scholarly journals Comparing Ficus vogelii leaf extract and omeprazole as therapy and prophylaxis for aspirin-induced gastric ulcer in wistar rat.

2019 ◽  
Vol 30 (5) ◽  
Author(s):  
Ezemagu UK ◽  
Akunna GG ◽  
Egwu OA ◽  
Uzomba GC ◽  
Nwite KN
Keyword(s):  
Gastric Ulcer ◽  
Leaf Extract ◽  
Wistar Rat

scholarly journals Azadirachta indica (Neem) Leaf Extract Effect as an Option of Treatment of Ibuprofen-induced Nephrotoxicity

2020 ◽  
pp. 56-62
Author(s):  
Ifeanacho Ezeteonu Abireh ◽  
Onyinye Mary Ozioko ◽  
Ignatius Ikemefuna Ozor ◽  
Elizabeth Finbarrs- Bello ◽  
Uche Sebastine Ozioko ◽  
...  
Keyword(s):  
Serum Creatinine ◽  
Azadirachta Indica ◽  
Leaf Extract ◽  
Kidney Injury ◽  
Wistar Rat ◽  
Male Wistar Rats ◽  
Oral Ibuprofen ◽  
Group 2 ◽  
Neem Leaf Extract ◽  
Group 1

Aim: This study investigated the curative effect of the aqueous leaf extract of Azadirachta indica on Ibuprofen-induced nephrotoxicity in Wistar rat Study Design: This is an experimental research Place of Research: Department of Anatomy, College of Medicine, Enugu State University of Science and Technology. Methodology: Twenty-four male Wistar rats were divided into 6 groups, with 4 rats in each group. Group 1 was control and received oral normal saline 0.5 ml daily. Group 2-6 had induction of nephrotoxicity using oral Ibuprofen 400 mg/Kg daily for 5 days. Group 3-5 were subsequently treated with gavage Azadirachta indica leaf extract 200 mg/Kg, 400 mg/Kg and 800 mg/Kg, respectively, for 5 days. And Group 6 was treated with oral Vitamin E 1000 iu/kg for 5 days. Results: Ibuprofen induced nephrotoxicity as evidenced by elevation of serum creatinine level in group 2 (1.99 ± 0.83), when compared to 0.48 ± 0.07 obtained in group 1 (control), and Bowman’s capsule enlargement with glomerular degeneration observed in group 2. The serum creatinine levels progressively approached the level of that of the control in groups treated with Azadirachta indica leaf extract, groups 3 (1.69 ± 0.52), 4 (0.69 ± 0.10) and 5 (0.49 ± 0.10). Also, the histoarchitecture progressively normalized to that of control with each increase in dose of the extract. Conclusion: Azadirachta indica (neem) leaf extract administration led to the resolution of Ibuprofen-induced kidney injury in this study. Thus, it can serve as a treatment option for kidney injury resulting from ingestion of Ibuprofen, after the identification of the molecule responsible for this effect.

scholarly journals Gastroprotective effect of the aqueous fraction of hydroacetonic leaf extract of Eugenia uniflora L. (Myrtaceae) (pitanga) against several gastric ulcer models in mice

2017 ◽  
Vol 11 (39) ◽  
pp. 603-612 ◽  
Author(s):  
Luís Rodrigues M. José ◽  
Moreira da S. Dayane ◽  
Oluwagbamigbe F. James ◽  
Mayra Hungria P. Emerith ◽  
de Souza G. Eric ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Leaf Extract ◽  
Aqueous Fraction ◽  
Eugenia Uniflora ◽  
Gastroprotective Effect

scholarly journals Costus afer (Costaceae, Zingiberales) leaf extract ameliorates naproxen-induced gastric ulcer in rats

2021 ◽  
Vol 19 (12) ◽  
pp. 2615-2622
Author(s):  
Hala AH Khattab ◽  
Buthaina M. Aljehany
Keyword(s):  
Nitric Oxide ◽  
Lipid Peroxidation ◽  
Gastric Ulcer ◽  
Gastric Acidity ◽  
Leaf Extract ◽  
Reduced Glutathione ◽  
Lipid Peroxide ◽  
Gastric Ph ◽  
Ulcer Index ◽  
Costus Afer

Purpose: To examine Costus afer leaf extract (CALE) protective effects against naproxen-induced gastric ulcer and the mechanisms of protection.Methods: Rats with naproxen-induced ulcer were pretreated with either CALE (800 mg/kg), pantoprazole (20 mg/kg), or a combination of both. Then the ulcer index, total gastric acidity, gastric pH, and curative index were evaluated. In addition, gastric mucin, pepsin, prostaglandin E2, nitric oxide, reduced glutathione, lipid peroxide, and superoxide dismutase were quantified. The gastric pathologicalchange was also evaluated.Results: Rats treated with CALE, pantoprazole, and their combination significantly decreased ulcer index, total gastric acidity, and gastric pH. All treatments induced a significant curative index in favor of the combination. The CALE significantly increased gastric mucin, prostaglandin E2, nitric oxide, reduced glutathione, and superoxide dismutase. However, the CALE significantly decreased pepsin and lipid peroxide product.Conclusion: These results reveal that CALE protects the stomach against naproxen-induced ulcer. This action is linked to increased gastroprotective factors, increased antioxidants, and decreased lipid peroxidation. The CALE may be used as an adjunctive treatment for ulcers caused by NSAIDs. Keywords: Costus afer, Naproxen, Gastric ulcer, Antioxidants, Lipid peroxidation

scholarly journals Effects of Moringa Leaf Extract and Moderate Intensity Exercise on Histopathological Appearance and Autophagy Gene Expression

