scholarly journals ASSESSMENT OF PATHOGENICITY OF SOIL FUNGI TRICHODERMA VIRIDE 505

2014 ◽  
Vol 20 ◽  
pp. 23-28
Author(s):  
N. О. Kravchenko ◽  
Ye. P. Kopylov ◽  
О. V. Holovach ◽  
О. М. Dmytruk
Keyword(s):  
Soil Fungi ◽  
Trichoderma Viride ◽  
Laboratory Animals ◽  
Mice Model ◽  
Internal Organs

Assessment of pathogenic properties of the soil antagonist fungus Trichoderma viride Pers was performed in vivisection on white mice model. During the experiments the LD50 of strain was established, followed by the study of pathological and bacteriological tests of the internal organs of laboratory animals. According to the results obtained, Trichoderma viride Pers 505 strain belongs to a group of the avirulent microorganisms, not capable to invade internal organs of studied warm-blooded animals and cannot be considered as pathogenic.

MICROSCOPIC CHANGES IN THE INTERNAL ORGANS OF WHITE MICE DURING EXPERIMENTAL IRON (IV) CLATHROCHELATE TOXICOSIS

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
B. V. Borysevych ◽  
◽  
V. V. Lisova ◽  
I. M. Derkach ◽  
S. S. Derkach ◽  
...  
Keyword(s):  
Biological Response ◽  
Organ Damage ◽  
The Body ◽  
New Drugs ◽  
Laboratory Animals ◽  
Internal Organs ◽  
Experimental Drug ◽  
Liver And Kidney ◽  
Preclinical And Clinical Studies ◽  
First Time

Iron (IV) clathrochelate based on a macrobicyclic ligand of the hexahydrazide type is a unique compound that contains iron in a rare high valence IV. Preclinical and clinical studies of this complex, which were started for the first time in Ukraine, have an important theoretical and practical consequence as this complex can be recommended as an active substance in iron-containing drugs with antianemic action. In conducting preclinical studies of new drugs, pathomorphological studies are important because they are a necessary step in studying the biological response of animals to the action of test substances. It was found that some pathological changes develop in the body of white mice under conditions of experimental acute and chronic iron (IV) clathrochelate intoxication. They correlated with the dose of the test compound. During chronic intoxication, the microscopic changes in the liver and kidney of white mice treated with iron (IV) clathrochelate at a dose of 1/10 DL50 were similar to the microscopic changes in the liver and kidney of mice treated with the experimental drug at a dose of 1/5 DL50. However, the severity of these changes was lower, reflecting a lower degree of organ damage. In the myocardium of mice treated with iron (IV) clathrochelate at a dose of 1/5 DL50 on the 10th day, as in acute iron (IV) clathrochelate poisoning, only edema was recorded. The prospects for further research are the study of microscopic changes in the organs of laboratory animals of other species during experimental iron (IV) clathrochelate toxicosis.

scholarly journals Distribution and Resorption of Intravenously Administrated Polymer Microparticles in Tissues of Internal Organs of Laboratory Animals

2009 ◽  
Vol 2 (4) ◽  
pp. 453-465 ◽  
Author(s):  
Shishatskaya Ekaterina I. ◽  
◽  
Goreva Anastasya V. ◽  
Kalacheva Galina S. ◽  
Volova Tatiana G. ◽  
...  
Keyword(s):  
Laboratory Animals ◽  
Internal Organs ◽  
Polymer Microparticles

scholarly journals In Vitro Antagonism of Trichoderma Verede and Aspergillus Spp. against a Pathogenic Seed Borne Fungus of Sesame

2019 ◽  
Vol 43 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Md Delwar Hosen ◽  
Shamim Shamsi
Keyword(s):  
Aspergillus Flavus ◽  
Soil Fungi ◽  
Trichoderma Viride ◽  
Dual Culture ◽  
Volatile Metabolites ◽  
Inhibiting Effect ◽  
Antagonistic Potential ◽  
Academy Of Sciences ◽  
Growth Inhibiting

Four soil fungi were isolated from the soil by serial dilution and were identified as Aspergillus flavus Link, A. fumigatus Fresenius, A. niger van Tieghem and Trichoderma viride Pers. The soil fungi were selected to evaluate their antagonistic potential against seed borne fungus Fusarium merismoides isolated from sesame. In dual culture colony interaction Trichoderma viride showed the highest (45.88%) growth inhibiting effect on F. merismoides followed by A. niger (40.00%), A. flavus (36.37) and A. fumigatus (30.77%). Volatile metabolites from T. viride showed the highest growth inhibiting effect on F. merismoides (67.69%) and non-volatile metabolites from T. viride showed the highest growth inhibiting effect on F. merismoides (75.00%). Journal of Bangladesh Academy of Sciences, Vol. 43, No. 1, 17-23, 2019

COMPARATIVE RESPONSE OF TWO SAPROPHYTIC AND TWO PLANT PARASITIC SOIL FUNGI TO TEMPERATURE, HYDROGEN-ION CONCENTRATION, AND NUTRITIONAL FACTORS

