scholarly journals Gastroprotective effect of the aqueous fraction of hydroacetonic leaf extract of Eugenia uniflora L. (Myrtaceae) (pitanga) against several gastric ulcer models in mice

2017 ◽  
Vol 11 (39) ◽  
pp. 603-612 ◽  
Author(s):  
Luís Rodrigues M. José ◽  
Moreira da S. Dayane ◽  
Oluwagbamigbe F. James ◽  
Mayra Hungria P. Emerith ◽  
de Souza G. Eric ◽  
...  
Keyword(s):  
Gastric Ulcer ◽  
Leaf Extract ◽  
Aqueous Fraction ◽  
Eugenia Uniflora ◽  
Gastroprotective Effect

ANTIFUNGAL ACTIVITY OF LEAF EXTRACT OF Cannabis sativa AGAINST Aspergillus flavipes

2020 ◽  
Vol 27 (2) ◽  
pp. 447-453
Author(s):  
Iqra Haider Khan ◽  
Arshad Javaid
Keyword(s):  
Antifungal Activity ◽  
Fungal Biomass ◽  
Leaf Extract ◽  
Cannabis Sativa ◽  
Aqueous Fraction ◽  
Antifungal Effect ◽  
Butanol Fraction ◽  
Aspergillus Flavipes ◽  
Antifungal Potential ◽  
Laboratory Bioassays

Cannabis sativa L. is a medicinally important weed of family Cannabaceae generally grows along road-sides and waste-lends in Punjab, Pakistan. In the present study, antifungal effect of leaf extract of this weed was assessed against Aspergillus flavipes. Methanolic leaf extract of the weed was partitioned into five fractions using organic solvents of variable polarities. A range of concentrations (1.562 to 200 mg mL-1) of each fraction was used in laboratory bioassays. n-Butanol fraction showed the highest antifungal activity followed by chloroform and n-hexane fractions causing 68–82%, 52–82% and 42–82% decrease in biomass of A. flavipes. Ethyl acetate showed a moderate antifungal potential while aqueous fraction showed the least antifungal activity causing 47–76% and 38–73% reduction in fungal biomass, respectively. This study concludes that n-butanol fraction of leaf extract of C. sativa is highly effective in controlling growth of A. flavipes.

Leaf extract of Eugenia uniflora L. prevents episodic memory impairment induced by streptozotocin in rats

2019 ◽  
Vol 11 (3) ◽  
pp. 329 ◽  
Author(s):  
IltonSantos da Silva ◽  
JoanaRosar Corbellini ◽  
Gabrielle Pfutzenreuter ◽  
LeilaTeresinha Maranho ◽  
MárciaRegina Pincerati
Keyword(s):  
Episodic Memory ◽  
Memory Impairment ◽  
Leaf Extract ◽  
Eugenia Uniflora

scholarly journals Protective Effect of Ocotillol, the Derivate of Ocotillol-Type Saponins in Panax Genus, against Acetic Acid-Induced Gastric Ulcer in Rats Based on Untargeted Metabolomics

2020 ◽  
Vol 21 (7) ◽  
pp. 2577 ◽  
Author(s):  
Cuizhu Wang ◽  
Yuze Yuan ◽  
He Pan ◽  
Alan Chen-Yu Hsu ◽  
Jinluan Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acetic Acid ◽  
Gastric Ulcer ◽  
Growth Factor ◽  
Gastric Mucosa ◽  
Epidermal Growth Factor ◽  
Serum Levels ◽  
Gastroprotective Effect ◽  
Epidermal Growth ◽  
Oxide Synthase

Gastric ulcer (GU), a prevalent digestive disease, has a high incidence and is seriously harmful to human health. Finding a natural drug with a gastroprotective effect is needed. Ocotillol, the derivate of ocotillol-type saponins in the Panax genus, possesses good anti-inflammatory activity. The study aimed to investigate the gastroprotective effect of ocotillol on acetic acid-induced GU rats. The serum levels of endothelin-1 (ET-1) and nitric oxide (NO), the gastric mucosa levels of epidermal growth factor, superoxide dismutase and NO were assessed. Hematoxylin and eosin staining of gastric mucosa for pathological changes and immunohistochemical staining of ET-1, epidermal growth factor receptors and inducible nitric oxide synthase were evaluated. A UPLC-QTOF-MS-based serum metabolomics approach was applied to explore the latent mechanism. A total of 21 potential metabolites involved in 7 metabolic pathways were identified. The study helps us to understand the pathogenesis of GU and to provide a potential natural anti-ulcer agent.