2021 ◽  
Vol 6 (1) ◽  
pp. 10-19
Author(s):  
Julia Windi Gunadi ◽  
Danti Dja Jatnika ◽  
Stephanie Astrid ◽  
Teresa Lucretia ◽  
Hamidie Ronald Daniel Ray ◽  
...  
Keyword(s):  
Gene Expression ◽  
Rat Liver ◽  
Leaf Extract ◽  
Wistar Rat ◽  
Exercise Group ◽  
Moderate Intensity ◽  
Control Group ◽  
Moderate Intensity Exercise ◽  
Autophagy Gene ◽  
Moringa Leaf Extract

The prevention of liver disease could be conducted through preventive strategies, such as antioxidants and exercise. Moringa leaf extract has substances that could act as antioxidant, while exercise is also known protecting the liver from disease by changing hepatic metabolism and autophagy. This study aimed to investigate the effect of moringa leaf extract and moderate intensity exercise on histopathological appearance and autophagy gene expression of wistar rat liver. The method used in this study was animal experiment using 24 male wistar rats divided into 4 groups, including control group, moringa group, exercise group, and moringa + exercise group. Moringa leaf extract was given in low dose (5.7 mg/kgW) per oral, 5 times a week, for 4 weeks. Meanwhile, the 20 m/minute treadmill exercise was given for 30 minutes per day, 5 times a week, for 4 weeks. Results showed a significant change on histopathological scoring in exercise group (p=0.011) compared to control group. Increased autophagy gene expression was found in moringa + exercise group compared to control group (LC3 0.90 fold; p62 0.87 fold). In summary, this study presented that moderate intensity exercise induced changes on histopathological appearance of wistar rat liver that might be associated with physiological inflammation. Moringa, with its antioxidant properties, combined with increased autophagy might improve histopathological changes in moringa + exercise group.

scholarly journals Anti-ulcer activity of aqueous leaf extract of Nauclea latifolia (rubiaceae) on indomethacin-induced gastric ulcer in rats

2013 ◽  
Vol 12 (32) ◽  
pp. 5080-5086 ◽  
Author(s):  
M E Balogun ◽  
J O Oji ◽  
E E Besong ◽  
A A Ajah ◽  
E M Michael
Keyword(s):  
Gastric Ulcer ◽  
Leaf Extract ◽  
Aqueous Leaf Extract ◽  
Nauclea Latifolia

scholarly journals ANTIOXIDANT AND ANTIULCER ACTIVITY OF ABRUS PRECATORIUS LEAF EXTRACT AGAINST ACETIC ACID-INDUCED GASTRIC ULCER IN RATS

2019 ◽  
pp. 218-220
Author(s):  
LALITA NAGDA ◽  
CHANDRA PRAKASH JOSHI ◽  
JYOTI MENARIA
Keyword(s):  
Acetic Acid ◽  
Gastric Ulcer ◽  
Leaf Extract ◽  
Defense Mechanism ◽  
Gastric Volume ◽  
Gastric Ulcers ◽  
Antiulcer Activity ◽  
Plant Leaves ◽  
Once Daily ◽  
Abrus Precatorius

Objective: The present study deals with the study of antiulcer activity of Abrus precatorius leaf extract in acetic acid-induced gastric ulcers was studied in rats. Methods: In the present study, A. precatorius leaf extract was carried out in antiulcer activity against acetic acid-induced gastric ulcer in rats. A. precatorius at doses of 150 mg/kg and 300 mg/kg were administered orally once daily for 10 days. Results: It was found that extract significantly reduced ulcer index. The plant leaves made gastric anti-secretory effect by decreasing gastric volume and acidity. Then, gastric mucin was increased, which showed gastric cytoprotective effect. The plant showed the prevention effect of increased lipid peroxidation during ulceration by acetic acid. Activities of the antioxidant enzymes were enhanced during ulceration by this plant leaves. Conclusion: Leaves of A. precatorius Linn. could decrease acetic acid-induced gastric ulcers in rats and this antiulcerogenic activity was mediated through antioxidant defense mechanism.

scholarly journals In Vivo Antioxidant and Antiulcer Activity of Parkia speciosa Ethanolic Leaf Extract against Ethanol-Induced Gastric Ulcer in Rats

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64751 ◽  
Author(s):  
Rami Al Batran ◽  
Fouad Al-Bayaty ◽  
Mazen M. Jamil Al-Obaidi ◽  
Abdualrahman Mohammed Abdualkader ◽  
Hamid A. Hadi ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Leaf Extract ◽  
Antiulcer Activity ◽  
Ethanolic Leaf Extract
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