1961 ◽  
Vol 39 (1) ◽  
pp. 65-79 ◽  
Author(s):  
E. W. B. Ward ◽  
A. W. Henry
Keyword(s):  
Soil Fungi ◽  
Inorganic Nitrogen ◽  
Synthetic Medium ◽  
Trichoderma Viride ◽  
Nitrogen Sources ◽  
Ion Concentration ◽  
Good Growth ◽  
Hydrogen Ion Concentration ◽  
Nutritional Factors ◽  
Ph Values

The behavior of two soil saprophytes, Trichoderma viride and Trichocladium asperum, and two root-infecting fungi, Ophiobolus graminis and Fomes annosus, was compared under various conditions in laboratory culture.On an agar-solidified organic medium optimum temperatures for growth were approximately: T. viride 25–30 °C, T. asperum 20–25 °C, O. graminis 20–25 °C, F. annosus 25 °C. T. viride rapidly outgrew the other fungi in the optimum range but this relationship changed at lower temperatures, its growth rate being equalled by that of O. graminis at 10 °C. T. viride was the only fungus to grow at 35 °C. In a synthetic liquid medium adjusted to pH values from 3.0–7.0 with a citrate–phosphate buffer, growth of O. graminis and F. annosus was sharply reduced at pH values below 5.0. T. viride made good growth at pH 3.1 and reduction in growth of T. asperum occurred only below pH 4.0. Both parasites required thiamine for growth in a synthetic medium and O. graminis also required biotin; in addition they showed a preference for organic as opposed to inorganic nitrogen sources. T. viride and T. asperum grew well with KNO3 as nitrogen source and neither required vitamins. D-Glucose, D-fructose, and D-mannose were readily utilized, and D-arabinose poorly utilized, by all four fungi. Utilization of other hexoses, pentoses, disaccharides, and polysaccharides varied considerably between the fungi.The relationship of the results obtained to the observations of others on the ecology of soil fungi is discussed and the possibility that combinations of physical and nutritional factors may favor specific fungi in the soil is considered.

GROWTH INHIBITION OF TWO SAPROPHYTIC AND TWO PLANT PARASITIC SOIL FUNGI BY ANTIBIOTICS

1961 ◽  
Vol 39 (3) ◽  
pp. 491-495
Author(s):  
E. W. B. Ward ◽  
A. W. Henry
Keyword(s):  
Growth Inhibition ◽  
Soil Fungi ◽  
Agar Medium ◽  
Trichoderma Viride ◽  
Natural Soil ◽  
Plant Parasitic

Comparisons were made of growth inhibition of two saprophytic (Trichoderma viride, Trichocladium asperum) and two plant parasitic soil fungi (Ophiobolus graminis, Fomes annosus) by antibiotics. The fungi were grown on an agar medium containing various concentrations of one of the antibiotics: acti-dione, gliotoxin, griseofulvin, patulin, or trichothecin. In general the two parasites tended to be more sensitive than the saprophytes, but there were several individual exceptions. Moreover, the comparative responses of the fungi at different antibiotic concentrations were frequently not proportionately related. The results are discussed in relation to the possible effects of antibiotics on fungi in natural soil.

scholarly journals Morphological Changes in the Internal Organs of Laboratory Animals under a Single Administration of Fe Nanoparticles

2011 ◽  
Vol 11 (2) ◽  
pp. 62-66
Author(s):  
Nikita Aleksandrovich Navolokin ◽  
◽  
Olga Viktorovna Matveeva ◽  
Galina Nikiforovna Maslyakova ◽  
Alla Borisovna Bucharskaya ◽  
...  
Keyword(s):  
Morphological Changes ◽  
Laboratory Animals ◽  
Single Administration ◽  
Internal Organs ◽  
Fe Nanoparticles

scholarly journals Synthesis and Properties of Zinc-Modified Hydroxyapatite

2020 ◽  
Vol 11 (1) ◽  
pp. 10
Author(s):  
Daria Lytkina ◽  
Anastasiya Gutsalova ◽  
Dmitriy Fedorishin ◽  
Natalya Korotchenko ◽  
Rafik Akhmedzhanov ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Functional Materials ◽  
Nitrogen Adsorption ◽  
Laboratory Animals ◽  
Zinc Ions ◽  
Internal Organs ◽  
Surgical Implants ◽  
Entire Experiment ◽  
Inorganic Components ◽  
Xrd Method

Hydroxyapatites modified with metal ions are the main inorganic components of bone tissue and are approved for use as components for biocomposites and coatings for surgical implants. This study examined prototypes of functional materials for bone implants based on hydroxyapatite modified with zinc ions. Zinc-modified hydroxyapatite was composed and synthesized. Using the XRD method, the phase composition was established. Using SEM, EPMA, and low-temperature nitrogen adsorption (BET) methods, surface properties were investigated. Antibacterial activity and biocompatibility have been established. The studied materials have antimicrobial activity; the samples did not cause significant changes in either the internal organs or the general condition of laboratory animals during the entire experiment.

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