Gastroprotective Effect of Saccharomyces boulardii in a Rat Model of Ibuprofen-Induced Gastric Ulcer

Pharmacology ◽  
2010 ◽  
Vol 85 (3) ◽  
pp. 188-193 ◽  
Author(s):  
Philippe Girard ◽  
Marie-Claude Coppé ◽  
Yannick Pansart ◽  
Jean-Marie Gillardin
Keyword(s):  
Gastric Ulcer ◽  
Rat Model ◽  
Saccharomyces Boulardii ◽  
Gastroprotective Effect

scholarly journals GASTROPROTECTIVE EFFECT OF SESBANIA GRANDIFLORA LINN. SEEDS EXTRACT.

2020 ◽  
Vol 9 (2) ◽  
Author(s):  
Pallavi. B ◽  
Sunil. N ◽  
Syed Mansoor Ahamed ◽  
Nandheesh R.
Keyword(s):  
Peptic Ulcer ◽  
Gastric Ulcer ◽  
Small Intestine ◽  
World Population ◽  
Total Acidity ◽  
Peptic Ulcers ◽  
Ulcer Index ◽  
Standard Drug ◽  
Sesbania Grandiflora ◽  
Gastroprotective Effect

Background: A peptic ulcer is a sore in the lining of the stomach or the first part of the small intestine. Ulcer can be developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Peptic ulcers are usually aggravated by an imbalance between destructive and defensive factors in the stomach, it affects nearly 10% of world population. The objective of the study was to investigate the protective effect of ethanolic extract of Sesbania grandiflora Linn. Seeds (SGEE) on peptic ulcer induced by ethanol in experimental rats. Objectives: Gastroprotective effect of Sesbania grandiflora Linn. Seeds extract on experimental Materials and Methods: The gastroprotective effect of SGEE was studied using ethanol (70% ) induced acute gastric ulcer models. The animals were divided into five groups, each group contains six animals. SGEE was administered in two doses, (200 mg/kg and 400 mg/kg, p.o). The parameters investigated include acid volume, pH, total acidity, ulcer index, total protein, glutathione, lipid peroxidase, catalase & histopathological studies. Results: 1. In gastroprotective effect study, SGEE significantly inhibited the development of ulcers induced by ethanol. The SGEE significantly reduced the acid volume, total acidity, total acidity, ulcer index, lipid peroxidation & increases in pH, glutathione & catalase level. Histopathogical studies also revealed that SGEE is gastro-protective. Ranitidine (100 mg/kg) is used as standard drug. Conclusion: All the observation implies that SGEE possess significant protective activity against ethanol induced gastric ulcer in experimental rats. 400 mg/kg doses has shown more protection compared to 200 mg/kg (dose dependent activity was obtained). Keywords: Antiulcer; Sesbania grandiflora; Ethanol; Ranitidine.

scholarly journals Gastroprotective Effect of Green Algae Extract (Ulva lactuca L) on Gastric Rats

2020 ◽  
Vol 7 (2) ◽  
pp. 73
Author(s):  
Wahyu Widyaningsih ◽  
Siti Nurasih Afdaliah
Keyword(s):  
Gastric Ulcer ◽  
Green Algae ◽  
Negative Control ◽  
Ulva Lactuca ◽  
P Value ◽  
Ulcer Index ◽  
Gastroprotective Effect ◽  
Group I ◽  
Significant Difference ◽  
Protection Ratio

Gastric ulcer is a disease of the digestive tract characterized by mucous damage to secretion of gastric acid and pepsin. One of the potential gastroprotector plants is green algae. The purpose of this study was to examine the gastroprotective effect of ethanol extract of green algae (EEGH) Ulva lactuca L on the gastric of ethanol-induced rats. This study used 36 rats, divided into 6 groups. Group I is a normal group. Group II negative control, ethanol 96% induced. Group III positive control, given comparison of ranitidine dose of 15.75 mg/kgBW. Groups IV, V and VI were given multilevel EEGH, namely 125, 250 and 500 mg/kgBW. The treatment was carried out for 14 days, on the 14th day ethanol 96% was induced and then dissected. Research data on gastric ulcer index and protection ratio were analyzed using One Way ANOVA with a confidence level of 95%. The results of the EEGH statistical test dose of 500 mg/kgBW with negative controls showed a significant difference with p value of 0.013 (p<0.05). The EEGH 500 mg/kgBW has the ability as an effective gastroprotector, as seen from the gastric ulcer index value of 0.5 and the protection ratio of 78.94%.Keywords: Ethanol, gastroprotector, protection ratio, ulcer index, Ulva lactuca L.78,94%. 

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