scholarly journals Hubungan antara Mikrobiota dan Psoriasis

2021 ◽  
Vol 1 (1) ◽  
pp. 7-11
Author(s):  
Alinta Ayuningtyas Alinta ◽  
◽  
Khairun Nisa Berawi ◽  
Nurul Islamy ◽  
◽  
...  
Keyword(s):  
Systematic Review ◽  
Skin Diseases ◽  
Plaque Formation ◽  
The Body ◽  
Therapeutic Interventions ◽  
Skin Microbiota ◽  
Inflammatory Skin Diseases ◽  
Environmental Interactions ◽  
Immune Mediated ◽  
Selective Modulation

Abstract As the largest organ of the human body, the skin is colonized by a variety of microorganisms, most of which are harmless and have benefits for the host. This microbiota contributes to the metabolism and immunity of the host. The human microbiota includes bacteria, fungi, viruses and archaea, which inhabit various areas of the body. Most of the microbiota resides in the intestine, only a small part of which inhabit epithelial surfaces such as the mouth, airways, vagina and skin. The total number of microbiota on the surface of the skin is usually in the range 104 to 106 cells per cm2. Psoriasis is one of the most common immune-mediated inflammatory skin diseases. The prevalence of disease has been reported, with a range of 0.09- 11.43% by the WHO Global Report 2016. To date the causes of this disease are not fully understood, genetic and environmental interactions play an important role in disease progression. Recently, immunological approaches have helped to clarify the pathophysiology of the disease significantly. The skin microbiota has been shown to play a role in the pathogenesis of lichenified plaque formation in psoriasis. Corynebacterium, Propionibacterium, Staphylococcus, and also Streptococcus have been identified as the main microbiota. It has not been determined whether these changes in the microbiota are a cause or consequence of psoriasis. For this reason, further research on selective modulation of the skin microbiota is needed. This systematic review aims to elucidate the correlation between the microbiome and pathogenesis of psoriasis and the modulation of the microbiota that could lead to possible therapeutic interventions. Keywords: Microbiota, Psoriasis, Skin

scholarly journals Relationship between Skin Microbiota and Skin Biophysical Parameters in Inflammatory Skin Disease: A Systematic Review

2021 ◽  
Vol 7 (1) ◽  
pp. 1-6
Author(s):  
Paola Perugini ◽  
Keyword(s):  
Systematic Review ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Bacterial Flora ◽  
Skin Microbiota ◽  
Biophysical Parameters ◽  
Microbial Composition ◽  
Inflammatory Skin Diseases ◽  
Starting Point ◽  
Inflammatory Skin

Many recent studies highlight the importance of skin microbiota for skin health. Alterations in the balance of bacterial flora cause the development of inflammatory skin diseases such as acne, atopic dermatitis, or psoriasis. This systematic review aims to investigate the relationship, in these skin diseases, between skin microbiota and skin biophysical parameters, such as pH, Transepidermal Water Loss (TEWL), Hydration (HI) and sebum levels. Google Scholar, Medline via Pubmed, and Web of Science were considered as scientific database to search studies about this topic. Research about acne and psoriasis did not produce any results. For this reason, in this review, only articles concerning atopic dermatitis were discussed. Therefore, a possible correlation between skin barrier functionality and microbial composition was also investigated. So, this could be a starting point for the diagnosis of atopic dermatitis or, more generally, for all inflammatory skin diseases.

scholarly journals Interplay Between Skin Microbiota Dysbiosis and the Host Immune System in Psoriasis: Potential Pathogenesis

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiaoqian Liang ◽  
Caixin Ou ◽  
Jiayi Zhuang ◽  
Jinsheng Li ◽  
Fangfei Zhang ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Skin Diseases ◽  
Cell Populations ◽  
Host Immune System ◽  
Skin Microbiota ◽  
Inflammatory Skin Diseases ◽  
Immune Mediated ◽  
Underlying Pathogenesis ◽  
Novel Therapeutic

Psoriasis is a multifactorial immune-mediated disease. The highly effective and eligible treatment for psoriasis is limited, for its specific pathogenesis is incompletely elucidated. Skin microbiota is a research hotspot in the pathogenesis of immune-mediated inflammatory skin diseases nowadays, and it may have significant involvement in the provocation or exacerbation of psoriasis with broadly applicable prospects. It is postulated that skin microbiota alternation may interplay with innate immunity such as antimicrobial peptides and Toll-like receptors to stimulate T-cell populations, resulting in immune cascade responses and ultimately psoriasis. Achieving a thorough understanding of its underlying pathogenesis is crucial. Herein, we discuss the potential immunopathogenesis of psoriasis from the aspect of skin microbiota in an attempt to yield insights for novel therapeutic and preventive modalities for psoriasis.

