scholarly journals Quality control in ultrasound: an experiment to assess the obsolescence of ultrasound probes with an agar gel phantom

2020 ◽  
Author(s):  
Collocola Alessio ◽  
Ortino Mario ◽  
Durante Stefano
Keyword(s):  
Quality Control ◽  
Low Cost ◽  
Control Programs ◽  
Global Status ◽  
Set Up ◽  
Almost All ◽  
And Storage ◽  
Ultrasound Scanner ◽  
Linear Geometry ◽  
Ultrasound Probes

The ultrasound scanner is the most installed equipment in the operating realities but it is not part of precise quality control programs like all other radiological equipment. Considering how many examinations are carried out, it seemed essential to set up intuitive and repeatable QCs, using instruments with low economic impact. The objectives were to test low-cost handmade phantoms to assess the uniformity and sensitivity of the ultrasound probes and the global status of the ultrasound scanners, confirm the goodness of the phantom in terms of use, functionality and storage, then compare the data collected between QC and the global status of the equipment looking for obsolescence causes. 25 linear geometry probes and 19 ultrasound scanners in 10 operating realities undergo quality control. To do this, a phantom in 5% agar-agar and a set of specially designed modules are created. The probes studied showed drops in uniformity and sensitivity already after 3 years with an average of 30 examinations and about 10h of power-on per day. In terms of uniformity, 65% of the probes did not reach acceptability. A condition of poor hygiene was detected in 74% of the ultrasound scanners. The phantom used was homogeneous and isoecogenic in almost all applications according to the professionals.

Assessment of computer workstations for compliance with ergonomic guidelines: A field study

Work ◽  
2021 ◽  
pp. 1-8
Author(s):  
Donna L Skelly
Keyword(s):  
Low Cost ◽  
Office Workers ◽  
Musculoskeletal Symptoms ◽  
Work Settings ◽  
Safe Work ◽  
Computer Workstation ◽  
Set Up ◽  
Almost All ◽  
Current Guidelines ◽  
Passing Score

BACKGROUND: Computer workstation use is a risk factor for the development of musculoskeletal disorders. Governmental guidelines have been developed as a resource for workstation set-up to minimize this risk. The degree of worksite compliance with guidelines has not been examined. OBJECTIVE: The purpose of this study was to examine workstations using the VDT Workstation Checklist to determine compliance, and potential modifications. METHODS: Subjects were recruited from a variety of work settings in Erie, PA. Workstations were assessed with the worker present, using the VDT Workstation Checklist. Adjustments and recommendations were made as appropriate. RESULTS: Of the 60 workstations examined, 48%did not receive a passing score. All but one were correctable to an acceptable level with minimal low-cost modifications. The recommendation for wrist rests (43%), changes in monitor height (30%) or position (27%) and reposition of the keyboard (13.3%) and mouse (13.3%) were the most frequent modifications. Ten (16.7%) workstations did not require modification. CONCLUSIONS: Almost half of workstations reviewed were not in compliance with current guidelines, however almost all (98%) could be brought into compliance with simple modifications. Office workers need guidance in setting up workspace and adjusting ergonomic equipment to provide comfortable and safe work settings and minimize musculoskeletal symptoms.

scholarly journals KASP: a genotyping method to rapid identification of resistance in Plasmodium falciparum

2020 ◽  
Author(s):  
Ana Alvarez-Fernandez ◽  
María J. Bernal ◽  
Isabel Fradejas Villajos ◽  
Alexandra Martín Ramírez ◽  
Noor Azian Md Yu ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Control ◽  
Low Cost ◽  
Reference Method ◽  
Rapid Identification ◽  
Control Programs ◽  
Specific Pcr ◽  
Antimalarial Resistance ◽  
Allele Specific ◽  
Almost All

