A CLINICAL STUDY OF PATIENT WITH FEBRILE ILLNESS HOSPITALIZED IN HAMIDIA HOSPITAL BHOPAL

2021 ◽  
pp. 24-26
Author(s):  
Manish Modi ◽  
R.S. Jagat ◽  
R.R. Barde ◽  
Sudha Alawe ◽  
K.K. Kawre

Background: A better understanding of the prevalence and causes of undifferentiated febrile illness in the concerned geographic area would help in limiting the vast diagnostic workup to nd aetiological agent and guide to an optimal treatment to avoid unwanted usage of antibiotics and antimalarials. The present study was thus conducted to study etiological, hematological, clinical prole of patients presenting with undifferentiated febrile illness. Methodology: This was a cross sectional study on adults with acute febrile illness admitted in tertiary care Hospital Bhopal for a period of 2 years on acute illinfected patient belonging to age group of 18-70 years. Detailed history regarding presenting complaints along with ndings of general and systemic examination were documented in questionnaire. Blood samples were subjected to investigations to identify underlying etiology. Results: Mean age of 200 patients presenting with undifferentiated febrile illness was 39.67±17.4 years. Acute febrile illness without localizing sign was documented in 30% cases followed by LRTI (16.5%), CKD (6.5%), pneumonia (6%) and TBM (5.5%). WBC counts were raised (>11000) in 30% patients indicative of bacterial etiology whereas it was WBC counts were reduced in 2% patients suggestive of viral etiology. Platelet counts were decreased in around 43.5% patients in present study. Malarial parasite was observed in 1 (0.5%) patient whereas Widal test was positive in 3.5% patients. Conclusions: Knowledge regarding cause and clinical prole of AFIs in particular geographical area is helpful in early diagnosis and management such cases. In present study, the febrile illness presented without localizing sign whereas malaria and enteric fever were conrmed in only few cases. However non-specic test such as CBC and RFT, LFT were helpful in identifying underlying etiology as bacterial or viral.

2019 ◽  
Vol 114 (6) ◽  
pp. 408-414
Author(s):  
Charmaine P Mutucumarana ◽  
Champica K Bodinayake ◽  
Ajith Nagahawatte ◽  
Vasantha Devasiri ◽  
Ruvini Kurukulasooriya ◽  
...  

Abstract Background Dengue is a major cause of acute febrile illness in Sri Lanka. Dengue has historically been considered an urban disease. In 2012–2013, we documented that acute dengue was surprisingly associated with self-reported rural residence in the Southern Province of Sri Lanka. Methods Patients admitted with an acute febrile illness were enrolled from June 2012–May 2013 in a cross-sectional surveillance study at the largest tertiary care hospital in the Southern Province. Acute dengue was diagnosed by serology and virology testing. Site visits were performed to collect residential geographical coordinates. Spatial variation in odds of acute dengue was modeled using a spatial generalized additive model predicted onto a grid of coordinate pairs covering the Southern Province. Results Of 800 patients, 333 (41.6%) had laboratory-confirmed acute dengue. Dengue was spatially heterogeneous (local probability of acute dengue 0.26 to 0.42). There were higher than average odds of acute dengue in the rural northeast of the Southern Province and lower than average odds in the urbanized southwest of the Southern Province, including the city Galle. Conclusions Our study further affirms the emergence of dengue in rural southern Sri Lanka and highlights both the need for real-time geospatial analyses to optimize public health activities as well as the importance of strengthening dengue surveillance in non-urban areas.


2020 ◽  
Vol 7 (3) ◽  
pp. 404
Author(s):  
Mariraj I. ◽  
Mohammed Adil ◽  
Ramkumar M. ◽  
Jagadeesan M. ◽  
Prasanna Karthik S. ◽  
...  

Background: Acute febrile illness is very common among patients seeking hospital care in tropical country like India. This study was conducted to evaluate etiology and clinical profile of Acute Undifferentiated Febrile Illness (AUFI) in a tertiary care hospital.Methods: This study was conducted in 175 patients with acute febrile illness who were admitted in the medical wards and ICU from January 2018 to June 2019 in a tertiary care hospital. Clinical examination and investigations like complete hemogram, liver function test, renal function test, smear for malarial parasite, widal test, urine analysis blood and urine culture, antibody titters for dengue, Leptospirosis and imaging were done.Results: Out of 175, 94 (54%) were males and 81 (46%) were females. The commonest etiology was dengue (19%) followed by enteric fever (18%), scrub typhus (16%), malaria (14%), tuberculosis (6%) and leptospirosis (5%). 138 (79%) patients had less than 14 days of fever of which dengue was the most common and 37 (21%) patients had more than 14 days of fever with tuberculosis being predominate. Other common symptoms were chills/rigors, headache and myalgia seen in 77%, 71% and 42% respectively. Icterus was seen in malaria (42%) and leptospirosis (38%). Elevated transaminases levels were observed with dengue, leptospirosis, scrub typhus, enteric fever and malaria. ARDS was most common in scrub typhus.Conclusions: Among acute febrile illness, dengue and enteric fever were the most common in this study. A thorough and probing search for an eschar is very important in scrub typhus. The treating physician has to keep in mind the comprehensive list of differential diagnosis for patients with febrile illness and anticipating the complications.


Vacunas ◽  
2020 ◽  
Vol 21 (2) ◽  
pp. 95-104 ◽  
Author(s):  
Y.M. AlGoraini ◽  
N.N. AlDujayn ◽  
M.A. AlRasheed ◽  
Y.E. Bashawri ◽  
S.S. Alsubaie ◽  
...  

Author(s):  
Nandini Chatterjee ◽  
Supratick Chakraborty ◽  
Mainak Mukhopadhyay ◽  
Sinjon Ghosh ◽  
Bikramjit Barkandaj ◽  
...  

2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Nearmeen M. Rashad ◽  
Marwa G. Amer ◽  
Waleed M. Reda Ashour ◽  
Hassan M. Hassanin

Abstract Background Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system with varied clinical features. Disease-modifying drugs (DMDs) of MS associated with different types of thyroiditis. In this cross-sectional study, we aimed to assess the prevalence of thyroid dysfunction in MS and to investigate the association between DMDs and the risk of thyroiditis in MS. A cross-sectional study included 100 patients with relapsing-remitting multiple sclerosis (RRMS) in relapse, and the diagnosed was according to revised McDonald’s criteria 2010. Results Our results revealed that the prevalence of thyroiditis was 40%; autoimmune (34%) and infective (6%) among patients with RRMS in relapse and cerebellar symptoms were significantly higher in patients with thyroiditis compared to patients without thyroiditis. Regarding the association between DMDs and thyroiditis, the prevalence of patients treated with interferon-beta-1b was higher in MS patients with thyroiditis compared to MS patients without thyroiditis. However, the prevalence of patients treated with interferon-beta-1a was lower in MS patients with thyroiditis compared to MS patients without thyroiditis. In addition, we found CMV infection was more common in patients treated by interferon beta-1b and candida infection was common in patients treated by fingolimod. Conclusions Thyroiditis is commonly observed in patients with RRMS in relapse and higher prevalence of patients treated with interferon-beta-1b which is commonly associated with thyroiditis and CMV infection; however, candida thyroid infection was common in MS patients treated by fingolimod.


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