Molecular Targets of Phytochemicals for Skin Inflammation

2018 ◽  
Vol 24 (14) ◽  
pp. 1533-1550 ◽  
Author(s):  
Jong-Eun Kim ◽  
Ki Won Lee
Keyword(s):  
Skin Diseases ◽  
Molecular Targets ◽  
Skin Inflammation ◽  
Mechanisms Of Action ◽  
The Body ◽  
Cellular Damage ◽  
Aesthetic Appearance ◽  
Immune Mediated ◽  
Skin Conditions ◽  
Effects Of Aging

Skin is a protective organ and the largest of the human body. Due to its pivotal role in aesthetic appearance, skin health has a significant impact on quality of life. Chronic inflammation of the skin often marks the beginning of various skin diseases. Immune-mediated responses serve to protect the body from external insults and require succinct control, and can lead to ongoing cellular damage and various skin conditions if left unchecked. Studies have shown that phytochemicals can alter processes involved in skin inflammation and alleviate the effects of aging, cancer, atopic dermatitis, psoriasis, and vitiligo. Direct molecular targets of some phytochemicals have been identified and their precise mechanisms of action investigated. In this review, we summarize recent findings on the effects of phytochemicals on skin inflammation and the mechanisms of action involved.

Anti-tumor necrosis factor-α therapies for immune-mediated and inflammatory skin diseases

2011 ◽  
Vol 72 (7) ◽  
pp. 615-622
Author(s):  
Clio Dessinioti ◽  
Alexander J. Stratigos ◽  
Andreas Katsambas ◽  
Christina Antoniou
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Skin Diseases ◽  
Inflammatory Skin Diseases ◽  
Immune Mediated ◽  
Inflammatory Skin ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Features of the Skin Microbiota in Common Inflammatory Skin Diseases

Life ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 962
Author(s):  
Iva Ferček ◽  
Liborija Lugović-Mihić ◽  
Arjana Tambić-Andrašević ◽  
Diana Ćesić ◽  
Ana Gverić Grginić ◽  
...  
Keyword(s):  
Skin Diseases ◽  
Seborrheic Dermatitis ◽  
Bacterial Species ◽  
Clinical Manifestations ◽  
Skin Microbiome ◽  
Bacterial Strains ◽  
Skin Microbiota ◽  
Inflammatory Skin Diseases ◽  
Bacterial Microbiome ◽  
Inflammatory Skin

Many relatively common chronic inflammatory skin diseases manifest on the face (seborrheic dermatitis, rosacea, acne, perioral/periorificial dermatitis, periocular dermatitis, etc.), thereby significantly impairing patient appearance and quality of life. Given the yet unexplained pathogenesis and numerous factors involved, these diseases often present therapeutic challenges. The term “microbiome” comprises the totality of microorganisms (microbiota), their genomes, and environmental factors in a particular environment. Changes in human skin microbiota composition and/or functionality are believed to trigger immune dysregulation, and consequently an inflammatory response, thereby playing a potentially significant role in the clinical manifestations and treatment of these diseases. Although cultivation methods have traditionally been used in studies of bacterial microbiome species, a large number of bacterial strains cannot be grown in the laboratory. Since standard culture-dependent methods detect fewer than 1% of all bacterial species, a metagenomic approach could be used to detect bacteria that cannot be cultivated. The skin microbiome exhibits spatial distribution associated with the microenvironment (sebaceous, moist, and dry areas). However, although disturbance of the skin microbiome can lead to a number of pathological conditions and diseases, it is still not clear whether skin diseases result from change in the microbiome or cause such a change. Thus far, the skin microbiome has been studied in atopic dermatitis, seborrheic dermatitis, psoriasis, acne, and rosacea. Studies on the possible association between changes in the microbiome and their association with skin diseases have improved the understanding of disease development, diagnostics, and therapeutics. The identification of the bacterial markers associated with particular inflammatory skin diseases would significantly accelerate the diagnostics and reduce treatment costs. Microbiota research and determination could facilitate the identification of potential causes of skin diseases that cannot be detected by simpler methods, thereby contributing to the design and development of more effective therapies.

Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence

2019 ◽  
Vol 21 (1) ◽  
pp. 21-39 ◽  
Author(s):  
Simran Dhaliwal ◽  
Mimi Nguyen ◽  
Alexandra R. Vaughn ◽  
Manisha Notay ◽  
Cindy J. Chambers ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Evidence ◽  
Skin Diseases ◽  
Zinc Supplementation ◽  
Inflammatory Skin Diseases ◽  
Inflammatory Skin

The Role of Bioactive Compounds and other Metabolites from Mushrooms against Skin Disorders- A Systematic Review Assessing their Cosmeceutical and Nutricosmetic Outcomes

2020 ◽  
Vol 27 (41) ◽  
pp. 6926-6965
Author(s):  
Oludemi Taofiq ◽  
Maria Filomena Barreiro ◽  
Isabel C.F.R. Ferreira
Keyword(s):  
Systematic Review ◽  
Bioactive Compounds ◽  
Skin Diseases ◽  
Scientific Data ◽  
Inflammatory Skin Diseases ◽  
Toxicological Studies ◽  
Pros And Cons ◽  
Long Term Studies

