SummaryCarbon particles cause platelet aggregation in vitro and in vivo. Prior studies established that substances which modify thrombocyte aggregation also influence the rate at which carbon is cleared from the blood.This study was performed in order to elucidate the mechanism by which the carbon-platelet aggregates specifically accumulate in the RES.Activation of fibrinolysis by urokinase or streptokinase reduced the carbon clearance rate, probably due to generated fibrinogen degradation products (FDP). Isolated FDP decreased the carbon clearance and caused disaggregation of platelets and particles in vitro. Inhibition of fibrinolysis by epsilon-amino-caproic acid (EACA), initially accelerated the disappearance of carbon and caused particle accumulation outside the RES, predominantly in the lungs. It is supposed that platelet aggregation and locally activated fibrinolysis act together in the clearance of particles. In the normal situation the RES with its well known low fibrinolytic activity, becomes the receptor of the particles.

scholarly journals Immunomodulatory activity of an aqueous extract of Polygonum minus Huds on Swiss albino mice using carbon clearance assay

2014 ◽  
Vol 4 (5) ◽  
pp. 398-400 ◽  
Author(s):  
Annie George ◽  
Sasikala Chinnappan ◽  
Yogendra Choudhary ◽  
Praveen Bommu ◽  
Murthy Sridhar
Keyword(s):  
Aqueous Extract ◽  
Immunomodulatory Activity ◽  
Swiss Albino Mice ◽  
Carbon Clearance ◽  
Polygonum Minus ◽  
Albino Mice

LC-MS Analysis and Structural Determination of New Amides from Javanese Long Pepper (Piper retrofractum)

1993 ◽  
Vol 57 (8) ◽  
pp. 1329-1333 ◽  
Author(s):  
Hiroe Kikuzaki ◽  
Marona Kawabata ◽  
Etsuko Ishida ◽  
Yoko Akazawa ◽  
Yoko Takei ◽  
...  
Keyword(s):  
Structural Determination ◽  
Ms Analysis ◽  
Piper Retrofractum

Successful invasion of the neotropical species Piper aduncum in rain forests in Papua New Guinea

2002 ◽  
Vol 5 (2) ◽  
pp. 255-262 ◽  
Author(s):  
Jan Lepš ◽  
Vojtěch Novotný ◽  
Lukáš Čížek ◽  
Kenneth Molem ◽  
Brus Isua ◽  
...  
Keyword(s):  
Papua New Guinea ◽  
New Guinea ◽  
Rain Forests ◽  
Neotropical Species ◽  
Piper Aduncum

Total syntheses (+)-adunctins C and D: confirmation and assignment of relative/absolute configurations

2021 ◽  
Author(s):  
Jian Xiao ◽  
Jun Zhao ◽  
Yawen Wang ◽  
Gan Luo ◽  
Yu Peng
Keyword(s):  
Total Syntheses ◽  
Piper Aduncum

The first total syntheses of (+)-adunctin C (ent-1) and (+)-adunctin D (2), two monoterpene-substitued dihydrochalcones isolated from Piper aduncum (Piperaceae), was achieved. A regioselective oxidative [3+2] cycloaddition of acylphloroglucinol with...

scholarly journals Fumigation and repellency of essential oils against Callosobruchus maculatus (Coleoptera: Chrysomelidae: Bruchinae) in cowpea

2017 ◽  
Vol 52 (1) ◽  
pp. 10-17 ◽  
Author(s):  
José Vargas de Oliveira ◽  
Solange Maria de França ◽  
Douglas Rafael e Silva Barbosa ◽  
Kamilla de Andrade Dutra ◽  
Alice Maria Nascimento de Araujo ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Essential Oils ◽  
Callosobruchus Maculatus ◽  
Ricinus Communis ◽  
Syzygium Aromaticum ◽  
Cymbopogon Citratus ◽  
Cinnamomum Zeylanicum ◽  
Main Component ◽  
Piper Aduncum

Abstract: The objective of this work was to assess the fumigant and repellent effects of essential oils on adults of Callosobruchus maculatus and to identify the chemical composition of two of the tested essential oils. For the fumigation test, the oils of Schinus terebinthifolius, Piper aduncum, Syzygium aromaticum, Piper hispidinervum, Cymbopogon citratus, Cinnamomum zeylanicum, and the eugenol compound were tested at different concentrations on C. maculatus adults. For the repellency test, the oils of S. terebinthifolius, P. aduncum, P. hispidinervum, S. aromaticum, Jatropha curcas, and Ricinus communis were evaluated. In the fumigation test, it was observed that P. aduncum and eugenol showed the highest and lowest LC50s, of 169.50 and 0.28 μL L-1 air, respectively. In the repellency test, the oils of S. aromaticum and P. hispidinervum were repellent to C. maculatus. Gas chromatography coupled to mass spectrometry (GC-MS) analysis of these two oils identified 42 compounds, of which safrole was the main component of P. hispidinervum and eugenol of S. aromaticum. The essential oils of S. aromaticum, C. zeylanicum, and the eugenol compound are the most promising to control C. maculatus, via fumigation.

scholarly journals In Vitro Antimicrobial Activity of Piper retrofractum Fruit Extracts against Microbial Pathogens Causing Infections in Human and Animals

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Wattana Panphut ◽  
Tanakwan Budsabun ◽  
Pakkakul Sangsuriya
Keyword(s):  
Opportunistic Infections ◽  
Colorimetric Assay ◽  
Disk Diffusion ◽  
Bioactive Metabolites ◽  
Diffusion Method ◽  
Klebsiella Pneumonia ◽  
Disk Diffusion Test ◽  
Animal Pathogens ◽  
Piper Retrofractum

Long pepper (Piper retrofractum Vahl) is a Thai medicinal herb which has been used as one of the common ingredients in variety of Thai foods. Here, we investigated antimicrobial activities of crude bioactive metabolites extracted from fruits of P. retrofractum against 10 pathogenic organisms (bacteria and yeast) causing opportunistic infections in human or animals including Bacillus subtilis ATCC6633, Staphylococcus aureus ATCC25923, Enterococcus faecalis ATCC2921, Escherichia coli ATCC25922, Klebsiella pneumonia TISTR1843, Pseudomonas aeruginosa ATCC741, Salmonella typhi (clinical isolate), Vibrio parahaemolyticus (XN98 and 5HP), and Candida albicans ATCC90020. The results of disk diffusion test showed that the extract from methanol solvent exhibited greater antibacterial activity than other solvents with inhibition zones ranging from 0.5 to 8.0 mm, respectively. Subsequently, minimal inhibition concentration (MIC) determined by the colorimetric assay confirmed that methanol extracts showed consistent results with disk diffusion method. In summary, in vitro assays suggest that methanol is the best solvent for extraction of bioactive metabolites from P. retrofractum fruits. This crude extract can inhibit the majority of human and animal pathogens. This opens up a potential use of pepper fruits in prevention of food-contaminating microorganisms.

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