Abstract BackgroundThe emergence and spread of antimalarial resistance continues to hinder malaria control. Plasmodium falciparum, the species that causes most human malaria cases and most deaths, has shown resistance to almost all known antimalarials. This antimalarial resistance arises from the development and subsequent expansion of Single Nucleotide Polymorfisms (SNPs) in specific parasite genes. A quick and cheap tool for the detection of drug resistance can be crucial and very useful for use in hospitals and in malaria control programs. It has been demonstrated in different contexts that genotyping by Kompetitive Allele Specific PCR (KASP), is a simple, fast and economical method that allows a high-precision biallelic characterization of SNPs, hence its possible utility in the study of resistance in P. falciparum.MethodsThree SNPs involved in most cases of resistance to the most widespread antimalarial treatments have been analyzed by PCR plus sequencing and by KASP (C580Y of the Kelch13 gene, Y86N of the Pfmdr1 gene and M133I of the Pfcytb gene). A total of 113 P. falciparum positive samples and 24 negative samples, previously analyzed by PCR and sequencing, were selected for this assay. Likewise, the samples were genotyped for the MSP-1 and MSP-2 genes, and the Multiplicity of Infection (MOI) and parasitaemia were measured to observe their possible influence on the KASP method.ResultsThe KASP results showed the same expected mutations and wild type genotypes as the reference method, with few exceptions that correlated with very low parasitaemia samples. In addition, two cases of heterozygotes that had not been detected by sequencing were found. No correlation was found between the MOI or parasitaemia and the KASP values of the sample. The reproducibility of the technique shows no oscillations between repetitions in any of the three SNPs analyzed.ConclusionsThe KASP assays developed in our study were efficient and versatile for the determination of the Plasmodium genotypes related to resistance. The method is simple, fast, reproducible with low cost in personnel, material and equipment and scalable, being able to core KASP arrays, including numerous SNPs, to complete the main pattern of mutations associated to P. falciparum resistance.

scholarly journals KASP: a genotyping method to rapid identification of resistance in Plasmodium falciparum

2020 ◽  
Author(s):  
Ana Alvarez-Fernandez ◽  
María J. Bernal ◽  
Isabel Fradejas Villajos ◽  
Alexandra Martín Ramírez ◽  
Noor Azian Md Yu ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Malaria Control ◽  
Low Cost ◽  
Reference Method ◽  
Rapid Identification ◽  
Control Programs ◽  
Specific Pcr ◽  
Antimalarial Resistance ◽  
Allele Specific ◽  
Almost All

Abstract Background The emergence and spread of antimalarial resistance continues to hinder malaria control. Plasmodium falciparum, the species that causes most human malaria cases and most deaths, has shown resistance to almost all known antimalarials. This antimalarial resistance arises from the development and subsequent expansion of Single Nucleotide Polymorfisms (SNPs) in specific parasite genes. A quick and cheap tool for the detection of drug resistance can be crucial and very useful for use in hospitals and in malaria control programs. It has been demonstrated in different contexts that genotyping by Kompetitive Allele Specific PCR (KASP), is a simple, fast and economical method that allows a high-precision biallelic characterization of SNPs, hence its possible utility in the study of resistance in P. falciparum. Methods Three SNPs involved in most cases of resistance to the most widespread antimalarial treatments have been analyzed by PCR plus sequencing and by KASP (C580Y of the Kelch13 gene, Y86N of the Pfmdr1 gene and M133I of the Pfcytb gene). A total of 113 P. falciparum positive samples and 24 negative samples, previously analyzed by PCR and sequencing, were selected for this assay. Likewise, the samples were genotyped for the MSP-1 and MSP-2 genes, and the Multiplicity of Infection (MOI) and parasitaemia were measured to observe their possible influence on the KASP method. Results The KASP results showed the same expected mutations and wild type genotypes as the reference method, with few exceptions that correlated with very low parasitaemia samples. In addition, two cases of heterozygotes that had not been detected by sequencing were found. No correlation was found between the MOI or parasitaemia and the KASP values of the sample. The reproducibility of the technique shows no oscillations between repetitions in any of the three SNPs analyzed. Conclusions The KASP assays developed in our study were efficient and versatile for the determination of the Plasmodium genotypes related to resistance. The method is simple, fast, reproducible with low cost in personnel, material and equipment and scalable, being able to core KASP arrays, including numerous SNPs, to complete the main pattern of mutations associated to P. falciparum resistance.

Characterization of Laboratory Working Standard for Quality Control of Immunometric and Radiometric Estrogen Receptor Assays. Clinical Evaluation on Breast Cancer Biopsies

1989 ◽  
Vol 75 (6) ◽  
pp. 550-556 ◽  
Author(s):  
Adriano Piffanelli ◽  
Dario Pelizzola ◽  
Gloria Giovannini ◽  
Laura Catozzi ◽  
Laura Faggioli ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Control ◽  
Estrogen Receptor ◽  
Monoclonal Antibodies ◽  
Low Cost ◽  
Working Standard ◽  
Standard Material ◽  
Quality Control Study ◽  
Receptor Assays ◽  
Set Up

The objective of the study was to characterize a low-cost and reliable working standard material for quality control of estrogen receptor (ER) determination with dextran-coated charcoal (DCC) and enzyme immunoassay (EIA) methods. Human fibromatous uterine lyophilized cytosol demonstrated good characteristics of stability and applicability for this purpose. Eleven laboratories participated in the intralaboratory and interlaboratory quality control study, and they achieved slightly higher coefficients of variation for ER-EIA (interlaboratory, 37.7 %; intralaboratory, 22.9 %) than for ER-DCC (Interlaboratory, 24.2 %; intralaboratory, 15.7 %). There was an excellent correlation between ER results with ER-EIA and ER-DCC for 268 breast cancer biopsies. Quality assurance for ER assays using DCC techniques and immunometric methods with monoclonal antibodies (ER-EIA) can be set up with this available material of human origin to satisfy the characteristics of both techniques and the species specificity of monoclonal antibodies.