Bioactive compounds derived from mushrooms have been shown to present promising potential as cosmeceutical or nutricosmetic ingredients. Scientific data reviewed herein showed that extracts prepared from medicinal and edible mushrooms and their individual metabolites presented antiinflammatory, antioxidant, photoprotective, antimicrobial, anti-tyrosinase, anti-elastase, and anticollagenase activities. These metabolites can be utilised as ingredients to suppress the severity of Inflammatory Skin Diseases, offer photoprotection to the skin, and correct Hyperpigmentation. However, studies regarding the molecular mechanism behind the mentioned bioactivities are still lacking. Challenges associated with the use of mushroom extracts and their associated metabolites as cosmeceutical and nutricosmetic ingredients include several steps from the fruiting bodies to the final product: extraction optimization, estimation of the efficacy and safety claims, the use of micro and nanocarriers to allow for controlled release and the pros and cons associated with the use of extracts vs individual compounds. This systematic review highlights that mushrooms contain diverse biomolecules that can be sustainably used in the development of nutricosmetic and cosmeceutical formulations. Reports regarding stability, compatibility, and safety assessment, but also toxicological studies are still needed to be considered. Furthermore, some of the constraints and limitations hindering the development of this type of ingredients still require long-term studies to achieve major breakthroughs.

Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy

2019 ◽  
Vol 11 (522) ◽  
pp. eaax2693 ◽  
Author(s):  
Jörg Klufa ◽  
Thomas Bauer ◽  
Buck Hanson ◽  
Craig Herbold ◽  
Philipp Starkl ◽  
...  
Keyword(s):  
Adverse Events ◽  
Skin Diseases ◽  
De Novo ◽  
Growth Factor Receptor ◽  
Erk Signaling ◽  
Skin Microbiota ◽  
Inflammatory Skin Diseases ◽  
Commensal Microbiota ◽  
Barrier Defect ◽  
Inflammatory Skin

Epidermal growth factor receptor (EGFR)–targeted anticancer therapy induces stigmatizing skin toxicities affecting patients’ quality of life and therapy adherence. The lack of mechanistic details underlying these adverse events hampers their management. We found that EGFR/ERK signaling is required in LRIG1-positive stem cells during de novo hair eruption to secure barrier integrity and prevent the invasion of commensal microbiota and inflammatory skin disease. EGFR-deficient epidermis is permissive for microbiota outgrowth and displays an atopic-like TH2-dominated signature. The opening of the follicular ostia during hair eruption allows invasion of commensal microbiota into the hair follicle, initiating an additional TH1 and TH17 response culminating in chronic folliculitis. Restoration of epidermal ERK signaling via prophylactic FGF7 treatment or transgenic SOS expression rescues the barrier defect in the absence of EGFR, highlighting a therapeutic anchor point. These data reveal that commensal skin microbiota provoke atopic-like inflammatory skin diseases by invading into the follicular opening of erupting hair.

Biopsies of Facial Dermatoses Made Simple

2014 ◽  
Vol 138 (4) ◽  
pp. 550-552 ◽  
Author(s):  
Faisal Al-Mohammedi ◽  
Richard I. Crawford ◽  
Magdalena Martinka
Keyword(s):  
Differential Diagnosis ◽  
Skin Diseases ◽  
English Literature ◽  
The Body ◽  
Inflammatory Skin Diseases ◽  
The Face ◽  
Inflammatory Skin ◽  
Skin Conditions ◽  
Facial Dermatitis

Context.—Biopsy of the face is rarely done for inflammatory skin diseases, unless the entire process is confined to the face. Objective.—We hypothesized that facial dermatitis has a differential diagnosis that is more limited than the differential diagnosis of inflammatory skin diseases that affect other parts of the body. To our knowledge, the classification of inflammatory skin diseases occurring on the face has never been conducted before in the English literature. Design.—The most-recent 100 facial biopsies of inflammatory skin conditions were retrieved from our files, and the cases were categorized into the main inflammatory skin patterns. Results.—Forty-seven cases (47%) were categorized as interface dermatitis, 2 cases (2%) as psoriasiform dermatitis, 11 cases (11%) as spongiotic dermatitis, 16 cases (16%) as diffuse and nodular dermatitis, 8 cases (8%) as perivascular dermatitis, 14 cases (14%) as folliculitis and perifolliculitis, 1 case (1%) as panniculitis, and 1 case (1%) as fibrosing dermatitis. The number of diagnostic entities represented within each of these patterns was small. Conclusions.—We believe that facial dermatitis should have its own more-circumscribed differential diagnosis. From a practical viewpoint, many of the inflammatory skin diseases that affect other parts of the body should be excluded from the differential diagnosis after the tissue is determined to be from a facial skin biopsy, and others should not be considered unless the biopsy is from the face.

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