Development of a Capacitor Probe to Detect Subsurface Deterioration in Concrete

1997 ◽  
Vol 503 ◽  
Author(s):  
B. K. Diefenderfer ◽  
I. L. Al-Qadi ◽  
J. J. Yoho ◽  
S. M. Riad ◽  
A. Loulizi
Keyword(s):  
Dielectric Constant ◽  
Portland Cement ◽  
Electromagnetic Waves ◽  
Low Cost ◽  
Complex Dielectric Constant ◽  
Life Cycle Costs ◽  
Parallel Plates ◽  
Portland Cement Concrete ◽  
Cement Concrete ◽  
Set Up

ABSTRACTPortland cement concrete (PCC) structures deteriorate with age and need to be maintained or replaced. Early detection of deterioration in PCC (e.g., alkali-silica reaction, freeze/thaw damage, or chloride presence) can lead to significant reductions in maintenance costs. However, it is often too late to perform low-cost preventative maintenance by the time deterioration becomes evident. By developing techniques that would enable civil engineers to evaluate PCC structures and detect deterioration at early stages (without causing further damage), optimization of life-cycle costs of the constructed facility and minimization of disturbance to the facility users can be achieved.Nondestructive evaluation (NDE) methods are potentially one of the most useful techniques ever developed for assessing constructed facilities. They are noninvasive and can be performed rapidly. Portland cement concrete can be nondestructively evaluated by electrically characterizing its complex dielectric constant. The real part of the dielectric constant depicts the velocity of electromagnetic waves in PCC. The imaginary part, termed the “loss factor,” describes the conductivity of PCC and the attenuation of electromagnetic waves.Dielectric properties of PCC have been investigated in a laboratory setting using a parallel plate capacitor operating in the frequency range of 0.1 to 40.1MIHz. This capacitor set-up consists of two horizontal-parallel plates with an adjustable separation for insertion of a dielectric specimen (PCC). While useful in research, this approach is not practical for field implementation. A new capacitor probe has been developed which consists of two plates, located within the same horizontal plane, for placement upon the specimen to be tested. Preliminary results show that this technique is feasible and results are promising; further testing and evaluation is currently underway.

HOUSEHOLD WATER BALANCE AND ASSESSMENT OF WATER VOLUME FOR IRRIGATION IN AGRO LANDSCAPES OF THE KYZYLSU-YUZHNAYA BASIN

2020 ◽  
pp. 102-109
Author(s):  
D.KH. DOMULLODZHANOV ◽  
◽  
R. RAHMATILLOEV
Keyword(s):  
Water Balance ◽  
River Basin ◽  
Water Use ◽  
Storage Systems ◽  
Low Cost ◽  
Field Studies ◽  
Water Volume ◽  
Land Productivity ◽  
Household Water ◽  
And Storage

The article presents the results of the field studies and observations that carried out on the territory of the hilly, low-mountain and foothill agro landscapes of the Kyzylsu-yuzhnaya (Kyzylsu-Southern) River Basin of Tajikistan. Taking into account the high-altitude location of households and the amount of precipitation in the river basin, the annual volumes of water accumulated with the use of low-cost systems of collection and storage of precipitation have been clarified. The amount of water accumulated in the precipitation collection and storage systems has been established, the volume of water used for communal and domestic needs,the watering of livestock and the amount of water that can be used to irrigate crops in the have been determined. Possible areas of irrigation of household plots depending on the different availability of precipitation have been determined. It has been established that in wet years (with precipitation of about 10%) the amount of water collected using drip irrigation will be sufficient for irrigation of 0.13 hectares, and in dry years (with 90% of precipitation) it will be possible to irrigate only 0.03 ha of the household plot. On the basis of the basin, the total area of irrigation in wet years can be 4497 ha, and in dry years only 1087 ha. Taking into account the forecasts of population growth by 2030 and an increase in the number of households, the total area of irrigation of farmlands in wet years may reach 5703 hectares,and in dry years – 1379 hectares. Growing crops on household plots under irrigation contributes to a significant increase in land productivity and increases the efficiency of water use of the Kyzylsu-yuzhnaya basin.

Fault Localization of Power-Ground Short via Signal Injection and Oscilloscope Technique

2010 ◽  
Author(s):  
Binh Nguyen
Keyword(s):  
Low Cost ◽  
Short Circuit ◽  
Fault Localization ◽  
Fault Isolation ◽  
Test Apparatus ◽  
Good Working ◽  
Signal Injection ◽  
Set Up ◽  
Non Destructive ◽  
Short Circuit Condition

Abstract For those attempting fault isolation on computer motherboard power-ground short issues, the optimal technique should utilize existing test equipment available in the debug facility, requiring no specialty equipment as well as needing a minimum of training to use effectively. The test apparatus should be both easy to set up and easy to use. This article describes the signal injection and oscilloscope technique which meets the above requirements. The signal injection and oscilloscope technique is based on the application of Ohm's law in a short-circuit condition. Two experiments were conducted to prove the effectiveness of these techniques. Both experiments simulate a short-circuit condition on the VCC3 power rail of a good working PC motherboard and then apply the signal injection and oscilloscope technique to localize the short. The technique described is a simple, low cost and non-destructive method that helps to find the location of the power-ground short quickly and effectively.

DRUG REGULATORY PROCEDURES IN TANZANIA: A GLIMPSE

2015 ◽  
Vol 3 (2) ◽  
pp. 1-7 ◽  
Author(s):  
Achin Jain ◽  
M P Venkatesh M P ◽  
Pramod T.M. Kumar
Keyword(s):  
Quality Control ◽  
Medical Devices ◽  
Emerging Market ◽  
Well Being ◽  
New Drugs ◽  
Regulatory Body ◽  
Herbal Drugs ◽  
Drug Products ◽  
Set Up

In Tanzania, Tanzania Food and Drugs Authority (TFDA), is a regulatory body responsible for controlling the quality,safety and effectiveness of food, drugs, herbal drugs, cosmetics and medical devices. The Authority has been ensuringsafety, efficacy and quality of medicines by quality control tests; in addition to other quality assessment mechanisms.The guidelines laid by TFDA have also emanated from commitment to democracy and gives strong emphasis to thefulfilment of the needs of the less privileged rural population.Tanzania is an emerging market; the pharmaceutical market is valued at over US$250 million, and is growing at anannual rate of around 16.5% and is expected to reach approximately US$550 billion in 2020. Currently, the market ishighly dependent on imports, which account for around 75% of the total pharmaceutical market.The procedures and approval requirements of new drugs, variations, import, export and disposal have been set up bythe TFDA, which help in maintaining quality of the drug products that are imported as well being produced locally 

scholarly journals Patients’ Perceived Satisfaction Through Telephone-Assisted Tele-Consultation During the SARS-CoV-2 Pandemic Period: Observational Single-Centre Study at a Tertiary-Referral Colorectal Surgery Department

2021 ◽  
pp. 155335062110080
Author(s):  
Lara Blanco Terés ◽  
Carlos Cerdán Santacruz ◽  
Javier García Septiem ◽  
Rocío Maqueda González ◽  
José María Lopesino González ◽  
...  
Keyword(s):  
Categorical Variables ◽  
Average Score ◽  
Job Status ◽  
Perceived Satisfaction ◽  
The Future ◽  
Chi Squared ◽  
Single Centre Study ◽  
Set Up ◽  
Almost All ◽  
Surgery Department

Introduction: The pandemic produced by SARS-CoV-2 has obliged us to set up the tele-assistance to offer a continuity of care. This implies an innovation, being the degree of satisfaction of patients unknown. Methods: A telephonic survey was conducted with the validated in the Spanish tool Telehealth Usability Questionnaire (Telehealth Usability Questionnaire; rating from 1-7) of all candidate patients assisted consecutively in the Coloproctology Unit. We included demographic variables, education level, job status, diagnosis and consultation type. A descriptive study was done. The relationship between the willingness of consultation model in the future (telemedicine vs traditional) and the categorical variables was analysed through the chi-squared test. Results: A total of 115 patients were included. The average age was 59.9 years, being 60% women. The average score in each of the survey items was higher than 6 in all the questions but 1. 26.1% of the surveyed patients confessed being advocated to tele-assistance in the future. The only factors related to greater willingness to tele-assistance were male gender (37% vs 18.8%; P = .03) and a higher academic preparation level in favour of higher technical studies (35.9%) and university studies (32.4%) opposite to the rest ( P = .043). The rest of variables studied, job status, labour regimen, diagnostic group and consultation type did not show any relationship. Conclusions: A vast majority of patients answered favourably to almost all the items of the survey. However, only 26.1% of them would choose a model of tele-assistance without restrictions.

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